Amino acid dipepetide frequency for Propionibacteriaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.831AlaAla: 17.831 ± 0.303	0.995AlaCys: 0.995 ± 0.048	7.755AlaAsp: 7.755 ± 0.133	7.227AlaGlu: 7.227 ± 0.145	3.421AlaPhe: 3.421 ± 0.098	11.8AlaGly: 11.8 ± 0.162	2.508AlaHis: 2.508 ± 0.079	4.256AlaIle: 4.256 ± 0.092	2.956AlaLys: 2.956 ± 0.101	12.886AlaLeu: 12.886 ± 0.212	2.49AlaMet: 2.49 ± 0.08	2.22AlaAsn: 2.22 ± 0.07	5.807AlaPro: 5.807 ± 0.143	3.899AlaGln: 3.899 ± 0.108	8.909AlaArg: 8.909 ± 0.158	6.711AlaSer: 6.711 ± 0.126	7.38AlaThr: 7.38 ± 0.139	11.206AlaVal: 11.206 ± 0.174	1.799AlaTrp: 1.799 ± 0.06	2.865AlaTyr: 2.865 ± 0.077	0.002AlaXaa: 0.002 ± 0.002
Cys	0.822CysAla: 0.822 ± 0.042	0.117CysCys: 0.117 ± 0.017	0.434CysAsp: 0.434 ± 0.033	0.326CysGlu: 0.326 ± 0.03	0.226CysPhe: 0.226 ± 0.021	0.818CysGly: 0.818 ± 0.049	0.16CysHis: 0.16 ± 0.017	0.215CysIle: 0.215 ± 0.02	0.117CysLys: 0.117 ± 0.018	0.66CysLeu: 0.66 ± 0.041	0.084CysMet: 0.084 ± 0.013	0.126CysAsn: 0.126 ± 0.019	0.441CysPro: 0.441 ± 0.032	0.171CysGln: 0.171 ± 0.019	0.558CysArg: 0.558 ± 0.037	0.481CysSer: 0.481 ± 0.034	0.49CysThr: 0.49 ± 0.037	0.605CysVal: 0.605 ± 0.041	0.129CysTrp: 0.129 ± 0.016	0.166CysTyr: 0.166 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	7.885AspAla: 7.885 ± 0.146	0.41AspCys: 0.41 ± 0.029	4.168AspAsp: 4.168 ± 0.111	3.992AspGlu: 3.992 ± 0.105	1.628AspPhe: 1.628 ± 0.061	5.947AspGly: 5.947 ± 0.122	1.584AspHis: 1.584 ± 0.067	1.797AspIle: 1.797 ± 0.065	1.225AspLys: 1.225 ± 0.061	7.128AspLeu: 7.128 ± 0.136	0.822AspMet: 0.822 ± 0.042	1.101AspAsn: 1.101 ± 0.058	4.345AspPro: 4.345 ± 0.111	1.959AspGln: 1.959 ± 0.07	5.1AspArg: 5.1 ± 0.112	2.555AspSer: 2.555 ± 0.079	3.044AspThr: 3.044 ± 0.088	6.224AspVal: 6.224 ± 0.124	0.913AspTrp: 0.913 ± 0.046	1.427AspTyr: 1.427 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	6.755GluAla: 6.755 ± 0.14	0.266GluCys: 0.266 ± 0.026	2.854GluAsp: 2.854 ± 0.083	2.692GluGlu: 2.692 ± 0.089	1.445GluPhe: 1.445 ± 0.058	4.152GluGly: 4.152 ± 0.096	1.655GluHis: 1.655 ± 0.062	2.286GluIle: 2.286 ± 0.078	1.23GluLys: 1.23 ± 0.057	5.862GluLeu: 5.862 ± 0.124	0.902GluMet: 0.902 ± 0.049	1.048GluAsn: 1.048 ± 0.047	3.062GluPro: 3.062 ± 0.079	2.309GluGln: 2.309 ± 0.074	4.954GluArg: 4.954 ± 0.125	2.371GluSer: 2.371 ± 0.078	2.734GluThr: 2.734 ± 0.075	5.309GluVal: 5.309 ± 0.116	0.596GluTrp: 0.596 ± 0.038	1.001GluTyr: 1.001 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.569PheAla: 3.569 ± 0.095	0.275PheCys: 0.275 ± 0.024	2.251PheAsp: 2.251 ± 0.071	1.405PheGlu: 1.405 ± 0.056	1.079PhePhe: 1.079 ± 0.051	3.153PheGly: 3.153 ± 0.092	0.558PheHis: 0.558 ± 0.031	0.809PheIle: 0.809 ± 0.047	0.636PheLys: 0.636 ± 0.044	2.756PheLeu: 2.756 ± 0.091	0.465PheMet: 0.465 ± 0.031	0.68PheAsn: 0.68 ± 0.038	1.305PhePro: 1.305 ± 0.049	0.78PheGln: 0.78 ± 0.041	1.755PheArg: 1.755 ± 0.068	1.642PheSer: 1.642 ± 0.062	2.074PheThr: 2.074 ± 0.07	2.743PheVal: 2.743 ± 0.085	0.432PheTrp: 0.432 ± 0.032	0.742PheTyr: 0.742 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	9.808GlyAla: 9.808 ± 0.16	0.747GlyCys: 0.747 ± 0.042	5.191GlyAsp: 5.191 ± 0.103	4.591GlyGlu: 4.591 ± 0.107	2.995GlyPhe: 2.995 ± 0.081	7.746GlyGly: 7.746 ± 0.173	2.032GlyHis: 2.032 ± 0.077	3.685GlyIle: 3.685 ± 0.1	2.453GlyLys: 2.453 ± 0.108	9.718GlyLeu: 9.718 ± 0.152	1.772GlyMet: 1.772 ± 0.059	1.719GlyAsn: 1.719 ± 0.065	4.783GlyPro: 4.783 ± 0.094	3.044GlyGln: 3.044 ± 0.089	7.365GlyArg: 7.365 ± 0.133	5.497GlySer: 5.497 ± 0.123	6.117GlyThr: 6.117 ± 0.125	8.226GlyVal: 8.226 ± 0.144	1.757GlyTrp: 1.757 ± 0.063	2.346GlyTyr: 2.346 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	2.388HisAla: 2.388 ± 0.082	0.155HisCys: 0.155 ± 0.018	1.465HisAsp: 1.465 ± 0.059	1.188HisGlu: 1.188 ± 0.056	0.58HisPhe: 0.58 ± 0.028	2.2HisGly: 2.2 ± 0.069	0.718HisHis: 0.718 ± 0.046	0.647HisIle: 0.647 ± 0.035	0.335HisLys: 0.335 ± 0.029	2.457HisLeu: 2.457 ± 0.088	0.286HisMet: 0.286 ± 0.027	0.439HisAsn: 0.439 ± 0.036	1.551HisPro: 1.551 ± 0.065	0.676HisGln: 0.676 ± 0.036	1.828HisArg: 1.828 ± 0.072	0.955HisSer: 0.955 ± 0.052	1.068HisThr: 1.068 ± 0.042	2.023HisVal: 2.023 ± 0.063	0.295HisTrp: 0.295 ± 0.028	0.452HisTyr: 0.452 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	4.6IleAla: 4.6 ± 0.106	0.286IleCys: 0.286 ± 0.023	2.661IleAsp: 2.661 ± 0.084	2.193IleGlu: 2.193 ± 0.074	0.966IlePhe: 0.966 ± 0.045	3.529IleGly: 3.529 ± 0.089	0.563IleHis: 0.563 ± 0.036	1.196IleIle: 1.196 ± 0.063	0.944IleLys: 0.944 ± 0.054	2.787IleLeu: 2.787 ± 0.091	0.585IleMet: 0.585 ± 0.036	0.919IleAsn: 0.919 ± 0.049	1.863IlePro: 1.863 ± 0.066	0.869IleGln: 0.869 ± 0.042	2.158IleArg: 2.158 ± 0.067	2.094IleSer: 2.094 ± 0.079	2.446IleThr: 2.446 ± 0.074	3.228IleVal: 3.228 ± 0.096	0.317IleTrp: 0.317 ± 0.027	0.756IleTyr: 0.756 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	2.933LysAla: 2.933 ± 0.092	0.113LysCys: 0.113 ± 0.019	1.263LysAsp: 1.263 ± 0.054	0.946LysGlu: 0.946 ± 0.047	0.507LysPhe: 0.507 ± 0.038	1.981LysGly: 1.981 ± 0.087	0.485LysHis: 0.485 ± 0.032	1.092LysIle: 1.092 ± 0.058	0.88LysLys: 0.88 ± 0.06	1.983LysLeu: 1.983 ± 0.076	0.463LysMet: 0.463 ± 0.033	0.638LysAsn: 0.638 ± 0.042	1.283LysPro: 1.283 ± 0.055	0.842LysGln: 0.842 ± 0.044	1.524LysArg: 1.524 ± 0.059	1.174LysSer: 1.174 ± 0.051	1.6LysThr: 1.6 ± 0.073	2.404LysVal: 2.404 ± 0.085	0.208LysTrp: 0.208 ± 0.022	0.49LysTyr: 0.49 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	13.599LeuAla: 13.599 ± 0.197	0.662LeuCys: 0.662 ± 0.039	6.986LeuAsp: 6.986 ± 0.131	5.171LeuGlu: 5.171 ± 0.12	2.741LeuPhe: 2.741 ± 0.084	9.299LeuGly: 9.299 ± 0.179	2.118LeuHis: 2.118 ± 0.066	3.315LeuIle: 3.315 ± 0.097	2.087LeuLys: 2.087 ± 0.078	10.178LeuLeu: 10.178 ± 0.19	1.755LeuMet: 1.755 ± 0.064	1.888LeuAsn: 1.888 ± 0.071	5.191LeuPro: 5.191 ± 0.112	2.672LeuGln: 2.672 ± 0.077	7.615LeuArg: 7.615 ± 0.153	5.512LeuSer: 5.512 ± 0.112	6.636LeuThr: 6.636 ± 0.133	10.382LeuVal: 10.382 ± 0.193	1.13LeuTrp: 1.13 ± 0.051	1.85LeuTyr: 1.85 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.196MetAla: 2.196 ± 0.067	0.124MetCys: 0.124 ± 0.016	0.906MetAsp: 0.906 ± 0.041	0.751MetGlu: 0.751 ± 0.047	0.474MetPhe: 0.474 ± 0.035	1.409MetGly: 1.409 ± 0.068	0.366MetHis: 0.366 ± 0.03	0.634MetIle: 0.634 ± 0.033	0.414MetLys: 0.414 ± 0.029	1.626MetLeu: 1.626 ± 0.058	0.275MetMet: 0.275 ± 0.023	0.461MetAsn: 0.461 ± 0.03	1.119MetPro: 1.119 ± 0.05	0.474MetGln: 0.474 ± 0.035	1.425MetArg: 1.425 ± 0.06	1.515MetSer: 1.515 ± 0.057	1.482MetThr: 1.482 ± 0.061	1.644MetVal: 1.644 ± 0.058	0.155MetTrp: 0.155 ± 0.018	0.315MetTyr: 0.315 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.563AsnAla: 2.563 ± 0.071	0.129AsnCys: 0.129 ± 0.015	1.108AsnAsp: 1.108 ± 0.053	1.001AsnGlu: 1.001 ± 0.052	0.616AsnPhe: 0.616 ± 0.041	1.897AsnGly: 1.897 ± 0.078	0.472AsnHis: 0.472 ± 0.032	0.771AsnIle: 0.771 ± 0.044	0.492AsnLys: 0.492 ± 0.04	2.089AsnLeu: 2.089 ± 0.075	0.37AsnMet: 0.37 ± 0.031	0.536AsnAsn: 0.536 ± 0.04	1.597AsnPro: 1.597 ± 0.062	0.625AsnGln: 0.625 ± 0.038	1.38AsnArg: 1.38 ± 0.059	0.86AsnSer: 0.86 ± 0.05	1.112AsnThr: 1.112 ± 0.055	1.77AsnVal: 1.77 ± 0.067	0.277AsnTrp: 0.277 ± 0.025	0.456AsnTyr: 0.456 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.895ProAla: 6.895 ± 0.138	0.348ProCys: 0.348 ± 0.029	4.358ProAsp: 4.358 ± 0.113	3.609ProGlu: 3.609 ± 0.096	1.604ProPhe: 1.604 ± 0.06	6.06ProGly: 6.06 ± 0.124	1.057ProHis: 1.057 ± 0.058	1.609ProIle: 1.609 ± 0.068	1.148ProLys: 1.148 ± 0.058	4.631ProLeu: 4.631 ± 0.107	0.837ProMet: 0.837 ± 0.043	0.97ProAsn: 0.97 ± 0.043	2.512ProPro: 2.512 ± 0.085	1.624ProGln: 1.624 ± 0.055	3.534ProArg: 3.534 ± 0.097	3.213ProSer: 3.213 ± 0.099	3.445ProThr: 3.445 ± 0.09	5.26ProVal: 5.26 ± 0.113	0.793ProTrp: 0.793 ± 0.041	1.276ProTyr: 1.276 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	4.012GlnAla: 4.012 ± 0.104	0.177GlnCys: 0.177 ± 0.02	1.498GlnAsp: 1.498 ± 0.059	1.316GlnGlu: 1.316 ± 0.058	0.8GlnPhe: 0.8 ± 0.039	2.506GlnGly: 2.506 ± 0.075	0.787GlnHis: 0.787 ± 0.042	1.192GlnIle: 1.192 ± 0.049	0.72GlnLys: 0.72 ± 0.045	3.315GlnLeu: 3.315 ± 0.099	0.6GlnMet: 0.6 ± 0.043	0.631GlnAsn: 0.631 ± 0.04	1.653GlnPro: 1.653 ± 0.059	1.445GlnGln: 1.445 ± 0.059	2.459GlnArg: 2.459 ± 0.081	1.462GlnSer: 1.462 ± 0.061	1.839GlnThr: 1.839 ± 0.068	3.135GlnVal: 3.135 ± 0.083	0.481GlnTrp: 0.481 ± 0.034	0.713GlnTyr: 0.713 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	8.554ArgAla: 8.554 ± 0.144	0.525ArgCys: 0.525 ± 0.036	4.391ArgAsp: 4.391 ± 0.112	4.132ArgGlu: 4.132 ± 0.11	2.231ArgPhe: 2.231 ± 0.065	5.98ArgGly: 5.98 ± 0.119	1.746ArgHis: 1.746 ± 0.062	2.73ArgIle: 2.73 ± 0.076	1.531ArgLys: 1.531 ± 0.062	7.675ArgLeu: 7.675 ± 0.144	1.573ArgMet: 1.573 ± 0.054	1.405ArgAsn: 1.405 ± 0.056	4.52ArgPro: 4.52 ± 0.106	2.342ArgGln: 2.342 ± 0.067	7.331ArgArg: 7.331 ± 0.163	4.347ArgSer: 4.347 ± 0.102	5.063ArgThr: 5.063 ± 0.13	6.396ArgVal: 6.396 ± 0.129	1.338ArgTrp: 1.338 ± 0.046	1.779ArgTyr: 1.779 ± 0.068	0.0ArgXaa: 0.0 ± 0.0
Ser	6.496SerAla: 6.496 ± 0.132	0.383SerCys: 0.383 ± 0.033	3.06SerAsp: 3.06 ± 0.085	2.572SerGlu: 2.572 ± 0.08	1.784SerPhe: 1.784 ± 0.06	5.761SerGly: 5.761 ± 0.119	1.004SerHis: 1.004 ± 0.048	2.114SerIle: 2.114 ± 0.076	1.216SerLys: 1.216 ± 0.056	5.165SerLeu: 5.165 ± 0.113	1.181SerMet: 1.181 ± 0.055	1.137SerAsn: 1.137 ± 0.049	2.98SerPro: 2.98 ± 0.081	1.597SerGln: 1.597 ± 0.06	3.893SerArg: 3.893 ± 0.096	3.707SerSer: 3.707 ± 0.111	3.984SerThr: 3.984 ± 0.113	4.801SerVal: 4.801 ± 0.117	1.019SerTrp: 1.019 ± 0.059	1.405SerTyr: 1.405 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	7.582ThrAla: 7.582 ± 0.125	0.481ThrCys: 0.481 ± 0.039	3.955ThrAsp: 3.955 ± 0.099	2.953ThrGlu: 2.953 ± 0.074	2.032ThrPhe: 2.032 ± 0.074	6.301ThrGly: 6.301 ± 0.13	1.194ThrHis: 1.194 ± 0.056	2.309ThrIle: 2.309 ± 0.068	1.509ThrLys: 1.509 ± 0.064	5.871ThrLeu: 5.871 ± 0.115	1.239ThrMet: 1.239 ± 0.052	1.32ThrAsn: 1.32 ± 0.053	3.866ThrPro: 3.866 ± 0.088	1.673ThrGln: 1.673 ± 0.063	4.021ThrArg: 4.021 ± 0.086	3.97ThrSer: 3.97 ± 0.1	4.617ThrThr: 4.617 ± 0.113	6.193ThrVal: 6.193 ± 0.115	0.99ThrTrp: 0.99 ± 0.055	1.62ThrTyr: 1.62 ± 0.067	0.0ThrXaa: 0.0 ± 0.0
Val	11.986ValAla: 11.986 ± 0.199	0.634ValCys: 0.634 ± 0.04	6.443ValAsp: 6.443 ± 0.126	5.661ValGlu: 5.661 ± 0.135	2.699ValPhe: 2.699 ± 0.093	7.724ValGly: 7.724 ± 0.14	1.95ValHis: 1.95 ± 0.074	3.133ValIle: 3.133 ± 0.095	2.167ValLys: 2.167 ± 0.077	10.367ValLeu: 10.367 ± 0.176	1.476ValMet: 1.476 ± 0.052	1.863ValAsn: 1.863 ± 0.065	5.078ValPro: 5.078 ± 0.119	2.55ValGln: 2.55 ± 0.081	6.822ValArg: 6.822 ± 0.136	5.016ValSer: 5.016 ± 0.107	6.197ValThr: 6.197 ± 0.142	10.653ValVal: 10.653 ± 0.17	1.219ValTrp: 1.219 ± 0.05	1.757ValTyr: 1.757 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	1.564TrpAla: 1.564 ± 0.062	0.131TrpCys: 0.131 ± 0.016	0.891TrpAsp: 0.891 ± 0.044	0.543TrpGlu: 0.543 ± 0.04	0.53TrpPhe: 0.53 ± 0.041	1.07TrpGly: 1.07 ± 0.056	0.31TrpHis: 0.31 ± 0.024	0.594TrpIle: 0.594 ± 0.038	0.308TrpLys: 0.308 ± 0.026	1.509TrpLeu: 1.509 ± 0.063	0.277TrpMet: 0.277 ± 0.022	0.425TrpAsn: 0.425 ± 0.031	0.738TrpPro: 0.738 ± 0.044	0.549TrpGln: 0.549 ± 0.032	1.192TrpArg: 1.192 ± 0.053	0.957TrpSer: 0.957 ± 0.048	1.057TrpThr: 1.057 ± 0.049	1.283TrpVal: 1.283 ± 0.052	0.295TrpTrp: 0.295 ± 0.026	0.321TrpTyr: 0.321 ± 0.031	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.885TyrAla: 2.885 ± 0.084	0.188TyrCys: 0.188 ± 0.021	1.617TyrAsp: 1.617 ± 0.068	1.212TyrGlu: 1.212 ± 0.053	0.751TyrPhe: 0.751 ± 0.047	2.26TyrGly: 2.26 ± 0.068	0.439TyrHis: 0.439 ± 0.032	0.578TyrIle: 0.578 ± 0.034	0.443TyrLys: 0.443 ± 0.032	2.125TyrLeu: 2.125 ± 0.074	0.31TyrMet: 0.31 ± 0.031	0.594TyrAsn: 0.594 ± 0.036	1.088TyrPro: 1.088 ± 0.046	0.643TyrGln: 0.643 ± 0.04	1.766TyrArg: 1.766 ± 0.065	1.219TyrSer: 1.219 ± 0.058	1.312TyrThr: 1.312 ± 0.047	1.908TyrVal: 1.908 ± 0.063	0.401TyrTrp: 0.401 ± 0.032	0.605TyrTyr: 0.605 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 2125 proteins (451348 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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