Amino acid dipepetide frequency for Paraeggerthella hongkongensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.873AlaAla: 15.873 ± 0.234	2.482AlaCys: 2.482 ± 0.072	6.877AlaAsp: 6.877 ± 0.101	6.882AlaGlu: 6.882 ± 0.118	4.899AlaPhe: 4.899 ± 0.095	9.432AlaGly: 9.432 ± 0.13	2.085AlaHis: 2.085 ± 0.053	5.533AlaIle: 5.533 ± 0.096	4.252AlaLys: 4.252 ± 0.085	12.301AlaLeu: 12.301 ± 0.161	3.073AlaMet: 3.073 ± 0.064	3.035AlaAsn: 3.035 ± 0.064	4.565AlaPro: 4.565 ± 0.093	3.957AlaGln: 3.957 ± 0.08	7.452AlaArg: 7.452 ± 0.146	7.577AlaSer: 7.577 ± 0.123	5.478AlaThr: 5.478 ± 0.084	9.551AlaVal: 9.551 ± 0.133	1.332AlaTrp: 1.332 ± 0.049	3.128AlaTyr: 3.128 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	1.959CysAla: 1.959 ± 0.055	0.285CysCys: 0.285 ± 0.021	1.011CysAsp: 1.011 ± 0.038	0.941CysGlu: 0.941 ± 0.035	0.624CysPhe: 0.624 ± 0.034	1.634CysGly: 1.634 ± 0.052	0.299CysHis: 0.299 ± 0.023	0.793CysIle: 0.793 ± 0.034	0.532CysLys: 0.532 ± 0.023	1.355CysLeu: 1.355 ± 0.048	0.42CysMet: 0.42 ± 0.025	0.387CysAsn: 0.387 ± 0.024	0.796CysPro: 0.796 ± 0.041	0.354CysGln: 0.354 ± 0.024	0.841CysArg: 0.841 ± 0.036	0.978CysSer: 0.978 ± 0.032	0.854CysThr: 0.854 ± 0.035	1.283CysVal: 1.283 ± 0.044	0.162CysTrp: 0.162 ± 0.016	0.422CysTyr: 0.422 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	7.895AspAla: 7.895 ± 0.117	0.714AspCys: 0.714 ± 0.03	3.681AspAsp: 3.681 ± 0.075	4.898AspGlu: 4.898 ± 0.09	2.35AspPhe: 2.35 ± 0.058	5.197AspGly: 5.197 ± 0.102	0.985AspHis: 0.985 ± 0.038	2.954AspIle: 2.954 ± 0.071	2.055AspLys: 2.055 ± 0.052	5.553AspLeu: 5.553 ± 0.091	1.503AspMet: 1.503 ± 0.043	1.461AspAsn: 1.461 ± 0.049	3.175AspPro: 3.175 ± 0.076	1.806AspGln: 1.806 ± 0.046	3.745AspArg: 3.745 ± 0.072	2.804AspSer: 2.804 ± 0.06	2.322AspThr: 2.322 ± 0.051	5.183AspVal: 5.183 ± 0.092	0.736AspTrp: 0.736 ± 0.034	1.816AspTyr: 1.816 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	7.696GluAla: 7.696 ± 0.134	0.694GluCys: 0.694 ± 0.029	3.711GluAsp: 3.711 ± 0.078	4.199GluGlu: 4.199 ± 0.09	2.083GluPhe: 2.083 ± 0.047	5.232GluGly: 5.232 ± 0.088	1.412GluHis: 1.412 ± 0.042	2.92GluIle: 2.92 ± 0.067	2.771GluLys: 2.771 ± 0.064	5.806GluLeu: 5.806 ± 0.093	1.508GluMet: 1.508 ± 0.043	2.059GluAsn: 2.059 ± 0.051	2.547GluPro: 2.547 ± 0.071	2.268GluGln: 2.268 ± 0.058	5.072GluArg: 5.072 ± 0.099	3.429GluSer: 3.429 ± 0.074	3.186GluThr: 3.186 ± 0.068	4.266GluVal: 4.266 ± 0.085	0.526GluTrp: 0.526 ± 0.026	1.649GluTyr: 1.649 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	4.692PheAla: 4.692 ± 0.095	0.694PheCys: 0.694 ± 0.033	2.967PheAsp: 2.967 ± 0.07	2.607PheGlu: 2.607 ± 0.059	1.712PhePhe: 1.712 ± 0.062	3.637PheGly: 3.637 ± 0.077	0.527PheHis: 0.527 ± 0.025	1.68PheIle: 1.68 ± 0.049	1.319PheLys: 1.319 ± 0.037	3.495PheLeu: 3.495 ± 0.072	1.018PheMet: 1.018 ± 0.036	1.136PheAsn: 1.136 ± 0.04	1.385PhePro: 1.385 ± 0.043	0.926PheGln: 0.926 ± 0.034	1.634PheArg: 1.634 ± 0.048	2.694PheSer: 2.694 ± 0.063	1.989PheThr: 1.989 ± 0.047	3.515PheVal: 3.515 ± 0.079	0.521PheTrp: 0.521 ± 0.028	1.078PheTyr: 1.078 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.908GlyAla: 8.908 ± 0.151	1.601GlyCys: 1.601 ± 0.05	4.362GlyAsp: 4.362 ± 0.092	4.507GlyGlu: 4.507 ± 0.075	3.623GlyPhe: 3.623 ± 0.076	6.595GlyGly: 6.595 ± 0.147	1.341GlyHis: 1.341 ± 0.04	4.724GlyIle: 4.724 ± 0.092	3.746GlyLys: 3.746 ± 0.074	7.373GlyLeu: 7.373 ± 0.106	2.553GlyMet: 2.553 ± 0.054	2.353GlyAsn: 2.353 ± 0.064	2.377GlyPro: 2.377 ± 0.056	2.252GlyGln: 2.252 ± 0.051	4.623GlyArg: 4.623 ± 0.089	5.641GlySer: 5.641 ± 0.105	4.57GlyThr: 4.57 ± 0.1	6.996GlyVal: 6.996 ± 0.1	1.034GlyTrp: 1.034 ± 0.048	2.623GlyTyr: 2.623 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.152HisAla: 2.152 ± 0.052	0.339HisCys: 0.339 ± 0.019	1.147HisAsp: 1.147 ± 0.04	1.099HisGlu: 1.099 ± 0.037	0.592HisPhe: 0.592 ± 0.025	1.511HisGly: 1.511 ± 0.039	0.376HisHis: 0.376 ± 0.024	0.842HisIle: 0.842 ± 0.035	0.501HisLys: 0.501 ± 0.024	1.493HisLeu: 1.493 ± 0.048	0.368HisMet: 0.368 ± 0.021	0.445HisAsn: 0.445 ± 0.025	1.048HisPro: 1.048 ± 0.035	0.398HisGln: 0.398 ± 0.022	1.033HisArg: 1.033 ± 0.032	0.862HisSer: 0.862 ± 0.038	0.765HisThr: 0.765 ± 0.032	1.602HisVal: 1.602 ± 0.043	0.153HisTrp: 0.153 ± 0.014	0.579HisTyr: 0.579 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.479IleAla: 6.479 ± 0.092	0.75IleCys: 0.75 ± 0.035	3.571IleAsp: 3.571 ± 0.079	3.719IleGlu: 3.719 ± 0.074	1.321IlePhe: 1.321 ± 0.047	4.188IleGly: 4.188 ± 0.089	0.661IleHis: 0.661 ± 0.026	2.224IleIle: 2.224 ± 0.06	1.77IleLys: 1.77 ± 0.057	3.687IleLeu: 3.687 ± 0.081	1.339IleMet: 1.339 ± 0.046	1.345IleAsn: 1.345 ± 0.041	2.225IlePro: 2.225 ± 0.054	1.065IleGln: 1.065 ± 0.039	2.219IleArg: 2.219 ± 0.056	2.702IleSer: 2.702 ± 0.064	2.487IleThr: 2.487 ± 0.052	4.895IleVal: 4.895 ± 0.093	0.442IleTrp: 0.442 ± 0.023	1.018IleTyr: 1.018 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.143LysAla: 4.143 ± 0.086	0.422LysCys: 0.422 ± 0.022	2.265LysAsp: 2.265 ± 0.062	2.364LysGlu: 2.364 ± 0.065	0.926LysPhe: 0.926 ± 0.033	2.865LysGly: 2.865 ± 0.072	0.723LysHis: 0.723 ± 0.027	1.707LysIle: 1.707 ± 0.047	2.156LysLys: 2.156 ± 0.069	3.484LysLeu: 3.484 ± 0.065	0.957LysMet: 0.957 ± 0.036	1.423LysAsn: 1.423 ± 0.043	1.941LysPro: 1.941 ± 0.052	1.401LysGln: 1.401 ± 0.047	2.825LysArg: 2.825 ± 0.056	2.269LysSer: 2.269 ± 0.053	2.404LysThr: 2.404 ± 0.047	2.516LysVal: 2.516 ± 0.062	0.344LysTrp: 0.344 ± 0.02	0.918LysTyr: 0.918 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	12.039LeuAla: 12.039 ± 0.171	1.423LeuCys: 1.423 ± 0.046	5.985LeuAsp: 5.985 ± 0.094	5.616LeuGlu: 5.616 ± 0.11	3.975LeuPhe: 3.975 ± 0.085	7.418LeuGly: 7.418 ± 0.106	1.607LeuHis: 1.607 ± 0.051	4.244LeuIle: 4.244 ± 0.086	3.268LeuLys: 3.268 ± 0.078	8.651LeuLeu: 8.651 ± 0.144	2.424LeuMet: 2.424 ± 0.062	2.301LeuAsn: 2.301 ± 0.059	4.477LeuPro: 4.477 ± 0.077	2.29LeuGln: 2.29 ± 0.052	5.332LeuArg: 5.332 ± 0.105	6.462LeuSer: 6.462 ± 0.086	4.694LeuThr: 4.694 ± 0.07	8.224LeuVal: 8.224 ± 0.132	0.868LeuTrp: 0.868 ± 0.033	2.516LeuTyr: 2.516 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	3.084MetAla: 3.084 ± 0.055	0.35MetCys: 0.35 ± 0.02	1.472MetAsp: 1.472 ± 0.045	1.508MetGlu: 1.508 ± 0.039	0.835MetPhe: 0.835 ± 0.032	2.203MetGly: 2.203 ± 0.057	0.46MetHis: 0.46 ± 0.023	1.183MetIle: 1.183 ± 0.038	1.199MetLys: 1.199 ± 0.038	2.659MetLeu: 2.659 ± 0.069	0.756MetMet: 0.756 ± 0.031	0.945MetAsn: 0.945 ± 0.033	1.313MetPro: 1.313 ± 0.042	0.923MetGln: 0.923 ± 0.034	1.8MetArg: 1.8 ± 0.05	1.68MetSer: 1.68 ± 0.05	1.57MetThr: 1.57 ± 0.051	1.948MetVal: 1.948 ± 0.048	0.231MetTrp: 0.231 ± 0.015	0.584MetTyr: 0.584 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.342AsnAla: 3.342 ± 0.06	0.375AsnCys: 0.375 ± 0.024	1.688AsnAsp: 1.688 ± 0.049	1.779AsnGlu: 1.779 ± 0.052	0.891AsnPhe: 0.891 ± 0.03	2.448AsnGly: 2.448 ± 0.063	0.45AsnHis: 0.45 ± 0.026	1.398AsnIle: 1.398 ± 0.043	1.013AsnLys: 1.013 ± 0.037	2.662AsnLeu: 2.662 ± 0.063	0.818AsnMet: 0.818 ± 0.033	0.794AsnAsn: 0.794 ± 0.033	1.924AsnPro: 1.924 ± 0.052	0.788AsnGln: 0.788 ± 0.029	1.657AsnArg: 1.657 ± 0.047	1.377AsnSer: 1.377 ± 0.049	1.371AsnThr: 1.371 ± 0.046	2.526AsnVal: 2.526 ± 0.055	0.306AsnTrp: 0.306 ± 0.02	0.798AsnTyr: 0.798 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.97ProAla: 4.97 ± 0.092	0.66ProCys: 0.66 ± 0.032	2.973ProAsp: 2.973 ± 0.066	3.306ProGlu: 3.306 ± 0.06	1.804ProPhe: 1.804 ± 0.048	3.357ProGly: 3.357 ± 0.072	0.797ProHis: 0.797 ± 0.033	1.925ProIle: 1.925 ± 0.053	1.526ProLys: 1.526 ± 0.046	4.072ProLeu: 4.072 ± 0.079	0.933ProMet: 0.933 ± 0.036	1.208ProAsn: 1.208 ± 0.042	1.281ProPro: 1.281 ± 0.046	1.525ProGln: 1.525 ± 0.043	2.174ProArg: 2.174 ± 0.058	2.7ProSer: 2.7 ± 0.067	2.183ProThr: 2.183 ± 0.057	3.807ProVal: 3.807 ± 0.072	0.472ProTrp: 0.472 ± 0.025	1.414ProTyr: 1.414 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.734GlnAla: 3.734 ± 0.075	0.316GlnCys: 0.316 ± 0.019	1.602GlnAsp: 1.602 ± 0.049	1.802GlnGlu: 1.802 ± 0.049	0.99GlnPhe: 0.99 ± 0.032	2.487GlnGly: 2.487 ± 0.058	0.614GlnHis: 0.614 ± 0.028	1.436GlnIle: 1.436 ± 0.041	1.219GlnLys: 1.219 ± 0.042	2.695GlnLeu: 2.695 ± 0.066	0.825GlnMet: 0.825 ± 0.033	0.92GlnAsn: 0.92 ± 0.035	1.361GlnPro: 1.361 ± 0.049	1.235GlnGln: 1.235 ± 0.049	1.964GlnArg: 1.964 ± 0.053	1.472GlnSer: 1.472 ± 0.041	1.542GlnThr: 1.542 ± 0.045	2.279GlnVal: 2.279 ± 0.048	0.317GlnTrp: 0.317 ± 0.022	0.737GlnTyr: 0.737 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.073ArgAla: 7.073 ± 0.131	0.956ArgCys: 0.956 ± 0.038	3.346ArgAsp: 3.346 ± 0.071	4.099ArgGlu: 4.099 ± 0.082	2.586ArgPhe: 2.586 ± 0.059	4.047ArgGly: 4.047 ± 0.064	1.01ArgHis: 1.01 ± 0.033	3.453ArgIle: 3.453 ± 0.074	2.443ArgLys: 2.443 ± 0.065	5.296ArgLeu: 5.296 ± 0.106	2.076ArgMet: 2.076 ± 0.057	1.731ArgAsn: 1.731 ± 0.048	2.256ArgPro: 2.256 ± 0.061	1.74ArgGln: 1.74 ± 0.049	4.23ArgArg: 4.23 ± 0.102	3.572ArgSer: 3.572 ± 0.079	3.213ArgThr: 3.213 ± 0.083	4.664ArgVal: 4.664 ± 0.085	0.6ArgTrp: 0.6 ± 0.029	1.811ArgTyr: 1.811 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.571SerAla: 6.571 ± 0.099	1.026SerCys: 1.026 ± 0.037	3.445SerAsp: 3.445 ± 0.066	3.373SerGlu: 3.373 ± 0.067	2.879SerPhe: 2.879 ± 0.061	5.445SerGly: 5.445 ± 0.114	1.022SerHis: 1.022 ± 0.04	3.154SerIle: 3.154 ± 0.065	2.267SerLys: 2.267 ± 0.051	5.872SerLeu: 5.872 ± 0.096	1.744SerMet: 1.744 ± 0.048	1.728SerAsn: 1.728 ± 0.049	2.453SerPro: 2.453 ± 0.06	1.805SerGln: 1.805 ± 0.045	3.215SerArg: 3.215 ± 0.063	4.142SerSer: 4.142 ± 0.1	3.158SerThr: 3.158 ± 0.067	4.886SerVal: 4.886 ± 0.091	0.809SerTrp: 0.809 ± 0.031	1.97SerTyr: 1.97 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.32ThrAla: 5.32 ± 0.098	0.855ThrCys: 0.855 ± 0.036	2.893ThrAsp: 2.893 ± 0.063	2.54ThrGlu: 2.54 ± 0.058	2.139ThrPhe: 2.139 ± 0.049	4.6ThrGly: 4.6 ± 0.092	0.947ThrHis: 0.947 ± 0.034	2.588ThrIle: 2.588 ± 0.069	1.755ThrLys: 1.755 ± 0.049	4.815ThrLeu: 4.815 ± 0.086	1.392ThrMet: 1.392 ± 0.041	1.414ThrAsn: 1.414 ± 0.049	2.593ThrPro: 2.593 ± 0.066	1.28ThrGln: 1.28 ± 0.04	2.5ThrArg: 2.5 ± 0.054	3.0ThrSer: 3.0 ± 0.062	2.721ThrThr: 2.721 ± 0.065	4.921ThrVal: 4.921 ± 0.084	0.683ThrTrp: 0.683 ± 0.031	1.652ThrTyr: 1.652 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	9.648ValAla: 9.648 ± 0.132	1.341ValCys: 1.341 ± 0.043	5.204ValAsp: 5.204 ± 0.088	5.353ValGlu: 5.353 ± 0.089	3.404ValPhe: 3.404 ± 0.076	6.157ValGly: 6.157 ± 0.091	1.308ValHis: 1.308 ± 0.043	3.768ValIle: 3.768 ± 0.073	3.024ValLys: 3.024 ± 0.073	8.454ValLeu: 8.454 ± 0.103	2.088ValMet: 2.088 ± 0.059	2.413ValAsn: 2.413 ± 0.054	3.783ValPro: 3.783 ± 0.071	2.259ValGln: 2.259 ± 0.057	5.157ValArg: 5.157 ± 0.082	5.577ValSer: 5.577 ± 0.091	4.145ValThr: 4.145 ± 0.079	7.516ValVal: 7.516 ± 0.126	0.781ValTrp: 0.781 ± 0.028	2.172ValTyr: 2.172 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	1.04TrpAla: 1.04 ± 0.036	0.202TrpCys: 0.202 ± 0.019	0.613TrpAsp: 0.613 ± 0.028	0.624TrpGlu: 0.624 ± 0.029	0.456TrpPhe: 0.456 ± 0.024	0.912TrpGly: 0.912 ± 0.036	0.218TrpHis: 0.218 ± 0.019	0.573TrpIle: 0.573 ± 0.03	0.421TrpLys: 0.421 ± 0.022	1.136TrpLeu: 1.136 ± 0.048	0.355TrpMet: 0.355 ± 0.017	0.409TrpAsn: 0.409 ± 0.021	0.361TrpPro: 0.361 ± 0.021	0.372TrpGln: 0.372 ± 0.023	0.671TrpArg: 0.671 ± 0.03	0.595TrpSer: 0.595 ± 0.027	0.527TrpThr: 0.527 ± 0.022	0.769TrpVal: 0.769 ± 0.032	0.164TrpTrp: 0.164 ± 0.016	0.381TrpTyr: 0.381 ± 0.034	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.145TyrAla: 3.145 ± 0.062	0.444TyrCys: 0.444 ± 0.027	2.019TyrAsp: 2.019 ± 0.053	1.816TyrGlu: 1.816 ± 0.046	1.139TyrPhe: 1.139 ± 0.038	2.435TyrGly: 2.435 ± 0.056	0.46TyrHis: 0.46 ± 0.025	1.006TyrIle: 1.006 ± 0.035	0.82TyrLys: 0.82 ± 0.035	2.956TyrLeu: 2.956 ± 0.069	0.557TyrMet: 0.557 ± 0.025	0.897TyrAsn: 0.897 ± 0.034	1.226TyrPro: 1.226 ± 0.04	0.902TyrGln: 0.902 ± 0.032	2.056TyrArg: 2.056 ± 0.062	1.429TyrSer: 1.429 ± 0.041	1.432TyrThr: 1.432 ± 0.05	2.207TyrVal: 2.207 ± 0.056	0.318TyrTrp: 0.318 ± 0.021	0.999TyrTyr: 0.999 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2391 proteins (817088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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