Amino acid dipepetide frequency for Halanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.104AlaAla: 8.104 ± 0.153
0.474AlaCys: 0.474 ± 0.029
4.343AlaAsp: 4.343 ± 0.093
7.326AlaGlu: 7.326 ± 0.115
2.79AlaPhe: 2.79 ± 0.061
5.96AlaGly: 5.96 ± 0.118
1.058AlaHis: 1.058 ± 0.04
5.299AlaIle: 5.299 ± 0.093
6.35AlaLys: 6.35 ± 0.116
7.283AlaLeu: 7.283 ± 0.133
1.571AlaMet: 1.571 ± 0.053
3.272AlaAsn: 3.272 ± 0.081
1.722AlaPro: 1.722 ± 0.048
2.84AlaGln: 2.84 ± 0.07
2.722AlaArg: 2.722 ± 0.074
3.818AlaSer: 3.818 ± 0.087
2.744AlaThr: 2.744 ± 0.067
5.366AlaVal: 5.366 ± 0.085
0.458AlaTrp: 0.458 ± 0.025
2.308AlaTyr: 2.308 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.353CysAla: 0.353 ± 0.024
0.074CysCys: 0.074 ± 0.011
0.351CysAsp: 0.351 ± 0.024
0.329CysGlu: 0.329 ± 0.021
0.203CysPhe: 0.203 ± 0.018
0.634CysGly: 0.634 ± 0.032
0.145CysHis: 0.145 ± 0.012
0.385CysIle: 0.385 ± 0.03
0.36CysLys: 0.36 ± 0.026
0.574CysLeu: 0.574 ± 0.034
0.104CysMet: 0.104 ± 0.012
0.31CysAsn: 0.31 ± 0.023
0.388CysPro: 0.388 ± 0.027
0.291CysGln: 0.291 ± 0.021
0.308CysArg: 0.308 ± 0.021
0.436CysSer: 0.436 ± 0.027
0.248CysThr: 0.248 ± 0.022
0.305CysVal: 0.305 ± 0.024
0.042CysTrp: 0.042 ± 0.008
0.221CysTyr: 0.221 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
2.631AspAla: 2.631 ± 0.066
0.381AspCys: 0.381 ± 0.024
2.275AspAsp: 2.275 ± 0.074
3.132AspGlu: 3.132 ± 0.089
3.39AspPhe: 3.39 ± 0.075
2.636AspGly: 2.636 ± 0.072
0.922AspHis: 0.922 ± 0.041
4.508AspIle: 4.508 ± 0.094
4.051AspLys: 4.051 ± 0.086
7.286AspLeu: 7.286 ± 0.105
0.969AspMet: 0.969 ± 0.039
2.636AspAsn: 2.636 ± 0.061
1.822AspPro: 1.822 ± 0.058
3.024AspGln: 3.024 ± 0.068
1.805AspArg: 1.805 ± 0.055
3.166AspSer: 3.166 ± 0.07
1.807AspThr: 1.807 ± 0.05
2.606AspVal: 2.606 ± 0.071
0.497AspTrp: 0.497 ± 0.029
2.837AspTyr: 2.837 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
6.129GluAla: 6.129 ± 0.118
0.325GluCys: 0.325 ± 0.022
3.506GluAsp: 3.506 ± 0.083
6.238GluGlu: 6.238 ± 0.126
3.154GluPhe: 3.154 ± 0.072
3.433GluGly: 3.433 ± 0.068
0.919GluHis: 0.919 ± 0.035
8.577GluIle: 8.577 ± 0.123
8.544GluLys: 8.544 ± 0.139
8.271GluLeu: 8.271 ± 0.138
2.178GluMet: 2.178 ± 0.053
5.298GluAsn: 5.298 ± 0.102
1.574GluPro: 1.574 ± 0.05
2.387GluGln: 2.387 ± 0.062
2.338GluArg: 2.338 ± 0.07
3.645GluSer: 3.645 ± 0.074
3.199GluThr: 3.199 ± 0.077
5.154GluVal: 5.154 ± 0.1
0.371GluTrp: 0.371 ± 0.025
2.518GluTyr: 2.518 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.24PheAla: 3.24 ± 0.083
0.289PheCys: 0.289 ± 0.023
2.372PheAsp: 2.372 ± 0.061
2.852PheGlu: 2.852 ± 0.068
2.17PhePhe: 2.17 ± 0.067
2.722PheGly: 2.722 ± 0.068
0.557PheHis: 0.557 ± 0.031
4.056PheIle: 4.056 ± 0.095
4.174PheLys: 4.174 ± 0.083
4.715PheLeu: 4.715 ± 0.094
0.987PheMet: 0.987 ± 0.045
2.575PheAsn: 2.575 ± 0.072
1.359PhePro: 1.359 ± 0.05
1.141PheGln: 1.141 ± 0.042
1.376PheArg: 1.376 ± 0.048
3.481PheSer: 3.481 ± 0.074
1.976PheThr: 1.976 ± 0.065
2.378PheVal: 2.378 ± 0.059
0.378PheTrp: 0.378 ± 0.026
1.755PheTyr: 1.755 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.529GlyAla: 4.529 ± 0.11
0.522GlyCys: 0.522 ± 0.032
3.068GlyAsp: 3.068 ± 0.072
4.425GlyGlu: 4.425 ± 0.084
2.886GlyPhe: 2.886 ± 0.073
4.529GlyGly: 4.529 ± 0.101
1.06GlyHis: 1.06 ± 0.045
5.633GlyIle: 5.633 ± 0.104
4.397GlyLys: 4.397 ± 0.081
6.143GlyLeu: 6.143 ± 0.113
1.549GlyMet: 1.549 ± 0.057
2.498GlyAsn: 2.498 ± 0.063
1.573GlyPro: 1.573 ± 0.058
2.157GlyGln: 2.157 ± 0.059
2.323GlyArg: 2.323 ± 0.051
3.896GlySer: 3.896 ± 0.08
3.025GlyThr: 3.025 ± 0.082
4.192GlyVal: 4.192 ± 0.085
0.525GlyTrp: 0.525 ± 0.03
2.507GlyTyr: 2.507 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
0.827HisAla: 0.827 ± 0.039
0.154HisCys: 0.154 ± 0.016
0.663HisAsp: 0.663 ± 0.033
0.679HisGlu: 0.679 ± 0.028
0.743HisPhe: 0.743 ± 0.03
0.937HisGly: 0.937 ± 0.043
0.353HisHis: 0.353 ± 0.025
0.996HisIle: 0.996 ± 0.042
0.909HisLys: 0.909 ± 0.039
1.651HisLeu: 1.651 ± 0.049
0.227HisMet: 0.227 ± 0.022
0.78HisAsn: 0.78 ± 0.033
0.757HisPro: 0.757 ± 0.032
0.793HisGln: 0.793 ± 0.035
0.52HisArg: 0.52 ± 0.029
0.98HisSer: 0.98 ± 0.034
0.562HisThr: 0.562 ± 0.029
0.609HisVal: 0.609 ± 0.03
0.107HisTrp: 0.107 ± 0.012
0.639HisTyr: 0.639 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.57IleAla: 6.57 ± 0.108
0.548IleCys: 0.548 ± 0.029
5.178IleAsp: 5.178 ± 0.09
6.879IleGlu: 6.879 ± 0.115
4.231IlePhe: 4.231 ± 0.107
5.099IleGly: 5.099 ± 0.095
0.981IleHis: 0.981 ± 0.035
8.758IleIle: 8.758 ± 0.14
8.477IleLys: 8.477 ± 0.131
8.627IleLeu: 8.627 ± 0.151
2.04IleMet: 2.04 ± 0.055
5.194IleAsn: 5.194 ± 0.107
3.212IlePro: 3.212 ± 0.072
2.025IleGln: 2.025 ± 0.06
2.756IleArg: 2.756 ± 0.066
6.086IleSer: 6.086 ± 0.113
4.196IleThr: 4.196 ± 0.091
4.97IleVal: 4.97 ± 0.09
0.577IleTrp: 0.577 ± 0.032
3.108IleTyr: 3.108 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
6.768LysAla: 6.768 ± 0.125
0.396LysCys: 0.396 ± 0.028
4.383LysAsp: 4.383 ± 0.079
8.7LysGlu: 8.7 ± 0.129
3.009LysPhe: 3.009 ± 0.073
4.254LysGly: 4.254 ± 0.079
1.076LysHis: 1.076 ± 0.036
9.284LysIle: 9.284 ± 0.146
9.946LysLys: 9.946 ± 0.167
9.05LysLeu: 9.05 ± 0.134
2.339LysMet: 2.339 ± 0.062
6.478LysAsn: 6.478 ± 0.12
1.853LysPro: 1.853 ± 0.057
2.613LysGln: 2.613 ± 0.071
3.199LysArg: 3.199 ± 0.079
4.646LysSer: 4.646 ± 0.087
4.339LysThr: 4.339 ± 0.083
5.092LysVal: 5.092 ± 0.085
0.5LysTrp: 0.5 ± 0.028
3.337LysTyr: 3.337 ± 0.087
0.0LysXaa: 0.0 ± 0.0
Leu
9.244LeuAla: 9.244 ± 0.148
0.437LeuCys: 0.437 ± 0.03
5.843LeuAsp: 5.843 ± 0.105
8.715LeuGlu: 8.715 ± 0.133
4.116LeuPhe: 4.116 ± 0.088
6.135LeuGly: 6.135 ± 0.123
1.156LeuHis: 1.156 ± 0.043
9.451LeuIle: 9.451 ± 0.156
10.716LeuLys: 10.716 ± 0.149
9.164LeuLeu: 9.164 ± 0.156
2.164LeuMet: 2.164 ± 0.062
6.291LeuAsn: 6.291 ± 0.121
3.3LeuPro: 3.3 ± 0.077
2.459LeuGln: 2.459 ± 0.063
3.343LeuArg: 3.343 ± 0.076
6.254LeuSer: 6.254 ± 0.113
5.239LeuThr: 5.239 ± 0.104
5.846LeuVal: 5.846 ± 0.105
0.544LeuTrp: 0.544 ± 0.033
2.902LeuTyr: 2.902 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
1.992MetAla: 1.992 ± 0.047
0.083MetCys: 0.083 ± 0.011
1.19MetAsp: 1.19 ± 0.055
1.672MetGlu: 1.672 ± 0.053
0.82MetPhe: 0.82 ± 0.047
1.66MetGly: 1.66 ± 0.047
0.292MetHis: 0.292 ± 0.022
1.927MetIle: 1.927 ± 0.057
1.886MetLys: 1.886 ± 0.044
2.077MetLeu: 2.077 ± 0.061
0.551MetMet: 0.551 ± 0.033
1.205MetAsn: 1.205 ± 0.046
0.845MetPro: 0.845 ± 0.04
0.915MetGln: 0.915 ± 0.036
0.848MetArg: 0.848 ± 0.033
1.275MetSer: 1.275 ± 0.046
1.131MetThr: 1.131 ± 0.039
1.328MetVal: 1.328 ± 0.045
0.125MetTrp: 0.125 ± 0.014
0.492MetTyr: 0.492 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.39AsnAla: 2.39 ± 0.067
0.442AsnCys: 0.442 ± 0.028
2.508AsnAsp: 2.508 ± 0.062
3.058AsnGlu: 3.058 ± 0.079
3.092AsnPhe: 3.092 ± 0.079
2.702AsnGly: 2.702 ± 0.065
0.796AsnHis: 0.796 ± 0.037
5.038AsnIle: 5.038 ± 0.094
5.683AsnLys: 5.683 ± 0.119
7.133AsnLeu: 7.133 ± 0.119
1.226AsnMet: 1.226 ± 0.048
4.008AsnAsn: 4.008 ± 0.092
2.163AsnPro: 2.163 ± 0.054
2.883AsnGln: 2.883 ± 0.076
1.794AsnArg: 1.794 ± 0.048
3.792AsnSer: 3.792 ± 0.092
2.129AsnThr: 2.129 ± 0.056
2.298AsnVal: 2.298 ± 0.081
0.547AsnTrp: 0.547 ± 0.031
3.108AsnTyr: 3.108 ± 0.076
0.0AsnXaa: 0.0 ± 0.0
Pro
2.612ProAla: 2.612 ± 0.067
0.182ProCys: 0.182 ± 0.019
1.703ProAsp: 1.703 ± 0.045
2.931ProGlu: 2.931 ± 0.072
1.392ProPhe: 1.392 ± 0.049
2.099ProGly: 2.099 ± 0.056
0.504ProHis: 0.504 ± 0.026
2.315ProIle: 2.315 ± 0.058
1.986ProLys: 1.986 ± 0.062
2.985ProLeu: 2.985 ± 0.067
0.612ProMet: 0.612 ± 0.033
1.27ProAsn: 1.27 ± 0.036
0.755ProPro: 0.755 ± 0.039
1.229ProGln: 1.229 ± 0.039
0.895ProArg: 0.895 ± 0.035
1.374ProSer: 1.374 ± 0.043
1.469ProThr: 1.469 ± 0.045
2.256ProVal: 2.256 ± 0.063
0.239ProTrp: 0.239 ± 0.019
1.168ProTyr: 1.168 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
3.261GlnAla: 3.261 ± 0.078
0.144GlnCys: 0.144 ± 0.014
1.715GlnAsp: 1.715 ± 0.052
2.599GlnGlu: 2.599 ± 0.066
1.204GlnPhe: 1.204 ± 0.045
2.063GlnGly: 2.063 ± 0.056
0.442GlnHis: 0.442 ± 0.026
3.34GlnIle: 3.34 ± 0.076
4.068GlnLys: 4.068 ± 0.091
3.481GlnLeu: 3.481 ± 0.084
0.784GlnMet: 0.784 ± 0.032
2.189GlnAsn: 2.189 ± 0.069
0.891GlnPro: 0.891 ± 0.035
1.316GlnGln: 1.316 ± 0.049
1.422GlnArg: 1.422 ± 0.049
1.931GlnSer: 1.931 ± 0.064
1.663GlnThr: 1.663 ± 0.048
2.044GlnVal: 2.044 ± 0.053
0.169GlnTrp: 0.169 ± 0.019
1.026GlnTyr: 1.026 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.45ArgAla: 2.45 ± 0.06
0.227ArgCys: 0.227 ± 0.02
1.927ArgAsp: 1.927 ± 0.059
2.948ArgGlu: 2.948 ± 0.071
1.502ArgPhe: 1.502 ± 0.051
2.084ArgGly: 2.084 ± 0.057
0.513ArgHis: 0.513 ± 0.029
2.83ArgIle: 2.83 ± 0.063
3.097ArgLys: 3.097 ± 0.074
3.252ArgLeu: 3.252 ± 0.07
0.777ArgMet: 0.777 ± 0.035
1.786ArgAsn: 1.786 ± 0.051
0.986ArgPro: 0.986 ± 0.042
1.196ArgGln: 1.196 ± 0.041
1.46ArgArg: 1.46 ± 0.053
1.966ArgSer: 1.966 ± 0.052
1.429ArgThr: 1.429 ± 0.044
2.191ArgVal: 2.191 ± 0.064
0.262ArgTrp: 0.262 ± 0.021
1.315ArgTyr: 1.315 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
3.953SerAla: 3.953 ± 0.09
0.436SerCys: 0.436 ± 0.025
3.125SerAsp: 3.125 ± 0.068
4.303SerGlu: 4.303 ± 0.085
3.089SerPhe: 3.089 ± 0.071
4.279SerGly: 4.279 ± 0.097
0.901SerHis: 0.901 ± 0.04
4.684SerIle: 4.684 ± 0.082
4.431SerLys: 4.431 ± 0.083
6.703SerLeu: 6.703 ± 0.113
1.165SerMet: 1.165 ± 0.038
2.883SerAsn: 2.883 ± 0.081
1.711SerPro: 1.711 ± 0.056
2.556SerGln: 2.556 ± 0.067
2.209SerArg: 2.209 ± 0.056
3.804SerSer: 3.804 ± 0.097
2.596SerThr: 2.596 ± 0.074
3.224SerVal: 3.224 ± 0.074
0.529SerTrp: 0.529 ± 0.033
2.249SerTyr: 2.249 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
4.321ThrAla: 4.321 ± 0.082
0.212ThrCys: 0.212 ± 0.016
2.41ThrAsp: 2.41 ± 0.061
3.561ThrGlu: 3.561 ± 0.075
1.709ThrPhe: 1.709 ± 0.05
3.666ThrGly: 3.666 ± 0.075
0.691ThrHis: 0.691 ± 0.032
3.777ThrIle: 3.777 ± 0.083
3.821ThrLys: 3.821 ± 0.081
3.863ThrLeu: 3.863 ± 0.084
0.937ThrMet: 0.937 ± 0.038
2.209ThrAsn: 2.209 ± 0.065
1.628ThrPro: 1.628 ± 0.049
1.104ThrGln: 1.104 ± 0.043
1.389ThrArg: 1.389 ± 0.048
2.129ThrSer: 2.129 ± 0.057
2.336ThrThr: 2.336 ± 0.066
2.994ThrVal: 2.994 ± 0.076
0.221ThrTrp: 0.221 ± 0.018
1.346ThrTyr: 1.346 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
4.152ValAla: 4.152 ± 0.106
0.411ValCys: 0.411 ± 0.023
3.541ValAsp: 3.541 ± 0.078
5.004ValGlu: 5.004 ± 0.098
2.584ValPhe: 2.584 ± 0.065
3.921ValGly: 3.921 ± 0.091
0.735ValHis: 0.735 ± 0.032
5.584ValIle: 5.584 ± 0.098
5.188ValLys: 5.188 ± 0.085
5.655ValLeu: 5.655 ± 0.096
1.419ValMet: 1.419 ± 0.054
3.166ValAsn: 3.166 ± 0.076
1.89ValPro: 1.89 ± 0.059
1.513ValGln: 1.513 ± 0.045
1.834ValArg: 1.834 ± 0.06
3.424ValSer: 3.424 ± 0.083
2.437ValThr: 2.437 ± 0.074
3.866ValVal: 3.866 ± 0.09
0.348ValTrp: 0.348 ± 0.025
1.774ValTyr: 1.774 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.382TrpAla: 0.382 ± 0.024
0.034TrpCys: 0.034 ± 0.008
0.406TrpAsp: 0.406 ± 0.025
0.486TrpGlu: 0.486 ± 0.029
0.296TrpPhe: 0.296 ± 0.023
0.476TrpGly: 0.476 ± 0.031
0.11TrpHis: 0.11 ± 0.012
0.491TrpIle: 0.491 ± 0.031
0.486TrpLys: 0.486 ± 0.028
0.775TrpLeu: 0.775 ± 0.04
0.163TrpMet: 0.163 ± 0.016
0.378TrpAsn: 0.378 ± 0.029
0.264TrpPro: 0.264 ± 0.021
0.457TrpGln: 0.457 ± 0.026
0.268TrpArg: 0.268 ± 0.018
0.384TrpSer: 0.384 ± 0.023
0.308TrpThr: 0.308 ± 0.022
0.323TrpVal: 0.323 ± 0.022
0.084TrpTrp: 0.084 ± 0.012
0.23TrpTyr: 0.23 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.902TyrAla: 1.902 ± 0.055
0.291TyrCys: 0.291 ± 0.021
1.872TyrAsp: 1.872 ± 0.066
1.921TyrGlu: 1.921 ± 0.056
2.173TyrPhe: 2.173 ± 0.065
2.143TyrGly: 2.143 ± 0.064
0.673TyrHis: 0.673 ± 0.033
2.581TyrIle: 2.581 ± 0.075
2.69TyrLys: 2.69 ± 0.077
4.632TyrLeu: 4.632 ± 0.084
0.55TyrMet: 0.55 ± 0.026
2.364TyrAsn: 2.364 ± 0.057
1.285TyrPro: 1.285 ± 0.042
2.852TyrGln: 2.852 ± 0.079
1.39TyrArg: 1.39 ± 0.052
2.344TyrSer: 2.344 ± 0.06
1.491TyrThr: 1.491 ± 0.046
1.404TyrVal: 1.404 ± 0.047
0.282TyrTrp: 0.282 ± 0.022
1.754TyrTyr: 1.754 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2055 proteins (674614 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski