Amino acid dipepetide frequency for Methanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.003AlaAla: 6.003 ± 0.105
0.928AlaCys: 0.928 ± 0.04
4.311AlaAsp: 4.311 ± 0.073
4.516AlaGlu: 4.516 ± 0.075
2.894AlaPhe: 2.894 ± 0.065
5.807AlaGly: 5.807 ± 0.118
1.383AlaHis: 1.383 ± 0.043
5.813AlaIle: 5.813 ± 0.095
3.988AlaLys: 3.988 ± 0.084
6.686AlaLeu: 6.686 ± 0.118
2.126AlaMet: 2.126 ± 0.059
2.487AlaAsn: 2.487 ± 0.057
2.034AlaPro: 2.034 ± 0.054
2.082AlaGln: 2.082 ± 0.052
3.337AlaArg: 3.337 ± 0.075
4.71AlaSer: 4.71 ± 0.082
3.787AlaThr: 3.787 ± 0.096
5.526AlaVal: 5.526 ± 0.099
0.637AlaTrp: 0.637 ± 0.038
2.328AlaTyr: 2.328 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.831CysAla: 0.831 ± 0.03
0.222CysCys: 0.222 ± 0.019
0.712CysAsp: 0.712 ± 0.03
0.734CysGlu: 0.734 ± 0.035
0.404CysPhe: 0.404 ± 0.026
1.221CysGly: 1.221 ± 0.048
0.319CysHis: 0.319 ± 0.022
0.988CysIle: 0.988 ± 0.043
0.734CysLys: 0.734 ± 0.035
0.885CysLeu: 0.885 ± 0.038
0.366CysMet: 0.366 ± 0.021
0.55CysAsn: 0.55 ± 0.028
0.777CysPro: 0.777 ± 0.041
0.345CysGln: 0.345 ± 0.021
0.599CysArg: 0.599 ± 0.03
0.869CysSer: 0.869 ± 0.036
0.694CysThr: 0.694 ± 0.032
0.744CysVal: 0.744 ± 0.033
0.078CysTrp: 0.078 ± 0.009
0.411CysTyr: 0.411 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
4.051AspAla: 4.051 ± 0.084
0.582AspCys: 0.582 ± 0.032
2.714AspAsp: 2.714 ± 0.063
3.921AspGlu: 3.921 ± 0.076
2.555AspPhe: 2.555 ± 0.064
3.665AspGly: 3.665 ± 0.075
1.147AspHis: 1.147 ± 0.036
5.579AspIle: 5.579 ± 0.088
3.393AspLys: 3.393 ± 0.072
5.401AspLeu: 5.401 ± 0.085
1.905AspMet: 1.905 ± 0.053
2.445AspAsn: 2.445 ± 0.064
2.638AspPro: 2.638 ± 0.063
1.316AspGln: 1.316 ± 0.044
2.467AspArg: 2.467 ± 0.062
3.265AspSer: 3.265 ± 0.074
3.178AspThr: 3.178 ± 0.077
4.547AspVal: 4.547 ± 0.086
0.573AspTrp: 0.573 ± 0.032
1.927AspTyr: 1.927 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.788GluAla: 4.788 ± 0.08
0.765GluCys: 0.765 ± 0.035
3.775GluAsp: 3.775 ± 0.069
5.586GluGlu: 5.586 ± 0.095
2.501GluPhe: 2.501 ± 0.052
4.175GluGly: 4.175 ± 0.083
1.601GluHis: 1.601 ± 0.053
5.868GluIle: 5.868 ± 0.108
5.724GluLys: 5.724 ± 0.104
6.764GluLeu: 6.764 ± 0.115
2.431GluMet: 2.431 ± 0.051
3.561GluAsn: 3.561 ± 0.065
2.1GluPro: 2.1 ± 0.055
2.28GluGln: 2.28 ± 0.057
3.178GluArg: 3.178 ± 0.062
3.653GluSer: 3.653 ± 0.076
3.354GluThr: 3.354 ± 0.073
4.835GluVal: 4.835 ± 0.089
0.678GluTrp: 0.678 ± 0.035
2.649GluTyr: 2.649 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
2.778PheAla: 2.778 ± 0.072
0.522PheCys: 0.522 ± 0.027
2.61PheAsp: 2.61 ± 0.066
2.621PheGlu: 2.621 ± 0.057
1.788PhePhe: 1.788 ± 0.061
2.83PheGly: 2.83 ± 0.07
0.681PheHis: 0.681 ± 0.033
3.162PheIle: 3.162 ± 0.061
2.192PheLys: 2.192 ± 0.062
3.672PheLeu: 3.672 ± 0.088
1.145PheMet: 1.145 ± 0.046
1.596PheAsn: 1.596 ± 0.047
1.431PhePro: 1.431 ± 0.043
0.957PheGln: 0.957 ± 0.036
1.744PheArg: 1.744 ± 0.052
3.001PheSer: 3.001 ± 0.062
2.258PheThr: 2.258 ± 0.056
2.763PheVal: 2.763 ± 0.062
0.35PheTrp: 0.35 ± 0.024
1.39PheTyr: 1.39 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
4.719GlyAla: 4.719 ± 0.092
0.963GlyCys: 0.963 ± 0.044
3.499GlyAsp: 3.499 ± 0.081
4.049GlyGlu: 4.049 ± 0.085
3.127GlyPhe: 3.127 ± 0.067
4.575GlyGly: 4.575 ± 0.108
1.446GlyHis: 1.446 ± 0.043
6.552GlyIle: 6.552 ± 0.087
5.155GlyLys: 5.155 ± 0.075
5.854GlyLeu: 5.854 ± 0.106
2.301GlyMet: 2.301 ± 0.062
3.279GlyAsn: 3.279 ± 0.093
1.95GlyPro: 1.95 ± 0.057
1.793GlyGln: 1.793 ± 0.054
2.931GlyArg: 2.931 ± 0.062
4.779GlySer: 4.779 ± 0.089
4.542GlyThr: 4.542 ± 0.09
4.893GlyVal: 4.893 ± 0.095
0.753GlyTrp: 0.753 ± 0.034
2.723GlyTyr: 2.723 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.434HisAla: 1.434 ± 0.046
0.334HisCys: 0.334 ± 0.021
1.128HisAsp: 1.128 ± 0.044
1.359HisGlu: 1.359 ± 0.044
0.787HisPhe: 0.787 ± 0.035
1.401HisGly: 1.401 ± 0.042
0.423HisHis: 0.423 ± 0.026
1.7HisIle: 1.7 ± 0.054
0.924HisLys: 0.924 ± 0.036
1.806HisLeu: 1.806 ± 0.051
0.617HisMet: 0.617 ± 0.028
0.867HisAsn: 0.867 ± 0.037
1.006HisPro: 1.006 ± 0.037
0.524HisGln: 0.524 ± 0.03
0.996HisArg: 0.996 ± 0.043
1.194HisSer: 1.194 ± 0.044
0.998HisThr: 0.998 ± 0.04
1.494HisVal: 1.494 ± 0.046
0.169HisTrp: 0.169 ± 0.015
0.703HisTyr: 0.703 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.336IleAla: 6.336 ± 0.099
0.988IleCys: 0.988 ± 0.034
5.129IleAsp: 5.129 ± 0.087
5.944IleGlu: 5.944 ± 0.099
3.042IlePhe: 3.042 ± 0.073
5.891IleGly: 5.891 ± 0.081
1.561IleHis: 1.561 ± 0.046
6.147IleIle: 6.147 ± 0.115
4.969IleLys: 4.969 ± 0.096
7.085IleLeu: 7.085 ± 0.107
2.125IleMet: 2.125 ± 0.052
3.31IleAsn: 3.31 ± 0.07
3.611IlePro: 3.611 ± 0.064
2.095IleGln: 2.095 ± 0.055
3.766IleArg: 3.766 ± 0.077
6.274IleSer: 6.274 ± 0.1
4.848IleThr: 4.848 ± 0.086
5.834IleVal: 5.834 ± 0.1
0.644IleTrp: 0.644 ± 0.033
2.541IleTyr: 2.541 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.484LysAla: 4.484 ± 0.085
0.831LysCys: 0.831 ± 0.037
3.945LysAsp: 3.945 ± 0.082
5.551LysGlu: 5.551 ± 0.108
1.971LysPhe: 1.971 ± 0.054
4.181LysGly: 4.181 ± 0.081
1.286LysHis: 1.286 ± 0.037
5.095LysIle: 5.095 ± 0.101
5.028LysLys: 5.028 ± 0.094
5.409LysLeu: 5.409 ± 0.096
2.042LysMet: 2.042 ± 0.052
3.044LysAsn: 3.044 ± 0.062
2.046LysPro: 2.046 ± 0.052
1.906LysGln: 1.906 ± 0.059
2.787LysArg: 2.787 ± 0.06
3.329LysSer: 3.329 ± 0.067
3.239LysThr: 3.239 ± 0.075
4.394LysVal: 4.394 ± 0.068
0.609LysTrp: 0.609 ± 0.031
2.431LysTyr: 2.431 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
6.713LeuAla: 6.713 ± 0.099
1.063LeuCys: 1.063 ± 0.041
5.163LeuAsp: 5.163 ± 0.091
6.596LeuGlu: 6.596 ± 0.092
3.722LeuPhe: 3.722 ± 0.088
5.962LeuGly: 5.962 ± 0.113
1.806LeuHis: 1.806 ± 0.058
6.884LeuIle: 6.884 ± 0.103
6.316LeuLys: 6.316 ± 0.102
8.817LeuLeu: 8.817 ± 0.143
2.611LeuMet: 2.611 ± 0.061
3.935LeuAsn: 3.935 ± 0.074
3.616LeuPro: 3.616 ± 0.08
2.934LeuGln: 2.934 ± 0.071
3.998LeuArg: 3.998 ± 0.081
6.516LeuSer: 6.516 ± 0.104
4.605LeuThr: 4.605 ± 0.075
5.992LeuVal: 5.992 ± 0.101
0.721LeuTrp: 0.721 ± 0.031
2.75LeuTyr: 2.75 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.186MetAla: 2.186 ± 0.058
0.373MetCys: 0.373 ± 0.023
1.87MetAsp: 1.87 ± 0.052
2.19MetGlu: 2.19 ± 0.064
1.037MetPhe: 1.037 ± 0.041
2.24MetGly: 2.24 ± 0.055
0.673MetHis: 0.673 ± 0.032
2.192MetIle: 2.192 ± 0.063
1.873MetLys: 1.873 ± 0.056
2.769MetLeu: 2.769 ± 0.063
0.911MetMet: 0.911 ± 0.04
1.322MetAsn: 1.322 ± 0.042
1.16MetPro: 1.16 ± 0.045
1.102MetGln: 1.102 ± 0.041
1.395MetArg: 1.395 ± 0.045
1.902MetSer: 1.902 ± 0.055
1.547MetThr: 1.547 ± 0.045
2.02MetVal: 2.02 ± 0.059
0.211MetTrp: 0.211 ± 0.02
0.871MetTyr: 0.871 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.087AsnAla: 3.087 ± 0.069
0.547AsnCys: 0.547 ± 0.027
2.247AsnAsp: 2.247 ± 0.059
2.737AsnGlu: 2.737 ± 0.062
1.512AsnPhe: 1.512 ± 0.048
3.008AsnGly: 3.008 ± 0.086
0.687AsnHis: 0.687 ± 0.035
4.173AsnIle: 4.173 ± 0.079
2.448AsnLys: 2.448 ± 0.059
3.628AsnLeu: 3.628 ± 0.078
1.326AsnMet: 1.326 ± 0.039
2.271AsnAsn: 2.271 ± 0.079
2.089AsnPro: 2.089 ± 0.059
1.108AsnGln: 1.108 ± 0.044
1.87AsnArg: 1.87 ± 0.05
2.874AsnSer: 2.874 ± 0.073
2.663AsnThr: 2.663 ± 0.07
3.311AsnVal: 3.311 ± 0.075
0.442AsnTrp: 0.442 ± 0.025
1.622AsnTyr: 1.622 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
2.794ProAla: 2.794 ± 0.063
0.447ProCys: 0.447 ± 0.025
2.391ProAsp: 2.391 ± 0.058
3.406ProGlu: 3.406 ± 0.069
1.61ProPhe: 1.61 ± 0.051
2.761ProGly: 2.761 ± 0.065
0.783ProHis: 0.783 ± 0.032
2.607ProIle: 2.607 ± 0.066
1.998ProLys: 1.998 ± 0.057
3.411ProLeu: 3.411 ± 0.062
0.908ProMet: 0.908 ± 0.033
1.343ProAsn: 1.343 ± 0.041
1.261ProPro: 1.261 ± 0.044
1.3ProGln: 1.3 ± 0.049
1.461ProArg: 1.461 ± 0.044
2.557ProSer: 2.557 ± 0.066
1.963ProThr: 1.963 ± 0.063
3.436ProVal: 3.436 ± 0.074
0.357ProTrp: 0.357 ± 0.022
1.36ProTyr: 1.36 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.047GlnAla: 2.047 ± 0.054
0.369GlnCys: 0.369 ± 0.022
1.481GlnAsp: 1.481 ± 0.046
2.188GlnGlu: 2.188 ± 0.055
1.018GlnPhe: 1.018 ± 0.038
1.689GlnGly: 1.689 ± 0.043
0.552GlnHis: 0.552 ± 0.029
2.41GlnIle: 2.41 ± 0.06
2.229GlnLys: 2.229 ± 0.06
2.752GlnLeu: 2.752 ± 0.063
1.0GlnMet: 1.0 ± 0.039
1.373GlnAsn: 1.373 ± 0.038
0.895GlnPro: 0.895 ± 0.036
1.166GlnGln: 1.166 ± 0.044
1.514GlnArg: 1.514 ± 0.046
1.617GlnSer: 1.617 ± 0.052
1.433GlnThr: 1.433 ± 0.042
1.976GlnVal: 1.976 ± 0.052
0.31GlnTrp: 0.31 ± 0.018
1.028GlnTyr: 1.028 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.808ArgAla: 2.808 ± 0.063
0.589ArgCys: 0.589 ± 0.033
2.581ArgAsp: 2.581 ± 0.062
3.359ArgGlu: 3.359 ± 0.064
1.842ArgPhe: 1.842 ± 0.052
2.562ArgGly: 2.562 ± 0.068
0.817ArgHis: 0.817 ± 0.037
3.777ArgIle: 3.777 ± 0.076
3.183ArgLys: 3.183 ± 0.068
3.871ArgLeu: 3.871 ± 0.08
1.43ArgMet: 1.43 ± 0.047
2.087ArgAsn: 2.087 ± 0.054
1.526ArgPro: 1.526 ± 0.044
1.36ArgGln: 1.36 ± 0.042
2.047ArgArg: 2.047 ± 0.056
2.996ArgSer: 2.996 ± 0.072
2.479ArgThr: 2.479 ± 0.055
2.763ArgVal: 2.763 ± 0.066
0.44ArgTrp: 0.44 ± 0.027
1.767ArgTyr: 1.767 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.251SerAla: 4.251 ± 0.09
0.758SerCys: 0.758 ± 0.033
3.591SerAsp: 3.591 ± 0.08
4.311SerGlu: 4.311 ± 0.079
2.786SerPhe: 2.786 ± 0.057
5.378SerGly: 5.378 ± 0.107
1.276SerHis: 1.276 ± 0.041
5.596SerIle: 5.596 ± 0.103
3.911SerLys: 3.911 ± 0.069
6.052SerLeu: 6.052 ± 0.091
2.029SerMet: 2.029 ± 0.049
2.746SerAsn: 2.746 ± 0.072
2.541SerPro: 2.541 ± 0.065
1.907SerGln: 1.907 ± 0.045
3.039SerArg: 3.039 ± 0.061
5.096SerSer: 5.096 ± 0.115
3.845SerThr: 3.845 ± 0.103
4.488SerVal: 4.488 ± 0.078
0.672SerTrp: 0.672 ± 0.037
2.292SerTyr: 2.292 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.076ThrAla: 4.076 ± 0.089
0.675ThrCys: 0.675 ± 0.027
3.232ThrAsp: 3.232 ± 0.083
3.603ThrGlu: 3.603 ± 0.073
2.073ThrPhe: 2.073 ± 0.058
4.706ThrGly: 4.706 ± 0.108
1.093ThrHis: 1.093 ± 0.037
4.574ThrIle: 4.574 ± 0.093
2.872ThrLys: 2.872 ± 0.057
4.901ThrLeu: 4.901 ± 0.077
1.411ThrMet: 1.411 ± 0.046
2.201ThrAsn: 2.201 ± 0.078
2.529ThrPro: 2.529 ± 0.063
1.422ThrGln: 1.422 ± 0.044
2.216ThrArg: 2.216 ± 0.054
3.768ThrSer: 3.768 ± 0.092
3.547ThrThr: 3.547 ± 0.114
4.149ThrVal: 4.149 ± 0.115
0.493ThrTrp: 0.493 ± 0.028
1.998ThrTyr: 1.998 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.072ValAla: 5.072 ± 0.091
0.978ValCys: 0.978 ± 0.042
4.129ValAsp: 4.129 ± 0.074
4.742ValGlu: 4.742 ± 0.082
2.933ValPhe: 2.933 ± 0.062
4.707ValGly: 4.707 ± 0.105
1.465ValHis: 1.465 ± 0.045
5.768ValIle: 5.768 ± 0.083
4.181ValLys: 4.181 ± 0.075
6.864ValLeu: 6.864 ± 0.104
2.043ValMet: 2.043 ± 0.052
2.826ValAsn: 2.826 ± 0.06
3.08ValPro: 3.08 ± 0.076
2.181ValGln: 2.181 ± 0.058
2.996ValArg: 2.996 ± 0.073
5.041ValSer: 5.041 ± 0.09
4.166ValThr: 4.166 ± 0.11
5.395ValVal: 5.395 ± 0.107
0.586ValTrp: 0.586 ± 0.034
2.384ValTyr: 2.384 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.58TrpAla: 0.58 ± 0.029
0.108TrpCys: 0.108 ± 0.012
0.644TrpAsp: 0.644 ± 0.039
0.599TrpGlu: 0.599 ± 0.03
0.399TrpPhe: 0.399 ± 0.024
0.569TrpGly: 0.569 ± 0.031
0.171TrpHis: 0.171 ± 0.016
0.679TrpIle: 0.679 ± 0.031
0.704TrpLys: 0.704 ± 0.033
0.854TrpLeu: 0.854 ± 0.039
0.268TrpMet: 0.268 ± 0.02
0.605TrpAsn: 0.605 ± 0.034
0.235TrpPro: 0.235 ± 0.018
0.296TrpGln: 0.296 ± 0.022
0.331TrpArg: 0.331 ± 0.021
0.596TrpSer: 0.596 ± 0.03
0.508TrpThr: 0.508 ± 0.034
0.563TrpVal: 0.563 ± 0.024
0.118TrpTrp: 0.118 ± 0.013
0.392TrpTyr: 0.392 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.344TyrAla: 2.344 ± 0.056
0.437TyrCys: 0.437 ± 0.026
2.117TyrAsp: 2.117 ± 0.068
2.253TyrGlu: 2.253 ± 0.06
1.491TyrPhe: 1.491 ± 0.049
2.549TyrGly: 2.549 ± 0.059
0.694TyrHis: 0.694 ± 0.027
2.577TyrIle: 2.577 ± 0.062
1.787TyrLys: 1.787 ± 0.056
3.242TyrLeu: 3.242 ± 0.066
0.85TyrMet: 0.85 ± 0.031
1.8TyrAsn: 1.8 ± 0.058
1.628TyrPro: 1.628 ± 0.048
0.972TyrGln: 0.972 ± 0.034
1.612TyrArg: 1.612 ± 0.048
2.529TyrSer: 2.529 ± 0.062
1.886TyrThr: 1.886 ± 0.057
2.417TyrVal: 2.417 ± 0.068
0.38TyrTrp: 0.38 ± 0.025
1.478TyrTyr: 1.478 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2551 proteins (771326 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski