Amino acid dipepetide frequency for Streptococcus phage Javan526

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.149AlaAla: 4.149 ± 1.186
0.407AlaCys: 0.407 ± 0.236
4.068AlaAsp: 4.068 ± 0.621
5.044AlaGlu: 5.044 ± 0.919
2.197AlaPhe: 2.197 ± 0.381
4.719AlaGly: 4.719 ± 0.803
0.814AlaHis: 0.814 ± 0.228
5.369AlaIle: 5.369 ± 0.726
6.915AlaLys: 6.915 ± 0.795
6.02AlaLeu: 6.02 ± 1.177
2.034AlaMet: 2.034 ± 0.399
3.905AlaAsn: 3.905 ± 0.506
1.464AlaPro: 1.464 ± 0.301
2.847AlaGln: 2.847 ± 0.649
2.441AlaArg: 2.441 ± 0.429
4.881AlaSer: 4.881 ± 0.73
4.719AlaThr: 4.719 ± 0.889
4.393AlaVal: 4.393 ± 0.867
0.895AlaTrp: 0.895 ± 0.281
2.034AlaTyr: 2.034 ± 0.325
0.0AlaXaa: 0.0 ± 0.0
Cys
0.163CysAla: 0.163 ± 0.106
0.0CysCys: 0.0 ± 0.0
0.407CysAsp: 0.407 ± 0.161
0.569CysGlu: 0.569 ± 0.215
0.407CysPhe: 0.407 ± 0.164
0.732CysGly: 0.732 ± 0.262
0.081CysHis: 0.081 ± 0.068
0.244CysIle: 0.244 ± 0.131
0.569CysLys: 0.569 ± 0.229
0.407CysLeu: 0.407 ± 0.15
0.081CysMet: 0.081 ± 0.095
0.325CysAsn: 0.325 ± 0.193
0.163CysPro: 0.163 ± 0.115
0.163CysGln: 0.163 ± 0.102
0.325CysArg: 0.325 ± 0.164
0.163CysSer: 0.163 ± 0.122
0.325CysThr: 0.325 ± 0.164
0.651CysVal: 0.651 ± 0.279
0.163CysTrp: 0.163 ± 0.116
0.244CysTyr: 0.244 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
3.742AspAla: 3.742 ± 0.496
0.325AspCys: 0.325 ± 0.171
4.23AspAsp: 4.23 ± 0.532
5.288AspGlu: 5.288 ± 0.692
3.091AspPhe: 3.091 ± 0.464
5.288AspGly: 5.288 ± 0.786
1.139AspHis: 1.139 ± 0.276
3.986AspIle: 3.986 ± 0.686
5.939AspLys: 5.939 ± 0.687
6.59AspLeu: 6.59 ± 0.654
2.034AspMet: 2.034 ± 0.447
4.312AspAsn: 4.312 ± 0.461
1.627AspPro: 1.627 ± 0.352
1.302AspGln: 1.302 ± 0.334
2.034AspArg: 2.034 ± 0.324
3.498AspSer: 3.498 ± 0.541
3.905AspThr: 3.905 ± 0.535
3.905AspVal: 3.905 ± 0.529
1.139AspTrp: 1.139 ± 0.4
3.091AspTyr: 3.091 ± 0.529
0.0AspXaa: 0.0 ± 0.0
Glu
4.963GluAla: 4.963 ± 0.754
0.569GluCys: 0.569 ± 0.222
3.498GluAsp: 3.498 ± 0.682
6.102GluGlu: 6.102 ± 0.925
3.254GluPhe: 3.254 ± 0.419
2.359GluGly: 2.359 ± 0.357
1.139GluHis: 1.139 ± 0.362
6.915GluIle: 6.915 ± 0.796
6.264GluLys: 6.264 ± 0.778
7.566GluLeu: 7.566 ± 0.761
1.952GluMet: 1.952 ± 0.386
3.091GluAsn: 3.091 ± 0.548
1.952GluPro: 1.952 ± 0.461
3.417GluGln: 3.417 ± 0.473
2.847GluArg: 2.847 ± 0.544
4.149GluSer: 4.149 ± 0.585
4.474GluThr: 4.474 ± 0.637
4.637GluVal: 4.637 ± 0.894
1.058GluTrp: 1.058 ± 0.224
2.603GluTyr: 2.603 ± 0.472
0.0GluXaa: 0.0 ± 0.0
Phe
2.522PheAla: 2.522 ± 0.401
0.244PheCys: 0.244 ± 0.147
3.091PheAsp: 3.091 ± 0.516
2.766PheGlu: 2.766 ± 0.464
1.302PhePhe: 1.302 ± 0.418
3.01PheGly: 3.01 ± 0.45
0.244PheHis: 0.244 ± 0.142
2.766PheIle: 2.766 ± 0.522
3.824PheLys: 3.824 ± 0.609
2.115PheLeu: 2.115 ± 0.426
0.976PheMet: 0.976 ± 0.298
2.115PheAsn: 2.115 ± 0.371
0.976PhePro: 0.976 ± 0.289
1.058PheGln: 1.058 ± 0.285
1.708PheArg: 1.708 ± 0.441
3.498PheSer: 3.498 ± 0.495
2.522PheThr: 2.522 ± 0.477
2.115PheVal: 2.115 ± 0.425
0.244PheTrp: 0.244 ± 0.14
1.546PheTyr: 1.546 ± 0.396
0.0PheXaa: 0.0 ± 0.0
Gly
3.58GlyAla: 3.58 ± 0.647
0.325GlyCys: 0.325 ± 0.165
4.393GlyAsp: 4.393 ± 0.61
3.254GlyGlu: 3.254 ± 0.617
2.685GlyPhe: 2.685 ± 0.527
4.556GlyGly: 4.556 ± 0.683
1.139GlyHis: 1.139 ± 0.266
4.963GlyIle: 4.963 ± 0.584
7.078GlyLys: 7.078 ± 0.684
5.451GlyLeu: 5.451 ± 0.907
1.79GlyMet: 1.79 ± 0.472
3.742GlyAsn: 3.742 ± 0.49
0.651GlyPro: 0.651 ± 0.256
2.115GlyGln: 2.115 ± 0.295
2.847GlyArg: 2.847 ± 0.437
2.847GlySer: 2.847 ± 0.462
2.847GlyThr: 2.847 ± 0.564
4.881GlyVal: 4.881 ± 0.48
1.302GlyTrp: 1.302 ± 0.414
2.766GlyTyr: 2.766 ± 0.527
0.0GlyXaa: 0.0 ± 0.0
His
1.058HisAla: 1.058 ± 0.298
0.0HisCys: 0.0 ± 0.0
0.814HisAsp: 0.814 ± 0.275
0.814HisGlu: 0.814 ± 0.208
0.895HisPhe: 0.895 ± 0.296
0.569HisGly: 0.569 ± 0.215
0.081HisHis: 0.081 ± 0.071
0.976HisIle: 0.976 ± 0.267
0.732HisLys: 0.732 ± 0.259
0.814HisLeu: 0.814 ± 0.239
0.244HisMet: 0.244 ± 0.159
0.814HisAsn: 0.814 ± 0.233
0.569HisPro: 0.569 ± 0.192
0.488HisGln: 0.488 ± 0.176
0.732HisArg: 0.732 ± 0.208
0.976HisSer: 0.976 ± 0.364
0.895HisThr: 0.895 ± 0.337
0.895HisVal: 0.895 ± 0.244
0.325HisTrp: 0.325 ± 0.146
0.814HisTyr: 0.814 ± 0.263
0.0HisXaa: 0.0 ± 0.0
Ile
5.044IleAla: 5.044 ± 0.675
0.407IleCys: 0.407 ± 0.179
6.183IleAsp: 6.183 ± 0.803
5.776IleGlu: 5.776 ± 0.601
1.79IlePhe: 1.79 ± 0.413
3.58IleGly: 3.58 ± 0.625
0.976IleHis: 0.976 ± 0.231
5.288IleIle: 5.288 ± 0.741
6.996IleLys: 6.996 ± 0.691
6.427IleLeu: 6.427 ± 0.862
0.976IleMet: 0.976 ± 0.246
5.125IleAsn: 5.125 ± 0.752
2.685IlePro: 2.685 ± 0.539
1.383IleGln: 1.383 ± 0.342
2.522IleArg: 2.522 ± 0.428
3.986IleSer: 3.986 ± 0.785
5.044IleThr: 5.044 ± 0.733
3.58IleVal: 3.58 ± 0.469
0.651IleTrp: 0.651 ± 0.268
3.173IleTyr: 3.173 ± 0.601
0.0IleXaa: 0.0 ± 0.0
Lys
6.671LysAla: 6.671 ± 0.932
0.651LysCys: 0.651 ± 0.212
5.369LysAsp: 5.369 ± 0.897
6.671LysGlu: 6.671 ± 0.846
2.766LysPhe: 2.766 ± 0.467
4.637LysGly: 4.637 ± 0.713
1.383LysHis: 1.383 ± 0.303
6.915LysIle: 6.915 ± 1.039
7.485LysLys: 7.485 ± 0.868
7.078LysLeu: 7.078 ± 0.837
2.522LysMet: 2.522 ± 0.427
6.264LysAsn: 6.264 ± 0.847
3.091LysPro: 3.091 ± 0.586
4.8LysGln: 4.8 ± 0.731
2.929LysArg: 2.929 ± 0.556
5.451LysSer: 5.451 ± 0.613
6.346LysThr: 6.346 ± 0.739
4.881LysVal: 4.881 ± 0.649
0.732LysTrp: 0.732 ± 0.228
3.417LysTyr: 3.417 ± 0.596
0.0LysXaa: 0.0 ± 0.0
Leu
6.264LeuAla: 6.264 ± 1.068
0.325LeuCys: 0.325 ± 0.164
6.671LeuAsp: 6.671 ± 0.638
7.078LeuGlu: 7.078 ± 1.105
3.091LeuPhe: 3.091 ± 0.509
4.881LeuGly: 4.881 ± 0.767
0.976LeuHis: 0.976 ± 0.335
5.939LeuIle: 5.939 ± 0.971
8.135LeuLys: 8.135 ± 1.121
6.59LeuLeu: 6.59 ± 0.643
2.115LeuMet: 2.115 ± 0.383
5.776LeuAsn: 5.776 ± 0.732
3.01LeuPro: 3.01 ± 0.469
3.824LeuGln: 3.824 ± 0.608
3.58LeuArg: 3.58 ± 0.574
5.288LeuSer: 5.288 ± 0.795
5.288LeuThr: 5.288 ± 0.643
4.556LeuVal: 4.556 ± 0.611
0.651LeuTrp: 0.651 ± 0.304
2.685LeuTyr: 2.685 ± 0.455
0.0LeuXaa: 0.0 ± 0.0
Met
2.115MetAla: 2.115 ± 0.404
0.163MetCys: 0.163 ± 0.111
1.546MetAsp: 1.546 ± 0.371
1.464MetGlu: 1.464 ± 0.394
1.302MetPhe: 1.302 ± 0.325
1.058MetGly: 1.058 ± 0.284
0.325MetHis: 0.325 ± 0.19
2.115MetIle: 2.115 ± 0.421
1.627MetLys: 1.627 ± 0.294
2.115MetLeu: 2.115 ± 0.48
0.488MetMet: 0.488 ± 0.22
1.22MetAsn: 1.22 ± 0.318
0.569MetPro: 0.569 ± 0.227
0.814MetGln: 0.814 ± 0.247
1.871MetArg: 1.871 ± 0.328
1.871MetSer: 1.871 ± 0.453
1.79MetThr: 1.79 ± 0.381
1.871MetVal: 1.871 ± 0.456
0.325MetTrp: 0.325 ± 0.15
0.732MetTyr: 0.732 ± 0.234
0.0MetXaa: 0.0 ± 0.0
Asn
3.58AsnAla: 3.58 ± 0.701
0.244AsnCys: 0.244 ± 0.174
3.742AsnAsp: 3.742 ± 0.44
3.986AsnGlu: 3.986 ± 0.525
2.197AsnPhe: 2.197 ± 0.422
5.207AsnGly: 5.207 ± 0.824
0.488AsnHis: 0.488 ± 0.228
3.661AsnIle: 3.661 ± 0.549
4.068AsnLys: 4.068 ± 0.651
5.776AsnLeu: 5.776 ± 0.521
1.708AsnMet: 1.708 ± 0.376
3.661AsnAsn: 3.661 ± 0.544
2.522AsnPro: 2.522 ± 0.371
2.441AsnGln: 2.441 ± 0.496
2.441AsnArg: 2.441 ± 0.417
3.498AsnSer: 3.498 ± 0.607
3.091AsnThr: 3.091 ± 0.53
3.091AsnVal: 3.091 ± 0.431
0.732AsnTrp: 0.732 ± 0.263
2.359AsnTyr: 2.359 ± 0.438
0.0AsnXaa: 0.0 ± 0.0
Pro
1.708ProAla: 1.708 ± 0.396
0.081ProCys: 0.081 ± 0.068
1.871ProAsp: 1.871 ± 0.402
2.197ProGlu: 2.197 ± 0.487
1.22ProPhe: 1.22 ± 0.313
0.814ProGly: 0.814 ± 0.25
0.407ProHis: 0.407 ± 0.156
1.546ProIle: 1.546 ± 0.376
3.254ProLys: 3.254 ± 0.673
2.929ProLeu: 2.929 ± 0.603
0.325ProMet: 0.325 ± 0.217
1.871ProAsn: 1.871 ± 0.456
0.569ProPro: 0.569 ± 0.22
1.139ProGln: 1.139 ± 0.295
0.651ProArg: 0.651 ± 0.246
1.708ProSer: 1.708 ± 0.359
2.359ProThr: 2.359 ± 0.412
1.708ProVal: 1.708 ± 0.399
0.163ProTrp: 0.163 ± 0.117
1.627ProTyr: 1.627 ± 0.51
0.0ProXaa: 0.0 ± 0.0
Gln
2.847GlnAla: 2.847 ± 0.369
0.407GlnCys: 0.407 ± 0.211
1.708GlnAsp: 1.708 ± 0.305
2.929GlnGlu: 2.929 ± 0.456
2.197GlnPhe: 2.197 ± 0.359
2.278GlnGly: 2.278 ± 0.467
0.407GlnHis: 0.407 ± 0.177
2.766GlnIle: 2.766 ± 0.506
3.742GlnLys: 3.742 ± 0.523
3.905GlnLeu: 3.905 ± 0.595
1.464GlnMet: 1.464 ± 0.333
2.034GlnAsn: 2.034 ± 0.493
0.814GlnPro: 0.814 ± 0.304
1.546GlnGln: 1.546 ± 0.46
1.139GlnArg: 1.139 ± 0.331
3.58GlnSer: 3.58 ± 0.602
2.115GlnThr: 2.115 ± 0.479
1.464GlnVal: 1.464 ± 0.344
0.407GlnTrp: 0.407 ± 0.21
1.058GlnTyr: 1.058 ± 0.314
0.0GlnXaa: 0.0 ± 0.0
Arg
2.441ArgAla: 2.441 ± 0.419
0.244ArgCys: 0.244 ± 0.194
2.766ArgAsp: 2.766 ± 0.498
2.441ArgGlu: 2.441 ± 0.39
1.546ArgPhe: 1.546 ± 0.446
2.278ArgGly: 2.278 ± 0.451
0.651ArgHis: 0.651 ± 0.257
3.01ArgIle: 3.01 ± 0.474
3.986ArgLys: 3.986 ± 0.674
3.498ArgLeu: 3.498 ± 0.548
0.814ArgMet: 0.814 ± 0.267
2.278ArgAsn: 2.278 ± 0.389
0.732ArgPro: 0.732 ± 0.259
1.627ArgGln: 1.627 ± 0.341
2.359ArgArg: 2.359 ± 0.56
1.952ArgSer: 1.952 ± 0.4
2.603ArgThr: 2.603 ± 0.548
2.603ArgVal: 2.603 ± 0.487
0.163ArgTrp: 0.163 ± 0.106
1.79ArgTyr: 1.79 ± 0.41
0.0ArgXaa: 0.0 ± 0.0
Ser
4.556SerAla: 4.556 ± 1.039
0.163SerCys: 0.163 ± 0.128
4.8SerAsp: 4.8 ± 0.586
4.474SerGlu: 4.474 ± 0.552
2.441SerPhe: 2.441 ± 0.469
5.125SerGly: 5.125 ± 0.819
1.058SerHis: 1.058 ± 0.317
3.824SerIle: 3.824 ± 0.646
4.8SerLys: 4.8 ± 0.63
4.149SerLeu: 4.149 ± 0.568
2.034SerMet: 2.034 ± 0.396
3.254SerAsn: 3.254 ± 0.507
1.464SerPro: 1.464 ± 0.342
3.01SerGln: 3.01 ± 0.428
1.952SerArg: 1.952 ± 0.434
3.824SerSer: 3.824 ± 0.72
3.254SerThr: 3.254 ± 0.744
3.905SerVal: 3.905 ± 0.61
0.895SerTrp: 0.895 ± 0.336
2.522SerTyr: 2.522 ± 0.435
0.0SerXaa: 0.0 ± 0.0
Thr
6.02ThrAla: 6.02 ± 0.99
0.244ThrCys: 0.244 ± 0.142
3.254ThrAsp: 3.254 ± 0.519
3.905ThrGlu: 3.905 ± 0.6
2.603ThrPhe: 2.603 ± 0.401
4.881ThrGly: 4.881 ± 0.595
0.814ThrHis: 0.814 ± 0.313
4.474ThrIle: 4.474 ± 0.561
4.8ThrLys: 4.8 ± 0.547
5.125ThrLeu: 5.125 ± 0.601
1.383ThrMet: 1.383 ± 0.347
3.091ThrAsn: 3.091 ± 0.417
2.278ThrPro: 2.278 ± 0.446
2.034ThrGln: 2.034 ± 0.441
2.278ThrArg: 2.278 ± 0.403
3.824ThrSer: 3.824 ± 0.563
3.498ThrThr: 3.498 ± 0.503
3.824ThrVal: 3.824 ± 0.597
0.814ThrTrp: 0.814 ± 0.192
1.952ThrTyr: 1.952 ± 0.458
0.0ThrXaa: 0.0 ± 0.0
Val
4.719ValAla: 4.719 ± 0.918
0.651ValCys: 0.651 ± 0.273
4.474ValAsp: 4.474 ± 0.62
4.637ValGlu: 4.637 ± 0.724
2.034ValPhe: 2.034 ± 0.433
4.312ValGly: 4.312 ± 0.57
0.814ValHis: 0.814 ± 0.349
3.905ValIle: 3.905 ± 0.581
5.613ValLys: 5.613 ± 0.778
5.857ValLeu: 5.857 ± 0.809
1.383ValMet: 1.383 ± 0.431
3.498ValAsn: 3.498 ± 0.59
1.22ValPro: 1.22 ± 0.278
1.383ValGln: 1.383 ± 0.313
2.359ValArg: 2.359 ± 0.395
3.824ValSer: 3.824 ± 0.53
3.336ValThr: 3.336 ± 0.507
2.766ValVal: 2.766 ± 0.36
0.325ValTrp: 0.325 ± 0.158
1.546ValTyr: 1.546 ± 0.403
0.0ValXaa: 0.0 ± 0.0
Trp
0.407TrpAla: 0.407 ± 0.19
0.244TrpCys: 0.244 ± 0.145
0.732TrpAsp: 0.732 ± 0.232
0.814TrpGlu: 0.814 ± 0.243
0.651TrpPhe: 0.651 ± 0.255
0.732TrpGly: 0.732 ± 0.3
0.163TrpHis: 0.163 ± 0.12
0.976TrpIle: 0.976 ± 0.404
1.302TrpLys: 1.302 ± 0.265
1.139TrpLeu: 1.139 ± 0.337
0.163TrpMet: 0.163 ± 0.122
0.407TrpAsn: 0.407 ± 0.21
0.325TrpPro: 0.325 ± 0.156
0.732TrpGln: 0.732 ± 0.227
0.569TrpArg: 0.569 ± 0.236
0.569TrpSer: 0.569 ± 0.152
0.569TrpThr: 0.569 ± 0.163
0.488TrpVal: 0.488 ± 0.189
0.081TrpTrp: 0.081 ± 0.074
0.325TrpTyr: 0.325 ± 0.2
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.766TyrAla: 2.766 ± 0.42
0.488TyrCys: 0.488 ± 0.255
2.847TyrAsp: 2.847 ± 0.603
2.603TyrGlu: 2.603 ± 0.462
0.976TyrPhe: 0.976 ± 0.313
2.197TyrGly: 2.197 ± 0.408
0.407TyrHis: 0.407 ± 0.192
1.952TyrIle: 1.952 ± 0.594
3.01TyrLys: 3.01 ± 0.548
3.173TyrLeu: 3.173 ± 0.491
0.814TyrMet: 0.814 ± 0.268
1.708TyrAsn: 1.708 ± 0.458
1.464TyrPro: 1.464 ± 0.559
2.685TyrGln: 2.685 ± 0.553
2.197TyrArg: 2.197 ± 0.491
2.115TyrSer: 2.115 ± 0.448
2.115TyrThr: 2.115 ± 0.44
2.441TyrVal: 2.441 ± 0.446
0.325TyrTrp: 0.325 ± 0.148
1.952TyrTyr: 1.952 ± 0.3
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 63 proteins (12293 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski