Amino acid dipepetide frequency for Diversispora epigaea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.133AlaAla: 2.133 ± 0.022	0.623AlaCys: 0.623 ± 0.009	1.91AlaAsp: 1.91 ± 0.015	3.287AlaGlu: 3.287 ± 0.04	2.298AlaPhe: 2.298 ± 0.033	1.619AlaGly: 1.619 ± 0.015	0.88AlaHis: 0.88 ± 0.011	3.707AlaIle: 3.707 ± 0.022	3.364AlaLys: 3.364 ± 0.022	3.849AlaLeu: 3.849 ± 0.03	0.753AlaMet: 0.753 ± 0.009	2.571AlaAsn: 2.571 ± 0.019	1.452AlaPro: 1.452 ± 0.013	1.555AlaGln: 1.555 ± 0.013	1.953AlaArg: 1.953 ± 0.016	3.193AlaSer: 3.193 ± 0.019	2.342AlaThr: 2.342 ± 0.02	1.879AlaVal: 1.879 ± 0.017	0.514AlaTrp: 0.514 ± 0.008	1.482AlaTyr: 1.482 ± 0.013	0.004AlaXaa: 0.004 ± 0.001
Cys	0.529CysAla: 0.529 ± 0.007	0.298CysCys: 0.298 ± 0.006	0.781CysAsp: 0.781 ± 0.01	0.926CysGlu: 0.926 ± 0.01	0.664CysPhe: 0.664 ± 0.009	0.807CysGly: 0.807 ± 0.011	0.493CysHis: 0.493 ± 0.007	1.098CysIle: 1.098 ± 0.011	1.126CysLys: 1.126 ± 0.012	1.405CysLeu: 1.405 ± 0.014	0.227CysMet: 0.227 ± 0.005	1.264CysAsn: 1.264 ± 0.012	0.719CysPro: 0.719 ± 0.01	0.494CysGln: 0.494 ± 0.008	0.711CysArg: 0.711 ± 0.009	1.005CysSer: 1.005 ± 0.012	0.679CysThr: 0.679 ± 0.008	0.579CysVal: 0.579 ± 0.008	0.404CysTrp: 0.404 ± 0.007	1.278CysTyr: 1.278 ± 0.034	0.001CysXaa: 0.001 ± 0.0
Asp	2.146AspAla: 2.146 ± 0.018	0.69AspCys: 0.69 ± 0.011	4.243AspAsp: 4.243 ± 0.036	5.058AspGlu: 5.058 ± 0.038	2.92AspPhe: 2.92 ± 0.021	2.424AspGly: 2.424 ± 0.018	0.944AspHis: 0.944 ± 0.011	4.757AspIle: 4.757 ± 0.023	3.903AspLys: 3.903 ± 0.024	5.078AspLeu: 5.078 ± 0.026	0.924AspMet: 0.924 ± 0.01	4.237AspAsn: 4.237 ± 0.03	2.053AspPro: 2.053 ± 0.017	1.7AspGln: 1.7 ± 0.016	1.984AspArg: 1.984 ± 0.018	3.791AspSer: 3.791 ± 0.024	2.525AspThr: 2.525 ± 0.02	2.547AspVal: 2.547 ± 0.019	0.647AspTrp: 0.647 ± 0.009	2.217AspTyr: 2.217 ± 0.015	0.006AspXaa: 0.006 ± 0.001
Glu	2.774GluAla: 2.774 ± 0.025	0.925GluCys: 0.925 ± 0.011	3.82GluAsp: 3.82 ± 0.028	7.277GluGlu: 7.277 ± 0.05	3.28GluPhe: 3.28 ± 0.022	3.124GluGly: 3.124 ± 0.042	1.217GluHis: 1.217 ± 0.013	7.1GluIle: 7.1 ± 0.035	6.8GluLys: 6.8 ± 0.042	6.475GluLeu: 6.475 ± 0.035	1.628GluMet: 1.628 ± 0.014	6.219GluAsn: 6.219 ± 0.035	1.789GluPro: 1.789 ± 0.017	2.256GluGln: 2.256 ± 0.021	2.91GluArg: 2.91 ± 0.03	4.91GluSer: 4.91 ± 0.029	3.81GluThr: 3.81 ± 0.028	3.479GluVal: 3.479 ± 0.02	1.071GluTrp: 1.071 ± 0.01	2.843GluTyr: 2.843 ± 0.02	0.007GluXaa: 0.007 ± 0.001
Phe	1.724PheAla: 1.724 ± 0.012	0.844PheCys: 0.844 ± 0.009	2.723PheAsp: 2.723 ± 0.016	3.424PheGlu: 3.424 ± 0.019	2.023PhePhe: 2.023 ± 0.019	2.691PheGly: 2.691 ± 0.023	1.315PheHis: 1.315 ± 0.012	3.402PheIle: 3.402 ± 0.022	3.289PheLys: 3.289 ± 0.022	3.771PheLeu: 3.771 ± 0.022	0.889PheMet: 0.889 ± 0.009	3.005PheAsn: 3.005 ± 0.019	1.665PhePro: 1.665 ± 0.016	2.296PheGln: 2.296 ± 0.031	1.767PheArg: 1.767 ± 0.015	3.851PheSer: 3.851 ± 0.022	2.372PheThr: 2.372 ± 0.016	2.174PheVal: 2.174 ± 0.016	0.658PheTrp: 0.658 ± 0.007	1.692PheTyr: 1.692 ± 0.014	0.005PheXaa: 0.005 ± 0.001
Gly	1.55GlyAla: 1.55 ± 0.015	0.708GlyCys: 0.708 ± 0.01	2.295GlyAsp: 2.295 ± 0.021	2.621GlyGlu: 2.621 ± 0.024	2.179GlyPhe: 2.179 ± 0.017	3.175GlyGly: 3.175 ± 0.04	0.992GlyHis: 0.992 ± 0.014	4.332GlyIle: 4.332 ± 0.041	3.377GlyLys: 3.377 ± 0.022	3.467GlyLeu: 3.467 ± 0.024	0.79GlyMet: 0.79 ± 0.015	3.543GlyAsn: 3.543 ± 0.036	1.186GlyPro: 1.186 ± 0.013	1.746GlyGln: 1.746 ± 0.033	1.941GlyArg: 1.941 ± 0.022	2.974GlySer: 2.974 ± 0.023	2.847GlyThr: 2.847 ± 0.037	2.153GlyVal: 2.153 ± 0.017	0.532GlyTrp: 0.532 ± 0.008	1.964GlyTyr: 1.964 ± 0.017	0.005GlyXaa: 0.005 ± 0.001
His	0.889HisAla: 0.889 ± 0.009	0.397HisCys: 0.397 ± 0.009	1.069HisAsp: 1.069 ± 0.01	1.262HisGlu: 1.262 ± 0.014	1.133HisPhe: 1.133 ± 0.011	0.94HisGly: 0.94 ± 0.012	0.768HisHis: 0.768 ± 0.013	1.696HisIle: 1.696 ± 0.012	1.503HisLys: 1.503 ± 0.015	2.01HisLeu: 2.01 ± 0.015	0.351HisMet: 0.351 ± 0.006	1.53HisAsn: 1.53 ± 0.017	1.183HisPro: 1.183 ± 0.011	0.892HisGln: 0.892 ± 0.011	1.027HisArg: 1.027 ± 0.011	1.933HisSer: 1.933 ± 0.017	0.91HisThr: 0.91 ± 0.01	1.018HisVal: 1.018 ± 0.011	0.295HisTrp: 0.295 ± 0.005	0.875HisTyr: 0.875 ± 0.009	0.002HisXaa: 0.002 ± 0.0
Ile	3.474IleAla: 3.474 ± 0.021	1.47IleCys: 1.47 ± 0.012	4.509IleAsp: 4.509 ± 0.023	5.684IleGlu: 5.684 ± 0.029	3.814IlePhe: 3.814 ± 0.024	3.603IleGly: 3.603 ± 0.039	1.951IleHis: 1.951 ± 0.014	7.246IleIle: 7.246 ± 0.036	6.705IleLys: 6.705 ± 0.029	7.246IleLeu: 7.246 ± 0.037	1.702IleMet: 1.702 ± 0.012	5.717IleAsn: 5.717 ± 0.035	3.982IlePro: 3.982 ± 0.026	3.075IleGln: 3.075 ± 0.021	3.449IleArg: 3.449 ± 0.018	6.762IleSer: 6.762 ± 0.032	4.622IleThr: 4.622 ± 0.025	3.863IleVal: 3.863 ± 0.019	0.997IleTrp: 0.997 ± 0.012	3.393IleTyr: 3.393 ± 0.018	0.01IleXaa: 0.01 ± 0.001
Lys	3.79LysAla: 3.79 ± 0.041	1.19LysCys: 1.19 ± 0.014	4.659LysAsp: 4.659 ± 0.042	6.23LysGlu: 6.23 ± 0.033	3.7LysPhe: 3.7 ± 0.023	3.058LysGly: 3.058 ± 0.024	1.466LysHis: 1.466 ± 0.014	6.852LysIle: 6.852 ± 0.035	8.235LysLys: 8.235 ± 0.048	7.215LysLeu: 7.215 ± 0.034	1.582LysMet: 1.582 ± 0.013	6.585LysAsn: 6.585 ± 0.029	2.546LysPro: 2.546 ± 0.019	2.765LysGln: 2.765 ± 0.02	4.006LysArg: 4.006 ± 0.027	6.382LysSer: 6.382 ± 0.038	4.204LysThr: 4.204 ± 0.029	3.543LysVal: 3.543 ± 0.02	1.152LysTrp: 1.152 ± 0.011	3.331LysTyr: 3.331 ± 0.022	0.011LysXaa: 0.011 ± 0.001
Leu	3.841LeuAla: 3.841 ± 0.023	1.343LeuCys: 1.343 ± 0.013	4.482LeuAsp: 4.482 ± 0.024	6.556LeuGlu: 6.556 ± 0.038	3.701LeuPhe: 3.701 ± 0.026	4.108LeuGly: 4.108 ± 0.04	2.044LeuHis: 2.044 ± 0.014	6.288LeuIle: 6.288 ± 0.036	8.278LeuLys: 8.278 ± 0.038	7.266LeuLeu: 7.266 ± 0.035	1.938LeuMet: 1.938 ± 0.016	5.831LeuAsn: 5.831 ± 0.03	3.988LeuPro: 3.988 ± 0.023	3.501LeuGln: 3.501 ± 0.024	4.305LeuArg: 4.305 ± 0.028	6.942LeuSer: 6.942 ± 0.032	4.457LeuThr: 4.457 ± 0.028	3.853LeuVal: 3.853 ± 0.023	1.053LeuTrp: 1.053 ± 0.011	2.923LeuTyr: 2.923 ± 0.022	0.011LeuXaa: 0.011 ± 0.001
Met	1.098MetAla: 1.098 ± 0.011	0.28MetCys: 0.28 ± 0.005	1.02MetAsp: 1.02 ± 0.011	1.445MetGlu: 1.445 ± 0.015	0.699MetPhe: 0.699 ± 0.008	0.808MetGly: 0.808 ± 0.013	0.473MetHis: 0.473 ± 0.007	1.578MetIle: 1.578 ± 0.014	1.862MetLys: 1.862 ± 0.018	1.44MetLeu: 1.44 ± 0.013	0.543MetMet: 0.543 ± 0.007	1.341MetAsn: 1.341 ± 0.013	0.6MetPro: 0.6 ± 0.008	0.656MetGln: 0.656 ± 0.007	0.794MetArg: 0.794 ± 0.01	1.578MetSer: 1.578 ± 0.013	1.109MetThr: 1.109 ± 0.01	1.024MetVal: 1.024 ± 0.01	0.212MetTrp: 0.212 ± 0.005	0.674MetTyr: 0.674 ± 0.008	0.003MetXaa: 0.003 ± 0.001
Asn	2.611AsnAla: 2.611 ± 0.019	1.052AsnCys: 1.052 ± 0.013	4.492AsnAsp: 4.492 ± 0.028	5.722AsnGlu: 5.722 ± 0.033	3.696AsnPhe: 3.696 ± 0.022	3.358AsnGly: 3.358 ± 0.032	1.439AsnHis: 1.439 ± 0.018	7.094AsnIle: 7.094 ± 0.033	5.712AsnLys: 5.712 ± 0.029	6.742AsnLeu: 6.742 ± 0.033	1.318AsnMet: 1.318 ± 0.01	10.521AsnAsn: 10.521 ± 0.108	2.675AsnPro: 2.675 ± 0.017	2.692AsnGln: 2.692 ± 0.023	2.718AsnArg: 2.718 ± 0.023	6.187AsnSer: 6.187 ± 0.035	3.454AsnThr: 3.454 ± 0.022	3.265AsnVal: 3.265 ± 0.022	0.889AsnTrp: 0.889 ± 0.01	2.964AsnTyr: 2.964 ± 0.02	0.011AsnXaa: 0.011 ± 0.001
Pro	1.344ProAla: 1.344 ± 0.014	0.502ProCys: 0.502 ± 0.007	1.921ProAsp: 1.921 ± 0.015	3.058ProGlu: 3.058 ± 0.024	1.76ProPhe: 1.76 ± 0.014	1.468ProGly: 1.468 ± 0.015	0.793ProHis: 0.793 ± 0.01	2.948ProIle: 2.948 ± 0.019	3.041ProLys: 3.041 ± 0.023	3.176ProLeu: 3.176 ± 0.021	0.552ProMet: 0.552 ± 0.008	2.831ProAsn: 2.831 ± 0.021	2.383ProPro: 2.383 ± 0.039	1.538ProGln: 1.538 ± 0.02	1.704ProArg: 1.704 ± 0.016	3.268ProSer: 3.268 ± 0.026	2.531ProThr: 2.531 ± 0.03	1.73ProVal: 1.73 ± 0.015	0.34ProTrp: 0.34 ± 0.006	1.819ProTyr: 1.819 ± 0.015	0.005ProXaa: 0.005 ± 0.001
Gln	1.375GlnAla: 1.375 ± 0.012	0.675GlnCys: 0.675 ± 0.011	1.871GlnAsp: 1.871 ± 0.016	2.789GlnGlu: 2.789 ± 0.022	1.487GlnPhe: 1.487 ± 0.013	1.066GlnGly: 1.066 ± 0.012	0.93GlnHis: 0.93 ± 0.012	3.194GlnIle: 3.194 ± 0.018	3.061GlnLys: 3.061 ± 0.023	3.342GlnLeu: 3.342 ± 0.022	0.799GlnMet: 0.799 ± 0.01	3.217GlnAsn: 3.217 ± 0.026	1.328GlnPro: 1.328 ± 0.017	2.411GlnGln: 2.411 ± 0.035	1.628GlnArg: 1.628 ± 0.015	2.46GlnSer: 2.46 ± 0.019	1.82GlnThr: 1.82 ± 0.016	1.635GlnVal: 1.635 ± 0.014	0.977GlnTrp: 0.977 ± 0.028	1.562GlnTyr: 1.562 ± 0.02	0.004GlnXaa: 0.004 ± 0.001
Arg	1.817ArgAla: 1.817 ± 0.016	0.815ArgCys: 0.815 ± 0.012	2.227ArgAsp: 2.227 ± 0.017	2.955ArgGlu: 2.955 ± 0.025	1.818ArgPhe: 1.818 ± 0.017	1.971ArgGly: 1.971 ± 0.023	0.967ArgHis: 0.967 ± 0.012	3.329ArgIle: 3.329 ± 0.02	4.102ArgLys: 4.102 ± 0.024	3.612ArgLeu: 3.612 ± 0.021	0.91ArgMet: 0.91 ± 0.009	3.255ArgAsn: 3.255 ± 0.023	1.986ArgPro: 1.986 ± 0.015	1.637ArgGln: 1.637 ± 0.014	2.58ArgArg: 2.58 ± 0.028	3.172ArgSer: 3.172 ± 0.035	2.13ArgThr: 2.13 ± 0.017	1.955ArgVal: 1.955 ± 0.017	0.572ArgTrp: 0.572 ± 0.01	1.699ArgTyr: 1.699 ± 0.013	0.004ArgXaa: 0.004 ± 0.001
Ser	3.638SerAla: 3.638 ± 0.037	0.98SerCys: 0.98 ± 0.01	4.511SerAsp: 4.511 ± 0.023	5.193SerGlu: 5.193 ± 0.032	3.387SerPhe: 3.387 ± 0.018	3.356SerGly: 3.356 ± 0.021	1.558SerHis: 1.558 ± 0.014	6.109SerIle: 6.109 ± 0.03	5.834SerLys: 5.834 ± 0.031	6.945SerLeu: 6.945 ± 0.031	1.25SerMet: 1.25 ± 0.01	6.149SerAsn: 6.149 ± 0.036	3.176SerPro: 3.176 ± 0.029	3.088SerGln: 3.088 ± 0.022	3.63SerArg: 3.63 ± 0.023	8.919SerSer: 8.919 ± 0.071	4.92SerThr: 4.92 ± 0.031	3.281SerVal: 3.281 ± 0.025	0.914SerTrp: 0.914 ± 0.009	2.564SerTyr: 2.564 ± 0.018	0.008SerXaa: 0.008 ± 0.001
Thr	2.354ThrAla: 2.354 ± 0.018	0.75ThrCys: 0.75 ± 0.012	2.566ThrAsp: 2.566 ± 0.024	3.409ThrGlu: 3.409 ± 0.025	2.467ThrPhe: 2.467 ± 0.019	2.202ThrGly: 2.202 ± 0.016	1.157ThrHis: 1.157 ± 0.011	4.609ThrIle: 4.609 ± 0.028	4.537ThrLys: 4.537 ± 0.031	4.655ThrLeu: 4.655 ± 0.027	0.868ThrMet: 0.868 ± 0.011	3.82ThrAsn: 3.82 ± 0.027	2.519ThrPro: 2.519 ± 0.029	1.941ThrGln: 1.941 ± 0.017	2.216ThrArg: 2.216 ± 0.017	4.996ThrSer: 4.996 ± 0.029	4.867ThrThr: 4.867 ± 0.049	2.426ThrVal: 2.426 ± 0.018	0.693ThrTrp: 0.693 ± 0.01	1.886ThrTyr: 1.886 ± 0.017	0.008ThrXaa: 0.008 ± 0.001
Val	2.247ValAla: 2.247 ± 0.017	0.662ValCys: 0.662 ± 0.01	2.542ValAsp: 2.542 ± 0.019	3.21ValGlu: 3.21 ± 0.023	1.957ValPhe: 1.957 ± 0.015	1.961ValGly: 1.961 ± 0.016	1.059ValHis: 1.059 ± 0.01	3.864ValIle: 3.864 ± 0.024	3.824ValLys: 3.824 ± 0.021	4.1ValLeu: 4.1 ± 0.023	1.001ValMet: 1.001 ± 0.01	2.921ValAsn: 2.921 ± 0.018	1.726ValPro: 1.726 ± 0.015	1.426ValGln: 1.426 ± 0.016	1.77ValArg: 1.77 ± 0.013	3.245ValSer: 3.245 ± 0.024	2.704ValThr: 2.704 ± 0.019	2.463ValVal: 2.463 ± 0.022	0.494ValTrp: 0.494 ± 0.007	1.825ValTyr: 1.825 ± 0.017	0.006ValXaa: 0.006 ± 0.001
Trp	0.479TrpAla: 0.479 ± 0.006	0.338TrpCys: 0.338 ± 0.007	0.986TrpAsp: 0.986 ± 0.015	0.823TrpGlu: 0.823 ± 0.009	0.54TrpPhe: 0.54 ± 0.008	0.514TrpGly: 0.514 ± 0.007	0.265TrpHis: 0.265 ± 0.005	1.196TrpIle: 1.196 ± 0.011	1.295TrpLys: 1.295 ± 0.012	0.911TrpLeu: 0.911 ± 0.009	0.286TrpMet: 0.286 ± 0.006	0.995TrpAsn: 0.995 ± 0.01	0.339TrpPro: 0.339 ± 0.007	0.333TrpGln: 0.333 ± 0.007	0.598TrpArg: 0.598 ± 0.008	0.753TrpSer: 0.753 ± 0.009	0.68TrpThr: 0.68 ± 0.008	0.5TrpVal: 0.5 ± 0.007	0.216TrpTrp: 0.216 ± 0.006	1.013TrpTyr: 1.013 ± 0.033	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.554TyrAla: 1.554 ± 0.014	0.944TyrCys: 0.944 ± 0.015	2.162TyrAsp: 2.162 ± 0.017	2.778TyrGlu: 2.778 ± 0.021	2.049TyrPhe: 2.049 ± 0.013	2.122TyrGly: 2.122 ± 0.019	0.968TyrHis: 0.968 ± 0.01	2.861TyrIle: 2.861 ± 0.018	2.647TyrLys: 2.647 ± 0.017	3.989TyrLeu: 3.989 ± 0.037	0.923TyrMet: 0.923 ± 0.012	3.051TyrAsn: 3.051 ± 0.019	1.412TyrPro: 1.412 ± 0.014	1.625TyrGln: 1.625 ± 0.018	1.818TyrArg: 1.818 ± 0.015	3.081TyrSer: 3.081 ± 0.021	1.958TyrThr: 1.958 ± 0.016	1.634TyrVal: 1.634 ± 0.013	0.428TyrTrp: 0.428 ± 0.007	1.953TyrTyr: 1.953 ± 0.022	0.004TyrXaa: 0.004 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.005XaaAsp: 0.005 ± 0.001	0.007XaaGlu: 0.007 ± 0.001	0.006XaaPhe: 0.006 ± 0.001	0.004XaaGly: 0.004 ± 0.001	0.003XaaHis: 0.003 ± 0.001	0.013XaaIle: 0.013 ± 0.001	0.009XaaLys: 0.009 ± 0.001	0.012XaaLeu: 0.012 ± 0.001	0.005XaaMet: 0.005 ± 0.001	0.008XaaAsn: 0.008 ± 0.001	0.004XaaPro: 0.004 ± 0.001	0.005XaaGln: 0.005 ± 0.001	0.005XaaArg: 0.005 ± 0.001	0.008XaaSer: 0.008 ± 0.001	0.006XaaThr: 0.006 ± 0.001	0.005XaaVal: 0.005 ± 0.001	0.002XaaTrp: 0.002 ± 0.0	0.005XaaTyr: 0.005 ± 0.001	0.309XaaXaa: 0.309 ± 0.06

Statistics based on 28108 proteins (10124451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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