Amino acid dipepetide frequency for Mycoplasma gallopavonis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.163AlaAla: 3.163 ± 0.161
0.257AlaCys: 0.257 ± 0.027
2.437AlaAsp: 2.437 ± 0.11
3.003AlaGlu: 3.003 ± 0.14
2.631AlaPhe: 2.631 ± 0.104
2.564AlaGly: 2.564 ± 0.129
0.986AlaHis: 0.986 ± 0.064
5.421AlaIle: 5.421 ± 0.148
6.333AlaLys: 6.333 ± 0.206
6.058AlaLeu: 6.058 ± 0.203
1.046AlaMet: 1.046 ± 0.062
4.342AlaAsn: 4.342 ± 0.186
1.388AlaPro: 1.388 ± 0.072
2.623AlaGln: 2.623 ± 0.134
2.073AlaArg: 2.073 ± 0.091
3.732AlaSer: 3.732 ± 0.13
3.245AlaThr: 3.245 ± 0.118
2.288AlaVal: 2.288 ± 0.116
0.469AlaTrp: 0.469 ± 0.041
1.95AlaTyr: 1.95 ± 0.106
0.0AlaXaa: 0.0 ± 0.0
Cys
0.234CysAla: 0.234 ± 0.032
0.019CysCys: 0.019 ± 0.009
0.22CysAsp: 0.22 ± 0.032
0.216CysGlu: 0.216 ± 0.029
0.346CysPhe: 0.346 ± 0.038
0.231CysGly: 0.231 ± 0.031
0.086CysHis: 0.086 ± 0.018
0.249CysIle: 0.249 ± 0.036
0.301CysLys: 0.301 ± 0.033
0.607CysLeu: 0.607 ± 0.058
0.112CysMet: 0.112 ± 0.02
0.301CysAsn: 0.301 ± 0.037
0.153CysPro: 0.153 ± 0.024
0.153CysGln: 0.153 ± 0.022
0.145CysArg: 0.145 ± 0.02
0.313CysSer: 0.313 ± 0.035
0.089CysThr: 0.089 ± 0.018
0.234CysVal: 0.234 ± 0.03
0.086CysTrp: 0.086 ± 0.019
0.119CysTyr: 0.119 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.055AspAla: 3.055 ± 0.176
0.201AspCys: 0.201 ± 0.03
2.363AspAsp: 2.363 ± 0.114
3.498AspGlu: 3.498 ± 0.118
3.881AspPhe: 3.881 ± 0.122
2.5AspGly: 2.5 ± 0.114
0.908AspHis: 0.908 ± 0.058
3.762AspIle: 3.762 ± 0.122
4.863AspLys: 4.863 ± 0.205
6.701AspLeu: 6.701 ± 0.165
0.688AspMet: 0.688 ± 0.046
3.073AspAsn: 3.073 ± 0.122
1.727AspPro: 1.727 ± 0.108
2.653AspGln: 2.653 ± 0.144
1.656AspArg: 1.656 ± 0.095
3.546AspSer: 3.546 ± 0.139
2.08AspThr: 2.08 ± 0.113
2.858AspVal: 2.858 ± 0.111
0.566AspTrp: 0.566 ± 0.044
2.605AspTyr: 2.605 ± 0.098
0.0AspXaa: 0.0 ± 0.0
Glu
4.141GluAla: 4.141 ± 0.174
0.253GluCys: 0.253 ± 0.039
3.122GluAsp: 3.122 ± 0.129
4.934GluGlu: 4.934 ± 0.203
3.561GluPhe: 3.561 ± 0.138
2.698GluGly: 2.698 ± 0.118
0.826GluHis: 0.826 ± 0.061
7.386GluIle: 7.386 ± 0.177
6.999GluLys: 6.999 ± 0.193
7.594GluLeu: 7.594 ± 0.185
1.284GluMet: 1.284 ± 0.077
5.377GluAsn: 5.377 ± 0.168
1.269GluPro: 1.269 ± 0.076
3.475GluGln: 3.475 ± 0.131
2.132GluArg: 2.132 ± 0.1
3.315GluSer: 3.315 ± 0.098
3.747GluThr: 3.747 ± 0.148
4.205GluVal: 4.205 ± 0.132
0.625GluTrp: 0.625 ± 0.059
2.765GluTyr: 2.765 ± 0.11
0.0GluXaa: 0.0 ± 0.0
Phe
3.103PheAla: 3.103 ± 0.124
0.368PheCys: 0.368 ± 0.036
3.472PheAsp: 3.472 ± 0.119
3.873PheGlu: 3.873 ± 0.139
2.798PhePhe: 2.798 ± 0.136
2.701PheGly: 2.701 ± 0.129
0.647PheHis: 0.647 ± 0.048
4.852PheIle: 4.852 ± 0.178
4.774PheLys: 4.774 ± 0.145
5.072PheLeu: 5.072 ± 0.201
0.74PheMet: 0.74 ± 0.059
3.725PheAsn: 3.725 ± 0.137
1.321PhePro: 1.321 ± 0.08
2.132PheGln: 2.132 ± 0.092
1.537PheArg: 1.537 ± 0.076
3.855PheSer: 3.855 ± 0.137
2.534PheThr: 2.534 ± 0.103
3.438PheVal: 3.438 ± 0.136
0.737PheTrp: 0.737 ± 0.054
2.128PheTyr: 2.128 ± 0.1
0.0PheXaa: 0.0 ± 0.0
Gly
2.515GlyAla: 2.515 ± 0.119
0.153GlyCys: 0.153 ± 0.023
2.266GlyAsp: 2.266 ± 0.099
2.724GlyGlu: 2.724 ± 0.108
2.768GlyPhe: 2.768 ± 0.122
2.623GlyGly: 2.623 ± 0.144
0.793GlyHis: 0.793 ± 0.062
4.42GlyIle: 4.42 ± 0.158
4.406GlyLys: 4.406 ± 0.142
4.387GlyLeu: 4.387 ± 0.15
1.008GlyMet: 1.008 ± 0.067
2.59GlyAsn: 2.59 ± 0.101
0.949GlyPro: 0.949 ± 0.07
1.983GlyGln: 1.983 ± 0.103
1.913GlyArg: 1.913 ± 0.105
2.861GlySer: 2.861 ± 0.109
2.649GlyThr: 2.649 ± 0.116
2.746GlyVal: 2.746 ± 0.129
0.469GlyTrp: 0.469 ± 0.042
2.218GlyTyr: 2.218 ± 0.097
0.0GlyXaa: 0.0 ± 0.0
His
0.737HisAla: 0.737 ± 0.047
0.115HisCys: 0.115 ± 0.022
0.759HisAsp: 0.759 ± 0.048
1.031HisGlu: 1.031 ± 0.057
1.02HisPhe: 1.02 ± 0.067
0.886HisGly: 0.886 ± 0.07
0.216HisHis: 0.216 ± 0.03
1.023HisIle: 1.023 ± 0.069
1.433HisLys: 1.433 ± 0.064
1.5HisLeu: 1.5 ± 0.079
0.268HisMet: 0.268 ± 0.032
0.982HisAsn: 0.982 ± 0.061
0.566HisPro: 0.566 ± 0.05
0.599HisGln: 0.599 ± 0.05
0.342HisArg: 0.342 ± 0.039
1.016HisSer: 1.016 ± 0.054
0.58HisThr: 0.58 ± 0.047
0.722HisVal: 0.722 ± 0.058
0.115HisTrp: 0.115 ± 0.02
0.767HisTyr: 0.767 ± 0.063
0.0HisXaa: 0.0 ± 0.0
Ile
5.593IleAla: 5.593 ± 0.156
0.458IleCys: 0.458 ± 0.043
5.648IleAsp: 5.648 ± 0.19
5.831IleGlu: 5.831 ± 0.152
4.588IlePhe: 4.588 ± 0.191
3.888IleGly: 3.888 ± 0.158
1.235IleHis: 1.235 ± 0.064
6.672IleIle: 6.672 ± 0.23
8.074IleLys: 8.074 ± 0.186
8.38IleLeu: 8.38 ± 0.255
1.254IleMet: 1.254 ± 0.069
7.029IleAsn: 7.029 ± 0.195
2.352IlePro: 2.352 ± 0.093
3.661IleGln: 3.661 ± 0.133
2.564IleArg: 2.564 ± 0.098
6.218IleSer: 6.218 ± 0.174
4.413IleThr: 4.413 ± 0.107
4.845IleVal: 4.845 ± 0.166
0.785IleTrp: 0.785 ± 0.062
3.673IleTyr: 3.673 ± 0.126
0.0IleXaa: 0.0 ± 0.0
Lys
5.176LysAla: 5.176 ± 0.226
0.22LysCys: 0.22 ± 0.028
5.161LysAsp: 5.161 ± 0.161
8.335LysGlu: 8.335 ± 0.196
4.353LysPhe: 4.353 ± 0.135
3.639LysGly: 3.639 ± 0.154
1.79LysHis: 1.79 ± 0.109
9.224LysIle: 9.224 ± 0.222
8.845LysLys: 8.845 ± 0.222
9.566LysLeu: 9.566 ± 0.226
2.303LysMet: 2.303 ± 0.092
7.87LysAsn: 7.87 ± 0.203
2.348LysPro: 2.348 ± 0.099
4.275LysGln: 4.275 ± 0.183
3.263LysArg: 3.263 ± 0.122
5.146LysSer: 5.146 ± 0.152
5.563LysThr: 5.563 ± 0.148
5.388LysVal: 5.388 ± 0.154
0.993LysTrp: 0.993 ± 0.069
4.886LysTyr: 4.886 ± 0.149
0.0LysXaa: 0.0 ± 0.0
Leu
6.244LeuAla: 6.244 ± 0.207
0.592LeuCys: 0.592 ± 0.048
5.745LeuAsp: 5.745 ± 0.182
7.628LeuGlu: 7.628 ± 0.221
4.871LeuPhe: 4.871 ± 0.182
4.953LeuGly: 4.953 ± 0.149
1.336LeuHis: 1.336 ± 0.065
9.526LeuIle: 9.526 ± 0.277
10.006LeuLys: 10.006 ± 0.223
8.301LeuLeu: 8.301 ± 0.214
1.537LeuMet: 1.537 ± 0.074
8.342LeuAsn: 8.342 ± 0.282
3.066LeuPro: 3.066 ± 0.127
3.233LeuGln: 3.233 ± 0.127
2.869LeuArg: 2.869 ± 0.093
7.133LeuSer: 7.133 ± 0.185
5.273LeuThr: 5.273 ± 0.173
6.214LeuVal: 6.214 ± 0.166
0.67LeuTrp: 0.67 ± 0.056
2.921LeuTyr: 2.921 ± 0.123
0.0LeuXaa: 0.0 ± 0.0
Met
0.908MetAla: 0.908 ± 0.064
0.063MetCys: 0.063 ± 0.016
0.897MetAsp: 0.897 ± 0.058
0.908MetGlu: 0.908 ± 0.053
0.867MetPhe: 0.867 ± 0.058
0.789MetGly: 0.789 ± 0.06
0.287MetHis: 0.287 ± 0.034
1.354MetIle: 1.354 ± 0.071
1.648MetLys: 1.648 ± 0.077
1.637MetLeu: 1.637 ± 0.083
0.275MetMet: 0.275 ± 0.034
1.269MetAsn: 1.269 ± 0.077
0.547MetPro: 0.547 ± 0.047
0.744MetGln: 0.744 ± 0.068
0.662MetArg: 0.662 ± 0.057
1.384MetSer: 1.384 ± 0.073
0.893MetThr: 0.893 ± 0.057
0.785MetVal: 0.785 ± 0.055
0.074MetTrp: 0.074 ± 0.016
0.532MetTyr: 0.532 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
3.646AsnAla: 3.646 ± 0.165
0.257AsnCys: 0.257 ± 0.034
3.933AsnAsp: 3.933 ± 0.17
5.016AsnGlu: 5.016 ± 0.18
4.32AsnPhe: 4.32 ± 0.175
3.371AsnGly: 3.371 ± 0.139
1.101AsnHis: 1.101 ± 0.071
5.6AsnIle: 5.6 ± 0.143
7.129AsnLys: 7.129 ± 0.213
9.127AsnLeu: 9.127 ± 0.312
1.172AsnMet: 1.172 ± 0.067
6.188AsnAsn: 6.188 ± 0.257
2.847AsnPro: 2.847 ± 0.111
4.212AsnGln: 4.212 ± 0.185
2.061AsnArg: 2.061 ± 0.09
5.399AsnSer: 5.399 ± 0.192
3.233AsnThr: 3.233 ± 0.146
3.516AsnVal: 3.516 ± 0.114
1.02AsnTrp: 1.02 ± 0.069
3.42AsnTyr: 3.42 ± 0.122
0.0AsnXaa: 0.0 ± 0.0
Pro
1.362ProAla: 1.362 ± 0.08
0.097ProCys: 0.097 ± 0.02
1.273ProAsp: 1.273 ± 0.071
2.482ProGlu: 2.482 ± 0.132
1.403ProPhe: 1.403 ± 0.078
1.399ProGly: 1.399 ± 0.092
0.469ProHis: 0.469 ± 0.043
2.344ProIle: 2.344 ± 0.101
2.634ProLys: 2.634 ± 0.095
2.426ProLeu: 2.426 ± 0.096
0.357ProMet: 0.357 ± 0.031
2.218ProAsn: 2.218 ± 0.097
0.391ProPro: 0.391 ± 0.041
1.369ProGln: 1.369 ± 0.131
0.819ProArg: 0.819 ± 0.065
1.887ProSer: 1.887 ± 0.096
1.633ProThr: 1.633 ± 0.079
1.38ProVal: 1.38 ± 0.083
0.253ProTrp: 0.253 ± 0.035
1.168ProTyr: 1.168 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
2.664GlnAla: 2.664 ± 0.123
0.056GlnCys: 0.056 ± 0.014
2.292GlnAsp: 2.292 ± 0.116
3.695GlnGlu: 3.695 ± 0.141
1.808GlnPhe: 1.808 ± 0.089
1.719GlnGly: 1.719 ± 0.084
0.357GlnHis: 0.357 ± 0.041
4.402GlnIle: 4.402 ± 0.147
5.139GlnLys: 5.139 ± 0.161
3.315GlnLeu: 3.315 ± 0.126
0.714GlnMet: 0.714 ± 0.056
3.918GlnAsn: 3.918 ± 0.184
1.243GlnPro: 1.243 ± 0.202
1.116GlnGln: 1.116 ± 0.07
1.392GlnArg: 1.392 ± 0.086
2.024GlnSer: 2.024 ± 0.091
2.739GlnThr: 2.739 ± 0.116
2.207GlnVal: 2.207 ± 0.1
0.35GlnTrp: 0.35 ± 0.039
1.299GlnTyr: 1.299 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
1.793ArgAla: 1.793 ± 0.1
0.093ArgCys: 0.093 ± 0.019
1.831ArgAsp: 1.831 ± 0.083
2.46ArgGlu: 2.46 ± 0.088
1.444ArgPhe: 1.444 ± 0.075
1.522ArgGly: 1.522 ± 0.087
0.376ArgHis: 0.376 ± 0.039
2.668ArgIle: 2.668 ± 0.107
3.557ArgLys: 3.557 ± 0.145
2.835ArgLeu: 2.835 ± 0.106
0.595ArgMet: 0.595 ± 0.053
2.329ArgAsn: 2.329 ± 0.094
1.005ArgPro: 1.005 ± 0.066
1.295ArgGln: 1.295 ± 0.062
1.295ArgArg: 1.295 ± 0.085
1.727ArgSer: 1.727 ± 0.076
1.667ArgThr: 1.667 ± 0.081
1.749ArgVal: 1.749 ± 0.091
0.246ArgTrp: 0.246 ± 0.029
1.418ArgTyr: 1.418 ± 0.088
0.0ArgXaa: 0.0 ± 0.0
Ser
3.033SerAla: 3.033 ± 0.115
0.346SerCys: 0.346 ± 0.035
3.341SerAsp: 3.341 ± 0.123
4.067SerGlu: 4.067 ± 0.14
4.298SerPhe: 4.298 ± 0.147
3.189SerGly: 3.189 ± 0.117
1.012SerHis: 1.012 ± 0.065
4.886SerIle: 4.886 ± 0.144
6.664SerLys: 6.664 ± 0.176
7.01SerLeu: 7.01 ± 0.182
0.964SerMet: 0.964 ± 0.05
5.053SerAsn: 5.053 ± 0.168
1.488SerPro: 1.488 ± 0.062
2.556SerGln: 2.556 ± 0.098
2.002SerArg: 2.002 ± 0.097
4.547SerSer: 4.547 ± 0.171
2.966SerThr: 2.966 ± 0.114
3.233SerVal: 3.233 ± 0.11
0.707SerTrp: 0.707 ± 0.061
2.947SerTyr: 2.947 ± 0.103
0.0SerXaa: 0.0 ± 0.0
Thr
2.348ThrAla: 2.348 ± 0.108
0.149ThrCys: 0.149 ± 0.023
2.247ThrAsp: 2.247 ± 0.11
2.947ThrGlu: 2.947 ± 0.113
2.802ThrPhe: 2.802 ± 0.108
2.508ThrGly: 2.508 ± 0.1
0.781ThrHis: 0.781 ± 0.062
4.897ThrIle: 4.897 ± 0.134
5.708ThrLys: 5.708 ± 0.15
5.135ThrLeu: 5.135 ± 0.127
0.618ThrMet: 0.618 ± 0.056
4.398ThrAsn: 4.398 ± 0.189
1.842ThrPro: 1.842 ± 0.08
1.682ThrGln: 1.682 ± 0.093
1.853ThrArg: 1.853 ± 0.077
3.431ThrSer: 3.431 ± 0.126
3.036ThrThr: 3.036 ± 0.122
2.448ThrVal: 2.448 ± 0.101
0.502ThrTrp: 0.502 ± 0.048
2.069ThrTyr: 2.069 ± 0.103
0.0ThrXaa: 0.0 ± 0.0
Val
3.762ValAla: 3.762 ± 0.123
0.253ValCys: 0.253 ± 0.03
3.341ValAsp: 3.341 ± 0.107
3.754ValGlu: 3.754 ± 0.123
2.969ValPhe: 2.969 ± 0.134
2.787ValGly: 2.787 ± 0.121
0.744ValHis: 0.744 ± 0.053
4.651ValIle: 4.651 ± 0.149
4.651ValLys: 4.651 ± 0.136
5.388ValLeu: 5.388 ± 0.157
0.807ValMet: 0.807 ± 0.057
3.825ValAsn: 3.825 ± 0.126
1.555ValPro: 1.555 ± 0.089
1.994ValGln: 1.994 ± 0.091
1.66ValArg: 1.66 ± 0.087
3.557ValSer: 3.557 ± 0.143
2.623ValThr: 2.623 ± 0.099
3.747ValVal: 3.747 ± 0.144
0.487ValTrp: 0.487 ± 0.043
1.994ValTyr: 1.994 ± 0.098
0.0ValXaa: 0.0 ± 0.0
Trp
0.521TrpAla: 0.521 ± 0.049
0.056TrpCys: 0.056 ± 0.014
0.51TrpAsp: 0.51 ± 0.051
0.785TrpGlu: 0.785 ± 0.06
0.569TrpPhe: 0.569 ± 0.051
0.513TrpGly: 0.513 ± 0.047
0.093TrpHis: 0.093 ± 0.017
1.083TrpIle: 1.083 ± 0.064
0.941TrpLys: 0.941 ± 0.055
0.781TrpLeu: 0.781 ± 0.058
0.212TrpMet: 0.212 ± 0.027
0.707TrpAsn: 0.707 ± 0.059
0.246TrpPro: 0.246 ± 0.03
0.272TrpGln: 0.272 ± 0.027
0.283TrpArg: 0.283 ± 0.029
0.502TrpSer: 0.502 ± 0.048
0.614TrpThr: 0.614 ± 0.054
0.521TrpVal: 0.521 ± 0.04
0.156TrpTrp: 0.156 ± 0.028
0.469TrpTyr: 0.469 ± 0.05
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.009TyrAla: 2.009 ± 0.091
0.208TyrCys: 0.208 ± 0.031
2.326TyrAsp: 2.326 ± 0.108
2.523TyrGlu: 2.523 ± 0.094
2.512TyrPhe: 2.512 ± 0.108
1.961TyrGly: 1.961 ± 0.095
0.633TyrHis: 0.633 ± 0.049
2.739TyrIle: 2.739 ± 0.104
4.242TyrLys: 4.242 ± 0.146
4.636TyrLeu: 4.636 ± 0.138
0.566TyrMet: 0.566 ± 0.053
3.033TyrAsn: 3.033 ± 0.12
1.064TyrPro: 1.064 ± 0.064
2.419TyrGln: 2.419 ± 0.113
1.384TyrArg: 1.384 ± 0.075
2.716TyrSer: 2.716 ± 0.104
1.823TyrThr: 1.823 ± 0.081
2.028TyrVal: 2.028 ± 0.091
0.525TyrTrp: 0.525 ± 0.044
1.756TyrTyr: 1.756 ± 0.093
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 714 proteins (268752 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski