Amino acid dipepetide frequency for Sewage-associated circular DNA virus-19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.587AlaAla: 12.587 ± 0.732
0.0AlaCys: 0.0 ± 0.0
4.196AlaAsp: 4.196 ± 1.897
5.594AlaGlu: 5.594 ± 3.244
2.797AlaPhe: 2.797 ± 0.551
11.189AlaGly: 11.189 ± 4.22
1.399AlaHis: 1.399 ± 1.346
2.797AlaIle: 2.797 ± 1.59
6.993AlaLys: 6.993 ± 1.834
5.594AlaLeu: 5.594 ± 1.039
0.0AlaMet: 0.0 ± 0.0
6.993AlaAsn: 6.993 ± 3.976
4.196AlaPro: 4.196 ± 0.244
1.399AlaGln: 1.399 ± 0.795
5.594AlaArg: 5.594 ± 3.244
5.594AlaSer: 5.594 ± 3.181
4.196AlaThr: 4.196 ± 2.385
2.797AlaVal: 2.797 ± 2.692
1.399AlaTrp: 1.399 ± 1.346
2.797AlaTyr: 2.797 ± 1.59
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.399CysAsp: 1.399 ± 1.346
0.0CysGlu: 0.0 ± 0.0
1.399CysPhe: 1.399 ± 0.795
0.0CysGly: 0.0 ± 0.0
1.399CysHis: 1.399 ± 1.346
0.0CysIle: 0.0 ± 0.0
1.399CysLys: 1.399 ± 0.795
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.399CysArg: 1.399 ± 1.346
1.399CysSer: 1.399 ± 0.795
0.0CysThr: 0.0 ± 0.0
2.797CysVal: 2.797 ± 1.59
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.797AspAla: 2.797 ± 2.692
0.0AspCys: 0.0 ± 0.0
2.797AspAsp: 2.797 ± 0.551
5.594AspGlu: 5.594 ± 1.102
2.797AspPhe: 2.797 ± 0.551
2.797AspGly: 2.797 ± 2.692
0.0AspHis: 0.0 ± 0.0
6.993AspIle: 6.993 ± 0.307
0.0AspLys: 0.0 ± 0.0
2.797AspLeu: 2.797 ± 0.551
0.0AspMet: 0.0 ± 0.0
2.797AspAsn: 2.797 ± 0.551
4.196AspPro: 4.196 ± 1.897
0.0AspGln: 0.0 ± 0.0
1.399AspArg: 1.399 ± 1.346
2.797AspSer: 2.797 ± 0.551
2.797AspThr: 2.797 ± 0.551
2.797AspVal: 2.797 ± 0.551
1.399AspTrp: 1.399 ± 1.346
1.399AspTyr: 1.399 ± 0.795
0.0AspXaa: 0.0 ± 0.0
Glu
4.196GluAla: 4.196 ± 1.897
0.0GluCys: 0.0 ± 0.0
2.797GluAsp: 2.797 ± 1.59
1.399GluGlu: 1.399 ± 1.346
1.399GluPhe: 1.399 ± 1.346
0.0GluGly: 0.0 ± 0.0
1.399GluHis: 1.399 ± 0.795
2.797GluIle: 2.797 ± 1.59
1.399GluLys: 1.399 ± 0.795
4.196GluLeu: 4.196 ± 0.244
0.0GluMet: 0.0 ± 0.0
2.797GluAsn: 2.797 ± 0.551
2.797GluPro: 2.797 ± 0.551
2.797GluGln: 2.797 ± 1.59
2.797GluArg: 2.797 ± 2.692
2.797GluSer: 2.797 ± 0.551
4.196GluThr: 4.196 ± 1.897
4.196GluVal: 4.196 ± 0.244
0.0GluTrp: 0.0 ± 0.0
1.399GluTyr: 1.399 ± 0.795
0.0GluXaa: 0.0 ± 0.0
Phe
5.594PheAla: 5.594 ± 1.039
1.399PheCys: 1.399 ± 1.346
1.399PheAsp: 1.399 ± 1.346
1.399PheGlu: 1.399 ± 1.346
5.594PhePhe: 5.594 ± 3.181
5.594PheGly: 5.594 ± 1.039
0.0PheHis: 0.0 ± 0.0
1.399PheIle: 1.399 ± 0.795
1.399PheLys: 1.399 ± 0.795
0.0PheLeu: 0.0 ± 0.0
0.0PheMet: 0.0 ± 0.0
1.399PheAsn: 1.399 ± 0.795
4.196PhePro: 4.196 ± 0.244
0.0PheGln: 0.0 ± 0.0
5.594PheArg: 5.594 ± 1.039
0.0PheSer: 0.0 ± 0.0
8.392PheThr: 8.392 ± 0.488
1.399PheVal: 1.399 ± 0.795
2.797PheTrp: 2.797 ± 2.692
1.399PheTyr: 1.399 ± 0.795
0.0PheXaa: 0.0 ± 0.0
Gly
4.196GlyAla: 4.196 ± 2.385
4.196GlyCys: 4.196 ± 2.385
1.399GlyAsp: 1.399 ± 1.346
2.797GlyGlu: 2.797 ± 0.551
1.399GlyPhe: 1.399 ± 1.346
8.392GlyGly: 8.392 ± 0.488
1.399GlyHis: 1.399 ± 0.795
1.399GlyIle: 1.399 ± 1.346
8.392GlyLys: 8.392 ± 2.63
8.392GlyLeu: 8.392 ± 0.488
1.399GlyMet: 1.399 ± 1.346
2.797GlyAsn: 2.797 ± 0.551
1.399GlyPro: 1.399 ± 0.795
1.399GlyGln: 1.399 ± 1.346
5.594GlyArg: 5.594 ± 1.102
5.594GlySer: 5.594 ± 1.039
9.79GlyThr: 9.79 ± 2.999
6.993GlyVal: 6.993 ± 1.834
0.0GlyTrp: 0.0 ± 0.0
2.797GlyTyr: 2.797 ± 0.551
0.0GlyXaa: 0.0 ± 0.0
His
4.196HisAla: 4.196 ± 1.897
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
1.399HisPhe: 1.399 ± 1.346
2.797HisGly: 2.797 ± 1.59
0.0HisHis: 0.0 ± 0.0
2.797HisIle: 2.797 ± 0.551
2.797HisLys: 2.797 ± 0.551
1.399HisLeu: 1.399 ± 1.346
0.0HisMet: 0.0 ± 0.0
1.399HisAsn: 1.399 ± 0.795
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.399HisArg: 1.399 ± 1.346
1.399HisSer: 1.399 ± 0.795
0.0HisThr: 0.0 ± 0.0
4.196HisVal: 4.196 ± 0.244
1.399HisTrp: 1.399 ± 1.346
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
6.993IleAla: 6.993 ± 1.834
0.0IleCys: 0.0 ± 0.0
2.797IleAsp: 2.797 ± 2.692
5.594IleGlu: 5.594 ± 3.181
4.196IlePhe: 4.196 ± 1.897
1.399IleGly: 1.399 ± 1.346
1.399IleHis: 1.399 ± 0.795
0.0IleIle: 0.0 ± 0.0
0.0IleLys: 0.0 ± 0.0
5.594IleLeu: 5.594 ± 1.039
1.399IleMet: 1.399 ± 0.817
1.399IleAsn: 1.399 ± 1.346
4.196IlePro: 4.196 ± 1.897
0.0IleGln: 0.0 ± 0.0
2.797IleArg: 2.797 ± 2.692
1.399IleSer: 1.399 ± 1.346
8.392IleThr: 8.392 ± 0.488
4.196IleVal: 4.196 ± 0.244
1.399IleTrp: 1.399 ± 0.795
1.399IleTyr: 1.399 ± 0.795
0.0IleXaa: 0.0 ± 0.0
Lys
1.399LysAla: 1.399 ± 0.795
0.0LysCys: 0.0 ± 0.0
5.594LysAsp: 5.594 ± 1.102
1.399LysGlu: 1.399 ± 0.795
5.594LysPhe: 5.594 ± 1.039
8.392LysGly: 8.392 ± 2.63
1.399LysHis: 1.399 ± 0.795
2.797LysIle: 2.797 ± 0.551
4.196LysLys: 4.196 ± 0.244
1.399LysLeu: 1.399 ± 0.795
2.797LysMet: 2.797 ± 1.59
1.399LysAsn: 1.399 ± 0.795
0.0LysPro: 0.0 ± 0.0
1.399LysGln: 1.399 ± 0.795
6.993LysArg: 6.993 ± 0.307
6.993LysSer: 6.993 ± 0.307
1.399LysThr: 1.399 ± 0.795
1.399LysVal: 1.399 ± 0.795
0.0LysTrp: 0.0 ± 0.0
5.594LysTyr: 5.594 ± 1.039
0.0LysXaa: 0.0 ± 0.0
Leu
9.79LeuAla: 9.79 ± 1.283
1.399LeuCys: 1.399 ± 0.795
4.196LeuAsp: 4.196 ± 1.897
8.392LeuGlu: 8.392 ± 0.488
4.196LeuPhe: 4.196 ± 2.385
2.797LeuGly: 2.797 ± 2.692
1.399LeuHis: 1.399 ± 1.346
1.399LeuIle: 1.399 ± 0.795
4.196LeuLys: 4.196 ± 0.244
5.594LeuLeu: 5.594 ± 1.102
1.399LeuMet: 1.399 ± 0.795
6.993LeuAsn: 6.993 ± 0.307
4.196LeuPro: 4.196 ± 1.897
0.0LeuGln: 0.0 ± 0.0
4.196LeuArg: 4.196 ± 1.897
0.0LeuSer: 0.0 ± 0.0
8.392LeuThr: 8.392 ± 2.63
2.797LeuVal: 2.797 ± 1.59
1.399LeuTrp: 1.399 ± 0.795
2.797LeuTyr: 2.797 ± 0.551
0.0LeuXaa: 0.0 ± 0.0
Met
4.196MetAla: 4.196 ± 0.244
0.0MetCys: 0.0 ± 0.0
2.797MetAsp: 2.797 ± 2.692
0.0MetGlu: 0.0 ± 0.0
1.399MetPhe: 1.399 ± 0.795
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
2.797MetLeu: 2.797 ± 1.59
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.399MetPro: 1.399 ± 0.795
0.0MetGln: 0.0 ± 0.0
2.797MetArg: 2.797 ± 1.59
2.797MetSer: 2.797 ± 0.551
1.399MetThr: 1.399 ± 0.795
1.399MetVal: 1.399 ± 0.795
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
6.993AsnAla: 6.993 ± 1.834
0.0AsnCys: 0.0 ± 0.0
1.399AsnAsp: 1.399 ± 0.795
0.0AsnGlu: 0.0 ± 0.0
0.0AsnPhe: 0.0 ± 0.0
1.399AsnGly: 1.399 ± 0.795
1.399AsnHis: 1.399 ± 1.346
5.594AsnIle: 5.594 ± 1.039
2.797AsnLys: 2.797 ± 1.59
5.594AsnLeu: 5.594 ± 1.102
1.399AsnMet: 1.399 ± 1.346
2.797AsnAsn: 2.797 ± 1.59
1.399AsnPro: 1.399 ± 0.795
6.993AsnGln: 6.993 ± 1.834
1.399AsnArg: 1.399 ± 0.795
4.196AsnSer: 4.196 ± 2.385
5.594AsnThr: 5.594 ± 3.181
2.797AsnVal: 2.797 ± 2.692
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.797ProAla: 2.797 ± 0.551
0.0ProCys: 0.0 ± 0.0
1.399ProAsp: 1.399 ± 1.346
0.0ProGlu: 0.0 ± 0.0
0.0ProPhe: 0.0 ± 0.0
2.797ProGly: 2.797 ± 1.59
1.399ProHis: 1.399 ± 1.346
5.594ProIle: 5.594 ± 1.102
4.196ProLys: 4.196 ± 0.244
4.196ProLeu: 4.196 ± 2.385
1.399ProMet: 1.399 ± 0.795
4.196ProAsn: 4.196 ± 0.244
4.196ProPro: 4.196 ± 0.244
2.797ProGln: 2.797 ± 1.59
5.594ProArg: 5.594 ± 1.102
1.399ProSer: 1.399 ± 0.795
1.399ProThr: 1.399 ± 1.346
1.399ProVal: 1.399 ± 1.346
0.0ProTrp: 0.0 ± 0.0
1.399ProTyr: 1.399 ± 1.346
0.0ProXaa: 0.0 ± 0.0
Gln
1.399GlnAla: 1.399 ± 1.346
0.0GlnCys: 0.0 ± 0.0
1.399GlnAsp: 1.399 ± 0.795
0.0GlnGlu: 0.0 ± 0.0
4.196GlnPhe: 4.196 ± 2.385
0.0GlnGly: 0.0 ± 0.0
1.399GlnHis: 1.399 ± 0.795
4.196GlnIle: 4.196 ± 0.244
2.797GlnLys: 2.797 ± 1.59
2.797GlnLeu: 2.797 ± 0.551
0.0GlnMet: 0.0 ± 0.0
1.399GlnAsn: 1.399 ± 0.795
1.399GlnPro: 1.399 ± 0.795
0.0GlnGln: 0.0 ± 0.0
2.797GlnArg: 2.797 ± 1.59
0.0GlnSer: 0.0 ± 0.0
0.0GlnThr: 0.0 ± 0.0
1.399GlnVal: 1.399 ± 0.795
1.399GlnTrp: 1.399 ± 1.346
1.399GlnTyr: 1.399 ± 1.346
0.0GlnXaa: 0.0 ± 0.0
Arg
5.594ArgAla: 5.594 ± 1.039
0.0ArgCys: 0.0 ± 0.0
1.399ArgAsp: 1.399 ± 0.795
2.797ArgGlu: 2.797 ± 0.551
2.797ArgPhe: 2.797 ± 0.551
5.594ArgGly: 5.594 ± 5.385
1.399ArgHis: 1.399 ± 1.346
1.399ArgIle: 1.399 ± 1.346
8.392ArgLys: 8.392 ± 0.488
5.594ArgLeu: 5.594 ± 3.244
1.399ArgMet: 1.399 ± 1.346
5.594ArgAsn: 5.594 ± 3.181
0.0ArgPro: 0.0 ± 0.0
1.399ArgGln: 1.399 ± 1.346
4.196ArgArg: 4.196 ± 4.039
6.993ArgSer: 6.993 ± 0.307
8.392ArgThr: 8.392 ± 1.653
4.196ArgVal: 4.196 ± 0.244
1.399ArgTrp: 1.399 ± 1.346
1.399ArgTyr: 1.399 ± 1.346
0.0ArgXaa: 0.0 ± 0.0
Ser
2.797SerAla: 2.797 ± 1.59
2.797SerCys: 2.797 ± 2.692
2.797SerAsp: 2.797 ± 0.551
2.797SerGlu: 2.797 ± 1.59
4.196SerPhe: 4.196 ± 0.244
5.594SerGly: 5.594 ± 1.039
1.399SerHis: 1.399 ± 1.346
4.196SerIle: 4.196 ± 0.244
0.0SerLys: 0.0 ± 0.0
4.196SerLeu: 4.196 ± 2.385
4.196SerMet: 4.196 ± 2.385
1.399SerAsn: 1.399 ± 1.346
4.196SerPro: 4.196 ± 2.385
2.797SerGln: 2.797 ± 0.551
2.797SerArg: 2.797 ± 0.551
5.594SerSer: 5.594 ± 1.039
2.797SerThr: 2.797 ± 1.59
2.797SerVal: 2.797 ± 0.551
0.0SerTrp: 0.0 ± 0.0
1.399SerTyr: 1.399 ± 0.795
0.0SerXaa: 0.0 ± 0.0
Thr
2.797ThrAla: 2.797 ± 1.59
0.0ThrCys: 0.0 ± 0.0
4.196ThrAsp: 4.196 ± 2.385
2.797ThrGlu: 2.797 ± 1.59
1.399ThrPhe: 1.399 ± 0.795
12.587ThrGly: 12.587 ± 1.409
2.797ThrHis: 2.797 ± 0.551
5.594ThrIle: 5.594 ± 3.244
5.594ThrLys: 5.594 ± 1.039
5.594ThrLeu: 5.594 ± 1.102
0.0ThrMet: 0.0 ± 0.617
4.196ThrAsn: 4.196 ± 2.385
4.196ThrPro: 4.196 ± 0.244
1.399ThrGln: 1.399 ± 0.795
4.196ThrArg: 4.196 ± 1.897
2.797ThrSer: 2.797 ± 0.551
4.196ThrThr: 4.196 ± 2.385
6.993ThrVal: 6.993 ± 1.834
0.0ThrTrp: 0.0 ± 0.0
5.594ThrTyr: 5.594 ± 3.181
0.0ThrXaa: 0.0 ± 0.0
Val
4.196ValAla: 4.196 ± 0.244
0.0ValCys: 0.0 ± 0.0
2.797ValAsp: 2.797 ± 2.692
1.399ValGlu: 1.399 ± 1.346
1.399ValPhe: 1.399 ± 0.795
2.797ValGly: 2.797 ± 1.59
4.196ValHis: 4.196 ± 0.244
2.797ValIle: 2.797 ± 0.551
5.594ValLys: 5.594 ± 1.102
2.797ValLeu: 2.797 ± 0.551
2.797ValMet: 2.797 ± 1.59
2.797ValAsn: 2.797 ± 0.551
1.399ValPro: 1.399 ± 0.795
4.196ValGln: 4.196 ± 2.385
4.196ValArg: 4.196 ± 0.244
5.594ValSer: 5.594 ± 1.039
2.797ValThr: 2.797 ± 1.59
8.392ValVal: 8.392 ± 5.936
1.399ValTrp: 1.399 ± 1.346
2.797ValTyr: 2.797 ± 0.551
0.0ValXaa: 0.0 ± 0.0
Trp
1.399TrpAla: 1.399 ± 1.346
0.0TrpCys: 0.0 ± 0.0
1.399TrpAsp: 1.399 ± 1.346
1.399TrpGlu: 1.399 ± 1.346
1.399TrpPhe: 1.399 ± 1.346
1.399TrpGly: 1.399 ± 1.346
0.0TrpHis: 0.0 ± 0.0
2.797TrpIle: 2.797 ± 2.692
0.0TrpLys: 0.0 ± 0.0
2.797TrpLeu: 2.797 ± 1.59
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.399TrpGln: 1.399 ± 1.346
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.399TrpTyr: 1.399 ± 1.346
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.196TyrAla: 4.196 ± 2.385
1.399TyrCys: 1.399 ± 0.795
0.0TyrAsp: 0.0 ± 0.0
0.0TyrGlu: 0.0 ± 0.0
1.399TyrPhe: 1.399 ± 0.795
4.196TyrGly: 4.196 ± 0.244
1.399TyrHis: 1.399 ± 0.795
0.0TyrIle: 0.0 ± 0.0
0.0TyrLys: 0.0 ± 0.0
4.196TyrLeu: 4.196 ± 1.897
1.399TyrMet: 1.399 ± 0.795
1.399TyrAsn: 1.399 ± 0.795
2.797TyrPro: 2.797 ± 2.692
0.0TyrGln: 0.0 ± 0.0
4.196TyrArg: 4.196 ± 0.244
1.399TyrSer: 1.399 ± 0.795
4.196TyrThr: 4.196 ± 2.385
1.399TyrVal: 1.399 ± 1.346
1.399TyrTrp: 1.399 ± 1.346
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (716 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski