Amino acid dipepetide frequency for Devosia sp. Root685

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.457AlaAla: 15.457 ± 0.143	0.702AlaCys: 0.702 ± 0.023	6.798AlaAsp: 6.798 ± 0.067	7.677AlaGlu: 7.677 ± 0.093	4.388AlaPhe: 4.388 ± 0.061	10.391AlaGly: 10.391 ± 0.105	1.997AlaHis: 1.997 ± 0.041	6.868AlaIle: 6.868 ± 0.082	4.007AlaLys: 4.007 ± 0.067	13.648AlaLeu: 13.648 ± 0.125	3.702AlaMet: 3.702 ± 0.054	3.317AlaAsn: 3.317 ± 0.055	5.372AlaPro: 5.372 ± 0.093	4.02AlaGln: 4.02 ± 0.059	7.288AlaArg: 7.288 ± 0.094	6.29AlaSer: 6.29 ± 0.078	6.062AlaThr: 6.062 ± 0.076	8.653AlaVal: 8.653 ± 0.088	1.373AlaTrp: 1.373 ± 0.033	2.514AlaTyr: 2.514 ± 0.055	0.001AlaXaa: 0.001 ± 0.001
Cys	0.719CysAla: 0.719 ± 0.026	0.085CysCys: 0.085 ± 0.008	0.435CysAsp: 0.435 ± 0.02	0.317CysGlu: 0.317 ± 0.014	0.253CysPhe: 0.253 ± 0.014	0.673CysGly: 0.673 ± 0.025	0.21CysHis: 0.21 ± 0.012	0.329CysIle: 0.329 ± 0.016	0.134CysLys: 0.134 ± 0.01	0.628CysLeu: 0.628 ± 0.02	0.123CysMet: 0.123 ± 0.01	0.173CysAsn: 0.173 ± 0.011	0.316CysPro: 0.316 ± 0.017	0.205CysGln: 0.205 ± 0.014	0.419CysArg: 0.419 ± 0.019	0.336CysSer: 0.336 ± 0.017	0.334CysThr: 0.334 ± 0.017	0.465CysVal: 0.465 ± 0.02	0.102CysTrp: 0.102 ± 0.009	0.155CysTyr: 0.155 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.556AspAla: 6.556 ± 0.081	0.375AspCys: 0.375 ± 0.022	2.973AspAsp: 2.973 ± 0.07	3.431AspGlu: 3.431 ± 0.062	2.456AspPhe: 2.456 ± 0.045	5.087AspGly: 5.087 ± 0.09	1.237AspHis: 1.237 ± 0.037	3.577AspIle: 3.577 ± 0.053	1.816AspLys: 1.816 ± 0.041	5.937AspLeu: 5.937 ± 0.07	1.371AspMet: 1.371 ± 0.035	1.587AspAsn: 1.587 ± 0.039	3.339AspPro: 3.339 ± 0.059	1.815AspGln: 1.815 ± 0.038	3.771AspArg: 3.771 ± 0.06	2.148AspSer: 2.148 ± 0.043	2.723AspThr: 2.723 ± 0.06	4.163AspVal: 4.163 ± 0.058	1.03AspTrp: 1.03 ± 0.027	1.593AspTyr: 1.593 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.575GluAla: 7.575 ± 0.09	0.274GluCys: 0.274 ± 0.018	2.803GluAsp: 2.803 ± 0.054	3.276GluGlu: 3.276 ± 0.066	1.967GluPhe: 1.967 ± 0.042	4.357GluGly: 4.357 ± 0.066	1.192GluHis: 1.192 ± 0.035	3.524GluIle: 3.524 ± 0.051	2.332GluLys: 2.332 ± 0.044	5.374GluLeu: 5.374 ± 0.063	1.56GluMet: 1.56 ± 0.033	1.769GluAsn: 1.769 ± 0.041	2.776GluPro: 2.776 ± 0.056	2.085GluGln: 2.085 ± 0.037	4.315GluArg: 4.315 ± 0.07	2.286GluSer: 2.286 ± 0.044	3.574GluThr: 3.574 ± 0.058	3.988GluVal: 3.988 ± 0.061	0.716GluTrp: 0.716 ± 0.021	0.987GluTyr: 0.987 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.951PheAla: 4.951 ± 0.074	0.359PheCys: 0.359 ± 0.017	2.811PheAsp: 2.811 ± 0.047	2.283PheGlu: 2.283 ± 0.043	1.666PhePhe: 1.666 ± 0.042	4.024PheGly: 4.024 ± 0.053	0.777PheHis: 0.777 ± 0.024	1.925PheIle: 1.925 ± 0.043	1.08PheLys: 1.08 ± 0.033	3.467PheLeu: 3.467 ± 0.062	0.868PheMet: 0.868 ± 0.026	1.205PheAsn: 1.205 ± 0.033	1.649PhePro: 1.649 ± 0.039	1.071PheGln: 1.071 ± 0.03	2.04PheArg: 2.04 ± 0.042	2.585PheSer: 2.585 ± 0.051	2.113PheThr: 2.113 ± 0.051	3.149PheVal: 3.149 ± 0.056	0.662PheTrp: 0.662 ± 0.028	0.991PheTyr: 0.991 ± 0.03	0.001PheXaa: 0.001 ± 0.001
Gly	9.096GlyAla: 9.096 ± 0.107	0.65GlyCys: 0.65 ± 0.025	4.392GlyAsp: 4.392 ± 0.064	4.942GlyGlu: 4.942 ± 0.068	3.797GlyPhe: 3.797 ± 0.063	7.229GlyGly: 7.229 ± 0.114	1.877GlyHis: 1.877 ± 0.04	4.982GlyIle: 4.982 ± 0.068	3.518GlyLys: 3.518 ± 0.055	9.112GlyLeu: 9.112 ± 0.099	2.32GlyMet: 2.32 ± 0.046	2.528GlyAsn: 2.528 ± 0.059	3.36GlyPro: 3.36 ± 0.054	3.203GlyGln: 3.203 ± 0.052	5.409GlyArg: 5.409 ± 0.068	4.592GlySer: 4.592 ± 0.078	5.023GlyThr: 5.023 ± 0.083	6.385GlyVal: 6.385 ± 0.074	1.362GlyTrp: 1.362 ± 0.034	2.311GlyTyr: 2.311 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.083HisAla: 2.083 ± 0.041	0.185HisCys: 0.185 ± 0.012	1.229HisAsp: 1.229 ± 0.03	1.057HisGlu: 1.057 ± 0.028	0.933HisPhe: 0.933 ± 0.027	1.818HisGly: 1.818 ± 0.041	0.535HisHis: 0.535 ± 0.024	1.072HisIle: 1.072 ± 0.028	0.523HisLys: 0.523 ± 0.022	2.0HisLeu: 2.0 ± 0.044	0.55HisMet: 0.55 ± 0.019	0.545HisAsn: 0.545 ± 0.021	1.225HisPro: 1.225 ± 0.035	0.623HisGln: 0.623 ± 0.023	1.318HisArg: 1.318 ± 0.036	0.908HisSer: 0.908 ± 0.027	0.86HisThr: 0.86 ± 0.028	1.444HisVal: 1.444 ± 0.035	0.329HisTrp: 0.329 ± 0.015	0.552HisTyr: 0.552 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.816IleAla: 7.816 ± 0.069	0.462IleCys: 0.462 ± 0.021	3.713IleAsp: 3.713 ± 0.06	3.754IleGlu: 3.754 ± 0.054	2.108IlePhe: 2.108 ± 0.042	5.479IleGly: 5.479 ± 0.079	0.937IleHis: 0.937 ± 0.028	2.802IleIle: 2.802 ± 0.051	1.619IleLys: 1.619 ± 0.038	4.87IleLeu: 4.87 ± 0.075	1.126IleMet: 1.126 ± 0.031	1.645IleAsn: 1.645 ± 0.038	2.409IlePro: 2.409 ± 0.044	1.252IleGln: 1.252 ± 0.033	3.011IleArg: 3.011 ± 0.058	3.309IleSer: 3.309 ± 0.054	3.039IleThr: 3.039 ± 0.053	4.602IleVal: 4.602 ± 0.064	0.713IleTrp: 0.713 ± 0.025	1.29IleTyr: 1.29 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.267LysAla: 4.267 ± 0.059	0.123LysCys: 0.123 ± 0.009	1.633LysAsp: 1.633 ± 0.04	1.468LysGlu: 1.468 ± 0.034	1.06LysPhe: 1.06 ± 0.03	2.542LysGly: 2.542 ± 0.055	0.629LysHis: 0.629 ± 0.02	1.734LysIle: 1.734 ± 0.049	1.187LysLys: 1.187 ± 0.036	3.444LysLeu: 3.444 ± 0.061	0.763LysMet: 0.763 ± 0.026	0.892LysAsn: 0.892 ± 0.027	2.058LysPro: 2.058 ± 0.039	0.968LysGln: 0.968 ± 0.028	2.251LysArg: 2.251 ± 0.044	2.004LysSer: 2.004 ± 0.037	2.047LysThr: 2.047 ± 0.044	2.596LysVal: 2.596 ± 0.046	0.392LysTrp: 0.392 ± 0.016	0.626LysTyr: 0.626 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.315LeuAla: 13.315 ± 0.142	0.692LeuCys: 0.692 ± 0.021	6.29LeuAsp: 6.29 ± 0.09	5.316LeuGlu: 5.316 ± 0.066	3.846LeuPhe: 3.846 ± 0.062	8.927LeuGly: 8.927 ± 0.105	1.74LeuHis: 1.74 ± 0.039	5.409LeuIle: 5.409 ± 0.081	3.581LeuLys: 3.581 ± 0.058	9.709LeuLeu: 9.709 ± 0.138	2.318LeuMet: 2.318 ± 0.046	2.913LeuAsn: 2.913 ± 0.054	5.498LeuPro: 5.498 ± 0.077	2.649LeuGln: 2.649 ± 0.049	6.187LeuArg: 6.187 ± 0.08	6.763LeuSer: 6.763 ± 0.077	5.925LeuThr: 5.925 ± 0.075	8.061LeuVal: 8.061 ± 0.084	1.115LeuTrp: 1.115 ± 0.033	2.183LeuTyr: 2.183 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.228MetAla: 3.228 ± 0.047	0.122MetCys: 0.122 ± 0.01	1.235MetAsp: 1.235 ± 0.036	1.103MetGlu: 1.103 ± 0.032	0.811MetPhe: 0.811 ± 0.023	1.98MetGly: 1.98 ± 0.038	0.439MetHis: 0.439 ± 0.017	1.393MetIle: 1.393 ± 0.032	0.819MetLys: 0.819 ± 0.028	2.614MetLeu: 2.614 ± 0.044	0.644MetMet: 0.644 ± 0.026	0.755MetAsn: 0.755 ± 0.024	1.474MetPro: 1.474 ± 0.04	0.823MetGln: 0.823 ± 0.025	1.777MetArg: 1.777 ± 0.038	1.766MetSer: 1.766 ± 0.038	1.944MetThr: 1.944 ± 0.038	1.938MetVal: 1.938 ± 0.042	0.21MetTrp: 0.21 ± 0.012	0.313MetTyr: 0.313 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.398AsnAla: 3.398 ± 0.059	0.2AsnCys: 0.2 ± 0.014	1.512AsnAsp: 1.512 ± 0.044	1.401AsnGlu: 1.401 ± 0.03	1.248AsnPhe: 1.248 ± 0.034	2.713AsnGly: 2.713 ± 0.068	0.542AsnHis: 0.542 ± 0.022	1.64AsnIle: 1.64 ± 0.036	0.783AsnLys: 0.783 ± 0.026	2.968AsnLeu: 2.968 ± 0.058	0.697AsnMet: 0.697 ± 0.021	0.829AsnAsn: 0.829 ± 0.035	1.975AsnPro: 1.975 ± 0.043	0.904AsnGln: 0.904 ± 0.023	1.839AsnArg: 1.839 ± 0.037	1.539AsnSer: 1.539 ± 0.036	1.443AsnThr: 1.443 ± 0.044	2.194AsnVal: 2.194 ± 0.049	0.505AsnTrp: 0.505 ± 0.021	0.819AsnTyr: 0.819 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.06ProAla: 6.06 ± 0.104	0.205ProCys: 0.205 ± 0.012	3.456ProAsp: 3.456 ± 0.057	3.614ProGlu: 3.614 ± 0.058	1.965ProPhe: 1.965 ± 0.043	4.181ProGly: 4.181 ± 0.059	1.09ProHis: 1.09 ± 0.031	2.539ProIle: 2.539 ± 0.049	1.702ProLys: 1.702 ± 0.035	4.738ProLeu: 4.738 ± 0.069	1.153ProMet: 1.153 ± 0.028	1.554ProAsn: 1.554 ± 0.041	2.062ProPro: 2.062 ± 0.049	1.723ProGln: 1.723 ± 0.037	2.616ProArg: 2.616 ± 0.049	2.608ProSer: 2.608 ± 0.044	2.671ProThr: 2.671 ± 0.053	4.072ProVal: 4.072 ± 0.059	0.672ProTrp: 0.672 ± 0.026	1.24ProTyr: 1.24 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.696GlnAla: 3.696 ± 0.065	0.173GlnCys: 0.173 ± 0.012	1.475GlnAsp: 1.475 ± 0.029	1.322GlnGlu: 1.322 ± 0.033	1.291GlnPhe: 1.291 ± 0.033	2.336GlnGly: 2.336 ± 0.045	0.669GlnHis: 0.669 ± 0.021	1.904GlnIle: 1.904 ± 0.04	1.093GlnLys: 1.093 ± 0.026	3.162GlnLeu: 3.162 ± 0.049	0.978GlnMet: 0.978 ± 0.029	1.033GlnAsn: 1.033 ± 0.032	1.683GlnPro: 1.683 ± 0.04	1.204GlnGln: 1.204 ± 0.034	2.536GlnArg: 2.536 ± 0.05	1.932GlnSer: 1.932 ± 0.041	1.872GlnThr: 1.872 ± 0.046	2.325GlnVal: 2.325 ± 0.044	0.415GlnTrp: 0.415 ± 0.018	0.73GlnTyr: 0.73 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.729ArgAla: 6.729 ± 0.078	0.369ArgCys: 0.369 ± 0.018	3.642ArgAsp: 3.642 ± 0.054	3.546ArgGlu: 3.546 ± 0.062	2.728ArgPhe: 2.728 ± 0.048	4.346ArgGly: 4.346 ± 0.072	1.558ArgHis: 1.558 ± 0.035	3.706ArgIle: 3.706 ± 0.054	2.057ArgLys: 2.057 ± 0.042	7.072ArgLeu: 7.072 ± 0.092	1.699ArgMet: 1.699 ± 0.036	1.883ArgAsn: 1.883 ± 0.038	3.141ArgPro: 3.141 ± 0.053	2.625ArgGln: 2.625 ± 0.05	4.383ArgArg: 4.383 ± 0.073	3.331ArgSer: 3.331 ± 0.06	3.1ArgThr: 3.1 ± 0.057	4.416ArgVal: 4.416 ± 0.068	0.848ArgTrp: 0.848 ± 0.027	1.617ArgTyr: 1.617 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.36SerAla: 6.36 ± 0.077	0.304SerCys: 0.304 ± 0.015	2.957SerAsp: 2.957 ± 0.051	2.764SerGlu: 2.764 ± 0.047	2.467SerPhe: 2.467 ± 0.045	5.781SerGly: 5.781 ± 0.085	1.13SerHis: 1.13 ± 0.028	3.116SerIle: 3.116 ± 0.051	1.588SerLys: 1.588 ± 0.037	5.513SerLeu: 5.513 ± 0.065	1.418SerMet: 1.418 ± 0.035	1.58SerAsn: 1.58 ± 0.045	2.626SerPro: 2.626 ± 0.049	1.742SerGln: 1.742 ± 0.043	3.376SerArg: 3.376 ± 0.06	2.971SerSer: 2.971 ± 0.059	2.895SerThr: 2.895 ± 0.055	4.431SerVal: 4.431 ± 0.068	0.78SerTrp: 0.78 ± 0.026	1.351SerTyr: 1.351 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.297ThrAla: 6.297 ± 0.079	0.324ThrCys: 0.324 ± 0.019	3.018ThrAsp: 3.018 ± 0.062	2.918ThrGlu: 2.918 ± 0.054	2.177ThrPhe: 2.177 ± 0.051	5.16ThrGly: 5.16 ± 0.082	1.08ThrHis: 1.08 ± 0.029	3.492ThrIle: 3.492 ± 0.057	1.564ThrLys: 1.564 ± 0.035	6.256ThrLeu: 6.256 ± 0.079	1.27ThrMet: 1.27 ± 0.035	1.6ThrAsn: 1.6 ± 0.046	3.171ThrPro: 3.171 ± 0.061	1.56ThrGln: 1.56 ± 0.039	3.124ThrArg: 3.124 ± 0.048	3.02ThrSer: 3.02 ± 0.057	3.123ThrThr: 3.123 ± 0.072	4.445ThrVal: 4.445 ± 0.071	0.676ThrTrp: 0.676 ± 0.024	1.304ThrTyr: 1.304 ± 0.03	0.002ThrXaa: 0.002 ± 0.001
Val	9.133ValAla: 9.133 ± 0.095	0.489ValCys: 0.489 ± 0.02	4.434ValAsp: 4.434 ± 0.059	4.73ValGlu: 4.73 ± 0.063	2.868ValPhe: 2.868 ± 0.049	5.957ValGly: 5.957 ± 0.068	1.359ValHis: 1.359 ± 0.034	4.316ValIle: 4.316 ± 0.055	2.225ValLys: 2.225 ± 0.046	7.928ValLeu: 7.928 ± 0.089	2.006ValMet: 2.006 ± 0.045	2.122ValAsn: 2.122 ± 0.041	3.922ValPro: 3.922 ± 0.057	2.005ValGln: 2.005 ± 0.04	4.558ValArg: 4.558 ± 0.066	4.67ValSer: 4.67 ± 0.066	4.842ValThr: 4.842 ± 0.07	6.366ValVal: 6.366 ± 0.088	0.889ValTrp: 0.889 ± 0.029	1.564ValTyr: 1.564 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.269TrpAla: 1.269 ± 0.031	0.116TrpCys: 0.116 ± 0.01	0.691TrpAsp: 0.691 ± 0.028	0.535TrpGlu: 0.535 ± 0.021	0.564TrpPhe: 0.564 ± 0.022	0.928TrpGly: 0.928 ± 0.028	0.319TrpHis: 0.319 ± 0.015	0.626TrpIle: 0.626 ± 0.024	0.435TrpLys: 0.435 ± 0.02	1.658TrpLeu: 1.658 ± 0.044	0.35TrpMet: 0.35 ± 0.017	0.52TrpAsn: 0.52 ± 0.02	0.711TrpPro: 0.711 ± 0.023	0.603TrpGln: 0.603 ± 0.022	0.968TrpArg: 0.968 ± 0.033	0.819TrpSer: 0.819 ± 0.028	0.862TrpThr: 0.862 ± 0.027	0.919TrpVal: 0.919 ± 0.029	0.24TrpTrp: 0.24 ± 0.014	0.301TrpTyr: 0.301 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.521TyrAla: 2.521 ± 0.049	0.2TyrCys: 0.2 ± 0.013	1.489TyrAsp: 1.489 ± 0.035	1.276TyrGlu: 1.276 ± 0.035	1.079TyrPhe: 1.079 ± 0.032	2.18TyrGly: 2.18 ± 0.04	0.469TyrHis: 0.469 ± 0.021	1.003TyrIle: 1.003 ± 0.029	0.621TyrLys: 0.621 ± 0.025	2.342TyrLeu: 2.342 ± 0.042	0.473TyrMet: 0.473 ± 0.018	0.7TyrAsn: 0.7 ± 0.023	1.155TyrPro: 1.155 ± 0.032	0.751TyrGln: 0.751 ± 0.026	1.608TyrArg: 1.608 ± 0.037	1.272TyrSer: 1.272 ± 0.033	1.127TyrThr: 1.127 ± 0.034	1.769TyrVal: 1.769 ± 0.038	0.405TyrTrp: 0.405 ± 0.017	0.643TyrTyr: 0.643 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.002XaaHis: 0.002 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4002 proteins (1280198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---