Amino acid dipepetide frequency for Bacteroides pyogenes JCM 6292

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.044AlaAla: 6.044 ± 0.096	1.085AlaCys: 1.085 ± 0.035	4.453AlaAsp: 4.453 ± 0.065	5.037AlaGlu: 5.037 ± 0.074	3.363AlaPhe: 3.363 ± 0.067	5.593AlaGly: 5.593 ± 0.081	1.295AlaHis: 1.295 ± 0.039	4.561AlaIle: 4.561 ± 0.076	4.161AlaLys: 4.161 ± 0.078	6.742AlaLeu: 6.742 ± 0.091	2.034AlaMet: 2.034 ± 0.045	3.162AlaAsn: 3.162 ± 0.066	2.317AlaPro: 2.317 ± 0.048	2.56AlaGln: 2.56 ± 0.047	3.539AlaArg: 3.539 ± 0.06	4.39AlaSer: 4.39 ± 0.085	3.712AlaThr: 3.712 ± 0.071	5.082AlaVal: 5.082 ± 0.084	0.898AlaTrp: 0.898 ± 0.029	3.04AlaTyr: 3.04 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.772CysAla: 0.772 ± 0.032	0.228CysCys: 0.228 ± 0.018	0.609CysAsp: 0.609 ± 0.028	0.683CysGlu: 0.683 ± 0.027	0.688CysPhe: 0.688 ± 0.029	1.016CysGly: 1.016 ± 0.037	0.279CysHis: 0.279 ± 0.017	0.88CysIle: 0.88 ± 0.031	0.71CysLys: 0.71 ± 0.03	1.082CysLeu: 1.082 ± 0.035	0.324CysMet: 0.324 ± 0.018	0.52CysAsn: 0.52 ± 0.024	0.525CysPro: 0.525 ± 0.025	0.284CysGln: 0.284 ± 0.017	0.766CysArg: 0.766 ± 0.029	0.799CysSer: 0.799 ± 0.031	0.621CysThr: 0.621 ± 0.023	0.722CysVal: 0.722 ± 0.025	0.142CysTrp: 0.142 ± 0.012	0.493CysTyr: 0.493 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.921AspAla: 3.921 ± 0.062	0.573AspCys: 0.573 ± 0.028	2.471AspAsp: 2.471 ± 0.052	3.953AspGlu: 3.953 ± 0.068	3.005AspPhe: 3.005 ± 0.052	3.942AspGly: 3.942 ± 0.081	0.79AspHis: 0.79 ± 0.03	3.855AspIle: 3.855 ± 0.065	3.836AspLys: 3.836 ± 0.073	4.592AspLeu: 4.592 ± 0.075	1.522AspMet: 1.522 ± 0.041	2.51AspAsn: 2.51 ± 0.051	1.891AspPro: 1.891 ± 0.041	0.993AspGln: 0.993 ± 0.035	2.764AspArg: 2.764 ± 0.059	3.054AspSer: 3.054 ± 0.062	2.684AspThr: 2.684 ± 0.053	3.49AspVal: 3.49 ± 0.069	0.791AspTrp: 0.791 ± 0.033	2.711AspTyr: 2.711 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.186GluAla: 5.186 ± 0.091	0.617GluCys: 0.617 ± 0.028	3.087GluAsp: 3.087 ± 0.064	5.541GluGlu: 5.541 ± 0.097	2.553GluPhe: 2.553 ± 0.056	4.282GluGly: 4.282 ± 0.077	1.269GluHis: 1.269 ± 0.039	4.678GluIle: 4.678 ± 0.072	5.582GluLys: 5.582 ± 0.084	6.199GluLeu: 6.199 ± 0.09	2.152GluMet: 2.152 ± 0.046	3.461GluAsn: 3.461 ± 0.056	1.81GluPro: 1.81 ± 0.046	2.621GluGln: 2.621 ± 0.058	3.61GluArg: 3.61 ± 0.065	3.427GluSer: 3.427 ± 0.064	3.436GluThr: 3.436 ± 0.052	4.429GluVal: 4.429 ± 0.063	0.87GluTrp: 0.87 ± 0.031	2.801GluTyr: 2.801 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.246PheAla: 3.246 ± 0.054	0.664PheCys: 0.664 ± 0.024	2.777PheAsp: 2.777 ± 0.055	2.629PheGlu: 2.629 ± 0.053	2.462PhePhe: 2.462 ± 0.059	3.266PheGly: 3.266 ± 0.073	0.956PheHis: 0.956 ± 0.03	3.042PheIle: 3.042 ± 0.055	2.456PheLys: 2.456 ± 0.048	4.195PheLeu: 4.195 ± 0.075	1.256PheMet: 1.256 ± 0.032	2.279PheAsn: 2.279 ± 0.053	1.83PhePro: 1.83 ± 0.046	1.196PheGln: 1.196 ± 0.034	2.491PheArg: 2.491 ± 0.057	3.512PheSer: 3.512 ± 0.063	2.769PheThr: 2.769 ± 0.05	2.87PheVal: 2.87 ± 0.054	0.514PheTrp: 0.514 ± 0.023	1.935PheTyr: 1.935 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.634GlyAla: 4.634 ± 0.073	0.865GlyCys: 0.865 ± 0.03	3.484GlyAsp: 3.484 ± 0.064	4.387GlyGlu: 4.387 ± 0.068	3.204GlyPhe: 3.204 ± 0.067	4.891GlyGly: 4.891 ± 0.083	1.28GlyHis: 1.28 ± 0.035	5.336GlyIle: 5.336 ± 0.071	5.611GlyLys: 5.611 ± 0.082	5.728GlyLeu: 5.728 ± 0.086	2.277GlyMet: 2.277 ± 0.047	3.521GlyAsn: 3.521 ± 0.065	1.277GlyPro: 1.277 ± 0.038	1.997GlyGln: 1.997 ± 0.045	3.19GlyArg: 3.19 ± 0.062	4.103GlySer: 4.103 ± 0.069	4.073GlyThr: 4.073 ± 0.066	4.856GlyVal: 4.856 ± 0.073	1.024GlyTrp: 1.024 ± 0.036	3.312GlyTyr: 3.312 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.311HisAla: 1.311 ± 0.033	0.28HisCys: 0.28 ± 0.018	0.887HisAsp: 0.887 ± 0.031	1.102HisGlu: 1.102 ± 0.038	1.056HisPhe: 1.056 ± 0.035	1.248HisGly: 1.248 ± 0.037	0.463HisHis: 0.463 ± 0.022	1.432HisIle: 1.432 ± 0.036	1.066HisLys: 1.066 ± 0.033	1.863HisLeu: 1.863 ± 0.047	0.326HisMet: 0.326 ± 0.017	0.841HisAsn: 0.841 ± 0.029	1.077HisPro: 1.077 ± 0.034	0.578HisGln: 0.578 ± 0.026	1.127HisArg: 1.127 ± 0.036	1.195HisSer: 1.195 ± 0.038	1.053HisThr: 1.053 ± 0.03	1.054HisVal: 1.054 ± 0.035	0.241HisTrp: 0.241 ± 0.017	0.877HisTyr: 0.877 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.374IleAla: 5.374 ± 0.075	0.891IleCys: 0.891 ± 0.027	4.26IleAsp: 4.26 ± 0.072	4.522IleGlu: 4.522 ± 0.09	2.646IlePhe: 2.646 ± 0.057	4.772IleGly: 4.772 ± 0.069	1.309IleHis: 1.309 ± 0.037	4.131IleIle: 4.131 ± 0.086	4.039IleLys: 4.039 ± 0.071	5.738IleLeu: 5.738 ± 0.089	1.432IleMet: 1.432 ± 0.044	3.126IleAsn: 3.126 ± 0.062	3.059IlePro: 3.059 ± 0.057	1.964IleGln: 1.964 ± 0.046	3.922IleArg: 3.922 ± 0.064	4.45IleSer: 4.45 ± 0.074	3.813IleThr: 3.813 ± 0.061	4.177IleVal: 4.177 ± 0.07	0.654IleTrp: 0.654 ± 0.028	2.632IleTyr: 2.632 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.199LysAla: 5.199 ± 0.076	0.55LysCys: 0.55 ± 0.023	3.788LysAsp: 3.788 ± 0.067	6.17LysGlu: 6.17 ± 0.091	2.169LysPhe: 2.169 ± 0.048	4.808LysGly: 4.808 ± 0.066	1.31LysHis: 1.31 ± 0.038	4.242LysIle: 4.242 ± 0.065	5.487LysLys: 5.487 ± 0.084	5.375LysLeu: 5.375 ± 0.077	2.115LysMet: 2.115 ± 0.055	3.489LysAsn: 3.489 ± 0.068	2.25LysPro: 2.25 ± 0.052	2.633LysGln: 2.633 ± 0.054	3.631LysArg: 3.631 ± 0.054	3.384LysSer: 3.384 ± 0.062	3.674LysThr: 3.674 ± 0.055	4.286LysVal: 4.286 ± 0.078	0.795LysTrp: 0.795 ± 0.029	2.877LysTyr: 2.877 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.275LeuAla: 6.275 ± 0.091	1.315LeuCys: 1.315 ± 0.037	4.338LeuAsp: 4.338 ± 0.066	4.985LeuGlu: 4.985 ± 0.07	4.649LeuPhe: 4.649 ± 0.085	5.44LeuGly: 5.44 ± 0.071	1.849LeuHis: 1.849 ± 0.053	5.626LeuIle: 5.626 ± 0.092	6.508LeuLys: 6.508 ± 0.087	9.051LeuLeu: 9.051 ± 0.129	2.427LeuMet: 2.427 ± 0.054	4.582LeuAsn: 4.582 ± 0.079	4.32LeuPro: 4.32 ± 0.069	3.255LeuGln: 3.255 ± 0.054	4.739LeuArg: 4.739 ± 0.073	6.85LeuSer: 6.85 ± 0.093	5.142LeuThr: 5.142 ± 0.072	4.799LeuVal: 4.799 ± 0.073	1.001LeuTrp: 1.001 ± 0.033	3.509LeuTyr: 3.509 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.09MetAla: 2.09 ± 0.05	0.227MetCys: 0.227 ± 0.015	1.428MetAsp: 1.428 ± 0.037	1.916MetGlu: 1.916 ± 0.046	1.045MetPhe: 1.045 ± 0.035	1.92MetGly: 1.92 ± 0.046	0.477MetHis: 0.477 ± 0.025	1.658MetIle: 1.658 ± 0.044	2.693MetLys: 2.693 ± 0.053	2.46MetLeu: 2.46 ± 0.051	0.814MetMet: 0.814 ± 0.033	1.697MetAsn: 1.697 ± 0.04	1.23MetPro: 1.23 ± 0.037	1.056MetGln: 1.056 ± 0.032	1.468MetArg: 1.468 ± 0.041	1.518MetSer: 1.518 ± 0.048	1.41MetThr: 1.41 ± 0.036	1.579MetVal: 1.579 ± 0.042	0.238MetTrp: 0.238 ± 0.015	0.883MetTyr: 0.883 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.436AsnAla: 3.436 ± 0.064	0.459AsnCys: 0.459 ± 0.023	2.479AsnAsp: 2.479 ± 0.056	3.03AsnGlu: 3.03 ± 0.05	2.149AsnPhe: 2.149 ± 0.051	3.62AsnGly: 3.62 ± 0.063	0.958AsnHis: 0.958 ± 0.034	3.614AsnIle: 3.614 ± 0.059	3.198AsnLys: 3.198 ± 0.071	4.245AsnLeu: 4.245 ± 0.073	1.304AsnMet: 1.304 ± 0.034	2.408AsnAsn: 2.408 ± 0.056	2.489AsnPro: 2.489 ± 0.049	1.427AsnGln: 1.427 ± 0.042	2.736AsnArg: 2.736 ± 0.054	2.67AsnSer: 2.67 ± 0.056	2.492AsnThr: 2.492 ± 0.052	3.163AsnVal: 3.163 ± 0.057	0.588AsnTrp: 0.588 ± 0.026	2.204AsnTyr: 2.204 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.964ProAla: 2.964 ± 0.066	0.408ProCys: 0.408 ± 0.022	2.583ProAsp: 2.583 ± 0.052	3.474ProGlu: 3.474 ± 0.064	1.909ProPhe: 1.909 ± 0.052	2.591ProGly: 2.591 ± 0.052	0.809ProHis: 0.809 ± 0.029	2.131ProIle: 2.131 ± 0.048	2.148ProLys: 2.148 ± 0.052	3.317ProLeu: 3.317 ± 0.064	0.944ProMet: 0.944 ± 0.031	1.641ProAsn: 1.641 ± 0.044	0.99ProPro: 0.99 ± 0.043	1.387ProGln: 1.387 ± 0.042	1.437ProArg: 1.437 ± 0.037	2.263ProSer: 2.263 ± 0.048	1.838ProThr: 1.838 ± 0.043	3.072ProVal: 3.072 ± 0.059	0.413ProTrp: 0.413 ± 0.023	1.677ProTyr: 1.677 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.473GlnAla: 2.473 ± 0.049	0.299GlnCys: 0.299 ± 0.018	1.397GlnAsp: 1.397 ± 0.041	2.346GlnGlu: 2.346 ± 0.05	1.199GlnPhe: 1.199 ± 0.035	1.962GlnGly: 1.962 ± 0.041	0.602GlnHis: 0.602 ± 0.027	2.228GlnIle: 2.228 ± 0.043	2.313GlnLys: 2.313 ± 0.055	3.117GlnLeu: 3.117 ± 0.055	1.058GlnMet: 1.058 ± 0.032	1.617GlnAsn: 1.617 ± 0.042	1.222GlnPro: 1.222 ± 0.037	1.435GlnGln: 1.435 ± 0.042	1.65GlnArg: 1.65 ± 0.039	1.859GlnSer: 1.859 ± 0.046	2.008GlnThr: 2.008 ± 0.043	1.927GlnVal: 1.927 ± 0.047	0.397GlnTrp: 0.397 ± 0.022	1.3GlnTyr: 1.3 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.093ArgAla: 3.093 ± 0.06	0.549ArgCys: 0.549 ± 0.025	2.259ArgAsp: 2.259 ± 0.049	3.455ArgGlu: 3.455 ± 0.07	2.615ArgPhe: 2.615 ± 0.055	2.783ArgGly: 2.783 ± 0.055	1.056ArgHis: 1.056 ± 0.035	3.971ArgIle: 3.971 ± 0.062	4.005ArgLys: 4.005 ± 0.066	5.043ArgLeu: 5.043 ± 0.082	1.91ArgMet: 1.91 ± 0.043	2.599ArgAsn: 2.599 ± 0.062	1.803ArgPro: 1.803 ± 0.041	2.032ArgGln: 2.032 ± 0.053	2.942ArgArg: 2.942 ± 0.067	2.825ArgSer: 2.825 ± 0.062	2.741ArgThr: 2.741 ± 0.059	2.877ArgVal: 2.877 ± 0.057	0.711ArgTrp: 0.711 ± 0.027	2.477ArgTyr: 2.477 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.383SerAla: 4.383 ± 0.064	0.885SerCys: 0.885 ± 0.033	3.18SerAsp: 3.18 ± 0.062	3.608SerGlu: 3.608 ± 0.055	3.49SerPhe: 3.49 ± 0.071	4.672SerGly: 4.672 ± 0.07	1.119SerHis: 1.119 ± 0.034	4.34SerIle: 4.34 ± 0.076	3.417SerLys: 3.417 ± 0.062	6.087SerLeu: 6.087 ± 0.083	1.529SerMet: 1.529 ± 0.036	2.621SerAsn: 2.621 ± 0.049	2.38SerPro: 2.38 ± 0.05	1.774SerGln: 1.774 ± 0.035	2.914SerArg: 2.914 ± 0.059	4.006SerSer: 4.006 ± 0.09	3.143SerThr: 3.143 ± 0.064	4.456SerVal: 4.456 ± 0.071	0.746SerTrp: 0.746 ± 0.028	2.675SerTyr: 2.675 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	4.151ThrAla: 4.151 ± 0.07	0.564ThrCys: 0.564 ± 0.026	3.259ThrAsp: 3.259 ± 0.061	3.338ThrGlu: 3.338 ± 0.063	2.623ThrPhe: 2.623 ± 0.052	4.397ThrGly: 4.397 ± 0.072	1.018ThrHis: 1.018 ± 0.034	3.55ThrIle: 3.55 ± 0.063	2.845ThrLys: 2.845 ± 0.06	5.208ThrLeu: 5.208 ± 0.072	1.243ThrMet: 1.243 ± 0.036	2.369ThrAsn: 2.369 ± 0.057	2.772ThrPro: 2.772 ± 0.06	1.658ThrGln: 1.658 ± 0.041	2.328ThrArg: 2.328 ± 0.055	3.17ThrSer: 3.17 ± 0.061	2.861ThrThr: 2.861 ± 0.06	3.957ThrVal: 3.957 ± 0.062	0.6ThrTrp: 0.6 ± 0.029	2.336ThrTyr: 2.336 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.642ValAla: 4.642 ± 0.078	0.993ValCys: 0.993 ± 0.035	3.549ValAsp: 3.549 ± 0.06	4.107ValGlu: 4.107 ± 0.065	3.005ValPhe: 3.005 ± 0.056	3.993ValGly: 3.993 ± 0.064	1.062ValHis: 1.062 ± 0.027	4.215ValIle: 4.215 ± 0.074	4.383ValLys: 4.383 ± 0.076	5.809ValLeu: 5.809 ± 0.086	1.666ValMet: 1.666 ± 0.037	3.21ValAsn: 3.21 ± 0.063	2.56ValPro: 2.56 ± 0.057	1.776ValGln: 1.776 ± 0.043	3.274ValArg: 3.274 ± 0.063	4.647ValSer: 4.647 ± 0.069	3.623ValThr: 3.623 ± 0.058	4.346ValVal: 4.346 ± 0.067	0.739ValTrp: 0.739 ± 0.025	2.649ValTyr: 2.649 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.755TrpAla: 0.755 ± 0.029	0.156TrpCys: 0.156 ± 0.011	0.641TrpAsp: 0.641 ± 0.027	0.831TrpGlu: 0.831 ± 0.028	0.523TrpPhe: 0.523 ± 0.025	0.924TrpGly: 0.924 ± 0.033	0.246TrpHis: 0.246 ± 0.016	0.768TrpIle: 0.768 ± 0.035	1.041TrpLys: 1.041 ± 0.033	1.092TrpLeu: 1.092 ± 0.039	0.424TrpMet: 0.424 ± 0.022	0.749TrpAsn: 0.749 ± 0.026	0.243TrpPro: 0.243 ± 0.018	0.491TrpGln: 0.491 ± 0.021	0.621TrpArg: 0.621 ± 0.026	0.62TrpSer: 0.62 ± 0.026	0.613TrpThr: 0.613 ± 0.023	0.7TrpVal: 0.7 ± 0.028	0.174TrpTrp: 0.174 ± 0.014	0.464TrpTyr: 0.464 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.122TyrAla: 3.122 ± 0.052	0.534TyrCys: 0.534 ± 0.025	2.418TyrAsp: 2.418 ± 0.047	2.498TyrGlu: 2.498 ± 0.056	1.993TyrPhe: 1.993 ± 0.054	2.927TyrGly: 2.927 ± 0.061	0.93TyrHis: 0.93 ± 0.032	2.652TyrIle: 2.652 ± 0.061	2.732TyrLys: 2.732 ± 0.051	3.717TyrLeu: 3.717 ± 0.056	1.05TyrMet: 1.05 ± 0.036	2.269TyrAsn: 2.269 ± 0.053	1.951TyrPro: 1.951 ± 0.048	1.294TyrGln: 1.294 ± 0.038	2.597TyrArg: 2.597 ± 0.055	2.682TyrSer: 2.682 ± 0.059	2.54TyrThr: 2.54 ± 0.053	2.405TyrVal: 2.405 ± 0.049	0.542TyrTrp: 0.542 ± 0.025	2.073TyrTyr: 2.073 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3340 proteins (982162 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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