Amino acid dipepetide frequency for Labrenzia sp. VG12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.305AlaAla: 14.305 ± 0.131
1.045AlaCys: 1.045 ± 0.023
7.002AlaAsp: 7.002 ± 0.071
7.584AlaGlu: 7.584 ± 0.09
4.605AlaPhe: 4.605 ± 0.053
9.921AlaGly: 9.921 ± 0.095
2.093AlaHis: 2.093 ± 0.033
5.66AlaIle: 5.66 ± 0.064
3.842AlaLys: 3.842 ± 0.056
12.283AlaLeu: 12.283 ± 0.118
3.064AlaMet: 3.064 ± 0.045
2.908AlaAsn: 2.908 ± 0.046
4.947AlaPro: 4.947 ± 0.069
3.543AlaGln: 3.543 ± 0.046
7.167AlaArg: 7.167 ± 0.078
6.215AlaSer: 6.215 ± 0.067
5.467AlaThr: 5.467 ± 0.069
8.008AlaVal: 8.008 ± 0.072
1.301AlaTrp: 1.301 ± 0.03
2.547AlaTyr: 2.547 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.94CysAla: 0.94 ± 0.025
0.131CysCys: 0.131 ± 0.009
0.558CysAsp: 0.558 ± 0.018
0.49CysGlu: 0.49 ± 0.017
0.368CysPhe: 0.368 ± 0.015
0.95CysGly: 0.95 ± 0.027
0.274CysHis: 0.274 ± 0.016
0.348CysIle: 0.348 ± 0.015
0.245CysLys: 0.245 ± 0.012
0.981CysLeu: 0.981 ± 0.026
0.169CysMet: 0.169 ± 0.011
0.26CysAsn: 0.26 ± 0.014
0.431CysPro: 0.431 ± 0.018
0.306CysGln: 0.306 ± 0.014
0.616CysArg: 0.616 ± 0.02
0.533CysSer: 0.533 ± 0.02
0.421CysThr: 0.421 ± 0.018
0.611CysVal: 0.611 ± 0.02
0.12CysTrp: 0.12 ± 0.009
0.22CysTyr: 0.22 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.393AspAla: 6.393 ± 0.082
0.531AspCys: 0.531 ± 0.023
3.409AspAsp: 3.409 ± 0.063
3.602AspGlu: 3.602 ± 0.058
2.442AspPhe: 2.442 ± 0.039
5.503AspGly: 5.503 ± 0.093
1.303AspHis: 1.303 ± 0.029
3.467AspIle: 3.467 ± 0.044
2.22AspLys: 2.22 ± 0.036
7.122AspLeu: 7.122 ± 0.069
1.585AspMet: 1.585 ± 0.03
1.587AspAsn: 1.587 ± 0.037
3.584AspPro: 3.584 ± 0.056
2.138AspGln: 2.138 ± 0.033
4.319AspArg: 4.319 ± 0.058
2.319AspSer: 2.319 ± 0.041
3.157AspThr: 3.157 ± 0.056
4.427AspVal: 4.427 ± 0.071
1.078AspTrp: 1.078 ± 0.025
1.719AspTyr: 1.719 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.858GluAla: 7.858 ± 0.078
0.367GluCys: 0.367 ± 0.016
3.93GluAsp: 3.93 ± 0.049
4.066GluGlu: 4.066 ± 0.06
2.03GluPhe: 2.03 ± 0.034
4.436GluGly: 4.436 ± 0.055
1.191GluHis: 1.191 ± 0.027
3.916GluIle: 3.916 ± 0.058
2.779GluLys: 2.779 ± 0.048
5.884GluLeu: 5.884 ± 0.06
1.507GluMet: 1.507 ± 0.032
2.065GluAsn: 2.065 ± 0.038
2.639GluPro: 2.639 ± 0.053
2.286GluGln: 2.286 ± 0.043
4.321GluArg: 4.321 ± 0.055
2.286GluSer: 2.286 ± 0.042
4.591GluThr: 4.591 ± 0.065
3.951GluVal: 3.951 ± 0.053
0.614GluTrp: 0.614 ± 0.019
0.986GluTyr: 0.986 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.508PheAla: 4.508 ± 0.049
0.475PheCys: 0.475 ± 0.017
2.867PheAsp: 2.867 ± 0.043
2.601PheGlu: 2.601 ± 0.038
1.656PhePhe: 1.656 ± 0.041
3.712PheGly: 3.712 ± 0.05
0.769PheHis: 0.769 ± 0.022
1.694PheIle: 1.694 ± 0.038
1.302PheLys: 1.302 ± 0.027
4.15PheLeu: 4.15 ± 0.05
0.883PheMet: 0.883 ± 0.025
1.181PheAsn: 1.181 ± 0.029
1.667PhePro: 1.667 ± 0.03
1.364PheGln: 1.364 ± 0.031
2.19PheArg: 2.19 ± 0.037
2.561PheSer: 2.561 ± 0.042
2.017PheThr: 2.017 ± 0.038
3.003PheVal: 3.003 ± 0.045
0.595PheTrp: 0.595 ± 0.021
0.986PheTyr: 0.986 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
8.4GlyAla: 8.4 ± 0.08
0.866GlyCys: 0.866 ± 0.026
4.732GlyAsp: 4.732 ± 0.072
4.824GlyGlu: 4.824 ± 0.054
3.82GlyPhe: 3.82 ± 0.05
6.843GlyGly: 6.843 ± 0.089
1.929GlyHis: 1.929 ± 0.039
4.347GlyIle: 4.347 ± 0.053
3.566GlyLys: 3.566 ± 0.051
9.147GlyLeu: 9.147 ± 0.08
2.142GlyMet: 2.142 ± 0.039
2.441GlyAsn: 2.441 ± 0.059
3.342GlyPro: 3.342 ± 0.049
2.865GlyGln: 2.865 ± 0.043
5.161GlyArg: 5.161 ± 0.06
4.773GlySer: 4.773 ± 0.07
4.749GlyThr: 4.749 ± 0.067
5.711GlyVal: 5.711 ± 0.063
1.273GlyTrp: 1.273 ± 0.027
2.416GlyTyr: 2.416 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
1.977HisAla: 1.977 ± 0.035
0.217HisCys: 0.217 ± 0.011
1.222HisAsp: 1.222 ± 0.032
1.061HisGlu: 1.061 ± 0.026
0.911HisPhe: 0.911 ± 0.024
1.794HisGly: 1.794 ± 0.039
0.581HisHis: 0.581 ± 0.026
0.931HisIle: 0.931 ± 0.022
0.637HisLys: 0.637 ± 0.019
2.185HisLeu: 2.185 ± 0.041
0.518HisMet: 0.518 ± 0.018
0.47HisAsn: 0.47 ± 0.015
1.244HisPro: 1.244 ± 0.03
0.679HisGln: 0.679 ± 0.018
1.231HisArg: 1.231 ± 0.029
0.928HisSer: 0.928 ± 0.024
0.869HisThr: 0.869 ± 0.026
1.452HisVal: 1.452 ± 0.028
0.324HisTrp: 0.324 ± 0.016
0.557HisTyr: 0.557 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
6.648IleAla: 6.648 ± 0.064
0.605IleCys: 0.605 ± 0.017
3.609IleAsp: 3.609 ± 0.053
3.526IleGlu: 3.526 ± 0.049
1.806IlePhe: 1.806 ± 0.039
4.928IleGly: 4.928 ± 0.069
0.903IleHis: 0.903 ± 0.024
2.142IleIle: 2.142 ± 0.046
1.567IleLys: 1.567 ± 0.029
4.911IleLeu: 4.911 ± 0.062
0.99IleMet: 0.99 ± 0.028
1.469IleAsn: 1.469 ± 0.029
2.225IlePro: 2.225 ± 0.039
1.381IleGln: 1.381 ± 0.03
3.232IleArg: 3.232 ± 0.04
3.218IleSer: 3.218 ± 0.057
2.739IleThr: 2.739 ± 0.05
3.947IleVal: 3.947 ± 0.057
0.644IleTrp: 0.644 ± 0.02
1.204IleTyr: 1.204 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
4.628LysAla: 4.628 ± 0.059
0.218LysCys: 0.218 ± 0.013
2.295LysAsp: 2.295 ± 0.038
1.993LysGlu: 1.993 ± 0.043
1.039LysPhe: 1.039 ± 0.028
2.896LysGly: 2.896 ± 0.042
0.699LysHis: 0.699 ± 0.021
2.075LysIle: 2.075 ± 0.033
1.619LysLys: 1.619 ± 0.034
3.606LysLeu: 3.606 ± 0.047
0.838LysMet: 0.838 ± 0.026
1.087LysAsn: 1.087 ± 0.026
2.058LysPro: 2.058 ± 0.041
1.196LysGln: 1.196 ± 0.027
2.537LysArg: 2.537 ± 0.037
2.271LysSer: 2.271 ± 0.037
2.43LysThr: 2.43 ± 0.041
2.847LysVal: 2.847 ± 0.046
0.397LysTrp: 0.397 ± 0.017
0.683LysTyr: 0.683 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
12.449LeuAla: 12.449 ± 0.107
0.958LeuCys: 0.958 ± 0.026
6.214LeuAsp: 6.214 ± 0.057
6.543LeuGlu: 6.543 ± 0.069
4.054LeuPhe: 4.054 ± 0.055
8.086LeuGly: 8.086 ± 0.082
1.78LeuHis: 1.78 ± 0.033
5.26LeuIle: 5.26 ± 0.071
4.705LeuLys: 4.705 ± 0.06
9.698LeuLeu: 9.698 ± 0.104
2.404LeuMet: 2.404 ± 0.037
2.999LeuAsn: 2.999 ± 0.045
5.427LeuPro: 5.427 ± 0.061
3.277LeuGln: 3.277 ± 0.052
5.812LeuArg: 5.812 ± 0.079
7.037LeuSer: 7.037 ± 0.07
6.128LeuThr: 6.128 ± 0.067
7.567LeuVal: 7.567 ± 0.077
1.105LeuTrp: 1.105 ± 0.029
2.198LeuTyr: 2.198 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.824MetAla: 2.824 ± 0.042
0.18MetCys: 0.18 ± 0.011
1.237MetAsp: 1.237 ± 0.031
1.279MetGlu: 1.279 ± 0.031
0.751MetPhe: 0.751 ± 0.024
1.72MetGly: 1.72 ± 0.031
0.43MetHis: 0.43 ± 0.016
1.44MetIle: 1.44 ± 0.027
1.075MetLys: 1.075 ± 0.025
2.272MetLeu: 2.272 ± 0.04
0.634MetMet: 0.634 ± 0.021
0.779MetAsn: 0.779 ± 0.024
1.339MetPro: 1.339 ± 0.031
0.803MetGln: 0.803 ± 0.021
1.643MetArg: 1.643 ± 0.031
1.802MetSer: 1.802 ± 0.035
1.9MetThr: 1.9 ± 0.035
1.66MetVal: 1.66 ± 0.033
0.206MetTrp: 0.206 ± 0.011
0.288MetTyr: 0.288 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.235AsnAla: 3.235 ± 0.049
0.27AsnCys: 0.27 ± 0.013
1.598AsnAsp: 1.598 ± 0.043
1.476AsnGlu: 1.476 ± 0.036
1.022AsnPhe: 1.022 ± 0.028
2.665AsnGly: 2.665 ± 0.061
0.541AsnHis: 0.541 ± 0.019
1.463AsnIle: 1.463 ± 0.025
0.921AsnLys: 0.921 ± 0.025
2.874AsnLeu: 2.874 ± 0.049
0.711AsnMet: 0.711 ± 0.018
0.829AsnAsn: 0.829 ± 0.026
1.845AsnPro: 1.845 ± 0.034
0.884AsnGln: 0.884 ± 0.024
1.963AsnArg: 1.963 ± 0.038
1.474AsnSer: 1.474 ± 0.036
1.425AsnThr: 1.425 ± 0.032
1.991AsnVal: 1.991 ± 0.038
0.473AsnTrp: 0.473 ± 0.017
0.697AsnTyr: 0.697 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
5.4ProAla: 5.4 ± 0.082
0.32ProCys: 0.32 ± 0.016
4.034ProAsp: 4.034 ± 0.05
4.013ProGlu: 4.013 ± 0.051
2.113ProPhe: 2.113 ± 0.038
4.156ProGly: 4.156 ± 0.054
0.968ProHis: 0.968 ± 0.026
2.13ProIle: 2.13 ± 0.036
1.788ProLys: 1.788 ± 0.034
4.48ProLeu: 4.48 ± 0.05
1.044ProMet: 1.044 ± 0.026
1.311ProAsn: 1.311 ± 0.026
2.047ProPro: 2.047 ± 0.041
1.538ProGln: 1.538 ± 0.034
2.303ProArg: 2.303 ± 0.036
2.604ProSer: 2.604 ± 0.041
2.191ProThr: 2.191 ± 0.038
4.393ProVal: 4.393 ± 0.062
0.603ProTrp: 0.603 ± 0.02
1.121ProTyr: 1.121 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.885GlnAla: 3.885 ± 0.05
0.21GlnCys: 0.21 ± 0.011
1.982GlnAsp: 1.982 ± 0.036
1.915GlnGlu: 1.915 ± 0.035
1.155GlnPhe: 1.155 ± 0.025
2.342GlnGly: 2.342 ± 0.033
0.627GlnHis: 0.627 ± 0.021
1.969GlnIle: 1.969 ± 0.038
1.429GlnLys: 1.429 ± 0.032
3.131GlnLeu: 3.131 ± 0.043
0.927GlnMet: 0.927 ± 0.023
1.064GlnAsn: 1.064 ± 0.023
1.631GlnPro: 1.631 ± 0.036
1.29GlnGln: 1.29 ± 0.034
2.198GlnArg: 2.198 ± 0.042
2.067GlnSer: 2.067 ± 0.035
1.976GlnThr: 1.976 ± 0.035
2.455GlnVal: 2.455 ± 0.046
0.324GlnTrp: 0.324 ± 0.013
0.571GlnTyr: 0.571 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
6.168ArgAla: 6.168 ± 0.076
0.483ArgCys: 0.483 ± 0.017
3.77ArgAsp: 3.77 ± 0.049
3.739ArgGlu: 3.739 ± 0.05
2.893ArgPhe: 2.893 ± 0.044
3.951ArgGly: 3.951 ± 0.049
1.42ArgHis: 1.42 ± 0.03
3.579ArgIle: 3.579 ± 0.043
2.61ArgLys: 2.61 ± 0.043
7.276ArgLeu: 7.276 ± 0.07
1.667ArgMet: 1.667 ± 0.032
1.84ArgAsn: 1.84 ± 0.031
2.976ArgPro: 2.976 ± 0.045
2.616ArgGln: 2.616 ± 0.045
4.368ArgArg: 4.368 ± 0.059
3.712ArgSer: 3.712 ± 0.053
3.093ArgThr: 3.093 ± 0.049
3.979ArgVal: 3.979 ± 0.056
0.809ArgTrp: 0.809 ± 0.024
1.517ArgTyr: 1.517 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.158SerAla: 6.158 ± 0.06
0.499SerCys: 0.499 ± 0.018
3.646SerAsp: 3.646 ± 0.066
3.435SerGlu: 3.435 ± 0.053
2.535SerPhe: 2.535 ± 0.047
5.921SerGly: 5.921 ± 0.068
1.115SerHis: 1.115 ± 0.028
2.763SerIle: 2.763 ± 0.048
1.87SerLys: 1.87 ± 0.03
5.944SerLeu: 5.944 ± 0.055
1.356SerMet: 1.356 ± 0.031
1.607SerAsn: 1.607 ± 0.039
2.644SerPro: 2.644 ± 0.044
1.865SerGln: 1.865 ± 0.032
3.451SerArg: 3.451 ± 0.05
3.281SerSer: 3.281 ± 0.052
2.82SerThr: 2.82 ± 0.059
4.261SerVal: 4.261 ± 0.053
0.783SerTrp: 0.783 ± 0.022
1.41SerTyr: 1.41 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.145ThrAla: 6.145 ± 0.074
0.519ThrCys: 0.519 ± 0.021
3.36ThrAsp: 3.36 ± 0.089
3.115ThrGlu: 3.115 ± 0.051
2.212ThrPhe: 2.212 ± 0.037
5.426ThrGly: 5.426 ± 0.071
0.988ThrHis: 0.988 ± 0.022
2.917ThrIle: 2.917 ± 0.061
1.581ThrLys: 1.581 ± 0.032
6.006ThrLeu: 6.006 ± 0.069
1.184ThrMet: 1.184 ± 0.029
1.359ThrAsn: 1.359 ± 0.033
3.067ThrPro: 3.067 ± 0.048
1.528ThrGln: 1.528 ± 0.035
3.272ThrArg: 3.272 ± 0.049
3.16ThrSer: 3.16 ± 0.054
2.73ThrThr: 2.73 ± 0.049
4.544ThrVal: 4.544 ± 0.075
0.704ThrTrp: 0.704 ± 0.019
1.332ThrTyr: 1.332 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
8.167ValAla: 8.167 ± 0.073
0.653ValCys: 0.653 ± 0.018
4.282ValAsp: 4.282 ± 0.062
4.498ValGlu: 4.498 ± 0.052
3.167ValPhe: 3.167 ± 0.045
5.189ValGly: 5.189 ± 0.053
1.328ValHis: 1.328 ± 0.031
4.022ValIle: 4.022 ± 0.054
2.407ValLys: 2.407 ± 0.042
7.706ValLeu: 7.706 ± 0.073
1.826ValMet: 1.826 ± 0.035
2.034ValAsn: 2.034 ± 0.034
3.653ValPro: 3.653 ± 0.046
2.083ValGln: 2.083 ± 0.037
4.161ValArg: 4.161 ± 0.057
4.976ValSer: 4.976 ± 0.06
4.606ValThr: 4.606 ± 0.093
5.509ValVal: 5.509 ± 0.063
0.894ValTrp: 0.894 ± 0.025
1.574ValTyr: 1.574 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.079TrpAla: 1.079 ± 0.025
0.151TrpCys: 0.151 ± 0.01
0.654TrpAsp: 0.654 ± 0.021
0.534TrpGlu: 0.534 ± 0.018
0.545TrpPhe: 0.545 ± 0.02
0.862TrpGly: 0.862 ± 0.023
0.319TrpHis: 0.319 ± 0.013
0.667TrpIle: 0.667 ± 0.021
0.495TrpLys: 0.495 ± 0.018
1.57TrpLeu: 1.57 ± 0.033
0.351TrpMet: 0.351 ± 0.014
0.43TrpAsn: 0.43 ± 0.017
0.683TrpPro: 0.683 ± 0.02
0.688TrpGln: 0.688 ± 0.02
0.906TrpArg: 0.906 ± 0.022
0.837TrpSer: 0.837 ± 0.022
0.74TrpThr: 0.74 ± 0.019
0.785TrpVal: 0.785 ± 0.022
0.205TrpTrp: 0.205 ± 0.011
0.308TrpTyr: 0.308 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.337TyrAla: 2.337 ± 0.043
0.271TyrCys: 0.271 ± 0.013
1.504TyrAsp: 1.504 ± 0.033
1.409TyrGlu: 1.409 ± 0.035
1.057TyrPhe: 1.057 ± 0.027
2.049TyrGly: 2.049 ± 0.04
0.529TyrHis: 0.529 ± 0.018
0.905TyrIle: 0.905 ± 0.022
0.755TyrLys: 0.755 ± 0.024
2.473TyrLeu: 2.473 ± 0.044
0.46TyrMet: 0.46 ± 0.017
0.636TyrAsn: 0.636 ± 0.019
1.107TyrPro: 1.107 ± 0.029
0.821TyrGln: 0.821 ± 0.024
1.614TyrArg: 1.614 ± 0.035
1.311TyrSer: 1.311 ± 0.028
1.098TyrThr: 1.098 ± 0.029
1.638TyrVal: 1.638 ± 0.032
0.36TyrTrp: 0.36 ± 0.016
0.61TyrTyr: 0.61 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5332 proteins (1710563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski