Amino acid dipepetide frequency for Clostridium algidicarnis DSM 15099

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.601AlaAla: 3.601 ± 0.096	0.559AlaCys: 0.559 ± 0.026	2.428AlaAsp: 2.428 ± 0.054	3.196AlaGlu: 3.196 ± 0.068	2.486AlaPhe: 2.486 ± 0.066	3.565AlaGly: 3.565 ± 0.086	0.811AlaHis: 0.811 ± 0.03	5.715AlaIle: 5.715 ± 0.104	4.786AlaLys: 4.786 ± 0.086	5.98AlaLeu: 5.98 ± 0.097	1.702AlaMet: 1.702 ± 0.048	2.371AlaAsn: 2.371 ± 0.061	1.419AlaPro: 1.419 ± 0.046	1.226AlaGln: 1.226 ± 0.036	1.852AlaArg: 1.852 ± 0.049	3.312AlaSer: 3.312 ± 0.068	2.796AlaThr: 2.796 ± 0.064	3.669AlaVal: 3.669 ± 0.072	0.287AlaTrp: 0.287 ± 0.021	2.07AlaTyr: 2.07 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.533CysAla: 0.533 ± 0.027	0.173CysCys: 0.173 ± 0.015	0.666CysAsp: 0.666 ± 0.027	0.674CysGlu: 0.674 ± 0.031	0.48CysPhe: 0.48 ± 0.025	0.91CysGly: 0.91 ± 0.038	0.21CysHis: 0.21 ± 0.016	1.005CysIle: 1.005 ± 0.032	0.99CysLys: 0.99 ± 0.039	0.786CysLeu: 0.786 ± 0.029	0.25CysMet: 0.25 ± 0.019	0.67CysAsn: 0.67 ± 0.031	0.429CysPro: 0.429 ± 0.023	0.184CysGln: 0.184 ± 0.017	0.347CysArg: 0.347 ± 0.02	0.728CysSer: 0.728 ± 0.031	0.546CysThr: 0.546 ± 0.027	0.57CysVal: 0.57 ± 0.028	0.059CysTrp: 0.059 ± 0.009	0.418CysTyr: 0.418 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.643AspAla: 2.643 ± 0.063	0.574AspCys: 0.574 ± 0.031	2.538AspAsp: 2.538 ± 0.062	4.65AspGlu: 4.65 ± 0.08	2.8AspPhe: 2.8 ± 0.059	3.29AspGly: 3.29 ± 0.071	0.633AspHis: 0.633 ± 0.027	7.227AspIle: 7.227 ± 0.105	5.958AspLys: 5.958 ± 0.092	5.262AspLeu: 5.262 ± 0.087	1.811AspMet: 1.811 ± 0.049	3.301AspAsn: 3.301 ± 0.07	1.492AspPro: 1.492 ± 0.044	0.878AspGln: 0.878 ± 0.033	1.762AspArg: 1.762 ± 0.05	3.374AspSer: 3.374 ± 0.059	2.693AspThr: 2.693 ± 0.064	3.696AspVal: 3.696 ± 0.06	0.314AspTrp: 0.314 ± 0.019	2.686AspTyr: 2.686 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.085GluAla: 4.085 ± 0.081	0.585GluCys: 0.585 ± 0.032	5.43GluAsp: 5.43 ± 0.092	7.361GluGlu: 7.361 ± 0.133	2.984GluPhe: 2.984 ± 0.066	4.636GluGly: 4.636 ± 0.076	0.858GluHis: 0.858 ± 0.029	7.295GluIle: 7.295 ± 0.108	7.837GluLys: 7.837 ± 0.129	6.678GluLeu: 6.678 ± 0.109	1.93GluMet: 1.93 ± 0.052	5.082GluAsn: 5.082 ± 0.089	1.5GluPro: 1.5 ± 0.044	1.519GluGln: 1.519 ± 0.045	2.698GluArg: 2.698 ± 0.064	4.205GluSer: 4.205 ± 0.083	2.97GluThr: 2.97 ± 0.067	5.037GluVal: 5.037 ± 0.097	0.378GluTrp: 0.378 ± 0.023	2.995GluTyr: 2.995 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	2.091PheAla: 2.091 ± 0.058	0.482PheCys: 0.482 ± 0.023	2.306PheAsp: 2.306 ± 0.052	2.737PheGlu: 2.737 ± 0.057	1.76PhePhe: 1.76 ± 0.058	2.73PheGly: 2.73 ± 0.074	0.566PheHis: 0.566 ± 0.026	4.793PheIle: 4.793 ± 0.092	4.165PheLys: 4.165 ± 0.069	3.782PheLeu: 3.782 ± 0.081	1.214PheMet: 1.214 ± 0.042	2.991PheAsn: 2.991 ± 0.067	1.163PhePro: 1.163 ± 0.039	0.973PheGln: 0.973 ± 0.034	1.148PheArg: 1.148 ± 0.04	3.091PheSer: 3.091 ± 0.069	2.119PheThr: 2.119 ± 0.056	2.512PheVal: 2.512 ± 0.071	0.262PheTrp: 0.262 ± 0.017	1.726PheTyr: 1.726 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	3.925GlyAla: 3.925 ± 0.089	0.802GlyCys: 0.802 ± 0.032	3.486GlyAsp: 3.486 ± 0.066	4.453GlyGlu: 4.453 ± 0.082	3.175GlyPhe: 3.175 ± 0.07	4.365GlyGly: 4.365 ± 0.094	0.983GlyHis: 0.983 ± 0.036	6.667GlyIle: 6.667 ± 0.112	5.663GlyLys: 5.663 ± 0.081	5.4GlyLeu: 5.4 ± 0.098	1.815GlyMet: 1.815 ± 0.055	3.288GlyAsn: 3.288 ± 0.065	1.331GlyPro: 1.331 ± 0.044	1.346GlyGln: 1.346 ± 0.042	2.437GlyArg: 2.437 ± 0.062	3.858GlySer: 3.858 ± 0.079	3.413GlyThr: 3.413 ± 0.066	4.617GlyVal: 4.617 ± 0.078	0.434GlyTrp: 0.434 ± 0.027	2.947GlyTyr: 2.947 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.642HisAla: 0.642 ± 0.03	0.192HisCys: 0.192 ± 0.016	0.655HisAsp: 0.655 ± 0.031	0.858HisGlu: 0.858 ± 0.034	0.59HisPhe: 0.59 ± 0.027	1.008HisGly: 1.008 ± 0.038	0.278HisHis: 0.278 ± 0.016	1.429HisIle: 1.429 ± 0.045	1.12HisLys: 1.12 ± 0.036	1.179HisLeu: 1.179 ± 0.036	0.341HisMet: 0.341 ± 0.021	0.775HisAsn: 0.775 ± 0.029	0.597HisPro: 0.597 ± 0.028	0.274HisGln: 0.274 ± 0.019	0.516HisArg: 0.516 ± 0.03	0.797HisSer: 0.797 ± 0.033	0.67HisThr: 0.67 ± 0.032	0.732HisVal: 0.732 ± 0.027	0.103HisTrp: 0.103 ± 0.011	0.555HisTyr: 0.555 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.635IleAla: 5.635 ± 0.106	1.171IleCys: 1.171 ± 0.034	5.998IleAsp: 5.998 ± 0.089	7.644IleGlu: 7.644 ± 0.121	4.159IlePhe: 4.159 ± 0.085	6.15IleGly: 6.15 ± 0.1	1.242IleHis: 1.242 ± 0.041	10.207IleIle: 10.207 ± 0.159	10.014IleLys: 10.014 ± 0.128	9.419IleLeu: 9.419 ± 0.135	2.646IleMet: 2.646 ± 0.059	6.487IleAsn: 6.487 ± 0.101	3.303IlePro: 3.303 ± 0.062	2.103IleGln: 2.103 ± 0.05	3.014IleArg: 3.014 ± 0.062	7.473IleSer: 7.473 ± 0.11	4.964IleThr: 4.964 ± 0.082	6.082IleVal: 6.082 ± 0.096	0.492IleTrp: 0.492 ± 0.026	3.717IleTyr: 3.717 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	5.166LysAla: 5.166 ± 0.085	0.742LysCys: 0.742 ± 0.037	7.622LysAsp: 7.622 ± 0.129	9.89LysGlu: 9.89 ± 0.16	3.078LysPhe: 3.078 ± 0.063	6.143LysGly: 6.143 ± 0.087	1.104LysHis: 1.104 ± 0.036	8.091LysIle: 8.091 ± 0.113	7.824LysLys: 7.824 ± 0.106	7.555LysLeu: 7.555 ± 0.096	2.358LysMet: 2.358 ± 0.052	5.754LysAsn: 5.754 ± 0.099	2.276LysPro: 2.276 ± 0.053	2.118LysGln: 2.118 ± 0.058	3.556LysArg: 3.556 ± 0.073	5.959LysSer: 5.959 ± 0.09	4.043LysThr: 4.043 ± 0.078	6.447LysVal: 6.447 ± 0.089	0.563LysTrp: 0.563 ± 0.025	3.903LysTyr: 3.903 ± 0.075	0.0LysXaa: 0.0 ± 0.0
Leu	4.901LeuAla: 4.901 ± 0.089	1.083LeuCys: 1.083 ± 0.039	5.496LeuAsp: 5.496 ± 0.086	6.733LeuGlu: 6.733 ± 0.096	3.627LeuPhe: 3.627 ± 0.075	6.034LeuGly: 6.034 ± 0.092	1.052LeuHis: 1.052 ± 0.04	8.518LeuIle: 8.518 ± 0.131	9.313LeuLys: 9.313 ± 0.116	7.771LeuLeu: 7.771 ± 0.106	2.416LeuMet: 2.416 ± 0.056	6.194LeuAsn: 6.194 ± 0.098	2.737LeuPro: 2.737 ± 0.06	2.157LeuGln: 2.157 ± 0.047	3.117LeuArg: 3.117 ± 0.059	6.91LeuSer: 6.91 ± 0.095	4.32LeuThr: 4.32 ± 0.066	5.201LeuVal: 5.201 ± 0.092	0.549LeuTrp: 0.549 ± 0.031	3.159LeuTyr: 3.159 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	1.874MetAla: 1.874 ± 0.045	0.279MetCys: 0.279 ± 0.018	1.849MetAsp: 1.849 ± 0.046	2.094MetGlu: 2.094 ± 0.053	0.982MetPhe: 0.982 ± 0.035	1.982MetGly: 1.982 ± 0.048	0.331MetHis: 0.331 ± 0.022	2.395MetIle: 2.395 ± 0.053	2.596MetLys: 2.596 ± 0.052	2.254MetLeu: 2.254 ± 0.055	0.697MetMet: 0.697 ± 0.031	1.616MetAsn: 1.616 ± 0.044	0.932MetPro: 0.932 ± 0.034	0.664MetGln: 0.664 ± 0.027	0.858MetArg: 0.858 ± 0.032	1.836MetSer: 1.836 ± 0.048	1.221MetThr: 1.221 ± 0.036	1.889MetVal: 1.889 ± 0.047	0.137MetTrp: 0.137 ± 0.013	0.853MetTyr: 0.853 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.696AsnAla: 2.696 ± 0.067	0.67AsnCys: 0.67 ± 0.032	2.706AsnAsp: 2.706 ± 0.054	4.167AsnGlu: 4.167 ± 0.087	2.513AsnPhe: 2.513 ± 0.051	3.239AsnGly: 3.239 ± 0.066	0.869AsnHis: 0.869 ± 0.036	7.539AsnIle: 7.539 ± 0.11	6.176AsnLys: 6.176 ± 0.093	5.673AsnLeu: 5.673 ± 0.081	1.736AsnMet: 1.736 ± 0.044	4.087AsnAsn: 4.087 ± 0.09	2.102AsnPro: 2.102 ± 0.053	1.262AsnGln: 1.262 ± 0.041	1.793AsnArg: 1.793 ± 0.051	3.84AsnSer: 3.84 ± 0.068	2.74AsnThr: 2.74 ± 0.055	3.523AsnVal: 3.523 ± 0.063	0.383AsnTrp: 0.383 ± 0.027	2.613AsnTyr: 2.613 ± 0.066	0.0AsnXaa: 0.0 ± 0.0
Pro	1.317ProAla: 1.317 ± 0.041	0.308ProCys: 0.308 ± 0.018	1.298ProAsp: 1.298 ± 0.042	2.171ProGlu: 2.171 ± 0.059	1.366ProPhe: 1.366 ± 0.047	1.697ProGly: 1.697 ± 0.048	0.495ProHis: 0.495 ± 0.024	2.899ProIle: 2.899 ± 0.068	2.524ProLys: 2.524 ± 0.056	2.699ProLeu: 2.699 ± 0.064	0.796ProMet: 0.796 ± 0.029	1.523ProAsn: 1.523 ± 0.04	0.626ProPro: 0.626 ± 0.034	0.712ProGln: 0.712 ± 0.032	0.923ProArg: 0.923 ± 0.037	2.003ProSer: 2.003 ± 0.051	1.484ProThr: 1.484 ± 0.044	1.967ProVal: 1.967 ± 0.056	0.227ProTrp: 0.227 ± 0.019	1.287ProTyr: 1.287 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.106GlnAla: 1.106 ± 0.036	0.263GlnCys: 0.263 ± 0.017	1.167GlnAsp: 1.167 ± 0.035	1.491GlnGlu: 1.491 ± 0.041	0.86GlnPhe: 0.86 ± 0.034	1.502GlnGly: 1.502 ± 0.039	0.298GlnHis: 0.298 ± 0.02	2.004GlnIle: 2.004 ± 0.06	1.931GlnLys: 1.931 ± 0.045	1.967GlnLeu: 1.967 ± 0.056	0.647GlnMet: 0.647 ± 0.031	1.361GlnAsn: 1.361 ± 0.041	0.488GlnPro: 0.488 ± 0.027	0.6GlnGln: 0.6 ± 0.028	0.936GlnArg: 0.936 ± 0.033	1.395GlnSer: 1.395 ± 0.041	0.891GlnThr: 0.891 ± 0.032	1.315GlnVal: 1.315 ± 0.035	0.229GlnTrp: 0.229 ± 0.018	1.051GlnTyr: 1.051 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.9ArgAla: 1.9 ± 0.051	0.393ArgCys: 0.393 ± 0.023	1.879ArgAsp: 1.879 ± 0.055	2.773ArgGlu: 2.773 ± 0.066	1.495ArgPhe: 1.495 ± 0.044	2.076ArgGly: 2.076 ± 0.058	0.459ArgHis: 0.459 ± 0.024	3.077ArgIle: 3.077 ± 0.071	2.873ArgLys: 2.873 ± 0.059	3.0ArgLeu: 3.0 ± 0.064	0.987ArgMet: 0.987 ± 0.039	1.868ArgAsn: 1.868 ± 0.053	0.912ArgPro: 0.912 ± 0.037	0.912ArgGln: 0.912 ± 0.036	1.369ArgArg: 1.369 ± 0.055	1.774ArgSer: 1.774 ± 0.042	1.54ArgThr: 1.54 ± 0.055	2.229ArgVal: 2.229 ± 0.06	0.246ArgTrp: 0.246 ± 0.018	1.535ArgTyr: 1.535 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.078SerAla: 3.078 ± 0.068	0.649SerCys: 0.649 ± 0.032	3.213SerAsp: 3.213 ± 0.062	4.171SerGlu: 4.171 ± 0.087	3.195SerPhe: 3.195 ± 0.074	4.386SerGly: 4.386 ± 0.07	0.915SerHis: 0.915 ± 0.033	7.191SerIle: 7.191 ± 0.103	6.662SerLys: 6.662 ± 0.09	6.708SerLeu: 6.708 ± 0.098	1.864SerMet: 1.864 ± 0.053	3.82SerAsn: 3.82 ± 0.079	1.78SerPro: 1.78 ± 0.045	1.392SerGln: 1.392 ± 0.044	2.011SerArg: 2.011 ± 0.047	4.519SerSer: 4.519 ± 0.081	3.12SerThr: 3.12 ± 0.064	3.761SerVal: 3.761 ± 0.072	0.412SerTrp: 0.412 ± 0.025	2.84SerTyr: 2.84 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	2.649ThrAla: 2.649 ± 0.068	0.439ThrCys: 0.439 ± 0.024	2.246ThrAsp: 2.246 ± 0.063	2.911ThrGlu: 2.911 ± 0.065	2.138ThrPhe: 2.138 ± 0.057	3.546ThrGly: 3.546 ± 0.075	0.738ThrHis: 0.738 ± 0.032	4.699ThrIle: 4.699 ± 0.078	3.975ThrLys: 3.975 ± 0.065	5.153ThrLeu: 5.153 ± 0.087	1.204ThrMet: 1.204 ± 0.036	2.49ThrAsn: 2.49 ± 0.058	1.8ThrPro: 1.8 ± 0.051	0.984ThrGln: 0.984 ± 0.032	1.441ThrArg: 1.441 ± 0.048	3.162ThrSer: 3.162 ± 0.07	2.592ThrThr: 2.592 ± 0.066	3.232ThrVal: 3.232 ± 0.069	0.329ThrTrp: 0.329 ± 0.02	1.815ThrTyr: 1.815 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	3.759ValAla: 3.759 ± 0.085	0.72ValCys: 0.72 ± 0.035	3.8ValAsp: 3.8 ± 0.074	4.634ValGlu: 4.634 ± 0.087	2.741ValPhe: 2.741 ± 0.058	4.193ValGly: 4.193 ± 0.086	0.815ValHis: 0.815 ± 0.034	6.364ValIle: 6.364 ± 0.09	5.367ValLys: 5.367 ± 0.093	5.939ValLeu: 5.939 ± 0.089	1.733ValMet: 1.733 ± 0.044	3.406ValAsn: 3.406 ± 0.062	2.026ValPro: 2.026 ± 0.049	1.385ValGln: 1.385 ± 0.041	1.993ValArg: 1.993 ± 0.052	4.355ValSer: 4.355 ± 0.067	3.239ValThr: 3.239 ± 0.087	4.354ValVal: 4.354 ± 0.082	0.34ValTrp: 0.34 ± 0.023	2.346ValTyr: 2.346 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.342TrpAla: 0.342 ± 0.025	0.09TrpCys: 0.09 ± 0.011	0.352TrpAsp: 0.352 ± 0.022	0.389TrpGlu: 0.389 ± 0.022	0.27TrpPhe: 0.27 ± 0.02	0.409TrpGly: 0.409 ± 0.024	0.108TrpHis: 0.108 ± 0.012	0.584TrpIle: 0.584 ± 0.028	0.457TrpLys: 0.457 ± 0.025	0.504TrpLeu: 0.504 ± 0.024	0.182TrpMet: 0.182 ± 0.014	0.43TrpAsn: 0.43 ± 0.022	0.171TrpPro: 0.171 ± 0.016	0.163TrpGln: 0.163 ± 0.016	0.229TrpArg: 0.229 ± 0.016	0.427TrpSer: 0.427 ± 0.026	0.26TrpThr: 0.26 ± 0.018	0.382TrpVal: 0.382 ± 0.022	0.064TrpTrp: 0.064 ± 0.009	0.251TrpTyr: 0.251 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.888TyrAla: 1.888 ± 0.044	0.456TyrCys: 0.456 ± 0.025	2.443TyrAsp: 2.443 ± 0.057	3.065TyrGlu: 3.065 ± 0.067	1.913TyrPhe: 1.913 ± 0.058	2.547TyrGly: 2.547 ± 0.051	0.546TyrHis: 0.546 ± 0.025	4.221TyrIle: 4.221 ± 0.086	3.959TyrLys: 3.959 ± 0.071	3.577TyrLeu: 3.577 ± 0.068	1.011TyrMet: 1.011 ± 0.034	2.815TyrAsn: 2.815 ± 0.078	1.236TyrPro: 1.236 ± 0.044	0.649TyrGln: 0.649 ± 0.031	1.301TyrArg: 1.301 ± 0.042	2.672TyrSer: 2.672 ± 0.057	1.922TyrThr: 1.922 ± 0.058	2.293TyrVal: 2.293 ± 0.055	0.256TyrTrp: 0.256 ± 0.018	1.806TyrTyr: 1.806 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2618 proteins (808886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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