Amino acid dipepetide frequency for Dysgonomonas capnocytophagoides

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.559AlaAla: 4.559 ± 0.075	0.72AlaCys: 0.72 ± 0.022	3.954AlaAsp: 3.954 ± 0.057	4.002AlaGlu: 4.002 ± 0.066	2.935AlaPhe: 2.935 ± 0.043	4.448AlaGly: 4.448 ± 0.065	0.979AlaHis: 0.979 ± 0.026	4.859AlaIle: 4.859 ± 0.072	4.331AlaLys: 4.331 ± 0.066	5.814AlaLeu: 5.814 ± 0.076	1.488AlaMet: 1.488 ± 0.038	3.248AlaAsn: 3.248 ± 0.046	1.853AlaPro: 1.853 ± 0.037	2.43AlaGln: 2.43 ± 0.048	2.357AlaArg: 2.357 ± 0.037	4.273AlaSer: 4.273 ± 0.06	3.29AlaThr: 3.29 ± 0.049	4.041AlaVal: 4.041 ± 0.066	0.643AlaTrp: 0.643 ± 0.022	2.855AlaTyr: 2.855 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.525CysAla: 0.525 ± 0.019	0.168CysCys: 0.168 ± 0.013	0.5CysAsp: 0.5 ± 0.02	0.519CysGlu: 0.519 ± 0.02	0.523CysPhe: 0.523 ± 0.021	0.766CysGly: 0.766 ± 0.022	0.185CysHis: 0.185 ± 0.013	0.858CysIle: 0.858 ± 0.026	0.561CysLys: 0.561 ± 0.019	0.847CysLeu: 0.847 ± 0.027	0.209CysMet: 0.209 ± 0.012	0.477CysAsn: 0.477 ± 0.021	0.38CysPro: 0.38 ± 0.017	0.244CysGln: 0.244 ± 0.016	0.383CysArg: 0.383 ± 0.017	0.72CysSer: 0.72 ± 0.025	0.522CysThr: 0.522 ± 0.021	0.516CysVal: 0.516 ± 0.018	0.12CysTrp: 0.12 ± 0.009	0.407CysTyr: 0.407 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.789AspAla: 3.789 ± 0.052	0.511AspCys: 0.511 ± 0.02	3.059AspAsp: 3.059 ± 0.052	3.599AspGlu: 3.599 ± 0.062	3.218AspPhe: 3.218 ± 0.054	4.096AspGly: 4.096 ± 0.071	0.857AspHis: 0.857 ± 0.025	5.149AspIle: 5.149 ± 0.059	4.963AspLys: 4.963 ± 0.054	5.243AspLeu: 5.243 ± 0.077	1.393AspMet: 1.393 ± 0.031	3.644AspAsn: 3.644 ± 0.059	2.012AspPro: 2.012 ± 0.04	1.727AspGln: 1.727 ± 0.034	2.357AspArg: 2.357 ± 0.041	3.67AspSer: 3.67 ± 0.057	2.682AspThr: 2.682 ± 0.05	3.413AspVal: 3.413 ± 0.053	0.816AspTrp: 0.816 ± 0.024	2.959AspTyr: 2.959 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	3.799GluAla: 3.799 ± 0.059	0.493GluCys: 0.493 ± 0.02	3.388GluAsp: 3.388 ± 0.063	4.054GluGlu: 4.054 ± 0.073	2.465GluPhe: 2.465 ± 0.042	3.49GluGly: 3.49 ± 0.056	0.986GluHis: 0.986 ± 0.028	5.023GluIle: 5.023 ± 0.06	5.363GluLys: 5.363 ± 0.073	5.476GluLeu: 5.476 ± 0.079	1.646GluMet: 1.646 ± 0.038	3.869GluAsn: 3.869 ± 0.05	1.521GluPro: 1.521 ± 0.033	2.208GluGln: 2.208 ± 0.043	2.65GluArg: 2.65 ± 0.053	3.769GluSer: 3.769 ± 0.052	3.248GluThr: 3.248 ± 0.051	3.706GluVal: 3.706 ± 0.047	0.773GluTrp: 0.773 ± 0.026	2.993GluTyr: 2.993 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.869PheAla: 2.869 ± 0.051	0.602PheCys: 0.602 ± 0.023	3.116PheAsp: 3.116 ± 0.045	2.704PheGlu: 2.704 ± 0.044	2.445PhePhe: 2.445 ± 0.06	3.222PheGly: 3.222 ± 0.049	0.72PheHis: 0.72 ± 0.022	3.77PheIle: 3.77 ± 0.063	2.92PheLys: 2.92 ± 0.047	4.002PheLeu: 4.002 ± 0.065	1.145PheMet: 1.145 ± 0.033	2.65PheAsn: 2.65 ± 0.049	1.585PhePro: 1.585 ± 0.037	1.258PheGln: 1.258 ± 0.032	1.899PheArg: 1.899 ± 0.043	3.955PheSer: 3.955 ± 0.052	2.828PheThr: 2.828 ± 0.051	2.879PheVal: 2.879 ± 0.051	0.587PheTrp: 0.587 ± 0.021	2.114PheTyr: 2.114 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.104GlyAla: 4.104 ± 0.061	0.688GlyCys: 0.688 ± 0.022	3.442GlyAsp: 3.442 ± 0.051	3.687GlyGlu: 3.687 ± 0.052	3.213GlyPhe: 3.213 ± 0.057	4.594GlyGly: 4.594 ± 0.077	1.117GlyHis: 1.117 ± 0.028	5.604GlyIle: 5.604 ± 0.076	5.153GlyLys: 5.153 ± 0.066	5.777GlyLeu: 5.777 ± 0.065	1.541GlyMet: 1.541 ± 0.032	3.63GlyAsn: 3.63 ± 0.063	1.073GlyPro: 1.073 ± 0.029	1.995GlyGln: 1.995 ± 0.036	2.528GlyArg: 2.528 ± 0.042	4.288GlySer: 4.288 ± 0.064	4.103GlyThr: 4.103 ± 0.071	4.469GlyVal: 4.469 ± 0.064	0.949GlyTrp: 0.949 ± 0.034	3.443GlyTyr: 3.443 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.913HisAla: 0.913 ± 0.025	0.203HisCys: 0.203 ± 0.013	0.83HisAsp: 0.83 ± 0.027	0.89HisGlu: 0.89 ± 0.025	0.886HisPhe: 0.886 ± 0.027	1.049HisGly: 1.049 ± 0.028	0.372HisHis: 0.372 ± 0.017	1.388HisIle: 1.388 ± 0.03	1.052HisLys: 1.052 ± 0.028	1.521HisLeu: 1.521 ± 0.037	0.334HisMet: 0.334 ± 0.014	0.977HisAsn: 0.977 ± 0.027	0.843HisPro: 0.843 ± 0.027	0.535HisGln: 0.535 ± 0.018	0.652HisArg: 0.652 ± 0.022	1.032HisSer: 1.032 ± 0.029	0.876HisThr: 0.876 ± 0.027	0.804HisVal: 0.804 ± 0.024	0.205HisTrp: 0.205 ± 0.012	0.746HisTyr: 0.746 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.32IleAla: 5.32 ± 0.072	0.858IleCys: 0.858 ± 0.024	5.113IleAsp: 5.113 ± 0.063	5.18IleGlu: 5.18 ± 0.066	3.365IlePhe: 3.365 ± 0.058	5.08IleGly: 5.08 ± 0.063	1.308IleHis: 1.308 ± 0.028	5.951IleIle: 5.951 ± 0.08	5.489IleLys: 5.489 ± 0.071	7.002IleLeu: 7.002 ± 0.095	1.436IleMet: 1.436 ± 0.03	4.568IleAsn: 4.568 ± 0.054	3.405IlePro: 3.405 ± 0.05	2.549IleGln: 2.549 ± 0.045	3.238IleArg: 3.238 ± 0.045	6.171IleSer: 6.171 ± 0.078	4.668IleThr: 4.668 ± 0.07	4.752IleVal: 4.752 ± 0.065	0.81IleTrp: 0.81 ± 0.031	3.341IleTyr: 3.341 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.721LysAla: 4.721 ± 0.069	0.427LysCys: 0.427 ± 0.017	5.111LysAsp: 5.111 ± 0.066	5.918LysGlu: 5.918 ± 0.074	2.539LysPhe: 2.539 ± 0.046	4.708LysGly: 4.708 ± 0.066	1.259LysHis: 1.259 ± 0.032	5.545LysIle: 5.545 ± 0.068	5.856LysLys: 5.856 ± 0.074	5.891LysLeu: 5.891 ± 0.065	2.054LysMet: 2.054 ± 0.036	4.401LysAsn: 4.401 ± 0.054	2.252LysPro: 2.252 ± 0.044	2.776LysGln: 2.776 ± 0.051	2.901LysArg: 2.901 ± 0.048	4.595LysSer: 4.595 ± 0.068	4.243LysThr: 4.243 ± 0.052	4.472LysVal: 4.472 ± 0.062	0.876LysTrp: 0.876 ± 0.025	3.832LysTyr: 3.832 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	5.596LeuAla: 5.596 ± 0.07	0.967LeuCys: 0.967 ± 0.03	5.028LeuAsp: 5.028 ± 0.063	4.792LeuGlu: 4.792 ± 0.07	4.57LeuPhe: 4.57 ± 0.066	5.359LeuGly: 5.359 ± 0.063	1.416LeuHis: 1.416 ± 0.037	6.536LeuIle: 6.536 ± 0.079	6.953LeuLys: 6.953 ± 0.077	8.336LeuLeu: 8.336 ± 0.111	2.02LeuMet: 2.02 ± 0.042	5.32LeuAsn: 5.32 ± 0.064	3.589LeuPro: 3.589 ± 0.052	3.002LeuGln: 3.002 ± 0.048	3.495LeuArg: 3.495 ± 0.06	7.618LeuSer: 7.618 ± 0.08	5.134LeuThr: 5.134 ± 0.063	4.685LeuVal: 4.685 ± 0.06	1.041LeuTrp: 1.041 ± 0.03	3.788LeuTyr: 3.788 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.542MetAla: 1.542 ± 0.034	0.18MetCys: 0.18 ± 0.011	1.273MetAsp: 1.273 ± 0.028	1.334MetGlu: 1.334 ± 0.034	0.945MetPhe: 0.945 ± 0.026	1.501MetGly: 1.501 ± 0.035	0.372MetHis: 0.372 ± 0.015	1.667MetIle: 1.667 ± 0.034	2.31MetLys: 2.31 ± 0.033	2.027MetLeu: 2.027 ± 0.041	0.635MetMet: 0.635 ± 0.023	1.409MetAsn: 1.409 ± 0.032	0.98MetPro: 0.98 ± 0.028	0.887MetGln: 0.887 ± 0.026	0.949MetArg: 0.949 ± 0.026	1.62MetSer: 1.62 ± 0.03	1.28MetThr: 1.28 ± 0.03	1.26MetVal: 1.26 ± 0.029	0.219MetTrp: 0.219 ± 0.013	0.901MetTyr: 0.901 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.344AsnAla: 3.344 ± 0.042	0.436AsnCys: 0.436 ± 0.019	3.04AsnAsp: 3.04 ± 0.045	3.292AsnGlu: 3.292 ± 0.054	2.528AsnPhe: 2.528 ± 0.046	3.969AsnGly: 3.969 ± 0.063	0.9AsnHis: 0.9 ± 0.027	5.28AsnIle: 5.28 ± 0.075	4.545AsnLys: 4.545 ± 0.057	5.049AsnLeu: 5.049 ± 0.07	1.355AsnMet: 1.355 ± 0.034	3.764AsnAsn: 3.764 ± 0.067	2.664AsnPro: 2.664 ± 0.043	1.948AsnGln: 1.948 ± 0.037	2.412AsnArg: 2.412 ± 0.045	3.723AsnSer: 3.723 ± 0.053	3.519AsnThr: 3.519 ± 0.062	3.198AsnVal: 3.198 ± 0.051	0.731AsnTrp: 0.731 ± 0.024	2.695AsnTyr: 2.695 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.227ProAla: 2.227 ± 0.043	0.256ProCys: 0.256 ± 0.014	2.501ProAsp: 2.501 ± 0.04	2.73ProGlu: 2.73 ± 0.038	1.73ProPhe: 1.73 ± 0.034	1.934ProGly: 1.934 ± 0.045	0.592ProHis: 0.592 ± 0.02	2.548ProIle: 2.548 ± 0.045	2.114ProLys: 2.114 ± 0.044	2.99ProLeu: 2.99 ± 0.046	0.799ProMet: 0.799 ± 0.022	1.838ProAsn: 1.838 ± 0.038	0.746ProPro: 0.746 ± 0.024	1.335ProGln: 1.335 ± 0.029	1.073ProArg: 1.073 ± 0.031	2.464ProSer: 2.464 ± 0.04	1.855ProThr: 1.855 ± 0.04	2.676ProVal: 2.676 ± 0.047	0.412ProTrp: 0.412 ± 0.019	1.647ProTyr: 1.647 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.171GlnAla: 2.171 ± 0.045	0.233GlnCys: 0.233 ± 0.013	1.756GlnAsp: 1.756 ± 0.036	1.996GlnGlu: 1.996 ± 0.041	1.456GlnPhe: 1.456 ± 0.032	1.916GlnGly: 1.916 ± 0.039	0.527GlnHis: 0.527 ± 0.019	2.754GlnIle: 2.754 ± 0.056	2.666GlnLys: 2.666 ± 0.042	3.062GlnLeu: 3.062 ± 0.051	0.904GlnMet: 0.904 ± 0.025	2.114GlnAsn: 2.114 ± 0.049	1.082GlnPro: 1.082 ± 0.03	1.373GlnGln: 1.373 ± 0.038	1.366GlnArg: 1.366 ± 0.038	2.293GlnSer: 2.293 ± 0.048	2.011GlnThr: 2.011 ± 0.039	1.895GlnVal: 1.895 ± 0.038	0.416GlnTrp: 0.416 ± 0.018	1.547GlnTyr: 1.547 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.158ArgAla: 2.158 ± 0.039	0.311ArgCys: 0.311 ± 0.015	2.028ArgAsp: 2.028 ± 0.04	2.252ArgGlu: 2.252 ± 0.048	2.02ArgPhe: 2.02 ± 0.043	2.139ArgGly: 2.139 ± 0.044	0.664ArgHis: 0.664 ± 0.024	3.468ArgIle: 3.468 ± 0.057	3.259ArgLys: 3.259 ± 0.047	3.75ArgLeu: 3.75 ± 0.064	1.118ArgMet: 1.118 ± 0.029	2.351ArgAsn: 2.351 ± 0.04	1.25ArgPro: 1.25 ± 0.031	1.344ArgGln: 1.344 ± 0.036	1.606ArgArg: 1.606 ± 0.037	2.297ArgSer: 2.297 ± 0.038	2.135ArgThr: 2.135 ± 0.043	2.267ArgVal: 2.267 ± 0.042	0.564ArgTrp: 0.564 ± 0.023	2.053ArgTyr: 2.053 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.385SerAla: 4.385 ± 0.06	0.693SerCys: 0.693 ± 0.021	4.372SerAsp: 4.372 ± 0.056	4.057SerGlu: 4.057 ± 0.053	3.854SerPhe: 3.854 ± 0.066	5.183SerGly: 5.183 ± 0.078	1.116SerHis: 1.116 ± 0.03	5.607SerIle: 5.607 ± 0.076	4.724SerLys: 4.724 ± 0.061	6.667SerLeu: 6.667 ± 0.067	1.463SerMet: 1.463 ± 0.034	3.706SerAsn: 3.706 ± 0.066	2.421SerPro: 2.421 ± 0.038	2.28SerGln: 2.28 ± 0.04	2.485SerArg: 2.485 ± 0.042	5.048SerSer: 5.048 ± 0.087	3.771SerThr: 3.771 ± 0.053	4.643SerVal: 4.643 ± 0.06	0.858SerTrp: 0.858 ± 0.026	3.267SerTyr: 3.267 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	3.741ThrAla: 3.741 ± 0.059	0.45ThrCys: 0.45 ± 0.018	3.701ThrAsp: 3.701 ± 0.055	3.347ThrGlu: 3.347 ± 0.051	2.732ThrPhe: 2.732 ± 0.046	4.33ThrGly: 4.33 ± 0.068	0.928ThrHis: 0.928 ± 0.025	4.499ThrIle: 4.499 ± 0.065	3.467ThrLys: 3.467 ± 0.052	5.017ThrLeu: 5.017 ± 0.067	1.025ThrMet: 1.025 ± 0.027	2.993ThrAsn: 2.993 ± 0.05	2.539ThrPro: 2.539 ± 0.05	1.843ThrGln: 1.843 ± 0.038	1.851ThrArg: 1.851 ± 0.033	3.922ThrSer: 3.922 ± 0.056	3.297ThrThr: 3.297 ± 0.063	3.737ThrVal: 3.737 ± 0.054	0.67ThrTrp: 0.67 ± 0.024	2.588ThrTyr: 2.588 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	3.806ValAla: 3.806 ± 0.058	0.696ValCys: 0.696 ± 0.023	3.565ValAsp: 3.565 ± 0.051	3.557ValGlu: 3.557 ± 0.051	3.015ValPhe: 3.015 ± 0.05	3.75ValGly: 3.75 ± 0.059	0.853ValHis: 0.853 ± 0.027	4.568ValIle: 4.568 ± 0.054	4.351ValLys: 4.351 ± 0.061	5.47ValLeu: 5.47 ± 0.07	1.317ValMet: 1.317 ± 0.03	3.427ValAsn: 3.427 ± 0.052	2.147ValPro: 2.147 ± 0.043	1.817ValGln: 1.817 ± 0.035	2.324ValArg: 2.324 ± 0.04	4.851ValSer: 4.851 ± 0.06	3.522ValThr: 3.522 ± 0.049	3.977ValVal: 3.977 ± 0.054	0.72ValTrp: 0.72 ± 0.028	2.736ValTyr: 2.736 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.759TrpAla: 0.759 ± 0.023	0.129TrpCys: 0.129 ± 0.009	0.736TrpAsp: 0.736 ± 0.025	0.675TrpGlu: 0.675 ± 0.026	0.521TrpPhe: 0.521 ± 0.023	0.965TrpGly: 0.965 ± 0.025	0.209TrpHis: 0.209 ± 0.016	0.928TrpIle: 0.928 ± 0.032	0.878TrpLys: 0.878 ± 0.026	1.092TrpLeu: 1.092 ± 0.03	0.365TrpMet: 0.365 ± 0.017	0.868TrpAsn: 0.868 ± 0.027	0.243TrpPro: 0.243 ± 0.015	0.452TrpGln: 0.452 ± 0.021	0.494TrpArg: 0.494 ± 0.021	0.77TrpSer: 0.77 ± 0.025	0.662TrpThr: 0.662 ± 0.024	0.742TrpVal: 0.742 ± 0.024	0.192TrpTrp: 0.192 ± 0.012	0.525TrpTyr: 0.525 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.75TyrAla: 2.75 ± 0.045	0.412TyrCys: 0.412 ± 0.017	2.643TyrAsp: 2.643 ± 0.046	2.336TyrGlu: 2.336 ± 0.04	2.31TyrPhe: 2.31 ± 0.045	2.898TyrGly: 2.898 ± 0.055	0.746TyrHis: 0.746 ± 0.024	3.603TyrIle: 3.603 ± 0.05	3.421TyrLys: 3.421 ± 0.053	4.212TyrLeu: 4.212 ± 0.055	1.042TyrMet: 1.042 ± 0.029	3.141TyrAsn: 3.141 ± 0.059	1.883TyrPro: 1.883 ± 0.042	1.536TyrGln: 1.536 ± 0.032	2.014TyrArg: 2.014 ± 0.043	3.521TyrSer: 3.521 ± 0.066	3.031TyrThr: 3.031 ± 0.057	2.336TyrVal: 2.336 ± 0.046	0.601TyrTrp: 0.601 ± 0.024	2.306TyrTyr: 2.306 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3764 proteins (1361703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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