Amino acid dipepetide frequency for Hubei tombus-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.299AlaAla: 5.299 ± 1.592
0.0AlaCys: 0.0 ± 0.0
7.57AlaAsp: 7.57 ± 1.7
6.813AlaGlu: 6.813 ± 3.374
3.028AlaPhe: 3.028 ± 1.355
4.542AlaGly: 4.542 ± 1.525
0.757AlaHis: 0.757 ± 0.507
2.271AlaIle: 2.271 ± 0.779
1.514AlaLys: 1.514 ± 1.014
3.028AlaLeu: 3.028 ± 1.623
0.757AlaMet: 0.757 ± 0.507
1.514AlaAsn: 1.514 ± 0.677
3.785AlaPro: 3.785 ± 3.62
2.271AlaGln: 2.271 ± 2.026
6.056AlaArg: 6.056 ± 3.089
6.813AlaSer: 6.813 ± 1.847
6.056AlaThr: 6.056 ± 2.699
8.327AlaVal: 8.327 ± 2.598
0.757AlaTrp: 0.757 ± 0.507
3.028AlaTyr: 3.028 ± 1.121
0.0AlaXaa: 0.0 ± 0.0
Cys
0.757CysAla: 0.757 ± 0.97
0.757CysCys: 0.757 ± 0.507
0.0CysAsp: 0.0 ± 0.0
0.757CysGlu: 0.757 ± 0.507
1.514CysPhe: 1.514 ± 0.677
0.757CysGly: 0.757 ± 0.507
0.0CysHis: 0.0 ± 0.0
1.514CysIle: 1.514 ± 1.014
0.757CysLys: 0.757 ± 0.507
1.514CysLeu: 1.514 ± 1.014
0.0CysMet: 0.0 ± 0.0
0.757CysAsn: 0.757 ± 0.507
3.785CysPro: 3.785 ± 1.039
0.757CysGln: 0.757 ± 0.507
0.757CysArg: 0.757 ± 0.507
0.757CysSer: 0.757 ± 0.507
0.0CysThr: 0.0 ± 0.0
2.271CysVal: 2.271 ± 0.933
0.0CysTrp: 0.0 ± 0.0
0.757CysTyr: 0.757 ± 0.507
0.0CysXaa: 0.0 ± 0.0
Asp
6.056AspAla: 6.056 ± 2.477
1.514AspCys: 1.514 ± 1.014
1.514AspAsp: 1.514 ± 0.805
4.542AspGlu: 4.542 ± 3.308
2.271AspPhe: 2.271 ± 0.779
6.056AspGly: 6.056 ± 1.793
0.757AspHis: 0.757 ± 0.507
1.514AspIle: 1.514 ± 0.822
1.514AspLys: 1.514 ± 0.805
3.028AspLeu: 3.028 ± 1.205
2.271AspMet: 2.271 ± 0.779
1.514AspAsn: 1.514 ± 0.805
4.542AspPro: 4.542 ± 1.201
2.271AspGln: 2.271 ± 1.521
1.514AspArg: 1.514 ± 1.292
4.542AspSer: 4.542 ± 2.415
3.028AspThr: 3.028 ± 1.944
6.813AspVal: 6.813 ± 1.171
0.0AspTrp: 0.0 ± 0.0
1.514AspTyr: 1.514 ± 1.014
0.0AspXaa: 0.0 ± 0.0
Glu
3.028GluAla: 3.028 ± 2.574
0.0GluCys: 0.0 ± 0.0
2.271GluAsp: 2.271 ± 0.971
3.785GluGlu: 3.785 ± 1.796
0.757GluPhe: 0.757 ± 0.507
5.299GluGly: 5.299 ± 2.236
0.757GluHis: 0.757 ± 0.507
3.028GluIle: 3.028 ± 1.365
1.514GluLys: 1.514 ± 1.014
7.57GluLeu: 7.57 ± 3.8
2.271GluMet: 2.271 ± 0.723
0.757GluAsn: 0.757 ± 0.666
3.028GluPro: 3.028 ± 0.739
0.757GluGln: 0.757 ± 0.507
7.57GluArg: 7.57 ± 2.843
2.271GluSer: 2.271 ± 0.994
1.514GluThr: 1.514 ± 1.014
3.785GluVal: 3.785 ± 2.401
2.271GluTrp: 2.271 ± 0.971
6.813GluTyr: 6.813 ± 2.089
0.0GluXaa: 0.0 ± 0.0
Phe
0.757PheAla: 0.757 ± 0.507
1.514PheCys: 1.514 ± 1.014
2.271PheAsp: 2.271 ± 1.521
0.757PheGlu: 0.757 ± 0.507
1.514PhePhe: 1.514 ± 0.97
3.785PheGly: 3.785 ± 1.053
1.514PheHis: 1.514 ± 1.014
2.271PheIle: 2.271 ± 1.493
0.757PheLys: 0.757 ± 0.97
1.514PheLeu: 1.514 ± 1.014
0.0PheMet: 0.0 ± 0.0
2.271PheAsn: 2.271 ± 1.521
3.028PhePro: 3.028 ± 1.877
0.757PheGln: 0.757 ± 0.666
1.514PheArg: 1.514 ± 0.805
3.028PheSer: 3.028 ± 0.785
5.299PheThr: 5.299 ± 1.917
2.271PheVal: 2.271 ± 0.723
0.757PheTrp: 0.757 ± 0.507
2.271PheTyr: 2.271 ± 1.521
0.0PheXaa: 0.0 ± 0.0
Gly
6.056GlyAla: 6.056 ± 1.531
0.757GlyCys: 0.757 ± 0.507
3.028GlyAsp: 3.028 ± 1.267
6.056GlyGlu: 6.056 ± 1.406
4.542GlyPhe: 4.542 ± 1.215
6.056GlyGly: 6.056 ± 3.127
2.271GlyHis: 2.271 ± 1.521
4.542GlyIle: 4.542 ± 2.409
6.056GlyLys: 6.056 ± 2.447
7.57GlyLeu: 7.57 ± 2.388
3.028GlyMet: 3.028 ± 2.027
1.514GlyAsn: 1.514 ± 0.805
1.514GlyPro: 1.514 ± 0.97
0.0GlyGln: 0.0 ± 0.0
4.542GlyArg: 4.542 ± 0.584
9.084GlySer: 9.084 ± 3.738
8.327GlyThr: 8.327 ± 1.464
3.785GlyVal: 3.785 ± 1.397
0.757GlyTrp: 0.757 ± 0.923
3.028GlyTyr: 3.028 ± 1.877
0.0GlyXaa: 0.0 ± 0.0
His
1.514HisAla: 1.514 ± 1.847
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.514HisGlu: 1.514 ± 1.014
1.514HisPhe: 1.514 ± 1.014
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.514HisLys: 1.514 ± 1.014
1.514HisLeu: 1.514 ± 1.014
0.757HisMet: 0.757 ± 0.507
1.514HisAsn: 1.514 ± 0.677
0.757HisPro: 0.757 ± 0.97
0.757HisGln: 0.757 ± 0.923
2.271HisArg: 2.271 ± 1.006
0.757HisSer: 0.757 ± 0.507
1.514HisThr: 1.514 ± 0.822
0.757HisVal: 0.757 ± 0.507
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.785IleAla: 3.785 ± 0.303
2.271IleCys: 2.271 ± 0.779
1.514IleAsp: 1.514 ± 1.292
3.028IleGlu: 3.028 ± 0.854
2.271IlePhe: 2.271 ± 0.933
3.785IleGly: 3.785 ± 1.889
0.757IleHis: 0.757 ± 0.923
0.0IleIle: 0.0 ± 0.0
3.028IleLys: 3.028 ± 0.854
3.785IleLeu: 3.785 ± 0.303
2.271IleMet: 2.271 ± 1.244
3.028IleAsn: 3.028 ± 1.121
2.271IlePro: 2.271 ± 0.971
0.757IleGln: 0.757 ± 0.666
0.757IleArg: 0.757 ± 0.666
3.785IleSer: 3.785 ± 1.889
1.514IleThr: 1.514 ± 1.332
2.271IleVal: 2.271 ± 1.709
0.0IleTrp: 0.0 ± 0.0
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
2.271LysAla: 2.271 ± 2.026
0.0LysCys: 0.0 ± 0.0
2.271LysAsp: 2.271 ± 0.933
2.271LysGlu: 2.271 ± 1.006
3.028LysPhe: 3.028 ± 1.61
6.813LysGly: 6.813 ± 1.754
0.0LysHis: 0.0 ± 0.0
1.514LysIle: 1.514 ± 0.805
3.785LysLys: 3.785 ± 1.107
3.028LysLeu: 3.028 ± 1.365
0.757LysMet: 0.757 ± 0.507
1.514LysAsn: 1.514 ± 0.805
3.785LysPro: 3.785 ± 1.107
0.757LysGln: 0.757 ± 0.97
3.785LysArg: 3.785 ± 1.667
3.028LysSer: 3.028 ± 1.992
3.028LysThr: 3.028 ± 0.766
3.028LysVal: 3.028 ± 0.739
1.514LysTrp: 1.514 ± 1.014
2.271LysTyr: 2.271 ± 0.723
0.0LysXaa: 0.0 ± 0.0
Leu
6.813LeuAla: 6.813 ± 2.201
0.757LeuCys: 0.757 ± 0.507
6.813LeuAsp: 6.813 ± 2.325
3.785LeuGlu: 3.785 ± 1.689
2.271LeuPhe: 2.271 ± 0.723
7.57LeuGly: 7.57 ± 2.43
0.757LeuHis: 0.757 ± 0.97
2.271LeuIle: 2.271 ± 0.723
3.028LeuLys: 3.028 ± 1.623
5.299LeuLeu: 5.299 ± 1.782
1.514LeuMet: 1.514 ± 0.584
3.785LeuAsn: 3.785 ± 1.018
3.785LeuPro: 3.785 ± 1.894
6.056LeuGln: 6.056 ± 1.269
5.299LeuArg: 5.299 ± 1.535
4.542LeuSer: 4.542 ± 2.329
3.785LeuThr: 3.785 ± 2.558
3.028LeuVal: 3.028 ± 0.739
0.0LeuTrp: 0.0 ± 0.0
0.757LeuTyr: 0.757 ± 0.507
0.0LeuXaa: 0.0 ± 0.0
Met
4.542MetAla: 4.542 ± 1.141
0.0MetCys: 0.0 ± 0.0
1.514MetAsp: 1.514 ± 1.068
1.514MetGlu: 1.514 ± 1.332
0.757MetPhe: 0.757 ± 0.507
1.514MetGly: 1.514 ± 0.822
0.757MetHis: 0.757 ± 0.507
0.0MetIle: 0.0 ± 0.0
0.757MetLys: 0.757 ± 0.507
0.757MetLeu: 0.757 ± 0.507
0.0MetMet: 0.0 ± 0.0
1.514MetAsn: 1.514 ± 1.014
3.785MetPro: 3.785 ± 1.091
0.0MetGln: 0.0 ± 0.0
0.757MetArg: 0.757 ± 0.923
2.271MetSer: 2.271 ± 0.723
0.757MetThr: 0.757 ± 0.97
3.028MetVal: 3.028 ± 1.425
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
5.299AsnAla: 5.299 ± 2.175
0.757AsnCys: 0.757 ± 0.507
3.028AsnAsp: 3.028 ± 1.355
0.757AsnGlu: 0.757 ± 0.507
1.514AsnPhe: 1.514 ± 0.677
2.271AsnGly: 2.271 ± 1.244
0.0AsnHis: 0.0 ± 0.0
3.785AsnIle: 3.785 ± 1.48
0.757AsnLys: 0.757 ± 0.507
3.028AsnLeu: 3.028 ± 0.785
0.757AsnMet: 0.757 ± 0.507
3.028AsnAsn: 3.028 ± 1.623
1.514AsnPro: 1.514 ± 0.822
1.514AsnGln: 1.514 ± 0.805
3.028AsnArg: 3.028 ± 1.623
0.757AsnSer: 0.757 ± 0.507
2.271AsnThr: 2.271 ± 1.006
1.514AsnVal: 1.514 ± 0.677
0.0AsnTrp: 0.0 ± 0.0
0.757AsnTyr: 0.757 ± 0.666
0.0AsnXaa: 0.0 ± 0.0
Pro
3.028ProAla: 3.028 ± 0.854
2.271ProCys: 2.271 ± 1.521
3.785ProAsp: 3.785 ± 1.018
0.757ProGlu: 0.757 ± 0.507
0.757ProPhe: 0.757 ± 0.507
6.056ProGly: 6.056 ± 1.531
0.757ProHis: 0.757 ± 0.923
0.757ProIle: 0.757 ± 0.507
3.785ProLys: 3.785 ± 3.81
3.028ProLeu: 3.028 ± 1.355
0.0ProMet: 0.0 ± 0.0
0.757ProAsn: 0.757 ± 0.666
3.028ProPro: 3.028 ± 1.205
1.514ProGln: 1.514 ± 1.068
6.056ProArg: 6.056 ± 1.768
3.785ProSer: 3.785 ± 1.799
2.271ProThr: 2.271 ± 1.493
8.327ProVal: 8.327 ± 2.625
3.785ProTrp: 3.785 ± 2.229
0.757ProTyr: 0.757 ± 0.507
0.0ProXaa: 0.0 ± 0.0
Gln
1.514GlnAla: 1.514 ± 0.822
0.0GlnCys: 0.0 ± 0.0
0.757GlnAsp: 0.757 ± 0.507
1.514GlnGlu: 1.514 ± 0.805
0.0GlnPhe: 0.0 ± 0.0
3.028GlnGly: 3.028 ± 0.785
1.514GlnHis: 1.514 ± 1.014
1.514GlnIle: 1.514 ± 0.805
1.514GlnLys: 1.514 ± 1.014
1.514GlnLeu: 1.514 ± 0.97
1.514GlnMet: 1.514 ± 0.757
0.0GlnAsn: 0.0 ± 0.0
3.028GlnPro: 3.028 ± 1.121
0.0GlnGln: 0.0 ± 0.0
3.785GlnArg: 3.785 ± 3.27
3.028GlnSer: 3.028 ± 1.61
1.514GlnThr: 1.514 ± 1.332
1.514GlnVal: 1.514 ± 0.805
0.757GlnTrp: 0.757 ± 0.666
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
6.813ArgAla: 6.813 ± 2.866
2.271ArgCys: 2.271 ± 1.521
4.542ArgAsp: 4.542 ± 2.378
3.785ArgGlu: 3.785 ± 2.469
2.271ArgPhe: 2.271 ± 0.994
4.542ArgGly: 4.542 ± 1.141
3.028ArgHis: 3.028 ± 0.785
2.271ArgIle: 2.271 ± 0.971
8.327ArgLys: 8.327 ± 1.664
4.542ArgLeu: 4.542 ± 1.558
1.514ArgMet: 1.514 ± 1.847
4.542ArgAsn: 4.542 ± 1.458
5.299ArgPro: 5.299 ± 2.683
1.514ArgGln: 1.514 ± 0.677
4.542ArgArg: 4.542 ± 3.346
2.271ArgSer: 2.271 ± 1.006
6.056ArgThr: 6.056 ± 1.871
3.028ArgVal: 3.028 ± 1.514
2.271ArgTrp: 2.271 ± 0.971
3.028ArgTyr: 3.028 ± 1.355
0.0ArgXaa: 0.0 ± 0.0
Ser
3.028SerAla: 3.028 ± 0.739
1.514SerCys: 1.514 ± 0.805
6.056SerAsp: 6.056 ± 3.207
1.514SerGlu: 1.514 ± 0.822
4.542SerPhe: 4.542 ± 1.201
5.299SerGly: 5.299 ± 2.354
1.514SerHis: 1.514 ± 1.847
4.542SerIle: 4.542 ± 1.558
2.271SerLys: 2.271 ± 0.933
9.084SerLeu: 9.084 ± 2.539
1.514SerMet: 1.514 ± 1.068
4.542SerAsn: 4.542 ± 2.234
3.785SerPro: 3.785 ± 1.689
1.514SerGln: 1.514 ± 1.014
8.327SerArg: 8.327 ± 1.4
1.514SerSer: 1.514 ± 1.939
2.271SerThr: 2.271 ± 1.244
5.299SerVal: 5.299 ± 1.83
1.514SerTrp: 1.514 ± 0.677
4.542SerTyr: 4.542 ± 1.554
0.0SerXaa: 0.0 ± 0.0
Thr
3.028ThrAla: 3.028 ± 2.136
1.514ThrCys: 1.514 ± 1.014
1.514ThrAsp: 1.514 ± 0.677
5.299ThrGlu: 5.299 ± 1.215
0.0ThrPhe: 0.0 ± 0.0
3.785ThrGly: 3.785 ± 1.889
0.757ThrHis: 0.757 ± 0.507
3.028ThrIle: 3.028 ± 1.205
3.785ThrLys: 3.785 ± 1.766
5.299ThrLeu: 5.299 ± 2.498
2.271ThrMet: 2.271 ± 1.222
0.757ThrAsn: 0.757 ± 0.923
2.271ThrPro: 2.271 ± 1.709
1.514ThrGln: 1.514 ± 0.677
6.056ThrArg: 6.056 ± 2.242
6.056ThrSer: 6.056 ± 2.559
2.271ThrThr: 2.271 ± 1.385
9.084ThrVal: 9.084 ± 1.902
0.757ThrTrp: 0.757 ± 0.507
2.271ThrTyr: 2.271 ± 0.779
0.0ThrXaa: 0.0 ± 0.0
Val
8.327ValAla: 8.327 ± 1.991
0.757ValCys: 0.757 ± 0.97
5.299ValAsp: 5.299 ± 1.617
3.028ValGlu: 3.028 ± 1.644
3.785ValPhe: 3.785 ± 1.107
8.327ValGly: 8.327 ± 1.386
0.757ValHis: 0.757 ± 0.507
4.542ValIle: 4.542 ± 2.321
3.028ValLys: 3.028 ± 0.766
3.028ValLeu: 3.028 ± 1.205
1.514ValMet: 1.514 ± 0.805
1.514ValAsn: 1.514 ± 0.677
2.271ValPro: 2.271 ± 0.779
1.514ValGln: 1.514 ± 1.847
6.056ValArg: 6.056 ± 3.483
7.57ValSer: 7.57 ± 1.793
5.299ValThr: 5.299 ± 0.398
7.57ValVal: 7.57 ± 2.345
2.271ValTrp: 2.271 ± 2.026
3.028ValTyr: 3.028 ± 2.027
0.0ValXaa: 0.0 ± 0.0
Trp
2.271TrpAla: 2.271 ± 1.493
0.0TrpCys: 0.0 ± 0.0
0.757TrpAsp: 0.757 ± 0.97
2.271TrpGlu: 2.271 ± 1.006
0.757TrpPhe: 0.757 ± 0.507
2.271TrpGly: 2.271 ± 2.026
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
2.271TrpLeu: 2.271 ± 0.971
0.757TrpMet: 0.757 ± 0.923
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
2.271TrpGln: 2.271 ± 1.006
1.514TrpArg: 1.514 ± 1.014
0.757TrpSer: 0.757 ± 0.923
0.757TrpThr: 0.757 ± 0.507
1.514TrpVal: 1.514 ± 0.822
2.271TrpTrp: 2.271 ± 2.77
0.757TrpTyr: 0.757 ± 0.97
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
1.514TyrCys: 1.514 ± 0.677
2.271TyrAsp: 2.271 ± 1.998
5.299TyrGlu: 5.299 ± 1.571
0.757TyrPhe: 0.757 ± 0.666
0.757TyrGly: 0.757 ± 0.666
0.0TyrHis: 0.0 ± 0.0
1.514TyrIle: 1.514 ± 0.822
0.757TyrLys: 0.757 ± 0.507
1.514TyrLeu: 1.514 ± 1.014
0.0TyrMet: 0.0 ± 0.0
1.514TyrAsn: 1.514 ± 1.014
0.0TyrPro: 0.0 ± 0.0
1.514TyrGln: 1.514 ± 1.068
2.271TyrArg: 2.271 ± 0.994
7.57TyrSer: 7.57 ± 1.321
4.542TyrThr: 4.542 ± 1.201
2.271TyrVal: 2.271 ± 0.779
1.514TyrTrp: 1.514 ± 0.822
1.514TyrTyr: 1.514 ± 0.677
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1322 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski