Amino acid dipepetide frequency for Thalassolituus oleivorans MIL-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.68AlaAla: 9.68 ± 0.136	0.969AlaCys: 0.969 ± 0.032	5.872AlaAsp: 5.872 ± 0.099	6.395AlaGlu: 6.395 ± 0.083	3.366AlaPhe: 3.366 ± 0.057	6.877AlaGly: 6.877 ± 0.109	1.833AlaHis: 1.833 ± 0.049	5.98AlaIle: 5.98 ± 0.083	4.17AlaLys: 4.17 ± 0.075	10.524AlaLeu: 10.524 ± 0.132	2.843AlaMet: 2.843 ± 0.051	3.675AlaAsn: 3.675 ± 0.073	3.443AlaPro: 3.443 ± 0.077	3.876AlaGln: 3.876 ± 0.066	4.467AlaArg: 4.467 ± 0.061	5.834AlaSer: 5.834 ± 0.089	5.154AlaThr: 5.154 ± 0.124	6.447AlaVal: 6.447 ± 0.085	1.196AlaTrp: 1.196 ± 0.038	2.439AlaTyr: 2.439 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.802CysAla: 0.802 ± 0.029	0.126CysCys: 0.126 ± 0.01	0.586CysAsp: 0.586 ± 0.027	0.537CysGlu: 0.537 ± 0.019	0.341CysPhe: 0.341 ± 0.018	0.819CysGly: 0.819 ± 0.029	0.31CysHis: 0.31 ± 0.02	0.569CysIle: 0.569 ± 0.028	0.387CysLys: 0.387 ± 0.021	0.964CysLeu: 0.964 ± 0.031	0.233CysMet: 0.233 ± 0.015	0.314CysAsn: 0.314 ± 0.017	0.489CysPro: 0.489 ± 0.023	0.417CysGln: 0.417 ± 0.018	0.543CysArg: 0.543 ± 0.024	0.603CysSer: 0.603 ± 0.024	0.466CysThr: 0.466 ± 0.023	0.642CysVal: 0.642 ± 0.025	0.114CysTrp: 0.114 ± 0.01	0.31CysTyr: 0.31 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.541AspAla: 5.541 ± 0.098	0.553AspCys: 0.553 ± 0.025	3.865AspAsp: 3.865 ± 0.086	4.063AspGlu: 4.063 ± 0.06	2.448AspPhe: 2.448 ± 0.051	4.593AspGly: 4.593 ± 0.133	1.24AspHis: 1.24 ± 0.034	4.14AspIle: 4.14 ± 0.066	2.516AspLys: 2.516 ± 0.06	5.831AspLeu: 5.831 ± 0.083	1.548AspMet: 1.548 ± 0.043	2.37AspAsn: 2.37 ± 0.064	2.288AspPro: 2.288 ± 0.05	2.243AspGln: 2.243 ± 0.049	2.795AspArg: 2.795 ± 0.055	3.617AspSer: 3.617 ± 0.069	3.178AspThr: 3.178 ± 0.072	4.453AspVal: 4.453 ± 0.083	0.961AspTrp: 0.961 ± 0.028	1.987AspTyr: 1.987 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.715GluAla: 5.715 ± 0.092	0.539GluCys: 0.539 ± 0.022	3.037GluAsp: 3.037 ± 0.055	3.637GluGlu: 3.637 ± 0.07	2.419GluPhe: 2.419 ± 0.048	3.714GluGly: 3.714 ± 0.062	1.675GluHis: 1.675 ± 0.042	3.595GluIle: 3.595 ± 0.063	3.116GluLys: 3.116 ± 0.067	6.846GluLeu: 6.846 ± 0.08	1.623GluMet: 1.623 ± 0.041	2.388GluAsn: 2.388 ± 0.047	2.075GluPro: 2.075 ± 0.048	3.618GluGln: 3.618 ± 0.072	4.029GluArg: 4.029 ± 0.068	3.455GluSer: 3.455 ± 0.059	3.031GluThr: 3.031 ± 0.061	4.187GluVal: 4.187 ± 0.067	0.879GluTrp: 0.879 ± 0.027	1.852GluTyr: 1.852 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.469PheAla: 3.469 ± 0.057	0.445PheCys: 0.445 ± 0.02	2.661PheAsp: 2.661 ± 0.063	2.215PheGlu: 2.215 ± 0.05	1.601PhePhe: 1.601 ± 0.044	2.901PheGly: 2.901 ± 0.061	0.739PheHis: 0.739 ± 0.027	2.38PheIle: 2.38 ± 0.051	1.611PheLys: 1.611 ± 0.041	3.273PheLeu: 3.273 ± 0.064	1.013PheMet: 1.013 ± 0.031	1.821PheAsn: 1.821 ± 0.04	1.469PhePro: 1.469 ± 0.043	1.202PheGln: 1.202 ± 0.036	1.77PheArg: 1.77 ± 0.046	2.956PheSer: 2.956 ± 0.057	2.228PheThr: 2.228 ± 0.05	2.511PheVal: 2.511 ± 0.058	0.554PheTrp: 0.554 ± 0.023	1.208PheTyr: 1.208 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.778GlyAla: 5.778 ± 0.095	0.845GlyCys: 0.845 ± 0.029	4.259GlyAsp: 4.259 ± 0.076	4.348GlyGlu: 4.348 ± 0.06	3.101GlyPhe: 3.101 ± 0.057	4.963GlyGly: 4.963 ± 0.088	1.628GlyHis: 1.628 ± 0.037	4.644GlyIle: 4.644 ± 0.068	3.428GlyLys: 3.428 ± 0.066	7.256GlyLeu: 7.256 ± 0.096	2.048GlyMet: 2.048 ± 0.049	2.62GlyAsn: 2.62 ± 0.065	1.831GlyPro: 1.831 ± 0.045	2.712GlyGln: 2.712 ± 0.05	3.683GlyArg: 3.683 ± 0.061	4.392GlySer: 4.392 ± 0.09	3.757GlyThr: 3.757 ± 0.074	5.278GlyVal: 5.278 ± 0.078	1.053GlyTrp: 1.053 ± 0.034	2.49GlyTyr: 2.49 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.769HisAla: 1.769 ± 0.046	0.326HisCys: 0.326 ± 0.017	1.205HisAsp: 1.205 ± 0.031	1.218HisGlu: 1.218 ± 0.035	1.003HisPhe: 1.003 ± 0.027	1.613HisGly: 1.613 ± 0.043	0.67HisHis: 0.67 ± 0.027	1.406HisIle: 1.406 ± 0.037	0.876HisLys: 0.876 ± 0.025	2.28HisLeu: 2.28 ± 0.048	0.568HisMet: 0.568 ± 0.025	0.799HisAsn: 0.799 ± 0.026	1.202HisPro: 1.202 ± 0.036	1.011HisGln: 1.011 ± 0.031	1.174HisArg: 1.174 ± 0.033	1.353HisSer: 1.353 ± 0.033	1.099HisThr: 1.099 ± 0.034	1.248HisVal: 1.248 ± 0.038	0.424HisTrp: 0.424 ± 0.021	0.772HisTyr: 0.772 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.364IleAla: 6.364 ± 0.084	0.57IleCys: 0.57 ± 0.026	4.143IleAsp: 4.143 ± 0.058	4.268IleGlu: 4.268 ± 0.064	1.976IlePhe: 1.976 ± 0.051	4.416IleGly: 4.416 ± 0.066	1.291IleHis: 1.291 ± 0.036	3.168IleIle: 3.168 ± 0.057	2.611IleLys: 2.611 ± 0.05	5.09IleLeu: 5.09 ± 0.076	1.262IleMet: 1.262 ± 0.035	2.744IleAsn: 2.744 ± 0.06	2.772IlePro: 2.772 ± 0.051	2.232IleGln: 2.232 ± 0.047	3.388IleArg: 3.388 ± 0.054	4.137IleSer: 4.137 ± 0.062	3.536IleThr: 3.536 ± 0.063	3.853IleVal: 3.853 ± 0.067	0.652IleTrp: 0.652 ± 0.026	1.536IleTyr: 1.536 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.569LysAla: 4.569 ± 0.081	0.294LysCys: 0.294 ± 0.017	2.595LysAsp: 2.595 ± 0.059	2.697LysGlu: 2.697 ± 0.064	1.23LysPhe: 1.23 ± 0.036	2.87LysGly: 2.87 ± 0.058	0.959LysHis: 0.959 ± 0.027	2.388LysIle: 2.388 ± 0.047	2.255LysLys: 2.255 ± 0.058	4.134LysLeu: 4.134 ± 0.065	1.099LysMet: 1.099 ± 0.031	1.867LysAsn: 1.867 ± 0.043	2.116LysPro: 2.116 ± 0.047	2.085LysGln: 2.085 ± 0.039	2.65LysArg: 2.65 ± 0.055	2.731LysSer: 2.731 ± 0.045	2.589LysThr: 2.589 ± 0.052	3.05LysVal: 3.05 ± 0.06	0.435LysTrp: 0.435 ± 0.019	1.121LysTyr: 1.121 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	10.66LeuAla: 10.66 ± 0.118	0.959LeuCys: 0.959 ± 0.032	6.068LeuAsp: 6.068 ± 0.09	5.92LeuGlu: 5.92 ± 0.097	3.744LeuPhe: 3.744 ± 0.077	6.894LeuGly: 6.894 ± 0.091	2.139LeuHis: 2.139 ± 0.047	5.912LeuIle: 5.912 ± 0.076	4.673LeuLys: 4.673 ± 0.076	11.073LeuLeu: 11.073 ± 0.165	2.698LeuMet: 2.698 ± 0.049	4.561LeuAsn: 4.561 ± 0.068	5.044LeuPro: 5.044 ± 0.069	4.234LeuGln: 4.234 ± 0.067	5.467LeuArg: 5.467 ± 0.074	7.359LeuSer: 7.359 ± 0.092	6.291LeuThr: 6.291 ± 0.1	6.884LeuVal: 6.884 ± 0.096	1.194LeuTrp: 1.194 ± 0.037	2.603LeuTyr: 2.603 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.745MetAla: 2.745 ± 0.047	0.192MetCys: 0.192 ± 0.012	1.381MetAsp: 1.381 ± 0.035	1.284MetGlu: 1.284 ± 0.036	0.782MetPhe: 0.782 ± 0.027	1.797MetGly: 1.797 ± 0.04	0.518MetHis: 0.518 ± 0.021	1.458MetIle: 1.458 ± 0.041	1.313MetLys: 1.313 ± 0.031	2.654MetLeu: 2.654 ± 0.056	0.79MetMet: 0.79 ± 0.03	1.15MetAsn: 1.15 ± 0.032	1.335MetPro: 1.335 ± 0.035	1.146MetGln: 1.146 ± 0.03	1.39MetArg: 1.39 ± 0.035	1.928MetSer: 1.928 ± 0.041	1.736MetThr: 1.736 ± 0.038	1.711MetVal: 1.711 ± 0.041	0.209MetTrp: 0.209 ± 0.015	0.474MetTyr: 0.474 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.882AsnAla: 3.882 ± 0.087	0.384AsnCys: 0.384 ± 0.02	2.576AsnAsp: 2.576 ± 0.054	2.305AsnGlu: 2.305 ± 0.048	1.4AsnPhe: 1.4 ± 0.04	3.098AsnGly: 3.098 ± 0.067	0.84AsnHis: 0.84 ± 0.031	2.491AsnIle: 2.491 ± 0.056	1.746AsnLys: 1.746 ± 0.042	3.727AsnLeu: 3.727 ± 0.055	0.954AsnMet: 0.954 ± 0.026	1.793AsnAsn: 1.793 ± 0.052	2.136AsnPro: 2.136 ± 0.049	1.67AsnGln: 1.67 ± 0.038	2.081AsnArg: 2.081 ± 0.044	2.685AsnSer: 2.685 ± 0.086	2.31AsnThr: 2.31 ± 0.065	2.474AsnVal: 2.474 ± 0.05	0.557AsnTrp: 0.557 ± 0.025	1.256AsnTyr: 1.256 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.801ProAla: 3.801 ± 0.064	0.308ProCys: 0.308 ± 0.016	2.776ProAsp: 2.776 ± 0.059	3.39ProGlu: 3.39 ± 0.059	1.615ProPhe: 1.615 ± 0.036	2.626ProGly: 2.626 ± 0.049	0.882ProHis: 0.882 ± 0.032	2.36ProIle: 2.36 ± 0.046	1.84ProLys: 1.84 ± 0.039	4.28ProLeu: 4.28 ± 0.066	1.124ProMet: 1.124 ± 0.03	1.733ProAsn: 1.733 ± 0.045	1.289ProPro: 1.289 ± 0.041	1.611ProGln: 1.611 ± 0.036	1.661ProArg: 1.661 ± 0.043	2.528ProSer: 2.528 ± 0.054	2.225ProThr: 2.225 ± 0.046	3.329ProVal: 3.329 ± 0.061	0.564ProTrp: 0.564 ± 0.024	1.164ProTyr: 1.164 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.41GlnAla: 4.41 ± 0.068	0.378GlnCys: 0.378 ± 0.02	1.88GlnAsp: 1.88 ± 0.043	2.251GlnGlu: 2.251 ± 0.052	1.64GlnPhe: 1.64 ± 0.04	2.782GlnGly: 2.782 ± 0.049	1.089GlnHis: 1.089 ± 0.033	2.354GlnIle: 2.354 ± 0.041	1.706GlnLys: 1.706 ± 0.04	4.982GlnLeu: 4.982 ± 0.078	1.041GlnMet: 1.041 ± 0.035	1.449GlnAsn: 1.449 ± 0.037	1.712GlnPro: 1.712 ± 0.043	2.897GlnGln: 2.897 ± 0.07	2.992GlnArg: 2.992 ± 0.059	2.47GlnSer: 2.47 ± 0.05	2.199GlnThr: 2.199 ± 0.048	3.0GlnVal: 3.0 ± 0.059	0.785GlnTrp: 0.785 ± 0.023	1.195GlnTyr: 1.195 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	4.275ArgAla: 4.275 ± 0.074	0.459ArgCys: 0.459 ± 0.021	3.037ArgAsp: 3.037 ± 0.06	3.387ArgGlu: 3.387 ± 0.062	2.364ArgPhe: 2.364 ± 0.045	3.023ArgGly: 3.023 ± 0.06	1.39ArgHis: 1.39 ± 0.036	3.584ArgIle: 3.584 ± 0.059	2.367ArgLys: 2.367 ± 0.053	6.005ArgLeu: 6.005 ± 0.08	1.503ArgMet: 1.503 ± 0.038	2.1ArgAsn: 2.1 ± 0.043	1.936ArgPro: 1.936 ± 0.05	2.546ArgGln: 2.546 ± 0.049	3.133ArgArg: 3.133 ± 0.066	3.09ArgSer: 3.09 ± 0.047	2.512ArgThr: 2.512 ± 0.05	3.61ArgVal: 3.61 ± 0.062	0.89ArgTrp: 0.89 ± 0.028	2.039ArgTyr: 2.039 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.195SerAla: 6.195 ± 0.086	0.558SerCys: 0.558 ± 0.025	4.041SerAsp: 4.041 ± 0.089	3.906SerGlu: 3.906 ± 0.059	2.43SerPhe: 2.43 ± 0.053	5.273SerGly: 5.273 ± 0.096	1.416SerHis: 1.416 ± 0.039	3.779SerIle: 3.779 ± 0.058	2.607SerLys: 2.607 ± 0.056	6.726SerLeu: 6.726 ± 0.087	1.63SerMet: 1.63 ± 0.038	2.556SerAsn: 2.556 ± 0.064	2.474SerPro: 2.474 ± 0.051	2.644SerGln: 2.644 ± 0.047	3.208SerArg: 3.208 ± 0.058	4.391SerSer: 4.391 ± 0.095	3.45SerThr: 3.45 ± 0.07	4.545SerVal: 4.545 ± 0.077	0.875SerTrp: 0.875 ± 0.028	2.011SerTyr: 2.011 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	5.222ThrAla: 5.222 ± 0.135	0.478ThrCys: 0.478 ± 0.021	3.53ThrAsp: 3.53 ± 0.079	3.176ThrGlu: 3.176 ± 0.062	1.981ThrPhe: 1.981 ± 0.072	4.419ThrGly: 4.419 ± 0.095	1.13ThrHis: 1.13 ± 0.034	3.143ThrIle: 3.143 ± 0.058	1.912ThrLys: 1.912 ± 0.049	6.506ThrLeu: 6.506 ± 0.086	1.128ThrMet: 1.128 ± 0.031	2.076ThrAsn: 2.076 ± 0.047	2.948ThrPro: 2.948 ± 0.062	2.186ThrGln: 2.186 ± 0.049	2.59ThrArg: 2.59 ± 0.049	3.573ThrSer: 3.573 ± 0.074	3.16ThrThr: 3.16 ± 0.066	3.794ThrVal: 3.794 ± 0.088	0.622ThrTrp: 0.622 ± 0.025	1.574ThrTyr: 1.574 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.803ValAla: 6.803 ± 0.103	0.709ValCys: 0.709 ± 0.024	4.323ValAsp: 4.323 ± 0.067	4.217ValGlu: 4.217 ± 0.066	2.704ValPhe: 2.704 ± 0.057	4.592ValGly: 4.592 ± 0.075	1.25ValHis: 1.25 ± 0.035	4.374ValIle: 4.374 ± 0.066	2.937ValLys: 2.937 ± 0.056	6.917ValLeu: 6.917 ± 0.082	1.917ValMet: 1.917 ± 0.049	2.809ValAsn: 2.809 ± 0.064	2.654ValPro: 2.654 ± 0.056	2.333ValGln: 2.333 ± 0.052	3.573ValArg: 3.573 ± 0.065	4.778ValSer: 4.778 ± 0.08	4.23ValThr: 4.23 ± 0.086	5.379ValVal: 5.379 ± 0.083	0.809ValTrp: 0.809 ± 0.03	1.793ValTyr: 1.793 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.988TrpAla: 0.988 ± 0.033	0.145TrpCys: 0.145 ± 0.011	0.682TrpAsp: 0.682 ± 0.03	0.554TrpGlu: 0.554 ± 0.024	0.577TrpPhe: 0.577 ± 0.025	0.78TrpGly: 0.78 ± 0.028	0.39TrpHis: 0.39 ± 0.019	0.727TrpIle: 0.727 ± 0.029	0.45TrpLys: 0.45 ± 0.021	2.08TrpLeu: 2.08 ± 0.059	0.39TrpMet: 0.39 ± 0.018	0.493TrpAsn: 0.493 ± 0.021	0.562TrpPro: 0.562 ± 0.019	0.964TrpGln: 0.964 ± 0.035	0.792TrpArg: 0.792 ± 0.025	0.804TrpSer: 0.804 ± 0.029	0.591TrpThr: 0.591 ± 0.027	0.918TrpVal: 0.918 ± 0.026	0.193TrpTrp: 0.193 ± 0.014	0.377TrpTyr: 0.377 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.373TyrAla: 2.373 ± 0.048	0.336TyrCys: 0.336 ± 0.016	1.717TyrAsp: 1.717 ± 0.041	1.663TyrGlu: 1.663 ± 0.04	1.308TyrPhe: 1.308 ± 0.036	2.062TyrGly: 2.062 ± 0.044	0.628TyrHis: 0.628 ± 0.026	1.556TyrIle: 1.556 ± 0.035	1.209TyrLys: 1.209 ± 0.032	3.23TyrLeu: 3.23 ± 0.058	0.581TyrMet: 0.581 ± 0.025	1.047TyrAsn: 1.047 ± 0.031	1.33TyrPro: 1.33 ± 0.036	1.587TyrGln: 1.587 ± 0.038	1.864TyrArg: 1.864 ± 0.046	2.031TyrSer: 2.031 ± 0.05	1.403TyrThr: 1.403 ± 0.04	1.787TyrVal: 1.787 ± 0.045	0.491TyrTrp: 0.491 ± 0.023	0.907TyrTyr: 0.907 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3634 proteins (1170392 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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