Amino acid dipepetide frequency for Trypanosoma cruzi Dm28c

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.365AlaAla: 10.365 ± 0.071	1.802AlaCys: 1.802 ± 0.025	3.386AlaAsp: 3.386 ± 0.027	5.636AlaGlu: 5.636 ± 0.038	2.883AlaPhe: 2.883 ± 0.024	5.17AlaGly: 5.17 ± 0.042	1.917AlaHis: 1.917 ± 0.021	3.126AlaIle: 3.126 ± 0.027	3.262AlaLys: 3.262 ± 0.032	8.585AlaLeu: 8.585 ± 0.055	2.205AlaMet: 2.205 ± 0.022	2.499AlaAsn: 2.499 ± 0.02	4.056AlaPro: 4.056 ± 0.031	2.813AlaGln: 2.813 ± 0.024	4.94AlaArg: 4.94 ± 0.037	7.002AlaSer: 7.002 ± 0.041	5.26AlaThr: 5.26 ± 0.038	7.162AlaVal: 7.162 ± 0.052	0.959AlaTrp: 0.959 ± 0.012	1.708AlaTyr: 1.708 ± 0.019	0.03AlaXaa: 0.03 ± 0.002
Cys	1.975CysAla: 1.975 ± 0.022	0.846CysCys: 0.846 ± 0.015	1.125CysAsp: 1.125 ± 0.014	1.077CysGlu: 1.077 ± 0.015	1.113CysPhe: 1.113 ± 0.018	2.09CysGly: 2.09 ± 0.025	0.553CysHis: 0.553 ± 0.011	0.883CysIle: 0.883 ± 0.014	0.638CysLys: 0.638 ± 0.012	1.899CysLeu: 1.899 ± 0.02	0.496CysMet: 0.496 ± 0.011	0.676CysAsn: 0.676 ± 0.012	0.929CysPro: 0.929 ± 0.015	0.569CysGln: 0.569 ± 0.01	1.544CysArg: 1.544 ± 0.019	1.754CysSer: 1.754 ± 0.019	1.207CysThr: 1.207 ± 0.017	2.371CysVal: 2.371 ± 0.032	0.272CysTrp: 0.272 ± 0.007	0.525CysTyr: 0.525 ± 0.012	0.009CysXaa: 0.009 ± 0.001
Asp	5.105AspAla: 5.105 ± 0.036	0.836AspCys: 0.836 ± 0.014	3.428AspAsp: 3.428 ± 0.039	3.86AspGlu: 3.86 ± 0.038	1.548AspPhe: 1.548 ± 0.019	4.789AspGly: 4.789 ± 0.046	0.847AspHis: 0.847 ± 0.014	1.994AspIle: 1.994 ± 0.019	1.764AspLys: 1.764 ± 0.024	3.305AspLeu: 3.305 ± 0.028	0.995AspMet: 0.995 ± 0.015	1.719AspAsn: 1.719 ± 0.018	2.197AspPro: 2.197 ± 0.025	0.977AspGln: 0.977 ± 0.013	2.333AspArg: 2.333 ± 0.022	3.132AspSer: 3.132 ± 0.024	2.671AspThr: 2.671 ± 0.024	4.275AspVal: 4.275 ± 0.029	0.521AspTrp: 0.521 ± 0.01	1.014AspTyr: 1.014 ± 0.015	0.011AspXaa: 0.011 ± 0.002
Glu	5.724GluAla: 5.724 ± 0.043	1.062GluCys: 1.062 ± 0.015	3.569GluAsp: 3.569 ± 0.03	7.831GluGlu: 7.831 ± 0.071	1.859GluPhe: 1.859 ± 0.022	4.81GluGly: 4.81 ± 0.032	1.409GluHis: 1.409 ± 0.018	2.344GluIle: 2.344 ± 0.026	4.65GluLys: 4.65 ± 0.045	5.891GluLeu: 5.891 ± 0.044	1.897GluMet: 1.897 ± 0.019	2.761GluAsn: 2.761 ± 0.028	2.131GluPro: 2.131 ± 0.023	2.49GluGln: 2.49 ± 0.026	5.096GluArg: 5.096 ± 0.039	4.303GluSer: 4.303 ± 0.031	3.471GluThr: 3.471 ± 0.028	4.499GluVal: 4.499 ± 0.035	0.893GluTrp: 0.893 ± 0.014	1.53GluTyr: 1.53 ± 0.016	0.015GluXaa: 0.015 ± 0.002
Phe	2.896PheAla: 2.896 ± 0.027	1.128PheCys: 1.128 ± 0.017	1.764PheAsp: 1.764 ± 0.02	1.65PheGlu: 1.65 ± 0.019	2.723PhePhe: 2.723 ± 0.032	2.197PheGly: 2.197 ± 0.02	0.93PheHis: 0.93 ± 0.013	1.649PheIle: 1.649 ± 0.02	1.006PheLys: 1.006 ± 0.016	4.42PheLeu: 4.42 ± 0.034	0.806PheMet: 0.806 ± 0.012	1.051PheAsn: 1.051 ± 0.016	1.894PhePro: 1.894 ± 0.018	1.049PheGln: 1.049 ± 0.014	1.96PheArg: 1.96 ± 0.018	3.5PheSer: 3.5 ± 0.028	2.155PheThr: 2.155 ± 0.019	2.983PheVal: 2.983 ± 0.028	0.416PheTrp: 0.416 ± 0.009	1.166PheTyr: 1.166 ± 0.015	0.014PheXaa: 0.014 ± 0.002
Gly	5.57GlyAla: 5.57 ± 0.051	1.535GlyCys: 1.535 ± 0.02	3.819GlyAsp: 3.819 ± 0.035	4.599GlyGlu: 4.599 ± 0.038	2.144GlyPhe: 2.144 ± 0.023	6.64GlyGly: 6.64 ± 0.074	1.424GlyHis: 1.424 ± 0.02	2.708GlyIle: 2.708 ± 0.027	3.349GlyLys: 3.349 ± 0.032	4.717GlyLeu: 4.717 ± 0.029	1.602GlyMet: 1.602 ± 0.017	3.089GlyAsn: 3.089 ± 0.034	2.242GlyPro: 2.242 ± 0.023	1.787GlyGln: 1.787 ± 0.02	4.431GlyArg: 4.431 ± 0.038	5.76GlySer: 5.76 ± 0.048	4.144GlyThr: 4.144 ± 0.033	5.608GlyVal: 5.608 ± 0.048	0.748GlyTrp: 0.748 ± 0.013	1.357GlyTyr: 1.357 ± 0.016	0.029GlyXaa: 0.029 ± 0.002
His	2.35HisAla: 2.35 ± 0.027	0.682HisCys: 0.682 ± 0.013	1.174HisAsp: 1.174 ± 0.014	1.536HisGlu: 1.536 ± 0.02	1.127HisPhe: 1.127 ± 0.015	1.758HisGly: 1.758 ± 0.02	1.002HisHis: 1.002 ± 0.018	1.076HisIle: 1.076 ± 0.014	0.882HisLys: 0.882 ± 0.015	2.343HisLeu: 2.343 ± 0.024	0.54HisMet: 0.54 ± 0.011	0.917HisAsn: 0.917 ± 0.014	1.464HisPro: 1.464 ± 0.019	0.974HisGln: 0.974 ± 0.014	2.127HisArg: 2.127 ± 0.026	2.023HisSer: 2.023 ± 0.021	1.779HisThr: 1.779 ± 0.021	2.033HisVal: 2.033 ± 0.02	0.319HisTrp: 0.319 ± 0.008	0.663HisTyr: 0.663 ± 0.012	0.006HisXaa: 0.006 ± 0.001
Ile	3.327IleAla: 3.327 ± 0.027	0.798IleCys: 0.798 ± 0.012	1.875IleAsp: 1.875 ± 0.02	2.149IleGlu: 2.149 ± 0.024	1.584IlePhe: 1.584 ± 0.021	2.348IleGly: 2.348 ± 0.025	1.125IleHis: 1.125 ± 0.015	1.784IleIle: 1.784 ± 0.02	1.451IleLys: 1.451 ± 0.018	3.579IleLeu: 3.579 ± 0.029	0.829IleMet: 0.829 ± 0.012	1.267IleAsn: 1.267 ± 0.019	2.312IlePro: 2.312 ± 0.019	1.363IleGln: 1.363 ± 0.018	2.398IleArg: 2.398 ± 0.024	3.018IleSer: 3.018 ± 0.027	2.302IleThr: 2.302 ± 0.024	2.932IleVal: 2.932 ± 0.027	0.35IleTrp: 0.35 ± 0.008	1.12IleTyr: 1.12 ± 0.016	0.011IleXaa: 0.011 ± 0.002
Lys	3.15LysAla: 3.15 ± 0.034	0.688LysCys: 0.688 ± 0.011	2.43LysAsp: 2.43 ± 0.029	4.244LysGlu: 4.244 ± 0.041	1.069LysPhe: 1.069 ± 0.016	3.071LysGly: 3.071 ± 0.033	1.046LysHis: 1.046 ± 0.016	1.599LysIle: 1.599 ± 0.021	3.858LysLys: 3.858 ± 0.044	3.59LysLeu: 3.59 ± 0.033	1.165LysMet: 1.165 ± 0.016	1.937LysAsn: 1.937 ± 0.022	1.631LysPro: 1.631 ± 0.019	1.85LysGln: 1.85 ± 0.018	3.468LysArg: 3.468 ± 0.033	2.793LysSer: 2.793 ± 0.028	2.559LysThr: 2.559 ± 0.022	2.358LysVal: 2.358 ± 0.024	0.591LysTrp: 0.591 ± 0.01	1.049LysTyr: 1.049 ± 0.016	0.016LysXaa: 0.016 ± 0.002
Leu	6.51LeuAla: 6.51 ± 0.046	2.545LeuCys: 2.545 ± 0.022	3.655LeuAsp: 3.655 ± 0.032	5.712LeuGlu: 5.712 ± 0.044	4.108LeuPhe: 4.108 ± 0.038	4.828LeuGly: 4.828 ± 0.032	2.935LeuHis: 2.935 ± 0.028	3.24LeuIle: 3.24 ± 0.028	3.51LeuLys: 3.51 ± 0.034	12.284LeuLeu: 12.284 ± 0.068	2.278LeuMet: 2.278 ± 0.021	2.929LeuAsn: 2.929 ± 0.024	5.435LeuPro: 5.435 ± 0.037	4.644LeuGln: 4.644 ± 0.036	7.823LeuArg: 7.823 ± 0.054	7.969LeuSer: 7.969 ± 0.043	4.99LeuThr: 4.99 ± 0.029	6.184LeuVal: 6.184 ± 0.044	1.41LeuTrp: 1.41 ± 0.016	2.608LeuTyr: 2.608 ± 0.026	0.027LeuXaa: 0.027 ± 0.002
Met	1.902MetAla: 1.902 ± 0.018	0.553MetCys: 0.553 ± 0.01	1.266MetAsp: 1.266 ± 0.016	1.841MetGlu: 1.841 ± 0.023	0.661MetPhe: 0.661 ± 0.012	1.345MetGly: 1.345 ± 0.015	0.714MetHis: 0.714 ± 0.013	0.779MetIle: 0.779 ± 0.012	1.191MetLys: 1.191 ± 0.015	2.35MetLeu: 2.35 ± 0.02	0.935MetMet: 0.935 ± 0.016	0.989MetAsn: 0.989 ± 0.015	1.197MetPro: 1.197 ± 0.018	1.098MetGln: 1.098 ± 0.015	2.005MetArg: 2.005 ± 0.019	1.748MetSer: 1.748 ± 0.018	1.397MetThr: 1.397 ± 0.015	1.339MetVal: 1.339 ± 0.016	0.3MetTrp: 0.3 ± 0.008	0.583MetTyr: 0.583 ± 0.01	0.006MetXaa: 0.006 ± 0.001
Asn	3.296AsnAla: 3.296 ± 0.024	0.759AsnCys: 0.759 ± 0.012	2.004AsnAsp: 2.004 ± 0.019	2.501AsnGlu: 2.501 ± 0.028	1.278AsnPhe: 1.278 ± 0.018	2.837AsnGly: 2.837 ± 0.026	0.737AsnHis: 0.737 ± 0.013	1.499AsnIle: 1.499 ± 0.02	1.794AsnLys: 1.794 ± 0.024	2.391AsnLeu: 2.391 ± 0.026	0.828AsnMet: 0.828 ± 0.014	1.821AsnAsn: 1.821 ± 0.029	1.613AsnPro: 1.613 ± 0.019	0.938AsnGln: 0.938 ± 0.013	2.067AsnArg: 2.067 ± 0.019	2.831AsnSer: 2.831 ± 0.026	2.357AsnThr: 2.357 ± 0.024	2.639AsnVal: 2.639 ± 0.026	0.359AsnTrp: 0.359 ± 0.008	0.865AsnTyr: 0.865 ± 0.014	0.008AsnXaa: 0.008 ± 0.001
Pro	3.75ProAla: 3.75 ± 0.034	0.958ProCys: 0.958 ± 0.017	1.772ProAsp: 1.772 ± 0.02	2.65ProGlu: 2.65 ± 0.025	2.011ProPhe: 2.011 ± 0.022	2.403ProGly: 2.403 ± 0.026	1.651ProHis: 1.651 ± 0.019	1.736ProIle: 1.736 ± 0.021	1.855ProLys: 1.855 ± 0.021	5.25ProLeu: 5.25 ± 0.038	0.994ProMet: 0.994 ± 0.014	1.55ProAsn: 1.55 ± 0.02	4.323ProPro: 4.323 ± 0.046	2.178ProGln: 2.178 ± 0.019	3.183ProArg: 3.183 ± 0.027	5.038ProSer: 5.038 ± 0.034	3.172ProThr: 3.172 ± 0.025	3.543ProVal: 3.543 ± 0.026	0.539ProTrp: 0.539 ± 0.01	1.073ProTyr: 1.073 ± 0.015	0.021ProXaa: 0.021 ± 0.002
Gln	2.307GlnAla: 2.307 ± 0.023	0.739GlnCys: 0.739 ± 0.012	1.239GlnAsp: 1.239 ± 0.016	2.782GlnGlu: 2.782 ± 0.025	1.111GlnPhe: 1.111 ± 0.015	1.955GlnGly: 1.955 ± 0.022	1.283GlnHis: 1.283 ± 0.019	1.247GlnIle: 1.247 ± 0.017	1.998GlnLys: 1.998 ± 0.022	4.151GlnLeu: 4.151 ± 0.036	0.924GlnMet: 0.924 ± 0.014	1.275GlnAsn: 1.275 ± 0.017	1.785GlnPro: 1.785 ± 0.022	3.075GlnGln: 3.075 ± 0.05	3.776GlnArg: 3.776 ± 0.031	2.552GlnSer: 2.552 ± 0.026	1.848GlnThr: 1.848 ± 0.02	1.971GlnVal: 1.971 ± 0.02	0.543GlnTrp: 0.543 ± 0.011	0.878GlnTyr: 0.878 ± 0.013	0.012GlnXaa: 0.012 ± 0.001
Arg	4.995ArgAla: 4.995 ± 0.036	1.794ArgCys: 1.794 ± 0.021	3.274ArgAsp: 3.274 ± 0.027	5.255ArgGlu: 5.255 ± 0.041	2.235ArgPhe: 2.235 ± 0.024	4.6ArgGly: 4.6 ± 0.032	2.426ArgHis: 2.426 ± 0.03	2.754ArgIle: 2.754 ± 0.028	3.054ArgLys: 3.054 ± 0.027	6.437ArgLeu: 6.437 ± 0.038	1.73ArgMet: 1.73 ± 0.02	2.479ArgAsn: 2.479 ± 0.022	3.101ArgPro: 3.101 ± 0.024	3.161ArgGln: 3.161 ± 0.032	7.355ArgArg: 7.355 ± 0.061	4.875ArgSer: 4.875 ± 0.037	3.419ArgThr: 3.419 ± 0.035	5.232ArgVal: 5.232 ± 0.036	0.978ArgTrp: 0.978 ± 0.017	1.652ArgTyr: 1.652 ± 0.019	0.021ArgXaa: 0.021 ± 0.002
Ser	6.446SerAla: 6.446 ± 0.04	1.723SerCys: 1.723 ± 0.024	3.545SerAsp: 3.545 ± 0.029	4.078SerGlu: 4.078 ± 0.03	3.235SerPhe: 3.235 ± 0.029	5.901SerGly: 5.901 ± 0.046	2.162SerHis: 2.162 ± 0.02	3.036SerIle: 3.036 ± 0.023	2.84SerLys: 2.84 ± 0.026	7.988SerLeu: 7.988 ± 0.045	1.747SerMet: 1.747 ± 0.021	2.624SerAsn: 2.624 ± 0.027	4.561SerPro: 4.561 ± 0.037	2.676SerGln: 2.676 ± 0.023	5.113SerArg: 5.113 ± 0.035	8.545SerSer: 8.545 ± 0.065	5.186SerThr: 5.186 ± 0.039	6.089SerVal: 6.089 ± 0.048	1.001SerTrp: 1.001 ± 0.013	1.569SerTyr: 1.569 ± 0.02	0.025SerXaa: 0.025 ± 0.002
Thr	5.865ThrAla: 5.865 ± 0.043	0.984ThrCys: 0.984 ± 0.014	2.578ThrAsp: 2.578 ± 0.025	3.646ThrGlu: 3.646 ± 0.027	1.924ThrPhe: 1.924 ± 0.02	3.588ThrGly: 3.588 ± 0.027	1.799ThrHis: 1.799 ± 0.022	2.265ThrIle: 2.265 ± 0.019	2.293ThrLys: 2.293 ± 0.024	5.526ThrLeu: 5.526 ± 0.037	1.277ThrMet: 1.277 ± 0.017	1.995ThrAsn: 1.995 ± 0.02	3.606ThrPro: 3.606 ± 0.028	2.124ThrGln: 2.124 ± 0.022	3.55ThrArg: 3.55 ± 0.031	4.552ThrSer: 4.552 ± 0.033	4.458ThrThr: 4.458 ± 0.045	4.845ThrVal: 4.845 ± 0.032	0.762ThrTrp: 0.762 ± 0.013	1.058ThrTyr: 1.058 ± 0.015	0.021ThrXaa: 0.021 ± 0.002
Val	6.498ValAla: 6.498 ± 0.047	2.137ValCys: 2.137 ± 0.028	3.684ValAsp: 3.684 ± 0.032	4.855ValGlu: 4.855 ± 0.035	3.198ValPhe: 3.198 ± 0.028	4.627ValGly: 4.627 ± 0.042	1.837ValHis: 1.837 ± 0.019	2.533ValIle: 2.533 ± 0.028	3.076ValLys: 3.076 ± 0.033	7.612ValLeu: 7.612 ± 0.056	1.877ValMet: 1.877 ± 0.02	2.357ValAsn: 2.357 ± 0.021	3.715ValPro: 3.715 ± 0.029	2.435ValGln: 2.435 ± 0.019	4.874ValArg: 4.874 ± 0.035	6.105ValSer: 6.105 ± 0.041	4.416ValThr: 4.416 ± 0.032	6.148ValVal: 6.148 ± 0.055	0.95ValTrp: 0.95 ± 0.014	1.802ValTyr: 1.802 ± 0.02	0.029ValXaa: 0.029 ± 0.002
Trp	0.79TrpAla: 0.79 ± 0.014	0.414TrpCys: 0.414 ± 0.009	0.542TrpAsp: 0.542 ± 0.01	0.833TrpGlu: 0.833 ± 0.014	0.364TrpPhe: 0.364 ± 0.008	0.774TrpGly: 0.774 ± 0.015	0.342TrpHis: 0.342 ± 0.008	0.511TrpIle: 0.511 ± 0.011	0.818TrpLys: 0.818 ± 0.015	1.107TrpLeu: 1.107 ± 0.015	0.401TrpMet: 0.401 ± 0.008	0.485TrpAsn: 0.485 ± 0.008	0.502TrpPro: 0.502 ± 0.01	0.505TrpGln: 0.505 ± 0.01	1.228TrpArg: 1.228 ± 0.016	0.92TrpSer: 0.92 ± 0.017	0.695TrpThr: 0.695 ± 0.012	0.714TrpVal: 0.714 ± 0.012	0.242TrpTrp: 0.242 ± 0.007	0.296TrpTyr: 0.296 ± 0.008	0.003TrpXaa: 0.003 ± 0.001
Tyr	1.925TyrAla: 1.925 ± 0.023	0.551TyrCys: 0.551 ± 0.01	1.182TyrAsp: 1.182 ± 0.015	1.487TyrGlu: 1.487 ± 0.02	1.159TyrPhe: 1.159 ± 0.017	1.547TyrGly: 1.547 ± 0.018	0.628TyrHis: 0.628 ± 0.011	1.149TyrIle: 1.149 ± 0.018	0.859TyrLys: 0.859 ± 0.015	2.169TyrLeu: 2.169 ± 0.022	0.666TyrMet: 0.666 ± 0.011	0.992TyrAsn: 0.992 ± 0.014	0.939TyrPro: 0.939 ± 0.017	0.737TyrGln: 0.737 ± 0.012	1.528TyrArg: 1.528 ± 0.018	1.646TyrSer: 1.646 ± 0.017	1.213TyrThr: 1.213 ± 0.017	1.817TyrVal: 1.817 ± 0.02	0.325TyrTrp: 0.325 ± 0.008	0.741TyrTyr: 0.741 ± 0.013	0.007TyrXaa: 0.007 ± 0.001
Xaa	0.022XaaAla: 0.022 ± 0.002	0.016XaaCys: 0.016 ± 0.002	0.011XaaAsp: 0.011 ± 0.001	0.013XaaGlu: 0.013 ± 0.001	0.023XaaPhe: 0.023 ± 0.002	0.023XaaGly: 0.023 ± 0.002	0.008XaaHis: 0.008 ± 0.001	0.009XaaIle: 0.009 ± 0.001	0.017XaaLys: 0.017 ± 0.002	0.031XaaLeu: 0.031 ± 0.003	0.009XaaMet: 0.009 ± 0.001	0.01XaaAsn: 0.01 ± 0.002	0.018XaaPro: 0.018 ± 0.002	0.009XaaGln: 0.009 ± 0.001	0.028XaaArg: 0.028 ± 0.002	0.023XaaSer: 0.023 ± 0.002	0.016XaaThr: 0.016 ± 0.002	0.021XaaVal: 0.021 ± 0.002	0.005XaaTrp: 0.005 ± 0.001	0.008XaaTyr: 0.008 ± 0.001	0.794XaaXaa: 0.794 ± 0.019

Statistics based on 11346 proteins (5280116 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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