Amino acid dipepetide frequency for Pseudoalteromonas denitrificans DSM 6059

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.399AlaAla: 5.399 ± 0.074	0.917AlaCys: 0.917 ± 0.028	3.813AlaAsp: 3.813 ± 0.048	3.953AlaGlu: 3.953 ± 0.054	3.209AlaPhe: 3.209 ± 0.05	4.63AlaGly: 4.63 ± 0.055	1.476AlaHis: 1.476 ± 0.03	5.751AlaIle: 5.751 ± 0.063	5.281AlaLys: 5.281 ± 0.064	8.511AlaLeu: 8.511 ± 0.077	1.983AlaMet: 1.983 ± 0.036	3.745AlaAsn: 3.745 ± 0.051	2.317AlaPro: 2.317 ± 0.042	3.778AlaGln: 3.778 ± 0.05	2.509AlaArg: 2.509 ± 0.044	4.953AlaSer: 4.953 ± 0.063	3.782AlaThr: 3.782 ± 0.056	4.418AlaVal: 4.418 ± 0.049	0.743AlaTrp: 0.743 ± 0.021	2.24AlaTyr: 2.24 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.681CysAla: 0.681 ± 0.021	0.14CysCys: 0.14 ± 0.01	0.614CysAsp: 0.614 ± 0.026	0.652CysGlu: 0.652 ± 0.023	0.522CysPhe: 0.522 ± 0.017	0.744CysGly: 0.744 ± 0.024	0.328CysHis: 0.328 ± 0.015	0.865CysIle: 0.865 ± 0.026	0.566CysLys: 0.566 ± 0.018	1.02CysLeu: 1.02 ± 0.026	0.238CysMet: 0.238 ± 0.012	0.486CysAsn: 0.486 ± 0.018	0.376CysPro: 0.376 ± 0.017	0.425CysGln: 0.425 ± 0.015	0.363CysArg: 0.363 ± 0.015	0.72CysSer: 0.72 ± 0.022	0.482CysThr: 0.482 ± 0.018	0.489CysVal: 0.489 ± 0.015	0.113CysTrp: 0.113 ± 0.008	0.349CysTyr: 0.349 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.795AspAla: 3.795 ± 0.049	0.498AspCys: 0.498 ± 0.019	3.069AspAsp: 3.069 ± 0.053	3.73AspGlu: 3.73 ± 0.053	2.846AspPhe: 2.846 ± 0.043	3.325AspGly: 3.325 ± 0.061	1.007AspHis: 1.007 ± 0.024	4.859AspIle: 4.859 ± 0.056	4.121AspLys: 4.121 ± 0.052	5.532AspLeu: 5.532 ± 0.055	1.314AspMet: 1.314 ± 0.031	3.097AspAsn: 3.097 ± 0.044	1.788AspPro: 1.788 ± 0.037	1.717AspGln: 1.717 ± 0.033	1.581AspArg: 1.581 ± 0.031	3.396AspSer: 3.396 ± 0.053	2.808AspThr: 2.808 ± 0.052	3.509AspVal: 3.509 ± 0.055	0.759AspTrp: 0.759 ± 0.021	2.072AspTyr: 2.072 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	3.966GluAla: 3.966 ± 0.06	0.467GluCys: 0.467 ± 0.017	2.652GluAsp: 2.652 ± 0.041	2.868GluGlu: 2.868 ± 0.064	2.803GluPhe: 2.803 ± 0.041	2.906GluGly: 2.906 ± 0.043	1.528GluHis: 1.528 ± 0.028	4.624GluIle: 4.624 ± 0.059	4.352GluLys: 4.352 ± 0.062	6.908GluLeu: 6.908 ± 0.067	1.375GluMet: 1.375 ± 0.033	3.575GluAsn: 3.575 ± 0.047	1.644GluPro: 1.644 ± 0.036	3.844GluGln: 3.844 ± 0.046	2.347GluArg: 2.347 ± 0.04	3.629GluSer: 3.629 ± 0.051	3.125GluThr: 3.125 ± 0.043	3.871GluVal: 3.871 ± 0.054	0.482GluTrp: 0.482 ± 0.017	1.995GluTyr: 1.995 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.023PheAla: 3.023 ± 0.045	0.535PheCys: 0.535 ± 0.017	3.063PheAsp: 3.063 ± 0.041	2.992PheGlu: 2.992 ± 0.043	1.846PhePhe: 1.846 ± 0.044	2.855PheGly: 2.855 ± 0.042	0.792PheHis: 0.792 ± 0.023	3.823PheIle: 3.823 ± 0.064	3.096PheLys: 3.096 ± 0.046	3.74PheLeu: 3.74 ± 0.055	1.054PheMet: 1.054 ± 0.027	2.992PheAsn: 2.992 ± 0.042	1.28PhePro: 1.28 ± 0.028	1.243PheGln: 1.243 ± 0.024	1.291PheArg: 1.291 ± 0.029	4.242PheSer: 4.242 ± 0.052	2.655PheThr: 2.655 ± 0.04	2.541PheVal: 2.541 ± 0.038	0.523PheTrp: 0.523 ± 0.018	1.704PheTyr: 1.704 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.233GlyAla: 4.233 ± 0.057	0.802GlyCys: 0.802 ± 0.021	3.261GlyAsp: 3.261 ± 0.049	3.649GlyGlu: 3.649 ± 0.043	3.329GlyPhe: 3.329 ± 0.051	3.991GlyGly: 3.991 ± 0.067	1.355GlyHis: 1.355 ± 0.029	4.682GlyIle: 4.682 ± 0.049	3.929GlyLys: 3.929 ± 0.052	6.197GlyLeu: 6.197 ± 0.071	1.523GlyMet: 1.523 ± 0.035	2.827GlyAsn: 2.827 ± 0.053	1.443GlyPro: 1.443 ± 0.03	2.373GlyGln: 2.373 ± 0.042	2.358GlyArg: 2.358 ± 0.035	3.954GlySer: 3.954 ± 0.054	3.23GlyThr: 3.23 ± 0.059	3.903GlyVal: 3.903 ± 0.051	0.743GlyTrp: 0.743 ± 0.021	2.332GlyTyr: 2.332 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.377HisAla: 1.377 ± 0.03	0.294HisCys: 0.294 ± 0.015	1.038HisAsp: 1.038 ± 0.023	1.125HisGlu: 1.125 ± 0.028	1.245HisPhe: 1.245 ± 0.028	1.242HisGly: 1.242 ± 0.03	0.61HisHis: 0.61 ± 0.02	1.739HisIle: 1.739 ± 0.03	1.397HisLys: 1.397 ± 0.026	2.225HisLeu: 2.225 ± 0.041	0.455HisMet: 0.455 ± 0.017	1.177HisAsn: 1.177 ± 0.027	0.885HisPro: 0.885 ± 0.024	1.106HisGln: 1.106 ± 0.029	0.738HisArg: 0.738 ± 0.02	1.506HisSer: 1.506 ± 0.033	1.08HisThr: 1.08 ± 0.022	1.101HisVal: 1.101 ± 0.027	0.347HisTrp: 0.347 ± 0.012	0.916HisTyr: 0.916 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.187IleAla: 6.187 ± 0.064	0.812IleCys: 0.812 ± 0.018	4.781IleAsp: 4.781 ± 0.064	5.349IleGlu: 5.349 ± 0.055	3.055IlePhe: 3.055 ± 0.045	4.404IleGly: 4.404 ± 0.058	1.413IleHis: 1.413 ± 0.027	4.917IleIle: 4.917 ± 0.062	5.797IleLys: 5.797 ± 0.064	6.522IleLeu: 6.522 ± 0.071	1.455IleMet: 1.455 ± 0.029	5.104IleAsn: 5.104 ± 0.067	2.657IlePro: 2.657 ± 0.037	2.582IleGln: 2.582 ± 0.036	2.542IleArg: 2.542 ± 0.036	6.289IleSer: 6.289 ± 0.06	4.632IleThr: 4.632 ± 0.054	3.953IleVal: 3.953 ± 0.05	0.722IleTrp: 0.722 ± 0.023	2.211IleTyr: 2.211 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.946LysAla: 4.946 ± 0.061	0.457LysCys: 0.457 ± 0.019	3.284LysAsp: 3.284 ± 0.053	3.82LysGlu: 3.82 ± 0.057	2.297LysPhe: 2.297 ± 0.041	3.68LysGly: 3.68 ± 0.047	1.635LysHis: 1.635 ± 0.035	5.057LysIle: 5.057 ± 0.059	5.019LysLys: 5.019 ± 0.062	7.438LysLeu: 7.438 ± 0.072	1.708LysMet: 1.708 ± 0.032	4.58LysAsn: 4.58 ± 0.059	2.566LysPro: 2.566 ± 0.04	3.803LysGln: 3.803 ± 0.051	2.771LysArg: 2.771 ± 0.04	4.763LysSer: 4.763 ± 0.051	4.025LysThr: 4.025 ± 0.046	4.457LysVal: 4.457 ± 0.046	0.637LysTrp: 0.637 ± 0.02	2.082LysTyr: 2.082 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	8.542LeuAla: 8.542 ± 0.074	1.088LeuCys: 1.088 ± 0.024	5.702LeuAsp: 5.702 ± 0.065	6.015LeuGlu: 6.015 ± 0.069	4.675LeuPhe: 4.675 ± 0.064	6.068LeuGly: 6.068 ± 0.069	1.868LeuHis: 1.868 ± 0.035	7.629LeuIle: 7.629 ± 0.08	7.322LeuLys: 7.322 ± 0.071	10.323LeuLeu: 10.323 ± 0.112	2.49LeuMet: 2.49 ± 0.042	6.468LeuAsn: 6.468 ± 0.076	4.286LeuPro: 4.286 ± 0.053	3.554LeuGln: 3.554 ± 0.055	3.355LeuArg: 3.355 ± 0.041	8.622LeuSer: 8.622 ± 0.072	6.472LeuThr: 6.472 ± 0.067	6.217LeuVal: 6.217 ± 0.074	0.975LeuTrp: 0.975 ± 0.023	2.923LeuTyr: 2.923 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.977MetAla: 1.977 ± 0.037	0.204MetCys: 0.204 ± 0.01	1.033MetAsp: 1.033 ± 0.024	0.98MetGlu: 0.98 ± 0.027	0.878MetPhe: 0.878 ± 0.022	1.415MetGly: 1.415 ± 0.031	0.51MetHis: 0.51 ± 0.016	1.499MetIle: 1.499 ± 0.029	1.626MetLys: 1.626 ± 0.033	2.485MetLeu: 2.485 ± 0.043	0.66MetMet: 0.66 ± 0.02	1.241MetAsn: 1.241 ± 0.027	1.114MetPro: 1.114 ± 0.026	1.163MetGln: 1.163 ± 0.028	0.944MetArg: 0.944 ± 0.022	1.908MetSer: 1.908 ± 0.034	1.441MetThr: 1.441 ± 0.029	1.342MetVal: 1.342 ± 0.027	0.176MetTrp: 0.176 ± 0.011	0.478MetTyr: 0.478 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	4.021AsnAla: 4.021 ± 0.05	0.58AsnCys: 0.58 ± 0.019	3.084AsnAsp: 3.084 ± 0.055	3.499AsnGlu: 3.499 ± 0.045	2.256AsnPhe: 2.256 ± 0.038	3.223AsnGly: 3.223 ± 0.051	1.183AsnHis: 1.183 ± 0.027	4.569AsnIle: 4.569 ± 0.059	4.581AsnLys: 4.581 ± 0.052	5.508AsnLeu: 5.508 ± 0.06	1.243AsnMet: 1.243 ± 0.027	3.674AsnAsn: 3.674 ± 0.052	1.947AsnPro: 1.947 ± 0.035	2.746AsnGln: 2.746 ± 0.044	1.922AsnArg: 1.922 ± 0.035	3.771AsnSer: 3.771 ± 0.059	3.338AsnThr: 3.338 ± 0.053	2.945AsnVal: 2.945 ± 0.052	0.767AsnTrp: 0.767 ± 0.023	1.943AsnTyr: 1.943 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.248ProAla: 2.248 ± 0.037	0.299ProCys: 0.299 ± 0.013	2.251ProAsp: 2.251 ± 0.04	2.683ProGlu: 2.683 ± 0.039	1.6ProPhe: 1.6 ± 0.028	1.968ProGly: 1.968 ± 0.04	0.715ProHis: 0.715 ± 0.018	2.623ProIle: 2.623 ± 0.044	2.327ProLys: 2.327 ± 0.037	3.583ProLeu: 3.583 ± 0.054	0.77ProMet: 0.77 ± 0.022	1.765ProAsn: 1.765 ± 0.03	0.916ProPro: 0.916 ± 0.029	1.437ProGln: 1.437 ± 0.03	1.002ProArg: 1.002 ± 0.025	2.285ProSer: 2.285 ± 0.04	1.701ProThr: 1.701 ± 0.034	2.479ProVal: 2.479 ± 0.041	0.445ProTrp: 0.445 ± 0.017	1.153ProTyr: 1.153 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.754GlnAla: 3.754 ± 0.047	0.382GlnCys: 0.382 ± 0.014	2.118GlnAsp: 2.118 ± 0.039	2.261GlnGlu: 2.261 ± 0.038	1.935GlnPhe: 1.935 ± 0.036	2.833GlnGly: 2.833 ± 0.042	0.95GlnHis: 0.95 ± 0.026	3.102GlnIle: 3.102 ± 0.045	3.065GlnLys: 3.065 ± 0.047	5.311GlnLeu: 5.311 ± 0.077	0.984GlnMet: 0.984 ± 0.024	2.502GlnAsn: 2.502 ± 0.04	1.278GlnPro: 1.278 ± 0.029	2.525GlnGln: 2.525 ± 0.047	1.658GlnArg: 1.658 ± 0.033	3.067GlnSer: 3.067 ± 0.047	2.43GlnThr: 2.43 ± 0.04	3.139GlnVal: 3.139 ± 0.042	0.589GlnTrp: 0.589 ± 0.017	1.607GlnTyr: 1.607 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.518ArgAla: 2.518 ± 0.04	0.345ArgCys: 0.345 ± 0.014	1.863ArgAsp: 1.863 ± 0.035	2.058ArgGlu: 2.058 ± 0.037	1.868ArgPhe: 1.868 ± 0.035	1.894ArgGly: 1.894 ± 0.032	0.858ArgHis: 0.858 ± 0.024	2.813ArgIle: 2.813 ± 0.04	2.186ArgLys: 2.186 ± 0.044	3.977ArgLeu: 3.977 ± 0.049	0.846ArgMet: 0.846 ± 0.024	1.741ArgAsn: 1.741 ± 0.035	1.104ArgPro: 1.104 ± 0.026	1.519ArgGln: 1.519 ± 0.028	1.473ArgArg: 1.473 ± 0.03	2.235ArgSer: 2.235 ± 0.035	1.793ArgThr: 1.793 ± 0.034	2.279ArgVal: 2.279 ± 0.031	0.427ArgTrp: 0.427 ± 0.017	1.483ArgTyr: 1.483 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	5.129SerAla: 5.129 ± 0.056	0.699SerCys: 0.699 ± 0.022	4.218SerAsp: 4.218 ± 0.066	4.346SerGlu: 4.346 ± 0.053	3.434SerPhe: 3.434 ± 0.051	5.104SerGly: 5.104 ± 0.065	1.762SerHis: 1.762 ± 0.038	5.356SerIle: 5.356 ± 0.061	4.454SerLys: 4.454 ± 0.053	7.742SerLeu: 7.742 ± 0.081	1.563SerMet: 1.563 ± 0.032	3.804SerAsn: 3.804 ± 0.056	2.411SerPro: 2.411 ± 0.038	3.47SerGln: 3.47 ± 0.049	2.469SerArg: 2.469 ± 0.038	4.917SerSer: 4.917 ± 0.067	3.527SerThr: 3.527 ± 0.048	4.277SerVal: 4.277 ± 0.055	0.879SerTrp: 0.879 ± 0.022	2.492SerTyr: 2.492 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.174ThrAla: 4.174 ± 0.054	0.486ThrCys: 0.486 ± 0.021	3.201ThrAsp: 3.201 ± 0.049	3.077ThrGlu: 3.077 ± 0.047	2.337ThrPhe: 2.337 ± 0.039	3.833ThrGly: 3.833 ± 0.06	1.354ThrHis: 1.354 ± 0.032	3.727ThrIle: 3.727 ± 0.054	3.208ThrLys: 3.208 ± 0.044	6.293ThrLeu: 6.293 ± 0.066	0.995ThrMet: 0.995 ± 0.028	2.587ThrAsn: 2.587 ± 0.045	2.498ThrPro: 2.498 ± 0.036	2.878ThrGln: 2.878 ± 0.048	1.89ThrArg: 1.89 ± 0.031	4.013ThrSer: 4.013 ± 0.06	2.9ThrThr: 2.9 ± 0.049	3.327ThrVal: 3.327 ± 0.053	0.645ThrTrp: 0.645 ± 0.019	1.678ThrTyr: 1.678 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	4.58ValAla: 4.58 ± 0.058	0.633ValCys: 0.633 ± 0.02	3.438ValAsp: 3.438 ± 0.046	3.854ValGlu: 3.854 ± 0.054	2.818ValPhe: 2.818 ± 0.044	3.409ValGly: 3.409 ± 0.047	1.075ValHis: 1.075 ± 0.027	4.858ValIle: 4.858 ± 0.058	4.13ValLys: 4.13 ± 0.053	6.002ValLeu: 6.002 ± 0.07	1.519ValMet: 1.519 ± 0.03	3.477ValAsn: 3.477 ± 0.049	2.02ValPro: 2.02 ± 0.035	2.052ValGln: 2.052 ± 0.034	2.045ValArg: 2.045 ± 0.034	4.654ValSer: 4.654 ± 0.058	3.588ValThr: 3.588 ± 0.05	3.786ValVal: 3.786 ± 0.056	0.626ValTrp: 0.626 ± 0.02	1.803ValTyr: 1.803 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.691TrpAla: 0.691 ± 0.02	0.139TrpCys: 0.139 ± 0.009	0.557TrpAsp: 0.557 ± 0.019	0.447TrpGlu: 0.447 ± 0.015	0.576TrpPhe: 0.576 ± 0.019	0.647TrpGly: 0.647 ± 0.019	0.387TrpHis: 0.387 ± 0.014	0.624TrpIle: 0.624 ± 0.017	0.463TrpLys: 0.463 ± 0.017	1.538TrpLeu: 1.538 ± 0.034	0.261TrpMet: 0.261 ± 0.014	0.455TrpAsn: 0.455 ± 0.019	0.422TrpPro: 0.422 ± 0.015	1.031TrpGln: 1.031 ± 0.026	0.508TrpArg: 0.508 ± 0.018	0.799TrpSer: 0.799 ± 0.024	0.446TrpThr: 0.446 ± 0.016	0.685TrpVal: 0.685 ± 0.019	0.16TrpTrp: 0.16 ± 0.011	0.373TrpTyr: 0.373 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.167TyrAla: 2.167 ± 0.034	0.394TyrCys: 0.394 ± 0.015	1.784TyrAsp: 1.784 ± 0.039	1.602TyrGlu: 1.602 ± 0.032	1.759TyrPhe: 1.759 ± 0.035	1.942TyrGly: 1.942 ± 0.036	0.799TyrHis: 0.799 ± 0.021	2.267TyrIle: 2.267 ± 0.033	2.102TyrLys: 2.102 ± 0.034	3.742TyrLeu: 3.742 ± 0.051	0.635TyrMet: 0.635 ± 0.019	1.501TyrAsn: 1.501 ± 0.034	1.298TyrPro: 1.298 ± 0.027	2.245TyrGln: 2.245 ± 0.041	1.516TyrArg: 1.516 ± 0.03	2.329TyrSer: 2.329 ± 0.036	1.646TyrThr: 1.646 ± 0.035	1.651TyrVal: 1.651 ± 0.03	0.453TyrTrp: 0.453 ± 0.016	1.17TyrTyr: 1.17 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5332 proteins (1773304 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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