Amino acid dipepetide frequency for Cryobacterium roopkundense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.839AlaAla: 18.839 ± 0.182	0.791AlaCys: 0.791 ± 0.029	7.57AlaAsp: 7.57 ± 0.096	7.329AlaGlu: 7.329 ± 0.1	3.977AlaPhe: 3.977 ± 0.064	11.639AlaGly: 11.639 ± 0.126	2.351AlaHis: 2.351 ± 0.047	5.936AlaIle: 5.936 ± 0.082	2.66AlaLys: 2.66 ± 0.057	13.94AlaLeu: 13.94 ± 0.132	2.655AlaMet: 2.655 ± 0.059	2.738AlaAsn: 2.738 ± 0.056	5.681AlaPro: 5.681 ± 0.09	3.859AlaGln: 3.859 ± 0.07	8.362AlaArg: 8.362 ± 0.118	7.519AlaSer: 7.519 ± 0.082	7.544AlaThr: 7.544 ± 0.1	11.032AlaVal: 11.032 ± 0.116	1.652AlaTrp: 1.652 ± 0.044	2.286AlaTyr: 2.286 ± 0.059	0.001AlaXaa: 0.001 ± 0.001
Cys	0.701CysAla: 0.701 ± 0.027	0.054CysCys: 0.054 ± 0.008	0.333CysAsp: 0.333 ± 0.018	0.315CysGlu: 0.315 ± 0.019	0.199CysPhe: 0.199 ± 0.013	0.631CysGly: 0.631 ± 0.027	0.13CysHis: 0.13 ± 0.011	0.231CysIle: 0.231 ± 0.015	0.082CysLys: 0.082 ± 0.01	0.52CysLeu: 0.52 ± 0.023	0.113CysMet: 0.113 ± 0.01	0.126CysAsn: 0.126 ± 0.011	0.31CysPro: 0.31 ± 0.019	0.14CysGln: 0.14 ± 0.011	0.364CysArg: 0.364 ± 0.02	0.436CysSer: 0.436 ± 0.022	0.422CysThr: 0.422 ± 0.023	0.518CysVal: 0.518 ± 0.024	0.082CysTrp: 0.082 ± 0.01	0.126CysTyr: 0.126 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.706AspAla: 7.706 ± 0.099	0.304AspCys: 0.304 ± 0.017	3.396AspAsp: 3.396 ± 0.078	3.595AspGlu: 3.595 ± 0.069	1.978AspPhe: 1.978 ± 0.045	5.083AspGly: 5.083 ± 0.086	1.112AspHis: 1.112 ± 0.035	2.476AspIle: 2.476 ± 0.053	1.103AspLys: 1.103 ± 0.033	6.266AspLeu: 6.266 ± 0.091	0.918AspMet: 0.918 ± 0.034	1.163AspAsn: 1.163 ± 0.032	3.623AspPro: 3.623 ± 0.063	1.614AspGln: 1.614 ± 0.06	3.842AspArg: 3.842 ± 0.068	3.124AspSer: 3.124 ± 0.059	3.239AspThr: 3.239 ± 0.062	5.133AspVal: 5.133 ± 0.08	0.895AspTrp: 0.895 ± 0.031	1.312AspTyr: 1.312 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.511GluAla: 6.511 ± 0.086	0.279GluCys: 0.279 ± 0.018	2.268GluAsp: 2.268 ± 0.051	2.571GluGlu: 2.571 ± 0.06	1.878GluPhe: 1.878 ± 0.039	3.537GluGly: 3.537 ± 0.065	1.398GluHis: 1.398 ± 0.039	2.883GluIle: 2.883 ± 0.062	1.479GluLys: 1.479 ± 0.046	6.352GluLeu: 6.352 ± 0.093	0.981GluMet: 0.981 ± 0.033	1.473GluAsn: 1.473 ± 0.04	2.695GluPro: 2.695 ± 0.053	2.074GluGln: 2.074 ± 0.049	4.348GluArg: 4.348 ± 0.078	3.079GluSer: 3.079 ± 0.067	3.104GluThr: 3.104 ± 0.063	4.141GluVal: 4.141 ± 0.073	0.832GluTrp: 0.832 ± 0.031	1.145GluTyr: 1.145 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.306PheAla: 4.306 ± 0.072	0.24PheCys: 0.24 ± 0.017	2.381PheAsp: 2.381 ± 0.056	1.776PheGlu: 1.776 ± 0.041	1.202PhePhe: 1.202 ± 0.041	3.504PheGly: 3.504 ± 0.068	0.608PheHis: 0.608 ± 0.025	1.456PheIle: 1.456 ± 0.038	0.576PheLys: 0.576 ± 0.024	2.988PheLeu: 2.988 ± 0.063	0.541PheMet: 0.541 ± 0.023	0.847PheAsn: 0.847 ± 0.03	1.481PhePro: 1.481 ± 0.043	0.81PheGln: 0.81 ± 0.032	1.782PheArg: 1.782 ± 0.04	2.067PheSer: 2.067 ± 0.047	2.349PheThr: 2.349 ± 0.053	3.027PheVal: 3.027 ± 0.065	0.484PheTrp: 0.484 ± 0.025	0.719PheTyr: 0.719 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.998GlyAla: 9.998 ± 0.12	0.634GlyCys: 0.634 ± 0.023	4.54GlyAsp: 4.54 ± 0.07	4.384GlyGlu: 4.384 ± 0.065	3.337GlyPhe: 3.337 ± 0.063	7.162GlyGly: 7.162 ± 0.108	1.922GlyHis: 1.922 ± 0.049	4.898GlyIle: 4.898 ± 0.071	2.35GlyLys: 2.35 ± 0.052	9.354GlyLeu: 9.354 ± 0.115	1.892GlyMet: 1.892 ± 0.045	1.952GlyAsn: 1.952 ± 0.048	3.602GlyPro: 3.602 ± 0.065	2.651GlyGln: 2.651 ± 0.054	5.679GlyArg: 5.679 ± 0.081	5.674GlySer: 5.674 ± 0.072	5.891GlyThr: 5.891 ± 0.088	7.675GlyVal: 7.675 ± 0.104	1.567GlyTrp: 1.567 ± 0.046	2.274GlyTyr: 2.274 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.258HisAla: 2.258 ± 0.049	0.152HisCys: 0.152 ± 0.012	1.289HisAsp: 1.289 ± 0.038	1.174HisGlu: 1.174 ± 0.035	0.583HisPhe: 0.583 ± 0.026	1.918HisGly: 1.918 ± 0.047	0.506HisHis: 0.506 ± 0.024	0.795HisIle: 0.795 ± 0.03	0.356HisLys: 0.356 ± 0.018	2.097HisLeu: 2.097 ± 0.052	0.316HisMet: 0.316 ± 0.017	0.505HisAsn: 0.505 ± 0.022	1.438HisPro: 1.438 ± 0.04	0.544HisGln: 0.544 ± 0.024	1.487HisArg: 1.487 ± 0.042	1.221HisSer: 1.221 ± 0.036	1.101HisThr: 1.101 ± 0.032	1.707HisVal: 1.707 ± 0.04	0.243HisTrp: 0.243 ± 0.015	0.464HisTyr: 0.464 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.645IleAla: 6.645 ± 0.09	0.313IleCys: 0.313 ± 0.018	3.492IleAsp: 3.492 ± 0.059	2.954IleGlu: 2.954 ± 0.065	1.409IlePhe: 1.409 ± 0.043	4.686IleGly: 4.686 ± 0.081	0.799IleHis: 0.799 ± 0.028	2.251IleIle: 2.251 ± 0.059	1.004IleLys: 1.004 ± 0.038	4.205IleLeu: 4.205 ± 0.072	0.793IleMet: 0.793 ± 0.031	1.237IleAsn: 1.237 ± 0.038	2.577IlePro: 2.577 ± 0.057	1.137IleGln: 1.137 ± 0.032	2.882IleArg: 2.882 ± 0.057	2.718IleSer: 2.718 ± 0.057	3.262IleThr: 3.262 ± 0.071	4.854IleVal: 4.854 ± 0.077	0.556IleTrp: 0.556 ± 0.026	0.867IleTyr: 0.867 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.683LysAla: 2.683 ± 0.052	0.073LysCys: 0.073 ± 0.008	1.128LysAsp: 1.128 ± 0.04	1.016LysGlu: 1.016 ± 0.041	0.703LysPhe: 0.703 ± 0.023	1.55LysGly: 1.55 ± 0.048	0.478LysHis: 0.478 ± 0.026	1.198LysIle: 1.198 ± 0.036	0.881LysLys: 0.881 ± 0.035	2.178LysLeu: 2.178 ± 0.048	0.514LysMet: 0.514 ± 0.026	0.713LysAsn: 0.713 ± 0.029	1.355LysPro: 1.355 ± 0.04	0.747LysGln: 0.747 ± 0.033	1.671LysArg: 1.671 ± 0.044	1.409LysSer: 1.409 ± 0.038	1.544LysThr: 1.544 ± 0.042	1.747LysVal: 1.747 ± 0.049	0.269LysTrp: 0.269 ± 0.017	0.535LysTyr: 0.535 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.579LeuAla: 14.579 ± 0.169	0.565LeuCys: 0.565 ± 0.024	6.364LeuAsp: 6.364 ± 0.085	5.255LeuGlu: 5.255 ± 0.076	3.055LeuPhe: 3.055 ± 0.071	9.63LeuGly: 9.63 ± 0.115	2.034LeuHis: 2.034 ± 0.049	4.98LeuIle: 4.98 ± 0.089	2.083LeuLys: 2.083 ± 0.051	10.78LeuLeu: 10.78 ± 0.157	1.842LeuMet: 1.842 ± 0.047	2.447LeuAsn: 2.447 ± 0.048	5.446LeuPro: 5.446 ± 0.074	2.594LeuGln: 2.594 ± 0.051	6.941LeuArg: 6.941 ± 0.107	6.499LeuSer: 6.499 ± 0.089	6.811LeuThr: 6.811 ± 0.091	9.556LeuVal: 9.556 ± 0.119	1.243LeuTrp: 1.243 ± 0.044	1.768LeuTyr: 1.768 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.257MetAla: 2.257 ± 0.05	0.098MetCys: 0.098 ± 0.01	0.821MetAsp: 0.821 ± 0.028	0.757MetGlu: 0.757 ± 0.026	0.586MetPhe: 0.586 ± 0.028	1.414MetGly: 1.414 ± 0.039	0.394MetHis: 0.394 ± 0.019	0.978MetIle: 0.978 ± 0.031	0.592MetLys: 0.592 ± 0.024	2.086MetLeu: 2.086 ± 0.049	0.367MetMet: 0.367 ± 0.019	0.582MetAsn: 0.582 ± 0.024	1.161MetPro: 1.161 ± 0.035	0.603MetGln: 0.603 ± 0.027	1.369MetArg: 1.369 ± 0.038	1.535MetSer: 1.535 ± 0.037	1.743MetThr: 1.743 ± 0.041	1.434MetVal: 1.434 ± 0.038	0.216MetTrp: 0.216 ± 0.014	0.296MetTyr: 0.296 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.917AsnAla: 2.917 ± 0.051	0.144AsnCys: 0.144 ± 0.013	1.383AsnAsp: 1.383 ± 0.041	1.261AsnGlu: 1.261 ± 0.042	0.844AsnPhe: 0.844 ± 0.032	2.25AsnGly: 2.25 ± 0.053	0.432AsnHis: 0.432 ± 0.018	1.047AsnIle: 1.047 ± 0.037	0.548AsnLys: 0.548 ± 0.026	2.416AsnLeu: 2.416 ± 0.05	0.478AsnMet: 0.478 ± 0.024	0.656AsnAsn: 0.656 ± 0.03	1.741AsnPro: 1.741 ± 0.041	0.756AsnGln: 0.756 ± 0.029	1.563AsnArg: 1.563 ± 0.045	1.354AsnSer: 1.354 ± 0.04	1.399AsnThr: 1.399 ± 0.041	2.063AsnVal: 2.063 ± 0.046	0.36AsnTrp: 0.36 ± 0.021	0.601AsnTyr: 0.601 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.539ProAla: 6.539 ± 0.095	0.211ProCys: 0.211 ± 0.015	3.387ProAsp: 3.387 ± 0.056	3.429ProGlu: 3.429 ± 0.067	1.699ProPhe: 1.699 ± 0.038	4.855ProGly: 4.855 ± 0.08	1.054ProHis: 1.054 ± 0.035	2.23ProIle: 2.23 ± 0.04	1.067ProLys: 1.067 ± 0.036	4.934ProLeu: 4.934 ± 0.076	0.903ProMet: 0.903 ± 0.032	1.234ProAsn: 1.234 ± 0.033	2.044ProPro: 2.044 ± 0.063	1.448ProGln: 1.448 ± 0.034	2.944ProArg: 2.944 ± 0.055	3.049ProSer: 3.049 ± 0.054	3.501ProThr: 3.501 ± 0.076	4.812ProVal: 4.812 ± 0.071	0.754ProTrp: 0.754 ± 0.028	0.962ProTyr: 0.962 ± 0.035	0.001ProXaa: 0.001 ± 0.001
Gln	3.828GlnAla: 3.828 ± 0.068	0.129GlnCys: 0.129 ± 0.012	1.283GlnAsp: 1.283 ± 0.038	1.212GlnGlu: 1.212 ± 0.037	0.96GlnPhe: 0.96 ± 0.028	2.142GlnGly: 2.142 ± 0.045	0.627GlnHis: 0.627 ± 0.026	1.637GlnIle: 1.637 ± 0.043	0.761GlnLys: 0.761 ± 0.03	3.34GlnLeu: 3.34 ± 0.058	0.572GlnMet: 0.572 ± 0.023	0.777GlnAsn: 0.777 ± 0.029	1.449GlnPro: 1.449 ± 0.044	1.193GlnGln: 1.193 ± 0.031	2.185GlnArg: 2.185 ± 0.053	1.754GlnSer: 1.754 ± 0.047	1.696GlnThr: 1.696 ± 0.041	2.549GlnVal: 2.549 ± 0.048	0.463GlnTrp: 0.463 ± 0.024	0.61GlnTyr: 0.61 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.841ArgAla: 7.841 ± 0.096	0.359ArgCys: 0.359 ± 0.018	3.719ArgAsp: 3.719 ± 0.068	3.689ArgGlu: 3.689 ± 0.065	2.368ArgPhe: 2.368 ± 0.052	4.969ArgGly: 4.969 ± 0.079	1.447ArgHis: 1.447 ± 0.038	3.387ArgIle: 3.387 ± 0.059	1.522ArgLys: 1.522 ± 0.045	7.011ArgLeu: 7.011 ± 0.103	1.681ArgMet: 1.681 ± 0.037	1.559ArgAsn: 1.559 ± 0.042	3.159ArgPro: 3.159 ± 0.067	2.036ArgGln: 2.036 ± 0.044	5.295ArgArg: 5.295 ± 0.108	4.153ArgSer: 4.153 ± 0.079	4.024ArgThr: 4.024 ± 0.074	5.674ArgVal: 5.674 ± 0.075	1.02ArgTrp: 1.02 ± 0.034	1.572ArgTyr: 1.572 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.693SerAla: 7.693 ± 0.087	0.338SerCys: 0.338 ± 0.017	3.3SerAsp: 3.3 ± 0.067	2.907SerGlu: 2.907 ± 0.062	2.129SerPhe: 2.129 ± 0.047	6.192SerGly: 6.192 ± 0.087	1.115SerHis: 1.115 ± 0.037	3.021SerIle: 3.021 ± 0.059	1.316SerLys: 1.316 ± 0.038	6.005SerLeu: 6.005 ± 0.081	1.321SerMet: 1.321 ± 0.036	1.441SerAsn: 1.441 ± 0.039	3.11SerPro: 3.11 ± 0.059	1.679SerGln: 1.679 ± 0.041	3.898SerArg: 3.898 ± 0.065	3.835SerSer: 3.835 ± 0.066	4.089SerThr: 4.089 ± 0.064	5.454SerVal: 5.454 ± 0.079	0.978SerTrp: 0.978 ± 0.033	1.345SerTyr: 1.345 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	7.908ThrAla: 7.908 ± 0.098	0.316ThrCys: 0.316 ± 0.016	3.869ThrAsp: 3.869 ± 0.063	3.308ThrGlu: 3.308 ± 0.059	2.031ThrPhe: 2.031 ± 0.049	6.126ThrGly: 6.126 ± 0.094	1.265ThrHis: 1.265 ± 0.035	3.1ThrIle: 3.1 ± 0.063	1.394ThrLys: 1.394 ± 0.039	6.564ThrLeu: 6.564 ± 0.081	1.144ThrMet: 1.144 ± 0.034	1.54ThrAsn: 1.54 ± 0.043	3.876ThrPro: 3.876 ± 0.07	1.589ThrGln: 1.589 ± 0.043	3.832ThrArg: 3.832 ± 0.065	3.847ThrSer: 3.847 ± 0.072	4.125ThrThr: 4.125 ± 0.083	6.032ThrVal: 6.032 ± 0.1	0.869ThrTrp: 0.869 ± 0.031	1.289ThrTyr: 1.289 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	11.307ValAla: 11.307 ± 0.129	0.581ValCys: 0.581 ± 0.024	5.347ValAsp: 5.347 ± 0.08	4.447ValGlu: 4.447 ± 0.072	2.896ValPhe: 2.896 ± 0.062	7.164ValGly: 7.164 ± 0.098	1.815ValHis: 1.815 ± 0.05	4.647ValIle: 4.647 ± 0.075	1.827ValLys: 1.827 ± 0.054	9.393ValLeu: 9.393 ± 0.116	1.616ValMet: 1.616 ± 0.04	2.233ValAsn: 2.233 ± 0.046	4.507ValPro: 4.507 ± 0.073	2.487ValGln: 2.487 ± 0.044	5.45ValArg: 5.45 ± 0.082	5.594ValSer: 5.594 ± 0.075	6.157ValThr: 6.157 ± 0.089	8.296ValVal: 8.296 ± 0.112	1.12ValTrp: 1.12 ± 0.037	1.605ValTyr: 1.605 ± 0.042	0.001ValXaa: 0.001 ± 0.001
Trp	1.53TrpAla: 1.53 ± 0.043	0.09TrpCys: 0.09 ± 0.009	0.698TrpAsp: 0.698 ± 0.025	0.573TrpGlu: 0.573 ± 0.023	0.518TrpPhe: 0.518 ± 0.022	1.048TrpGly: 1.048 ± 0.029	0.333TrpHis: 0.333 ± 0.019	0.71TrpIle: 0.71 ± 0.027	0.377TrpLys: 0.377 ± 0.021	1.742TrpLeu: 1.742 ± 0.052	0.35TrpMet: 0.35 ± 0.021	0.472TrpAsn: 0.472 ± 0.021	0.716TrpPro: 0.716 ± 0.03	0.563TrpGln: 0.563 ± 0.027	1.06TrpArg: 1.06 ± 0.036	0.93TrpSer: 0.93 ± 0.033	0.836TrpThr: 0.836 ± 0.032	1.111TrpVal: 1.111 ± 0.034	0.299TrpTrp: 0.299 ± 0.02	0.271TrpTyr: 0.271 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.315TyrAla: 2.315 ± 0.049	0.162TyrCys: 0.162 ± 0.014	1.313TyrAsp: 1.313 ± 0.036	1.072TyrGlu: 1.072 ± 0.035	0.793TyrPhe: 0.793 ± 0.033	1.939TyrGly: 1.939 ± 0.049	0.333TyrHis: 0.333 ± 0.019	0.781TyrIle: 0.781 ± 0.03	0.414TyrLys: 0.414 ± 0.022	2.3TyrLeu: 2.3 ± 0.056	0.291TyrMet: 0.291 ± 0.018	0.516TyrAsn: 0.516 ± 0.023	1.089TyrPro: 1.089 ± 0.036	0.643TyrGln: 0.643 ± 0.029	1.533TyrArg: 1.533 ± 0.041	1.37TyrSer: 1.37 ± 0.039	1.188TyrThr: 1.188 ± 0.036	1.674TyrVal: 1.674 ± 0.039	0.325TyrTrp: 0.325 ± 0.018	0.48TyrTyr: 0.48 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3249 proteins (988510 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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