Amino acid dipepetide frequency for Salinadaptatus halalkaliphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.717AlaAla: 11.717 ± 0.133
0.73AlaCys: 0.73 ± 0.025
9.895AlaAsp: 9.895 ± 0.111
7.723AlaGlu: 7.723 ± 0.095
3.839AlaPhe: 3.839 ± 0.06
8.917AlaGly: 8.917 ± 0.094
1.759AlaHis: 1.759 ± 0.042
5.94AlaIle: 5.94 ± 0.085
1.696AlaLys: 1.696 ± 0.043
9.727AlaLeu: 9.727 ± 0.112
1.997AlaMet: 1.997 ± 0.041
2.424AlaAsn: 2.424 ± 0.05
3.486AlaPro: 3.486 ± 0.057
2.292AlaGln: 2.292 ± 0.043
5.551AlaArg: 5.551 ± 0.082
5.436AlaSer: 5.436 ± 0.062
7.636AlaThr: 7.636 ± 0.095
9.937AlaVal: 9.937 ± 0.103
1.032AlaTrp: 1.032 ± 0.028
2.657AlaTyr: 2.657 ± 0.047
0.001AlaXaa: 0.001 ± 0.001
Cys
0.576CysAla: 0.576 ± 0.025
0.109CysCys: 0.109 ± 0.01
0.617CysAsp: 0.617 ± 0.023
0.618CysGlu: 0.618 ± 0.024
0.197CysPhe: 0.197 ± 0.014
0.846CysGly: 0.846 ± 0.03
0.219CysHis: 0.219 ± 0.016
0.245CysIle: 0.245 ± 0.015
0.136CysLys: 0.136 ± 0.011
0.688CysLeu: 0.688 ± 0.027
0.111CysMet: 0.111 ± 0.009
0.177CysAsn: 0.177 ± 0.014
0.528CysPro: 0.528 ± 0.025
0.199CysGln: 0.199 ± 0.013
0.557CysArg: 0.557 ± 0.024
0.492CysSer: 0.492 ± 0.022
0.453CysThr: 0.453 ± 0.02
0.488CysVal: 0.488 ± 0.018
0.098CysTrp: 0.098 ± 0.009
0.238CysTyr: 0.238 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
9.493AspAla: 9.493 ± 0.096
0.688AspCys: 0.688 ± 0.029
9.548AspAsp: 9.548 ± 0.132
8.737AspGlu: 8.737 ± 0.102
1.801AspPhe: 1.801 ± 0.039
8.261AspGly: 8.261 ± 0.096
2.083AspHis: 2.083 ± 0.05
3.809AspIle: 3.809 ± 0.063
0.952AspLys: 0.952 ± 0.036
7.165AspLeu: 7.165 ± 0.087
1.1AspMet: 1.1 ± 0.033
1.413AspAsn: 1.413 ± 0.04
4.74AspPro: 4.74 ± 0.067
2.075AspGln: 2.075 ± 0.042
6.953AspArg: 6.953 ± 0.088
3.959AspSer: 3.959 ± 0.066
4.288AspThr: 4.288 ± 0.069
7.458AspVal: 7.458 ± 0.097
0.983AspTrp: 0.983 ± 0.032
1.826AspTyr: 1.826 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
8.611GluAla: 8.611 ± 0.094
0.559GluCys: 0.559 ± 0.026
6.389GluAsp: 6.389 ± 0.083
6.393GluGlu: 6.393 ± 0.098
3.004GluPhe: 3.004 ± 0.05
5.222GluGly: 5.222 ± 0.072
2.091GluHis: 2.091 ± 0.044
4.604GluIle: 4.604 ± 0.064
1.679GluLys: 1.679 ± 0.045
7.995GluLeu: 7.995 ± 0.079
1.873GluMet: 1.873 ± 0.037
2.33GluAsn: 2.33 ± 0.049
4.546GluPro: 4.546 ± 0.073
3.148GluGln: 3.148 ± 0.06
7.383GluArg: 7.383 ± 0.085
5.583GluSer: 5.583 ± 0.076
7.872GluThr: 7.872 ± 0.095
5.106GluVal: 5.106 ± 0.069
1.135GluTrp: 1.135 ± 0.03
2.912GluTyr: 2.912 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.456PheAla: 3.456 ± 0.068
0.31PheCys: 0.31 ± 0.016
3.364PheAsp: 3.364 ± 0.05
3.249PheGlu: 3.249 ± 0.047
1.004PhePhe: 1.004 ± 0.031
3.13PheGly: 3.13 ± 0.055
0.621PheHis: 0.621 ± 0.022
1.039PheIle: 1.039 ± 0.033
0.419PheLys: 0.419 ± 0.018
2.742PheLeu: 2.742 ± 0.058
0.494PheMet: 0.494 ± 0.022
0.661PheAsn: 0.661 ± 0.026
1.212PhePro: 1.212 ± 0.033
0.78PheGln: 0.78 ± 0.023
1.574PheArg: 1.574 ± 0.036
1.599PheSer: 1.599 ± 0.041
1.771PheThr: 1.771 ± 0.038
3.33PheVal: 3.33 ± 0.059
0.382PheTrp: 0.382 ± 0.018
0.864PheTyr: 0.864 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
7.474GlyAla: 7.474 ± 0.1
0.774GlyCys: 0.774 ± 0.028
6.594GlyAsp: 6.594 ± 0.089
6.738GlyGlu: 6.738 ± 0.084
2.992GlyPhe: 2.992 ± 0.06
6.556GlyGly: 6.556 ± 0.09
1.684GlyHis: 1.684 ± 0.039
4.59GlyIle: 4.59 ± 0.071
1.689GlyLys: 1.689 ± 0.042
7.302GlyLeu: 7.302 ± 0.104
1.575GlyMet: 1.575 ± 0.04
1.897GlyAsn: 1.897 ± 0.045
3.265GlyPro: 3.265 ± 0.054
2.068GlyGln: 2.068 ± 0.037
4.557GlyArg: 4.557 ± 0.06
4.998GlySer: 4.998 ± 0.067
5.859GlyThr: 5.859 ± 0.074
6.989GlyVal: 6.989 ± 0.089
1.128GlyTrp: 1.128 ± 0.032
2.731GlyTyr: 2.731 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.993HisAla: 1.993 ± 0.041
0.211HisCys: 0.211 ± 0.014
1.94HisAsp: 1.94 ± 0.041
1.788HisGlu: 1.788 ± 0.044
0.516HisPhe: 0.516 ± 0.023
2.027HisGly: 2.027 ± 0.044
0.574HisHis: 0.574 ± 0.021
0.705HisIle: 0.705 ± 0.023
0.311HisLys: 0.311 ± 0.017
1.661HisLeu: 1.661 ± 0.039
0.284HisMet: 0.284 ± 0.015
0.458HisAsn: 0.458 ± 0.019
1.235HisPro: 1.235 ± 0.032
0.545HisGln: 0.545 ± 0.019
1.389HisArg: 1.389 ± 0.033
0.943HisSer: 0.943 ± 0.028
1.134HisThr: 1.134 ± 0.03
1.882HisVal: 1.882 ± 0.046
0.228HisTrp: 0.228 ± 0.013
0.572HisTyr: 0.572 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.448IleAla: 5.448 ± 0.075
0.334IleCys: 0.334 ± 0.017
5.155IleAsp: 5.155 ± 0.059
4.764IleGlu: 4.764 ± 0.073
1.144IlePhe: 1.144 ± 0.034
4.361IleGly: 4.361 ± 0.065
0.874IleHis: 0.874 ± 0.03
1.482IleIle: 1.482 ± 0.041
0.724IleLys: 0.724 ± 0.027
3.372IleLeu: 3.372 ± 0.061
0.56IleMet: 0.56 ± 0.02
1.013IleAsn: 1.013 ± 0.03
2.135IlePro: 2.135 ± 0.05
1.247IleGln: 1.247 ± 0.04
2.542IleArg: 2.542 ± 0.042
2.368IleSer: 2.368 ± 0.044
2.829IleThr: 2.829 ± 0.051
4.696IleVal: 4.696 ± 0.066
0.403IleTrp: 0.403 ± 0.018
1.077IleTyr: 1.077 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
1.618LysAla: 1.618 ± 0.044
0.113LysCys: 0.113 ± 0.01
0.991LysAsp: 0.991 ± 0.033
1.122LysGlu: 1.122 ± 0.039
0.467LysPhe: 0.467 ± 0.021
1.194LysGly: 1.194 ± 0.031
0.476LysHis: 0.476 ± 0.024
0.806LysIle: 0.806 ± 0.03
0.471LysLys: 0.471 ± 0.024
1.605LysLeu: 1.605 ± 0.041
0.345LysMet: 0.345 ± 0.017
0.519LysAsn: 0.519 ± 0.023
0.919LysPro: 0.919 ± 0.029
0.721LysGln: 0.721 ± 0.027
1.607LysArg: 1.607 ± 0.034
1.088LysSer: 1.088 ± 0.032
1.261LysThr: 1.261 ± 0.036
0.949LysVal: 0.949 ± 0.03
0.208LysTrp: 0.208 ± 0.013
0.525LysTyr: 0.525 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
10.707LeuAla: 10.707 ± 0.114
0.65LeuCys: 0.65 ± 0.023
5.581LeuAsp: 5.581 ± 0.067
12.311LeuGlu: 12.311 ± 0.122
3.085LeuPhe: 3.085 ± 0.06
7.198LeuGly: 7.198 ± 0.101
1.444LeuHis: 1.444 ± 0.037
3.154LeuIle: 3.154 ± 0.065
1.398LeuLys: 1.398 ± 0.038
8.44LeuLeu: 8.44 ± 0.111
1.127LeuMet: 1.127 ± 0.031
1.628LeuAsn: 1.628 ± 0.038
4.004LeuPro: 4.004 ± 0.064
2.195LeuGln: 2.195 ± 0.043
4.686LeuArg: 4.686 ± 0.069
5.354LeuSer: 5.354 ± 0.074
5.212LeuThr: 5.212 ± 0.06
8.307LeuVal: 8.307 ± 0.112
0.86LeuTrp: 0.86 ± 0.028
2.182LeuTyr: 2.182 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
1.885MetAla: 1.885 ± 0.046
0.112MetCys: 0.112 ± 0.01
1.202MetAsp: 1.202 ± 0.033
1.008MetGlu: 1.008 ± 0.026
0.484MetPhe: 0.484 ± 0.019
1.441MetGly: 1.441 ± 0.036
0.339MetHis: 0.339 ± 0.015
0.756MetIle: 0.756 ± 0.024
0.387MetLys: 0.387 ± 0.018
1.503MetLeu: 1.503 ± 0.033
0.311MetMet: 0.311 ± 0.016
0.577MetAsn: 0.577 ± 0.022
0.792MetPro: 0.792 ± 0.023
0.499MetGln: 0.499 ± 0.021
0.934MetArg: 0.934 ± 0.027
1.414MetSer: 1.414 ± 0.032
1.532MetThr: 1.532 ± 0.033
1.268MetVal: 1.268 ± 0.037
0.15MetTrp: 0.15 ± 0.011
0.415MetTyr: 0.415 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.497AsnAla: 2.497 ± 0.05
0.212AsnCys: 0.212 ± 0.014
1.79AsnAsp: 1.79 ± 0.039
1.88AsnGlu: 1.88 ± 0.041
0.614AsnPhe: 0.614 ± 0.02
1.953AsnGly: 1.953 ± 0.043
0.548AsnHis: 0.548 ± 0.021
0.892AsnIle: 0.892 ± 0.03
0.434AsnLys: 0.434 ± 0.019
1.857AsnLeu: 1.857 ± 0.04
0.386AsnMet: 0.386 ± 0.016
0.523AsnAsn: 0.523 ± 0.023
1.482AsnPro: 1.482 ± 0.037
0.639AsnGln: 0.639 ± 0.027
1.714AsnArg: 1.714 ± 0.039
0.954AsnSer: 0.954 ± 0.031
1.265AsnThr: 1.265 ± 0.037
2.272AsnVal: 2.272 ± 0.045
0.341AsnTrp: 0.341 ± 0.018
0.668AsnTyr: 0.668 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
4.773ProAla: 4.773 ± 0.074
0.252ProCys: 0.252 ± 0.014
5.011ProAsp: 5.011 ± 0.075
4.25ProGlu: 4.25 ± 0.065
1.509ProPhe: 1.509 ± 0.038
3.463ProGly: 3.463 ± 0.051
0.902ProHis: 0.902 ± 0.024
2.372ProIle: 2.372 ± 0.041
0.794ProLys: 0.794 ± 0.026
3.636ProLeu: 3.636 ± 0.065
0.842ProMet: 0.842 ± 0.027
1.188ProAsn: 1.188 ± 0.032
2.219ProPro: 2.219 ± 0.046
1.073ProGln: 1.073 ± 0.03
2.172ProArg: 2.172 ± 0.039
2.692ProSer: 2.692 ± 0.052
3.523ProThr: 3.523 ± 0.052
3.955ProVal: 3.955 ± 0.062
0.494ProTrp: 0.494 ± 0.022
1.085ProTyr: 1.085 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.588GlnAla: 2.588 ± 0.048
0.193GlnCys: 0.193 ± 0.011
1.537GlnAsp: 1.537 ± 0.047
1.856GlnGlu: 1.856 ± 0.043
1.102GlnPhe: 1.102 ± 0.031
1.608GlnGly: 1.608 ± 0.034
0.567GlnHis: 0.567 ± 0.021
1.291GlnIle: 1.291 ± 0.037
0.54GlnLys: 0.54 ± 0.026
2.785GlnLeu: 2.785 ± 0.049
0.538GlnMet: 0.538 ± 0.02
0.719GlnAsn: 0.719 ± 0.023
1.332GlnPro: 1.332 ± 0.031
1.219GlnGln: 1.219 ± 0.043
2.12GlnArg: 2.12 ± 0.045
1.706GlnSer: 1.706 ± 0.043
1.895GlnThr: 1.895 ± 0.037
1.8GlnVal: 1.8 ± 0.038
0.354GlnTrp: 0.354 ± 0.019
0.981GlnTyr: 0.981 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
5.717ArgAla: 5.717 ± 0.08
0.482ArgCys: 0.482 ± 0.021
4.835ArgAsp: 4.835 ± 0.066
6.273ArgGlu: 6.273 ± 0.087
2.17ArgPhe: 2.17 ± 0.045
4.066ArgGly: 4.066 ± 0.058
1.256ArgHis: 1.256 ± 0.034
3.142ArgIle: 3.142 ± 0.048
1.33ArgLys: 1.33 ± 0.034
6.025ArgLeu: 6.025 ± 0.076
1.231ArgMet: 1.231 ± 0.029
1.621ArgAsn: 1.621 ± 0.039
2.551ArgPro: 2.551 ± 0.043
1.903ArgGln: 1.903 ± 0.039
4.819ArgArg: 4.819 ± 0.076
3.903ArgSer: 3.903 ± 0.066
4.289ArgThr: 4.289 ± 0.058
4.653ArgVal: 4.653 ± 0.066
0.737ArgTrp: 0.737 ± 0.026
1.921ArgTyr: 1.921 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.143SerAla: 5.143 ± 0.07
0.357SerCys: 0.357 ± 0.017
4.59SerAsp: 4.59 ± 0.066
4.254SerGlu: 4.254 ± 0.071
1.92SerPhe: 1.92 ± 0.04
4.842SerGly: 4.842 ± 0.067
1.07SerHis: 1.07 ± 0.03
2.974SerIle: 2.974 ± 0.051
1.147SerLys: 1.147 ± 0.033
5.041SerLeu: 5.041 ± 0.067
1.201SerMet: 1.201 ± 0.033
1.445SerAsn: 1.445 ± 0.038
2.657SerPro: 2.657 ± 0.052
1.554SerGln: 1.554 ± 0.041
3.332SerArg: 3.332 ± 0.051
3.609SerSer: 3.609 ± 0.072
3.871SerThr: 3.871 ± 0.065
4.925SerVal: 4.925 ± 0.074
0.643SerTrp: 0.643 ± 0.022
1.459SerTyr: 1.459 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
7.355ThrAla: 7.355 ± 0.085
0.426ThrCys: 0.426 ± 0.019
6.682ThrAsp: 6.682 ± 0.086
4.957ThrGlu: 4.957 ± 0.07
2.065ThrPhe: 2.065 ± 0.043
5.782ThrGly: 5.782 ± 0.073
1.253ThrHis: 1.253 ± 0.034
3.911ThrIle: 3.911 ± 0.063
1.048ThrLys: 1.048 ± 0.034
6.068ThrLeu: 6.068 ± 0.067
1.127ThrMet: 1.127 ± 0.033
1.627ThrAsn: 1.627 ± 0.04
3.218ThrPro: 3.218 ± 0.053
1.513ThrGln: 1.513 ± 0.038
3.356ThrArg: 3.356 ± 0.051
3.103ThrSer: 3.103 ± 0.055
4.788ThrThr: 4.788 ± 0.071
7.292ThrVal: 7.292 ± 0.107
0.614ThrTrp: 0.614 ± 0.022
1.767ThrTyr: 1.767 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
9.677ValAla: 9.677 ± 0.11
0.7ValCys: 0.7 ± 0.022
7.95ValAsp: 7.95 ± 0.092
7.136ValGlu: 7.136 ± 0.082
2.839ValPhe: 2.839 ± 0.056
7.501ValGly: 7.501 ± 0.11
1.665ValHis: 1.665 ± 0.039
3.432ValIle: 3.432 ± 0.062
1.148ValLys: 1.148 ± 0.033
8.109ValLeu: 8.109 ± 0.111
1.31ValMet: 1.31 ± 0.036
1.714ValAsn: 1.714 ± 0.035
4.225ValPro: 4.225 ± 0.058
1.934ValGln: 1.934 ± 0.037
5.016ValArg: 5.016 ± 0.074
5.062ValSer: 5.062 ± 0.066
6.217ValThr: 6.217 ± 0.087
8.705ValVal: 8.705 ± 0.119
0.763ValTrp: 0.763 ± 0.026
2.104ValTyr: 2.104 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.877TrpAla: 0.877 ± 0.027
0.107TrpCys: 0.107 ± 0.01
0.813TrpAsp: 0.813 ± 0.029
0.844TrpGlu: 0.844 ± 0.029
0.429TrpPhe: 0.429 ± 0.019
0.776TrpGly: 0.776 ± 0.027
0.292TrpHis: 0.292 ± 0.015
0.615TrpIle: 0.615 ± 0.022
0.256TrpLys: 0.256 ± 0.019
1.314TrpLeu: 1.314 ± 0.04
0.224TrpMet: 0.224 ± 0.014
0.37TrpAsn: 0.37 ± 0.018
0.441TrpPro: 0.441 ± 0.023
0.401TrpGln: 0.401 ± 0.017
0.73TrpArg: 0.73 ± 0.026
0.581TrpSer: 0.581 ± 0.025
0.747TrpThr: 0.747 ± 0.024
0.756TrpVal: 0.756 ± 0.027
0.195TrpTrp: 0.195 ± 0.013
0.349TrpTyr: 0.349 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.785TyrAla: 2.785 ± 0.048
0.272TyrCys: 0.272 ± 0.014
2.851TyrAsp: 2.851 ± 0.061
2.536TyrGlu: 2.536 ± 0.047
0.819TyrPhe: 0.819 ± 0.024
2.314TyrGly: 2.314 ± 0.046
0.682TyrHis: 0.682 ± 0.023
0.768TyrIle: 0.768 ± 0.029
0.446TyrLys: 0.446 ± 0.019
2.486TyrLeu: 2.486 ± 0.053
0.371TyrMet: 0.371 ± 0.017
0.618TyrAsn: 0.618 ± 0.021
1.218TyrPro: 1.218 ± 0.031
0.722TyrGln: 0.722 ± 0.023
1.935TyrArg: 1.935 ± 0.046
1.189TyrSer: 1.189 ± 0.031
1.511TyrThr: 1.511 ± 0.03
2.436TyrVal: 2.436 ± 0.046
0.37TyrTrp: 0.37 ± 0.02
0.905TyrTyr: 0.905 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 4165 proteins (1243612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski