Amino acid dipepetide frequency for Dokdonella fugitiva

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.263AlaAla: 21.263 ± 0.23	1.603AlaCys: 1.603 ± 0.039	8.365AlaAsp: 8.365 ± 0.103	6.781AlaGlu: 6.781 ± 0.096	4.853AlaPhe: 4.853 ± 0.068	12.496AlaGly: 12.496 ± 0.13	3.245AlaHis: 3.245 ± 0.062	6.249AlaIle: 6.249 ± 0.088	3.408AlaLys: 3.408 ± 0.069	16.436AlaLeu: 16.436 ± 0.194	3.03AlaMet: 3.03 ± 0.055	3.491AlaAsn: 3.491 ± 0.071	7.39AlaPro: 7.39 ± 0.09	4.814AlaGln: 4.814 ± 0.073	12.244AlaArg: 12.244 ± 0.167	7.392AlaSer: 7.392 ± 0.113	7.79AlaThr: 7.79 ± 0.122	8.812AlaVal: 8.812 ± 0.093	2.377AlaTrp: 2.377 ± 0.048	2.788AlaTyr: 2.788 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.402CysAla: 1.402 ± 0.033	0.117CysCys: 0.117 ± 0.009	0.534CysAsp: 0.534 ± 0.02	0.469CysGlu: 0.469 ± 0.019	0.258CysPhe: 0.258 ± 0.013	1.009CysGly: 1.009 ± 0.032	0.227CysHis: 0.227 ± 0.017	0.383CysIle: 0.383 ± 0.019	0.152CysLys: 0.152 ± 0.011	0.783CysLeu: 0.783 ± 0.024	0.135CysMet: 0.135 ± 0.01	0.257CysAsn: 0.257 ± 0.014	0.464CysPro: 0.464 ± 0.022	0.184CysGln: 0.184 ± 0.012	0.642CysArg: 0.642 ± 0.022	0.556CysSer: 0.556 ± 0.022	0.59CysThr: 0.59 ± 0.029	0.744CysVal: 0.744 ± 0.023	0.137CysTrp: 0.137 ± 0.014	0.226CysTyr: 0.226 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	10.664AspAla: 10.664 ± 0.139	0.512AspCys: 0.512 ± 0.023	3.949AspAsp: 3.949 ± 0.065	3.503AspGlu: 3.503 ± 0.06	2.048AspPhe: 2.048 ± 0.041	6.783AspGly: 6.783 ± 0.115	1.227AspHis: 1.227 ± 0.03	2.324AspIle: 2.324 ± 0.042	1.259AspLys: 1.259 ± 0.035	5.845AspLeu: 5.845 ± 0.074	0.908AspMet: 0.908 ± 0.027	1.181AspAsn: 1.181 ± 0.034	3.633AspPro: 3.633 ± 0.062	1.436AspGln: 1.436 ± 0.035	4.114AspArg: 4.114 ± 0.063	2.191AspSer: 2.191 ± 0.041	2.762AspThr: 2.762 ± 0.047	4.827AspVal: 4.827 ± 0.069	1.048AspTrp: 1.048 ± 0.029	1.61AspTyr: 1.61 ± 0.035	0.001AspXaa: 0.001 ± 0.001
Glu	6.94GluAla: 6.94 ± 0.1	0.375GluCys: 0.375 ± 0.016	2.255GluAsp: 2.255 ± 0.046	2.124GluGlu: 2.124 ± 0.054	1.771GluPhe: 1.771 ± 0.039	3.581GluGly: 3.581 ± 0.056	1.422GluHis: 1.422 ± 0.034	2.359GluIle: 2.359 ± 0.052	1.336GluLys: 1.336 ± 0.038	5.935GluLeu: 5.935 ± 0.097	0.873GluMet: 0.873 ± 0.026	1.074GluAsn: 1.074 ± 0.032	2.649GluPro: 2.649 ± 0.048	2.222GluGln: 2.222 ± 0.056	5.885GluArg: 5.885 ± 0.105	2.223GluSer: 2.223 ± 0.042	2.298GluThr: 2.298 ± 0.049	3.521GluVal: 3.521 ± 0.064	0.74GluTrp: 0.74 ± 0.025	1.063GluTyr: 1.063 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	5.22PheAla: 5.22 ± 0.081	0.316PheCys: 0.316 ± 0.016	2.906PheAsp: 2.906 ± 0.053	2.006PheGlu: 2.006 ± 0.043	1.067PhePhe: 1.067 ± 0.032	3.392PheGly: 3.392 ± 0.065	0.779PheHis: 0.779 ± 0.026	1.092PheIle: 1.092 ± 0.028	0.69PheLys: 0.69 ± 0.027	2.773PheLeu: 2.773 ± 0.062	0.549PheMet: 0.549 ± 0.022	0.911PheAsn: 0.911 ± 0.03	1.44PhePro: 1.44 ± 0.037	0.808PheGln: 0.808 ± 0.024	2.228PheArg: 2.228 ± 0.042	1.769PheSer: 1.769 ± 0.044	1.846PheThr: 1.846 ± 0.043	2.87PheVal: 2.87 ± 0.055	0.442PheTrp: 0.442 ± 0.022	0.727PheTyr: 0.727 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.111GlyAla: 11.111 ± 0.119	0.903GlyCys: 0.903 ± 0.029	5.542GlyAsp: 5.542 ± 0.076	4.957GlyGlu: 4.957 ± 0.07	3.284GlyPhe: 3.284 ± 0.058	8.199GlyGly: 8.199 ± 0.149	2.038GlyHis: 2.038 ± 0.041	3.947GlyIle: 3.947 ± 0.062	2.555GlyLys: 2.555 ± 0.053	7.79GlyLeu: 7.79 ± 0.108	1.941GlyMet: 1.941 ± 0.041	2.645GlyAsn: 2.645 ± 0.07	3.154GlyPro: 3.154 ± 0.064	2.43GlyGln: 2.43 ± 0.056	6.421GlyArg: 6.421 ± 0.082	5.392GlySer: 5.392 ± 0.098	5.127GlyThr: 5.127 ± 0.102	6.629GlyVal: 6.629 ± 0.068	1.557GlyTrp: 1.557 ± 0.033	2.352GlyTyr: 2.352 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	4.005HisAla: 4.005 ± 0.063	0.257HisCys: 0.257 ± 0.014	1.444HisAsp: 1.444 ± 0.036	1.215HisGlu: 1.215 ± 0.031	0.838HisPhe: 0.838 ± 0.021	2.411HisGly: 2.411 ± 0.045	0.535HisHis: 0.535 ± 0.023	0.635HisIle: 0.635 ± 0.023	0.369HisLys: 0.369 ± 0.018	2.159HisLeu: 2.159 ± 0.039	0.392HisMet: 0.392 ± 0.017	0.414HisAsn: 0.414 ± 0.018	1.494HisPro: 1.494 ± 0.037	0.476HisGln: 0.476 ± 0.02	1.732HisArg: 1.732 ± 0.043	0.881HisSer: 0.881 ± 0.027	0.844HisThr: 0.844 ± 0.03	1.938HisVal: 1.938 ± 0.046	0.42HisTrp: 0.42 ± 0.019	0.598HisTyr: 0.598 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.993IleAla: 6.993 ± 0.085	0.332IleCys: 0.332 ± 0.019	3.547IleAsp: 3.547 ± 0.058	3.105IleGlu: 3.105 ± 0.057	1.037IlePhe: 1.037 ± 0.028	4.322IleGly: 4.322 ± 0.066	0.767IleHis: 0.767 ± 0.025	1.173IleIle: 1.173 ± 0.043	0.928IleLys: 0.928 ± 0.033	2.789IleLeu: 2.789 ± 0.051	0.483IleMet: 0.483 ± 0.023	1.008IleAsn: 1.008 ± 0.033	1.825IlePro: 1.825 ± 0.043	0.876IleGln: 0.876 ± 0.028	2.478IleArg: 2.478 ± 0.043	1.831IleSer: 1.831 ± 0.046	2.043IleThr: 2.043 ± 0.057	3.605IleVal: 3.605 ± 0.058	0.409IleTrp: 0.409 ± 0.022	0.845IleTyr: 0.845 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.198LysAla: 3.198 ± 0.069	0.124LysCys: 0.124 ± 0.011	1.41LysAsp: 1.41 ± 0.042	1.072LysGlu: 1.072 ± 0.036	0.656LysPhe: 0.656 ± 0.023	1.758LysGly: 1.758 ± 0.038	0.502LysHis: 0.502 ± 0.019	1.002LysIle: 1.002 ± 0.029	0.88LysLys: 0.88 ± 0.038	2.665LysLeu: 2.665 ± 0.055	0.424LysMet: 0.424 ± 0.019	0.562LysAsn: 0.562 ± 0.023	1.724LysPro: 1.724 ± 0.041	0.859LysGln: 0.859 ± 0.03	1.895LysArg: 1.895 ± 0.048	1.172LysSer: 1.172 ± 0.034	1.276LysThr: 1.276 ± 0.041	1.806LysVal: 1.806 ± 0.044	0.238LysTrp: 0.238 ± 0.014	0.543LysTyr: 0.543 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	17.328LeuAla: 17.328 ± 0.18	0.935LeuCys: 0.935 ± 0.028	7.041LeuAsp: 7.041 ± 0.082	5.032LeuGlu: 5.032 ± 0.078	3.296LeuPhe: 3.296 ± 0.065	8.699LeuGly: 8.699 ± 0.091	2.424LeuHis: 2.424 ± 0.047	3.043LeuIle: 3.043 ± 0.061	2.509LeuLys: 2.509 ± 0.052	10.869LeuLeu: 10.869 ± 0.153	1.593LeuMet: 1.593 ± 0.039	1.91LeuAsn: 1.91 ± 0.043	6.071LeuPro: 6.071 ± 0.073	2.852LeuGln: 2.852 ± 0.047	9.053LeuArg: 9.053 ± 0.108	4.749LeuSer: 4.749 ± 0.068	4.283LeuThr: 4.283 ± 0.062	8.665LeuVal: 8.665 ± 0.107	1.218LeuTrp: 1.218 ± 0.031	2.114LeuTyr: 2.114 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.036MetAla: 2.036 ± 0.043	0.129MetCys: 0.129 ± 0.01	0.87MetAsp: 0.87 ± 0.028	0.676MetGlu: 0.676 ± 0.025	0.565MetPhe: 0.565 ± 0.02	1.12MetGly: 1.12 ± 0.031	0.485MetHis: 0.485 ± 0.019	0.815MetIle: 0.815 ± 0.031	0.674MetLys: 0.674 ± 0.027	2.154MetLeu: 2.154 ± 0.041	0.34MetMet: 0.34 ± 0.019	0.659MetAsn: 0.659 ± 0.018	1.349MetPro: 1.349 ± 0.037	0.757MetGln: 0.757 ± 0.026	1.736MetArg: 1.736 ± 0.042	1.25MetSer: 1.25 ± 0.03	1.137MetThr: 1.137 ± 0.029	1.148MetVal: 1.148 ± 0.031	0.138MetTrp: 0.138 ± 0.011	0.318MetTyr: 0.318 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.32AsnAla: 3.32 ± 0.065	0.233AsnCys: 0.233 ± 0.014	1.404AsnAsp: 1.404 ± 0.037	1.002AsnGlu: 1.002 ± 0.025	0.785AsnPhe: 0.785 ± 0.029	2.513AsnGly: 2.513 ± 0.063	0.52AsnHis: 0.52 ± 0.022	0.93AsnIle: 0.93 ± 0.033	0.501AsnLys: 0.501 ± 0.022	2.366AsnLeu: 2.366 ± 0.052	0.354AsnMet: 0.354 ± 0.018	0.749AsnAsn: 0.749 ± 0.041	1.659AsnPro: 1.659 ± 0.039	0.649AsnGln: 0.649 ± 0.024	1.641AsnArg: 1.641 ± 0.043	1.104AsnSer: 1.104 ± 0.038	1.409AsnThr: 1.409 ± 0.055	1.925AsnVal: 1.925 ± 0.048	0.364AsnTrp: 0.364 ± 0.018	0.658AsnTyr: 0.658 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.299ProAla: 8.299 ± 0.108	0.404ProCys: 0.404 ± 0.019	3.565ProAsp: 3.565 ± 0.06	2.74ProGlu: 2.74 ± 0.048	1.717ProPhe: 1.717 ± 0.032	4.909ProGly: 4.909 ± 0.072	1.15ProHis: 1.15 ± 0.032	1.949ProIle: 1.949 ± 0.037	1.207ProLys: 1.207 ± 0.034	5.408ProLeu: 5.408 ± 0.068	1.147ProMet: 1.147 ± 0.032	1.259ProAsn: 1.259 ± 0.035	3.256ProPro: 3.256 ± 0.076	1.695ProGln: 1.695 ± 0.041	3.759ProArg: 3.759 ± 0.069	2.824ProSer: 2.824 ± 0.053	2.505ProThr: 2.505 ± 0.052	4.014ProVal: 4.014 ± 0.07	0.828ProTrp: 0.828 ± 0.028	1.197ProTyr: 1.197 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.358GlnAla: 4.358 ± 0.071	0.236GlnCys: 0.236 ± 0.015	1.299GlnAsp: 1.299 ± 0.035	1.062GlnGlu: 1.062 ± 0.033	0.93GlnPhe: 0.93 ± 0.025	2.375GlnGly: 2.375 ± 0.046	0.738GlnHis: 0.738 ± 0.024	1.174GlnIle: 1.174 ± 0.037	0.754GlnLys: 0.754 ± 0.029	3.267GlnLeu: 3.267 ± 0.054	0.545GlnMet: 0.545 ± 0.022	0.627GlnAsn: 0.627 ± 0.024	1.931GlnPro: 1.931 ± 0.044	1.277GlnGln: 1.277 ± 0.037	3.079GlnArg: 3.079 ± 0.051	1.425GlnSer: 1.425 ± 0.034	1.245GlnThr: 1.245 ± 0.034	2.333GlnVal: 2.333 ± 0.045	0.464GlnTrp: 0.464 ± 0.018	0.672GlnTyr: 0.672 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	10.781ArgAla: 10.781 ± 0.146	0.71ArgCys: 0.71 ± 0.027	4.849ArgAsp: 4.849 ± 0.066	4.916ArgGlu: 4.916 ± 0.083	2.977ArgPhe: 2.977 ± 0.052	5.774ArgGly: 5.774 ± 0.076	2.096ArgHis: 2.096 ± 0.045	4.039ArgIle: 4.039 ± 0.056	1.905ArgLys: 1.905 ± 0.05	8.829ArgLeu: 8.829 ± 0.108	1.814ArgMet: 1.814 ± 0.041	1.838ArgAsn: 1.838 ± 0.042	3.498ArgPro: 3.498 ± 0.061	2.179ArgGln: 2.179 ± 0.05	7.009ArgArg: 7.009 ± 0.107	3.79ArgSer: 3.79 ± 0.056	3.569ArgThr: 3.569 ± 0.062	6.03ArgVal: 6.03 ± 0.087	1.49ArgTrp: 1.49 ± 0.033	2.182ArgTyr: 2.182 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.453SerAla: 6.453 ± 0.1	0.455SerCys: 0.455 ± 0.023	2.731SerAsp: 2.731 ± 0.047	2.226SerGlu: 2.226 ± 0.04	1.734SerPhe: 1.734 ± 0.038	5.49SerGly: 5.49 ± 0.095	1.06SerHis: 1.06 ± 0.03	2.29SerIle: 2.29 ± 0.049	1.094SerLys: 1.094 ± 0.031	5.104SerLeu: 5.104 ± 0.07	1.013SerMet: 1.013 ± 0.029	1.395SerAsn: 1.395 ± 0.047	2.824SerPro: 2.824 ± 0.063	1.3SerGln: 1.3 ± 0.033	3.36SerArg: 3.36 ± 0.054	2.738SerSer: 2.738 ± 0.066	2.912SerThr: 2.912 ± 0.06	3.62SerVal: 3.62 ± 0.07	0.793SerTrp: 0.793 ± 0.028	1.228SerTyr: 1.228 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.992ThrAla: 5.992 ± 0.094	0.571ThrCys: 0.571 ± 0.035	2.711ThrAsp: 2.711 ± 0.067	1.831ThrGlu: 1.831 ± 0.04	1.839ThrPhe: 1.839 ± 0.046	4.569ThrGly: 4.569 ± 0.075	1.111ThrHis: 1.111 ± 0.033	2.721ThrIle: 2.721 ± 0.066	0.954ThrLys: 0.954 ± 0.031	5.869ThrLeu: 5.869 ± 0.078	0.925ThrMet: 0.925 ± 0.028	1.235ThrAsn: 1.235 ± 0.045	3.615ThrPro: 3.615 ± 0.067	1.459ThrGln: 1.459 ± 0.032	3.763ThrArg: 3.763 ± 0.056	2.727ThrSer: 2.727 ± 0.061	3.12ThrThr: 3.12 ± 0.076	3.944ThrVal: 3.944 ± 0.096	0.755ThrTrp: 0.755 ± 0.027	1.248ThrTyr: 1.248 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	10.902ValAla: 10.902 ± 0.112	0.659ValCys: 0.659 ± 0.022	5.141ValAsp: 5.141 ± 0.077	4.317ValGlu: 4.317 ± 0.064	2.689ValPhe: 2.689 ± 0.046	5.66ValGly: 5.66 ± 0.082	1.792ValHis: 1.792 ± 0.04	2.938ValIle: 2.938 ± 0.056	1.684ValLys: 1.684 ± 0.048	8.233ValLeu: 8.233 ± 0.095	1.247ValMet: 1.247 ± 0.036	1.784ValAsn: 1.784 ± 0.043	4.027ValPro: 4.027 ± 0.057	2.138ValGln: 2.138 ± 0.04	5.748ValArg: 5.748 ± 0.075	3.65ValSer: 3.65 ± 0.056	4.057ValThr: 4.057 ± 0.096	6.508ValVal: 6.508 ± 0.087	0.848ValTrp: 0.848 ± 0.025	1.638ValTyr: 1.638 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.224TrpAla: 1.224 ± 0.03	0.168TrpCys: 0.168 ± 0.013	0.686TrpAsp: 0.686 ± 0.024	0.457TrpGlu: 0.457 ± 0.018	0.627TrpPhe: 0.627 ± 0.022	0.902TrpGly: 0.902 ± 0.032	0.429TrpHis: 0.429 ± 0.018	0.682TrpIle: 0.682 ± 0.026	0.443TrpLys: 0.443 ± 0.02	2.127TrpLeu: 2.127 ± 0.05	0.328TrpMet: 0.328 ± 0.015	0.527TrpAsn: 0.527 ± 0.021	0.783TrpPro: 0.783 ± 0.027	0.686TrpGln: 0.686 ± 0.026	1.478TrpArg: 1.478 ± 0.038	0.975TrpSer: 0.975 ± 0.03	0.863TrpThr: 0.863 ± 0.034	0.892TrpVal: 0.892 ± 0.028	0.28TrpTrp: 0.28 ± 0.013	0.376TrpTyr: 0.376 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.34TyrAla: 3.34 ± 0.057	0.227TyrCys: 0.227 ± 0.013	1.577TyrAsp: 1.577 ± 0.047	1.155TyrGlu: 1.155 ± 0.03	0.859TyrPhe: 0.859 ± 0.023	2.01TyrGly: 2.01 ± 0.05	0.508TyrHis: 0.508 ± 0.022	0.653TyrIle: 0.653 ± 0.022	0.465TyrLys: 0.465 ± 0.019	2.283TyrLeu: 2.283 ± 0.047	0.314TyrMet: 0.314 ± 0.015	0.564TyrAsn: 0.564 ± 0.027	1.045TyrPro: 1.045 ± 0.031	0.694TyrGln: 0.694 ± 0.026	2.009TyrArg: 2.009 ± 0.046	1.181TyrSer: 1.181 ± 0.034	1.285TyrThr: 1.285 ± 0.041	1.828TyrVal: 1.828 ± 0.044	0.386TyrTrp: 0.386 ± 0.02	0.63TyrTyr: 0.63 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3614 proteins (1270453 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---