Amino acid dipepetide frequency for Common bottlenose dolphin gammaherpesvirus 1 strain Sarasota

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.857AlaAla: 8.857 ± 0.546
2.214AlaCys: 2.214 ± 0.223
3.223AlaAsp: 3.223 ± 0.301
3.475AlaGlu: 3.475 ± 0.315
3.279AlaPhe: 3.279 ± 0.289
5.269AlaGly: 5.269 ± 0.274
2.691AlaHis: 2.691 ± 0.366
3.896AlaIle: 3.896 ± 0.336
2.719AlaLys: 2.719 ± 0.307
8.044AlaLeu: 8.044 ± 0.565
2.074AlaMet: 2.074 ± 0.234
2.803AlaAsn: 2.803 ± 0.32
6.39AlaPro: 6.39 ± 0.767
3.139AlaGln: 3.139 ± 0.263
4.484AlaArg: 4.484 ± 0.501
6.026AlaSer: 6.026 ± 0.409
4.624AlaThr: 4.624 ± 0.324
5.101AlaVal: 5.101 ± 0.363
1.065AlaTrp: 1.065 ± 0.177
2.074AlaTyr: 2.074 ± 0.234
0.0AlaXaa: 0.0 ± 0.0
Cys
1.626CysAla: 1.626 ± 0.257
0.561CysCys: 0.561 ± 0.135
0.897CysAsp: 0.897 ± 0.154
0.757CysGlu: 0.757 ± 0.145
1.093CysPhe: 1.093 ± 0.192
1.261CysGly: 1.261 ± 0.214
0.897CysHis: 0.897 ± 0.143
1.037CysIle: 1.037 ± 0.149
0.953CysLys: 0.953 ± 0.175
2.775CysLeu: 2.775 ± 0.293
0.476CysMet: 0.476 ± 0.119
0.813CysAsn: 0.813 ± 0.179
2.747CysPro: 2.747 ± 1.269
1.009CysGln: 1.009 ± 0.183
1.513CysArg: 1.513 ± 0.187
1.962CysSer: 1.962 ± 0.289
1.289CysThr: 1.289 ± 0.182
1.485CysVal: 1.485 ± 0.217
0.364CysTrp: 0.364 ± 0.131
0.645CysTyr: 0.645 ± 0.115
0.0CysXaa: 0.0 ± 0.0
Asp
4.652AspAla: 4.652 ± 0.452
1.037AspCys: 1.037 ± 0.192
2.915AspAsp: 2.915 ± 0.376
2.747AspGlu: 2.747 ± 0.581
2.13AspPhe: 2.13 ± 0.273
2.999AspGly: 2.999 ± 0.291
1.261AspHis: 1.261 ± 0.232
2.691AspIle: 2.691 ± 0.264
2.27AspLys: 2.27 ± 0.24
4.905AspLeu: 4.905 ± 0.279
0.925AspMet: 0.925 ± 0.2
2.13AspAsn: 2.13 ± 0.215
3.531AspPro: 3.531 ± 0.346
1.177AspGln: 1.177 ± 0.147
2.522AspArg: 2.522 ± 0.345
3.167AspSer: 3.167 ± 0.328
2.691AspThr: 2.691 ± 0.301
3.924AspVal: 3.924 ± 0.361
0.701AspTrp: 0.701 ± 0.148
1.598AspTyr: 1.598 ± 0.218
0.0AspXaa: 0.0 ± 0.0
Glu
3.924GluAla: 3.924 ± 0.336
1.093GluCys: 1.093 ± 0.178
3.643GluAsp: 3.643 ± 0.548
3.84GluGlu: 3.84 ± 0.515
2.214GluPhe: 2.214 ± 0.293
2.494GluGly: 2.494 ± 0.356
1.57GluHis: 1.57 ± 0.218
2.354GluIle: 2.354 ± 0.221
2.382GluLys: 2.382 ± 0.223
4.484GluLeu: 4.484 ± 0.352
1.429GluMet: 1.429 ± 0.15
2.775GluAsn: 2.775 ± 0.322
2.438GluPro: 2.438 ± 0.314
1.317GluGln: 1.317 ± 0.191
2.494GluArg: 2.494 ± 0.254
3.475GluSer: 3.475 ± 0.402
3.7GluThr: 3.7 ± 0.395
2.915GluVal: 2.915 ± 0.332
0.701GluTrp: 0.701 ± 0.169
1.485GluTyr: 1.485 ± 0.218
0.0GluXaa: 0.0 ± 0.0
Phe
2.635PheAla: 2.635 ± 0.248
1.373PheCys: 1.373 ± 0.202
2.046PheAsp: 2.046 ± 0.195
1.794PheGlu: 1.794 ± 0.196
2.466PhePhe: 2.466 ± 0.328
2.102PheGly: 2.102 ± 0.251
1.289PheHis: 1.289 ± 0.189
2.663PheIle: 2.663 ± 0.259
3.279PheLys: 3.279 ± 0.34
5.129PheLeu: 5.129 ± 0.545
1.373PheMet: 1.373 ± 0.19
2.438PheAsn: 2.438 ± 0.235
2.859PhePro: 2.859 ± 0.354
1.289PheGln: 1.289 ± 0.188
2.046PheArg: 2.046 ± 0.298
3.419PheSer: 3.419 ± 0.33
2.186PheThr: 2.186 ± 0.193
2.803PheVal: 2.803 ± 0.348
0.364PheTrp: 0.364 ± 0.091
2.13PheTyr: 2.13 ± 0.249
0.0PheXaa: 0.0 ± 0.0
Gly
4.989GlyAla: 4.989 ± 0.396
1.009GlyCys: 1.009 ± 0.188
3.475GlyAsp: 3.475 ± 0.381
3.447GlyGlu: 3.447 ± 0.296
2.663GlyPhe: 2.663 ± 0.336
4.064GlyGly: 4.064 ± 0.386
2.074GlyHis: 2.074 ± 0.205
2.13GlyIle: 2.13 ± 0.252
2.018GlyLys: 2.018 ± 0.207
5.746GlyLeu: 5.746 ± 0.459
0.757GlyMet: 0.757 ± 0.124
2.635GlyAsn: 2.635 ± 0.295
4.54GlyPro: 4.54 ± 0.492
2.018GlyGln: 2.018 ± 0.287
3.391GlyArg: 3.391 ± 0.301
4.176GlySer: 4.176 ± 0.383
3.111GlyThr: 3.111 ± 0.237
3.7GlyVal: 3.7 ± 0.38
0.533GlyTrp: 0.533 ± 0.124
1.149GlyTyr: 1.149 ± 0.211
0.0GlyXaa: 0.0 ± 0.0
His
2.803HisAla: 2.803 ± 0.356
0.729HisCys: 0.729 ± 0.171
1.401HisAsp: 1.401 ± 0.196
1.485HisGlu: 1.485 ± 0.23
1.261HisPhe: 1.261 ± 0.227
2.158HisGly: 2.158 ± 0.26
0.757HisHis: 0.757 ± 0.152
1.149HisIle: 1.149 ± 0.187
1.345HisLys: 1.345 ± 0.17
3.419HisLeu: 3.419 ± 0.271
0.533HisMet: 0.533 ± 0.121
1.317HisAsn: 1.317 ± 0.196
2.719HisPro: 2.719 ± 0.362
1.037HisGln: 1.037 ± 0.197
2.074HisArg: 2.074 ± 0.241
1.99HisSer: 1.99 ± 0.231
1.513HisThr: 1.513 ± 0.202
2.326HisVal: 2.326 ± 0.253
0.196HisTrp: 0.196 ± 0.099
0.841HisTyr: 0.841 ± 0.159
0.0HisXaa: 0.0 ± 0.0
Ile
2.999IleAla: 2.999 ± 0.311
0.925IleCys: 0.925 ± 0.166
2.27IleAsp: 2.27 ± 0.251
2.13IleGlu: 2.13 ± 0.291
2.831IlePhe: 2.831 ± 0.312
2.354IleGly: 2.354 ± 0.295
1.57IleHis: 1.57 ± 0.206
3.167IleIle: 3.167 ± 0.293
2.27IleLys: 2.27 ± 0.302
5.465IleLeu: 5.465 ± 0.413
1.261IleMet: 1.261 ± 0.198
2.354IleAsn: 2.354 ± 0.264
2.747IlePro: 2.747 ± 0.294
2.046IleGln: 2.046 ± 0.286
2.27IleArg: 2.27 ± 0.22
4.596IleSer: 4.596 ± 0.378
3.279IleThr: 3.279 ± 0.396
2.803IleVal: 2.803 ± 0.332
0.392IleTrp: 0.392 ± 0.113
2.018IleTyr: 2.018 ± 0.266
0.0IleXaa: 0.0 ± 0.0
Lys
2.691LysAla: 2.691 ± 0.31
0.841LysCys: 0.841 ± 0.136
2.719LysAsp: 2.719 ± 0.324
2.214LysGlu: 2.214 ± 0.29
1.541LysPhe: 1.541 ± 0.208
2.13LysGly: 2.13 ± 0.217
1.766LysHis: 1.766 ± 0.177
2.803LysIle: 2.803 ± 0.271
2.607LysLys: 2.607 ± 0.36
4.316LysLeu: 4.316 ± 0.355
1.093LysMet: 1.093 ± 0.161
3.111LysAsn: 3.111 ± 0.324
1.962LysPro: 1.962 ± 0.298
1.598LysGln: 1.598 ± 0.213
2.971LysArg: 2.971 ± 0.327
2.943LysSer: 2.943 ± 0.318
3.447LysThr: 3.447 ± 0.3
2.578LysVal: 2.578 ± 0.34
0.336LysTrp: 0.336 ± 0.08
1.485LysTyr: 1.485 ± 0.177
0.0LysXaa: 0.0 ± 0.0
Leu
7.988LeuAla: 7.988 ± 0.6
2.999LeuCys: 2.999 ± 0.649
5.381LeuAsp: 5.381 ± 0.387
5.661LeuGlu: 5.661 ± 0.501
4.877LeuPhe: 4.877 ± 0.386
4.709LeuGly: 4.709 ± 0.391
3.027LeuHis: 3.027 ± 0.306
4.344LeuIle: 4.344 ± 0.399
5.129LeuLys: 5.129 ± 0.363
10.006LeuLeu: 10.006 ± 0.556
2.046LeuMet: 2.046 ± 0.256
3.98LeuAsn: 3.98 ± 0.396
5.213LeuPro: 5.213 ± 0.397
3.587LeuGln: 3.587 ± 0.36
5.549LeuArg: 5.549 ± 0.419
8.38LeuSer: 8.38 ± 0.661
5.521LeuThr: 5.521 ± 0.446
6.362LeuVal: 6.362 ± 0.49
1.205LeuTrp: 1.205 ± 0.214
3.419LeuTyr: 3.419 ± 0.379
0.0LeuXaa: 0.0 ± 0.0
Met
2.41MetAla: 2.41 ± 0.229
0.476MetCys: 0.476 ± 0.12
0.953MetAsp: 0.953 ± 0.162
1.177MetGlu: 1.177 ± 0.167
1.177MetPhe: 1.177 ± 0.217
1.149MetGly: 1.149 ± 0.146
0.645MetHis: 0.645 ± 0.149
0.897MetIle: 0.897 ± 0.179
0.673MetLys: 0.673 ± 0.149
1.738MetLeu: 1.738 ± 0.223
0.42MetMet: 0.42 ± 0.101
0.673MetAsn: 0.673 ± 0.132
1.317MetPro: 1.317 ± 0.178
0.533MetGln: 0.533 ± 0.172
1.429MetArg: 1.429 ± 0.21
1.71MetSer: 1.71 ± 0.188
1.121MetThr: 1.121 ± 0.202
0.785MetVal: 0.785 ± 0.154
0.308MetTrp: 0.308 ± 0.081
1.121MetTyr: 1.121 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
3.559AsnAla: 3.559 ± 0.285
0.757AsnCys: 0.757 ± 0.193
1.85AsnAsp: 1.85 ± 0.224
2.13AsnGlu: 2.13 ± 0.293
1.906AsnPhe: 1.906 ± 0.218
2.635AsnGly: 2.635 ± 0.298
1.093AsnHis: 1.093 ± 0.171
2.887AsnIle: 2.887 ± 0.303
2.354AsnLys: 2.354 ± 0.265
4.344AsnLeu: 4.344 ± 0.313
0.897AsnMet: 0.897 ± 0.165
1.85AsnAsn: 1.85 ± 0.207
2.635AsnPro: 2.635 ± 0.34
1.429AsnGln: 1.429 ± 0.177
1.766AsnArg: 1.766 ± 0.256
3.195AsnSer: 3.195 ± 0.326
2.466AsnThr: 2.466 ± 0.238
2.971AsnVal: 2.971 ± 0.359
0.42AsnTrp: 0.42 ± 0.114
1.205AsnTyr: 1.205 ± 0.153
0.0AsnXaa: 0.0 ± 0.0
Pro
6.082ProAla: 6.082 ± 0.589
1.99ProCys: 1.99 ± 0.535
3.195ProAsp: 3.195 ± 0.335
3.587ProGlu: 3.587 ± 0.41
2.326ProPhe: 2.326 ± 0.245
5.129ProGly: 5.129 ± 0.507
2.102ProHis: 2.102 ± 0.389
2.747ProIle: 2.747 ± 0.295
2.663ProLys: 2.663 ± 0.253
6.53ProLeu: 6.53 ± 1.306
1.289ProMet: 1.289 ± 0.215
1.682ProAsn: 1.682 ± 0.228
7.904ProPro: 7.904 ± 1.741
2.186ProGln: 2.186 ± 0.463
5.157ProArg: 5.157 ± 0.588
5.437ProSer: 5.437 ± 0.76
4.288ProThr: 4.288 ± 0.541
4.905ProVal: 4.905 ± 0.399
0.869ProTrp: 0.869 ± 0.143
1.289ProTyr: 1.289 ± 0.235
0.0ProXaa: 0.0 ± 0.0
Gln
2.27GlnAla: 2.27 ± 0.257
0.841GlnCys: 0.841 ± 0.142
1.457GlnAsp: 1.457 ± 0.209
1.654GlnGlu: 1.654 ± 0.233
1.766GlnPhe: 1.766 ± 0.241
2.102GlnGly: 2.102 ± 0.309
1.121GlnHis: 1.121 ± 0.168
1.906GlnIle: 1.906 ± 0.19
1.429GlnLys: 1.429 ± 0.186
3.447GlnLeu: 3.447 ± 0.275
0.561GlnMet: 0.561 ± 0.144
1.878GlnAsn: 1.878 ± 0.226
2.41GlnPro: 2.41 ± 0.429
1.541GlnGln: 1.541 ± 0.283
1.822GlnArg: 1.822 ± 0.263
2.298GlnSer: 2.298 ± 0.299
2.102GlnThr: 2.102 ± 0.284
1.962GlnVal: 1.962 ± 0.189
0.476GlnTrp: 0.476 ± 0.105
1.261GlnTyr: 1.261 ± 0.213
0.0GlnXaa: 0.0 ± 0.0
Arg
5.129ArgAla: 5.129 ± 0.511
1.289ArgCys: 1.289 ± 0.231
2.999ArgAsp: 2.999 ± 0.268
3.419ArgGlu: 3.419 ± 0.357
1.822ArgPhe: 1.822 ± 0.237
4.008ArgGly: 4.008 ± 0.389
2.242ArgHis: 2.242 ± 0.251
2.466ArgIle: 2.466 ± 0.236
2.522ArgLys: 2.522 ± 0.309
5.241ArgLeu: 5.241 ± 0.523
0.897ArgMet: 0.897 ± 0.181
2.046ArgAsn: 2.046 ± 0.201
4.316ArgPro: 4.316 ± 0.484
2.046ArgGln: 2.046 ± 0.28
3.672ArgArg: 3.672 ± 0.335
3.055ArgSer: 3.055 ± 0.255
2.158ArgThr: 2.158 ± 0.312
3.896ArgVal: 3.896 ± 0.348
0.645ArgTrp: 0.645 ± 0.129
1.289ArgTyr: 1.289 ± 0.219
0.0ArgXaa: 0.0 ± 0.0
Ser
5.914SerAla: 5.914 ± 0.414
1.738SerCys: 1.738 ± 0.2
4.008SerAsp: 4.008 ± 0.414
3.868SerGlu: 3.868 ± 0.32
3.924SerPhe: 3.924 ± 0.278
4.064SerGly: 4.064 ± 0.401
2.578SerHis: 2.578 ± 0.282
3.419SerIle: 3.419 ± 0.316
3.223SerLys: 3.223 ± 0.327
7.091SerLeu: 7.091 ± 0.419
1.71SerMet: 1.71 ± 0.226
2.55SerAsn: 2.55 ± 0.234
6.811SerPro: 6.811 ± 0.956
2.466SerGln: 2.466 ± 0.266
4.176SerArg: 4.176 ± 0.341
6.194SerSer: 6.194 ± 0.659
4.512SerThr: 4.512 ± 0.324
4.344SerVal: 4.344 ± 0.366
0.841SerTrp: 0.841 ± 0.143
1.906SerTyr: 1.906 ± 0.241
0.0SerXaa: 0.0 ± 0.0
Thr
4.484ThrAla: 4.484 ± 0.565
1.485ThrCys: 1.485 ± 0.178
2.915ThrAsp: 2.915 ± 0.287
2.354ThrGlu: 2.354 ± 0.303
3.055ThrPhe: 3.055 ± 0.277
3.279ThrGly: 3.279 ± 0.317
1.906ThrHis: 1.906 ± 0.266
2.943ThrIle: 2.943 ± 0.261
1.738ThrLys: 1.738 ± 0.243
6.418ThrLeu: 6.418 ± 0.516
1.205ThrMet: 1.205 ± 0.188
2.186ThrAsn: 2.186 ± 0.279
4.793ThrPro: 4.793 ± 0.377
2.018ThrGln: 2.018 ± 0.222
2.747ThrArg: 2.747 ± 0.292
4.877ThrSer: 4.877 ± 0.405
3.559ThrThr: 3.559 ± 0.348
4.512ThrVal: 4.512 ± 0.325
0.476ThrTrp: 0.476 ± 0.107
2.13ThrTyr: 2.13 ± 0.239
0.0ThrXaa: 0.0 ± 0.0
Val
5.381ValAla: 5.381 ± 0.408
1.822ValCys: 1.822 ± 0.221
3.027ValAsp: 3.027 ± 0.355
3.083ValGlu: 3.083 ± 0.333
3.419ValPhe: 3.419 ± 0.325
3.279ValGly: 3.279 ± 0.359
1.57ValHis: 1.57 ± 0.176
3.615ValIle: 3.615 ± 0.314
3.447ValLys: 3.447 ± 0.348
5.914ValLeu: 5.914 ± 0.428
1.093ValMet: 1.093 ± 0.189
2.719ValAsn: 2.719 ± 0.268
3.672ValPro: 3.672 ± 0.28
2.214ValGln: 2.214 ± 0.282
2.887ValArg: 2.887 ± 0.282
5.437ValSer: 5.437 ± 0.433
4.372ValThr: 4.372 ± 0.501
4.428ValVal: 4.428 ± 0.392
0.533ValTrp: 0.533 ± 0.108
2.831ValTyr: 2.831 ± 0.344
0.0ValXaa: 0.0 ± 0.0
Trp
0.813TrpAla: 0.813 ± 0.15
0.196TrpCys: 0.196 ± 0.061
0.308TrpAsp: 0.308 ± 0.085
0.561TrpGlu: 0.561 ± 0.127
0.336TrpPhe: 0.336 ± 0.1
0.617TrpGly: 0.617 ± 0.144
0.196TrpHis: 0.196 ± 0.067
0.533TrpIle: 0.533 ± 0.1
0.504TrpLys: 0.504 ± 0.112
1.345TrpLeu: 1.345 ± 0.179
0.056TrpMet: 0.056 ± 0.039
0.701TrpAsn: 0.701 ± 0.102
0.813TrpPro: 0.813 ± 0.126
0.589TrpGln: 0.589 ± 0.117
0.476TrpArg: 0.476 ± 0.11
0.729TrpSer: 0.729 ± 0.172
1.121TrpThr: 1.121 ± 0.198
0.645TrpVal: 0.645 ± 0.129
0.028TrpTrp: 0.028 ± 0.025
0.196TrpTyr: 0.196 ± 0.075
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.242TyrAla: 2.242 ± 0.246
0.785TyrCys: 0.785 ± 0.156
1.289TyrAsp: 1.289 ± 0.171
1.345TyrGlu: 1.345 ± 0.204
1.598TyrPhe: 1.598 ± 0.286
1.822TyrGly: 1.822 ± 0.285
0.701TyrHis: 0.701 ± 0.137
2.102TyrIle: 2.102 ± 0.241
1.626TyrLys: 1.626 ± 0.188
3.027TyrLeu: 3.027 ± 0.35
0.589TyrMet: 0.589 ± 0.122
1.71TyrAsn: 1.71 ± 0.229
1.541TyrPro: 1.541 ± 0.185
1.065TyrGln: 1.065 ± 0.186
1.738TyrArg: 1.738 ± 0.244
2.27TyrSer: 2.27 ± 0.344
2.018TyrThr: 2.018 ± 0.207
2.298TyrVal: 2.298 ± 0.299
0.308TyrTrp: 0.308 ± 0.101
1.177TyrTyr: 1.177 ± 0.208
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (35681 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski