Amino acid dipepetide frequency for Mycoplasma cloacale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.445AlaAla: 2.445 ± 0.17
0.363AlaCys: 0.363 ± 0.042
2.217AlaAsp: 2.217 ± 0.11
3.022AlaGlu: 3.022 ± 0.155
2.46AlaPhe: 2.46 ± 0.107
2.49AlaGly: 2.49 ± 0.134
0.8AlaHis: 0.8 ± 0.061
6.154AlaIle: 6.154 ± 0.222
5.637AlaLys: 5.637 ± 0.263
5.169AlaLeu: 5.169 ± 0.182
1.248AlaMet: 1.248 ± 0.081
3.753AlaAsn: 3.753 ± 0.176
1.248AlaPro: 1.248 ± 0.084
1.7AlaGln: 1.7 ± 0.13
1.839AlaArg: 1.839 ± 0.112
3.683AlaSer: 3.683 ± 0.158
3.191AlaThr: 3.191 ± 0.172
2.406AlaVal: 2.406 ± 0.128
0.442AlaTrp: 0.442 ± 0.052
2.301AlaTyr: 2.301 ± 0.116
0.0AlaXaa: 0.0 ± 0.0
Cys
0.308CysAla: 0.308 ± 0.039
0.094CysCys: 0.094 ± 0.025
0.383CysAsp: 0.383 ± 0.043
0.383CysGlu: 0.383 ± 0.044
0.363CysPhe: 0.363 ± 0.046
0.378CysGly: 0.378 ± 0.042
0.124CysHis: 0.124 ± 0.04
0.522CysIle: 0.522 ± 0.05
0.442CysLys: 0.442 ± 0.05
0.676CysLeu: 0.676 ± 0.062
0.099CysMet: 0.099 ± 0.023
0.432CysAsn: 0.432 ± 0.054
0.159CysPro: 0.159 ± 0.031
0.229CysGln: 0.229 ± 0.036
0.134CysArg: 0.134 ± 0.024
0.308CysSer: 0.308 ± 0.036
0.204CysThr: 0.204 ± 0.037
0.333CysVal: 0.333 ± 0.039
0.06CysTrp: 0.06 ± 0.017
0.333CysTyr: 0.333 ± 0.047
0.0CysXaa: 0.0 ± 0.0
Asp
3.007AspAla: 3.007 ± 0.191
0.343AspCys: 0.343 ± 0.04
2.863AspAsp: 2.863 ± 0.143
4.235AspGlu: 4.235 ± 0.177
3.4AspPhe: 3.4 ± 0.164
2.286AspGly: 2.286 ± 0.111
0.741AspHis: 0.741 ± 0.065
5.448AspIle: 5.448 ± 0.199
5.239AspLys: 5.239 ± 0.172
5.632AspLeu: 5.632 ± 0.149
0.8AspMet: 0.8 ± 0.076
4.131AspAsn: 4.131 ± 0.183
1.576AspPro: 1.576 ± 0.101
1.407AspGln: 1.407 ± 0.083
1.282AspArg: 1.282 ± 0.085
3.037AspSer: 3.037 ± 0.167
2.406AspThr: 2.406 ± 0.12
3.271AspVal: 3.271 ± 0.113
0.552AspTrp: 0.552 ± 0.054
2.739AspTyr: 2.739 ± 0.134
0.0AspXaa: 0.0 ± 0.0
Glu
3.783GluAla: 3.783 ± 0.217
0.288GluCys: 0.288 ± 0.039
2.992GluAsp: 2.992 ± 0.135
5.448GluGlu: 5.448 ± 0.214
3.569GluPhe: 3.569 ± 0.133
2.356GluGly: 2.356 ± 0.136
1.089GluHis: 1.089 ± 0.078
8.246GluIle: 8.246 ± 0.212
7.003GluLys: 7.003 ± 0.214
7.655GluLeu: 7.655 ± 0.246
1.65GluMet: 1.65 ± 0.089
5.895GluAsn: 5.895 ± 0.22
1.327GluPro: 1.327 ± 0.096
2.46GluGln: 2.46 ± 0.117
2.147GluArg: 2.147 ± 0.129
3.151GluSer: 3.151 ± 0.129
3.822GluThr: 3.822 ± 0.148
3.703GluVal: 3.703 ± 0.15
0.741GluTrp: 0.741 ± 0.065
3.35GluTyr: 3.35 ± 0.143
0.0GluXaa: 0.0 ± 0.0
Phe
2.808PheAla: 2.808 ± 0.144
0.313PheCys: 0.313 ± 0.033
3.345PheAsp: 3.345 ± 0.152
3.35PheGlu: 3.35 ± 0.16
2.341PhePhe: 2.341 ± 0.148
2.48PheGly: 2.48 ± 0.129
0.646PheHis: 0.646 ± 0.059
5.453PheIle: 5.453 ± 0.243
5.08PheLys: 5.08 ± 0.183
4.215PheLeu: 4.215 ± 0.174
0.84PheMet: 0.84 ± 0.075
4.578PheAsn: 4.578 ± 0.236
1.054PhePro: 1.054 ± 0.071
1.223PheGln: 1.223 ± 0.09
1.178PheArg: 1.178 ± 0.079
3.643PheSer: 3.643 ± 0.177
2.361PheThr: 2.361 ± 0.107
2.982PheVal: 2.982 ± 0.138
0.467PheTrp: 0.467 ± 0.052
2.187PheTyr: 2.187 ± 0.11
0.0PheXaa: 0.0 ± 0.0
Gly
2.431GlyAla: 2.431 ± 0.146
0.244GlyCys: 0.244 ± 0.037
2.142GlyAsp: 2.142 ± 0.115
2.426GlyGlu: 2.426 ± 0.114
2.441GlyPhe: 2.441 ± 0.109
2.49GlyGly: 2.49 ± 0.151
0.974GlyHis: 0.974 ± 0.073
4.563GlyIle: 4.563 ± 0.173
3.912GlyLys: 3.912 ± 0.162
4.116GlyLeu: 4.116 ± 0.167
0.9GlyMet: 0.9 ± 0.064
2.406GlyAsn: 2.406 ± 0.113
0.964GlyPro: 0.964 ± 0.079
1.332GlyGln: 1.332 ± 0.096
1.496GlyArg: 1.496 ± 0.097
2.719GlySer: 2.719 ± 0.133
2.356GlyThr: 2.356 ± 0.123
2.774GlyVal: 2.774 ± 0.14
0.403GlyTrp: 0.403 ± 0.041
2.157GlyTyr: 2.157 ± 0.133
0.0GlyXaa: 0.0 ± 0.0
His
0.79HisAla: 0.79 ± 0.069
0.114HisCys: 0.114 ± 0.024
0.77HisAsp: 0.77 ± 0.062
0.949HisGlu: 0.949 ± 0.065
0.81HisPhe: 0.81 ± 0.074
0.79HisGly: 0.79 ± 0.064
0.353HisHis: 0.353 ± 0.042
1.506HisIle: 1.506 ± 0.085
1.491HisLys: 1.491 ± 0.072
1.615HisLeu: 1.615 ± 0.092
0.258HisMet: 0.258 ± 0.034
1.422HisAsn: 1.422 ± 0.081
0.611HisPro: 0.611 ± 0.059
0.542HisGln: 0.542 ± 0.055
0.482HisArg: 0.482 ± 0.05
1.193HisSer: 1.193 ± 0.088
0.731HisThr: 0.731 ± 0.059
0.805HisVal: 0.805 ± 0.07
0.184HisTrp: 0.184 ± 0.032
0.726HisTyr: 0.726 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
5.95IleAla: 5.95 ± 0.194
0.641IleCys: 0.641 ± 0.066
6.949IleAsp: 6.949 ± 0.206
7.341IleGlu: 7.341 ± 0.193
5.11IlePhe: 5.11 ± 0.253
4.096IleGly: 4.096 ± 0.17
1.501IleHis: 1.501 ± 0.1
9.2IleIle: 9.2 ± 0.325
9.916IleLys: 9.916 ± 0.275
8.977IleLeu: 8.977 ± 0.267
1.551IleMet: 1.551 ± 0.106
9.325IleAsn: 9.325 ± 0.337
2.803IlePro: 2.803 ± 0.126
3.077IleGln: 3.077 ± 0.122
2.61IleArg: 2.61 ± 0.132
6.849IleSer: 6.849 ± 0.224
5.075IleThr: 5.075 ± 0.178
5.825IleVal: 5.825 ± 0.217
0.815IleTrp: 0.815 ± 0.071
4.076IleTyr: 4.076 ± 0.158
0.0IleXaa: 0.0 ± 0.0
Lys
4.777LysAla: 4.777 ± 0.183
0.398LysCys: 0.398 ± 0.05
5.085LysAsp: 5.085 ± 0.201
8.559LysGlu: 8.559 ± 0.25
4.051LysPhe: 4.051 ± 0.135
3.191LysGly: 3.191 ± 0.129
1.809LysHis: 1.809 ± 0.1
9.583LysIle: 9.583 ± 0.263
9.086LysLys: 9.086 ± 0.22
8.957LysLeu: 8.957 ± 0.294
2.565LysMet: 2.565 ± 0.118
8.271LysAsn: 8.271 ± 0.264
2.764LysPro: 2.764 ± 0.118
3.971LysGln: 3.971 ± 0.147
3.102LysArg: 3.102 ± 0.123
5.254LysSer: 5.254 ± 0.166
6.009LysThr: 6.009 ± 0.224
4.28LysVal: 4.28 ± 0.159
0.939LysTrp: 0.939 ± 0.072
5.085LysTyr: 5.085 ± 0.151
0.0LysXaa: 0.0 ± 0.0
Leu
5.045LeuAla: 5.045 ± 0.18
0.621LeuCys: 0.621 ± 0.063
5.473LeuAsp: 5.473 ± 0.203
6.213LeuGlu: 6.213 ± 0.211
4.806LeuPhe: 4.806 ± 0.187
4.409LeuGly: 4.409 ± 0.171
1.382LeuHis: 1.382 ± 0.094
9.683LeuIle: 9.683 ± 0.296
9.305LeuLys: 9.305 ± 0.239
8.862LeuLeu: 8.862 ± 0.297
1.824LeuMet: 1.824 ± 0.09
9.101LeuAsn: 9.101 ± 0.338
2.808LeuPro: 2.808 ± 0.126
2.749LeuGln: 2.749 ± 0.142
2.654LeuArg: 2.654 ± 0.123
6.651LeuSer: 6.651 ± 0.202
5.731LeuThr: 5.731 ± 0.174
4.613LeuVal: 4.613 ± 0.163
0.676LeuTrp: 0.676 ± 0.065
3.375LeuTyr: 3.375 ± 0.127
0.0LeuXaa: 0.0 ± 0.0
Met
1.044MetAla: 1.044 ± 0.076
0.104MetCys: 0.104 ± 0.024
0.81MetAsp: 0.81 ± 0.069
1.188MetGlu: 1.188 ± 0.078
1.098MetPhe: 1.098 ± 0.1
0.736MetGly: 0.736 ± 0.075
0.383MetHis: 0.383 ± 0.046
1.784MetIle: 1.784 ± 0.101
2.033MetLys: 2.033 ± 0.096
1.819MetLeu: 1.819 ± 0.109
0.432MetMet: 0.432 ± 0.054
1.645MetAsn: 1.645 ± 0.098
0.626MetPro: 0.626 ± 0.057
0.641MetGln: 0.641 ± 0.06
0.522MetArg: 0.522 ± 0.048
1.297MetSer: 1.297 ± 0.084
0.979MetThr: 0.979 ± 0.081
0.969MetVal: 0.969 ± 0.071
0.144MetTrp: 0.144 ± 0.029
0.567MetTyr: 0.567 ± 0.059
0.0MetXaa: 0.0 ± 0.0
Asn
4.046AsnAla: 4.046 ± 0.24
0.447AsnCys: 0.447 ± 0.054
4.707AsnAsp: 4.707 ± 0.187
6.74AsnGlu: 6.74 ± 0.243
3.698AsnPhe: 3.698 ± 0.156
3.315AsnGly: 3.315 ± 0.129
1.193AsnHis: 1.193 ± 0.081
8.032AsnIle: 8.032 ± 0.269
8.45AsnLys: 8.45 ± 0.271
7.6AsnLeu: 7.6 ± 0.277
1.258AsnMet: 1.258 ± 0.092
7.51AsnAsn: 7.51 ± 0.34
2.729AsnPro: 2.729 ± 0.167
3.161AsnGln: 3.161 ± 0.159
2.167AsnArg: 2.167 ± 0.105
4.866AsnSer: 4.866 ± 0.259
3.489AsnThr: 3.489 ± 0.148
4.399AsnVal: 4.399 ± 0.172
0.855AsnTrp: 0.855 ± 0.078
3.708AsnTyr: 3.708 ± 0.166
0.0AsnXaa: 0.0 ± 0.0
Pro
1.382ProAla: 1.382 ± 0.099
0.149ProCys: 0.149 ± 0.03
1.287ProAsp: 1.287 ± 0.082
2.112ProGlu: 2.112 ± 0.143
1.427ProPhe: 1.427 ± 0.092
1.148ProGly: 1.148 ± 0.09
0.557ProHis: 0.557 ± 0.049
2.629ProIle: 2.629 ± 0.135
2.48ProLys: 2.48 ± 0.116
2.45ProLeu: 2.45 ± 0.117
0.422ProMet: 0.422 ± 0.046
2.127ProAsn: 2.127 ± 0.115
0.393ProPro: 0.393 ± 0.049
0.9ProGln: 0.9 ± 0.07
0.641ProArg: 0.641 ± 0.058
1.755ProSer: 1.755 ± 0.091
1.695ProThr: 1.695 ± 0.096
1.526ProVal: 1.526 ± 0.088
0.278ProTrp: 0.278 ± 0.037
1.203ProTyr: 1.203 ± 0.105
0.0ProXaa: 0.0 ± 0.0
Gln
1.854GlnAla: 1.854 ± 0.112
0.169GlnCys: 0.169 ± 0.03
1.456GlnAsp: 1.456 ± 0.079
2.371GlnGlu: 2.371 ± 0.157
1.571GlnPhe: 1.571 ± 0.09
1.248GlnGly: 1.248 ± 0.079
0.532GlnHis: 0.532 ± 0.053
3.077GlnIle: 3.077 ± 0.112
3.141GlnLys: 3.141 ± 0.139
3.44GlnLeu: 3.44 ± 0.151
0.631GlnMet: 0.631 ± 0.062
2.699GlnAsn: 2.699 ± 0.124
0.959GlnPro: 0.959 ± 0.089
1.188GlnGln: 1.188 ± 0.078
1.143GlnArg: 1.143 ± 0.089
1.511GlnSer: 1.511 ± 0.078
2.058GlnThr: 2.058 ± 0.097
1.238GlnVal: 1.238 ± 0.096
0.378GlnTrp: 0.378 ± 0.045
1.655GlnTyr: 1.655 ± 0.086
0.0GlnXaa: 0.0 ± 0.0
Arg
1.451ArgAla: 1.451 ± 0.096
0.179ArgCys: 0.179 ± 0.029
1.655ArgAsp: 1.655 ± 0.093
2.132ArgGlu: 2.132 ± 0.122
1.451ArgPhe: 1.451 ± 0.084
1.352ArgGly: 1.352 ± 0.092
0.537ArgHis: 0.537 ± 0.052
2.793ArgIle: 2.793 ± 0.113
2.779ArgLys: 2.779 ± 0.126
2.575ArgLeu: 2.575 ± 0.112
0.731ArgMet: 0.731 ± 0.06
2.331ArgAsn: 2.331 ± 0.107
0.716ArgPro: 0.716 ± 0.06
0.979ArgGln: 0.979 ± 0.085
1.074ArgArg: 1.074 ± 0.09
1.531ArgSer: 1.531 ± 0.091
1.471ArgThr: 1.471 ± 0.08
1.571ArgVal: 1.571 ± 0.095
0.273ArgTrp: 0.273 ± 0.033
1.312ArgTyr: 1.312 ± 0.079
0.0ArgXaa: 0.0 ± 0.0
Ser
2.878SerAla: 2.878 ± 0.144
0.437SerCys: 0.437 ± 0.045
3.176SerAsp: 3.176 ± 0.136
3.862SerGlu: 3.862 ± 0.137
3.524SerPhe: 3.524 ± 0.151
3.107SerGly: 3.107 ± 0.144
0.895SerHis: 0.895 ± 0.066
6.73SerIle: 6.73 ± 0.22
6.154SerLys: 6.154 ± 0.174
6.487SerLeu: 6.487 ± 0.212
1.049SerMet: 1.049 ± 0.064
4.951SerAsn: 4.951 ± 0.196
1.317SerPro: 1.317 ± 0.081
1.943SerGln: 1.943 ± 0.099
1.839SerArg: 1.839 ± 0.093
4.578SerSer: 4.578 ± 0.193
3.161SerThr: 3.161 ± 0.133
3.002SerVal: 3.002 ± 0.118
0.587SerTrp: 0.587 ± 0.063
2.928SerTyr: 2.928 ± 0.13
0.0SerXaa: 0.0 ± 0.0
Thr
2.754ThrAla: 2.754 ± 0.135
0.278ThrCys: 0.278 ± 0.05
2.525ThrAsp: 2.525 ± 0.122
3.29ThrGlu: 3.29 ± 0.17
2.769ThrPhe: 2.769 ± 0.135
2.376ThrGly: 2.376 ± 0.145
0.964ThrHis: 0.964 ± 0.069
5.557ThrIle: 5.557 ± 0.19
5.328ThrLys: 5.328 ± 0.176
5.125ThrLeu: 5.125 ± 0.189
0.775ThrMet: 0.775 ± 0.064
4.011ThrAsn: 4.011 ± 0.146
1.879ThrPro: 1.879 ± 0.1
1.511ThrGln: 1.511 ± 0.082
1.456ThrArg: 1.456 ± 0.086
3.519ThrSer: 3.519 ± 0.15
3.385ThrThr: 3.385 ± 0.186
2.614ThrVal: 2.614 ± 0.138
0.462ThrTrp: 0.462 ± 0.058
2.431ThrTyr: 2.431 ± 0.121
0.0ThrXaa: 0.0 ± 0.0
Val
3.241ValAla: 3.241 ± 0.172
0.427ValCys: 0.427 ± 0.054
3.33ValAsp: 3.33 ± 0.137
3.663ValGlu: 3.663 ± 0.146
2.614ValPhe: 2.614 ± 0.113
2.381ValGly: 2.381 ± 0.128
0.736ValHis: 0.736 ± 0.066
5.438ValIle: 5.438 ± 0.183
5.05ValLys: 5.05 ± 0.153
5.105ValLeu: 5.105 ± 0.177
0.805ValMet: 0.805 ± 0.075
3.534ValAsn: 3.534 ± 0.141
1.332ValPro: 1.332 ± 0.089
1.417ValGln: 1.417 ± 0.084
1.367ValArg: 1.367 ± 0.088
3.619ValSer: 3.619 ± 0.137
2.272ValThr: 2.272 ± 0.113
3.539ValVal: 3.539 ± 0.161
0.517ValTrp: 0.517 ± 0.051
2.053ValTyr: 2.053 ± 0.093
0.0ValXaa: 0.0 ± 0.0
Trp
0.368TrpAla: 0.368 ± 0.045
0.05TrpCys: 0.05 ± 0.014
0.552TrpAsp: 0.552 ± 0.063
0.572TrpGlu: 0.572 ± 0.058
0.572TrpPhe: 0.572 ± 0.054
0.432TrpGly: 0.432 ± 0.042
0.139TrpHis: 0.139 ± 0.026
1.029TrpIle: 1.029 ± 0.074
1.034TrpLys: 1.034 ± 0.078
0.785TrpLeu: 0.785 ± 0.058
0.293TrpMet: 0.293 ± 0.039
0.875TrpAsn: 0.875 ± 0.07
0.209TrpPro: 0.209 ± 0.037
0.263TrpGln: 0.263 ± 0.038
0.278TrpArg: 0.278 ± 0.041
0.537TrpSer: 0.537 ± 0.06
0.532TrpThr: 0.532 ± 0.056
0.413TrpVal: 0.413 ± 0.049
0.084TrpTrp: 0.084 ± 0.024
0.398TrpTyr: 0.398 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.207TyrAla: 2.207 ± 0.107
0.303TyrCys: 0.303 ± 0.045
2.674TyrAsp: 2.674 ± 0.131
2.823TyrGlu: 2.823 ± 0.119
2.47TyrPhe: 2.47 ± 0.138
2.182TyrGly: 2.182 ± 0.123
0.79TyrHis: 0.79 ± 0.071
4.26TyrIle: 4.26 ± 0.133
4.175TyrLys: 4.175 ± 0.148
4.722TyrLeu: 4.722 ± 0.194
0.686TyrMet: 0.686 ± 0.059
3.375TyrAsn: 3.375 ± 0.149
1.089TyrPro: 1.089 ± 0.084
1.625TyrGln: 1.625 ± 0.084
1.481TyrArg: 1.481 ± 0.088
2.903TyrSer: 2.903 ± 0.144
2.083TyrThr: 2.083 ± 0.094
2.177TyrVal: 2.177 ± 0.112
0.557TyrTrp: 0.557 ± 0.053
2.043TyrTyr: 2.043 ± 0.119
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 539 proteins (201187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski