Amino acid dipepetide frequency for Erythrobacter litoralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.655AlaAla: 17.655 ± 0.218	1.168AlaCys: 1.168 ± 0.033	7.274AlaAsp: 7.274 ± 0.096	9.111AlaGlu: 9.111 ± 0.109	4.509AlaPhe: 4.509 ± 0.085	11.683AlaGly: 11.683 ± 0.119	2.29AlaHis: 2.29 ± 0.055	6.642AlaIle: 6.642 ± 0.089	4.032AlaLys: 4.032 ± 0.073	14.248AlaLeu: 14.248 ± 0.159	3.923AlaMet: 3.923 ± 0.073	3.109AlaAsn: 3.109 ± 0.061	6.208AlaPro: 6.208 ± 0.104	4.143AlaGln: 4.143 ± 0.083	10.419AlaArg: 10.419 ± 0.136	6.757AlaSer: 6.757 ± 0.092	5.361AlaThr: 5.361 ± 0.077	8.071AlaVal: 8.071 ± 0.105	1.491AlaTrp: 1.491 ± 0.04	2.409AlaTyr: 2.409 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.116CysAla: 1.116 ± 0.037	0.079CysCys: 0.079 ± 0.009	0.585CysAsp: 0.585 ± 0.026	0.583CysGlu: 0.583 ± 0.026	0.277CysPhe: 0.277 ± 0.017	0.857CysGly: 0.857 ± 0.034	0.217CysHis: 0.217 ± 0.023	0.37CysIle: 0.37 ± 0.02	0.177CysLys: 0.177 ± 0.014	0.764CysLeu: 0.764 ± 0.027	0.151CysMet: 0.151 ± 0.012	0.223CysAsn: 0.223 ± 0.015	0.436CysPro: 0.436 ± 0.025	0.199CysGln: 0.199 ± 0.015	0.529CysArg: 0.529 ± 0.022	0.431CysSer: 0.431 ± 0.021	0.371CysThr: 0.371 ± 0.021	0.561CysVal: 0.561 ± 0.025	0.104CysTrp: 0.104 ± 0.01	0.162CysTyr: 0.162 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.433AspAla: 7.433 ± 0.087	0.544AspCys: 0.544 ± 0.028	3.423AspAsp: 3.423 ± 0.069	4.415AspGlu: 4.415 ± 0.073	2.446AspPhe: 2.446 ± 0.061	5.45AspGly: 5.45 ± 0.087	1.231AspHis: 1.231 ± 0.039	3.041AspIle: 3.041 ± 0.055	1.625AspLys: 1.625 ± 0.044	5.953AspLeu: 5.953 ± 0.081	1.508AspMet: 1.508 ± 0.041	1.479AspAsn: 1.479 ± 0.041	4.143AspPro: 4.143 ± 0.065	1.512AspGln: 1.512 ± 0.042	4.77AspArg: 4.77 ± 0.073	2.334AspSer: 2.334 ± 0.049	2.745AspThr: 2.745 ± 0.055	3.874AspVal: 3.874 ± 0.069	1.172AspTrp: 1.172 ± 0.039	1.644AspTyr: 1.644 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	9.706GluAla: 9.706 ± 0.108	0.42GluCys: 0.42 ± 0.021	4.151GluAsp: 4.151 ± 0.071	4.837GluGlu: 4.837 ± 0.087	1.992GluPhe: 1.992 ± 0.047	6.104GluGly: 6.104 ± 0.083	1.231GluHis: 1.231 ± 0.037	3.605GluIle: 3.605 ± 0.071	2.413GluLys: 2.413 ± 0.054	5.928GluLeu: 5.928 ± 0.083	1.834GluMet: 1.834 ± 0.047	1.79GluAsn: 1.79 ± 0.043	3.27GluPro: 3.27 ± 0.071	2.43GluGln: 2.43 ± 0.058	6.178GluArg: 6.178 ± 0.099	2.738GluSer: 2.738 ± 0.057	3.847GluThr: 3.847 ± 0.057	4.405GluVal: 4.405 ± 0.069	1.05GluTrp: 1.05 ± 0.037	1.247GluTyr: 1.247 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	5.251PheAla: 5.251 ± 0.074	0.33PheCys: 0.33 ± 0.021	2.802PheAsp: 2.802 ± 0.068	2.615PheGlu: 2.615 ± 0.059	1.375PhePhe: 1.375 ± 0.045	3.835PheGly: 3.835 ± 0.073	0.709PheHis: 0.709 ± 0.027	1.553PheIle: 1.553 ± 0.042	0.814PheLys: 0.814 ± 0.031	3.082PheLeu: 3.082 ± 0.079	0.802PheMet: 0.802 ± 0.028	1.037PheAsn: 1.037 ± 0.042	1.565PhePro: 1.565 ± 0.04	0.799PheGln: 0.799 ± 0.026	2.182PheArg: 2.182 ± 0.048	1.957PheSer: 1.957 ± 0.053	2.101PheThr: 2.101 ± 0.056	2.718PheVal: 2.718 ± 0.058	0.503PheTrp: 0.503 ± 0.028	0.966PheTyr: 0.966 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.338GlyAla: 10.338 ± 0.123	0.859GlyCys: 0.859 ± 0.031	5.16GlyAsp: 5.16 ± 0.082	6.883GlyGlu: 6.883 ± 0.114	3.8GlyPhe: 3.8 ± 0.069	8.33GlyGly: 8.33 ± 0.13	1.778GlyHis: 1.778 ± 0.046	4.468GlyIle: 4.468 ± 0.077	3.148GlyLys: 3.148 ± 0.073	8.592GlyLeu: 8.592 ± 0.121	2.428GlyMet: 2.428 ± 0.056	2.238GlyAsn: 2.238 ± 0.058	3.935GlyPro: 3.935 ± 0.069	2.732GlyGln: 2.732 ± 0.058	6.479GlyArg: 6.479 ± 0.082	4.999GlySer: 4.999 ± 0.078	4.815GlyThr: 4.815 ± 0.09	5.907GlyVal: 5.907 ± 0.085	1.54GlyTrp: 1.54 ± 0.042	2.179GlyTyr: 2.179 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.341HisAla: 2.341 ± 0.052	0.263HisCys: 0.263 ± 0.017	1.226HisAsp: 1.226 ± 0.037	1.197HisGlu: 1.197 ± 0.034	0.842HisPhe: 0.842 ± 0.032	1.877HisGly: 1.877 ± 0.043	0.509HisHis: 0.509 ± 0.029	0.81HisIle: 0.81 ± 0.031	0.438HisLys: 0.438 ± 0.024	1.703HisLeu: 1.703 ± 0.043	0.404HisMet: 0.404 ± 0.023	0.394HisAsn: 0.394 ± 0.021	1.241HisPro: 1.241 ± 0.037	0.465HisGln: 0.465 ± 0.022	1.406HisArg: 1.406 ± 0.041	0.964HisSer: 0.964 ± 0.036	0.687HisThr: 0.687 ± 0.029	1.391HisVal: 1.391 ± 0.048	0.309HisTrp: 0.309 ± 0.019	0.551HisTyr: 0.551 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.961IleAla: 7.961 ± 0.082	0.413IleCys: 0.413 ± 0.019	3.802IleAsp: 3.802 ± 0.068	4.269IleGlu: 4.269 ± 0.065	1.513IlePhe: 1.513 ± 0.044	4.935IleGly: 4.935 ± 0.068	0.874IleHis: 0.874 ± 0.035	1.923IleIle: 1.923 ± 0.049	1.103IleLys: 1.103 ± 0.036	3.733IleLeu: 3.733 ± 0.065	0.895IleMet: 0.895 ± 0.034	1.205IleAsn: 1.205 ± 0.033	2.229IlePro: 2.229 ± 0.05	0.96IleGln: 0.96 ± 0.034	3.113IleArg: 3.113 ± 0.053	2.446IleSer: 2.446 ± 0.049	2.426IleThr: 2.426 ± 0.056	3.864IleVal: 3.864 ± 0.068	0.596IleTrp: 0.596 ± 0.026	1.011IleTyr: 1.011 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.91LysAla: 3.91 ± 0.07	0.168LysCys: 0.168 ± 0.014	1.579LysAsp: 1.579 ± 0.044	1.508LysGlu: 1.508 ± 0.044	0.743LysPhe: 0.743 ± 0.027	2.712LysGly: 2.712 ± 0.054	0.54LysHis: 0.54 ± 0.023	1.253LysIle: 1.253 ± 0.037	1.172LysLys: 1.172 ± 0.052	2.905LysLeu: 2.905 ± 0.052	0.662LysMet: 0.662 ± 0.029	0.66LysAsn: 0.66 ± 0.025	1.725LysPro: 1.725 ± 0.051	0.868LysGln: 0.868 ± 0.036	2.406LysArg: 2.406 ± 0.054	1.408LysSer: 1.408 ± 0.042	1.486LysThr: 1.486 ± 0.044	2.192LysVal: 2.192 ± 0.056	0.385LysTrp: 0.385 ± 0.021	0.555LysTyr: 0.555 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.036LeuAla: 15.036 ± 0.158	0.775LeuCys: 0.775 ± 0.027	6.012LeuAsp: 6.012 ± 0.081	6.211LeuGlu: 6.211 ± 0.093	3.607LeuPhe: 3.607 ± 0.071	8.518LeuGly: 8.518 ± 0.1	1.691LeuHis: 1.691 ± 0.043	4.338LeuIle: 4.338 ± 0.078	2.708LeuLys: 2.708 ± 0.054	8.782LeuLeu: 8.782 ± 0.115	2.14LeuMet: 2.14 ± 0.049	2.059LeuAsn: 2.059 ± 0.046	5.296LeuPro: 5.296 ± 0.081	2.094LeuGln: 2.094 ± 0.05	6.565LeuArg: 6.565 ± 0.078	5.622LeuSer: 5.622 ± 0.076	5.214LeuThr: 5.214 ± 0.085	7.579LeuVal: 7.579 ± 0.097	1.085LeuTrp: 1.085 ± 0.036	1.865LeuTyr: 1.865 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.182MetAla: 3.182 ± 0.059	0.172MetCys: 0.172 ± 0.013	1.209MetAsp: 1.209 ± 0.033	1.351MetGlu: 1.351 ± 0.039	0.66MetPhe: 0.66 ± 0.028	2.005MetGly: 2.005 ± 0.052	0.436MetHis: 0.436 ± 0.023	1.286MetIle: 1.286 ± 0.041	1.031MetLys: 1.031 ± 0.036	2.582MetLeu: 2.582 ± 0.053	0.678MetMet: 0.678 ± 0.029	0.752MetAsn: 0.752 ± 0.033	1.479MetPro: 1.479 ± 0.042	0.763MetGln: 0.763 ± 0.029	1.893MetArg: 1.893 ± 0.04	1.418MetSer: 1.418 ± 0.037	1.658MetThr: 1.658 ± 0.042	1.614MetVal: 1.614 ± 0.039	0.226MetTrp: 0.226 ± 0.015	0.249MetTyr: 0.249 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.146AsnAla: 3.146 ± 0.053	0.243AsnCys: 0.243 ± 0.016	1.356AsnAsp: 1.356 ± 0.04	1.375AsnGlu: 1.375 ± 0.039	0.998AsnPhe: 0.998 ± 0.035	2.107AsnGly: 2.107 ± 0.054	0.477AsnHis: 0.477 ± 0.023	1.254AsnIle: 1.254 ± 0.039	0.491AsnLys: 0.491 ± 0.026	2.445AsnLeu: 2.445 ± 0.054	0.559AsnMet: 0.559 ± 0.027	0.572AsnAsn: 0.572 ± 0.03	1.779AsnPro: 1.779 ± 0.042	0.661AsnGln: 0.661 ± 0.028	1.785AsnArg: 1.785 ± 0.043	1.189AsnSer: 1.189 ± 0.036	1.148AsnThr: 1.148 ± 0.038	1.8AsnVal: 1.8 ± 0.05	0.404AsnTrp: 0.404 ± 0.023	0.626AsnTyr: 0.626 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.575ProAla: 6.575 ± 0.088	0.34ProCys: 0.34 ± 0.018	4.025ProAsp: 4.025 ± 0.069	4.387ProGlu: 4.387 ± 0.078	2.017ProPhe: 2.017 ± 0.047	5.065ProGly: 5.065 ± 0.087	0.983ProHis: 0.983 ± 0.033	2.384ProIle: 2.384 ± 0.053	1.416ProLys: 1.416 ± 0.043	4.831ProLeu: 4.831 ± 0.082	1.116ProMet: 1.116 ± 0.041	1.211ProAsn: 1.211 ± 0.038	2.814ProPro: 2.814 ± 0.095	1.694ProGln: 1.694 ± 0.046	3.215ProArg: 3.215 ± 0.052	2.635ProSer: 2.635 ± 0.061	2.251ProThr: 2.251 ± 0.047	4.067ProVal: 4.067 ± 0.07	0.632ProTrp: 0.632 ± 0.024	1.029ProTyr: 1.029 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.598GlnAla: 3.598 ± 0.072	0.226GlnCys: 0.226 ± 0.015	1.495GlnAsp: 1.495 ± 0.039	1.494GlnGlu: 1.494 ± 0.043	1.132GlnPhe: 1.132 ± 0.036	2.4GlnGly: 2.4 ± 0.048	0.573GlnHis: 0.573 ± 0.024	1.548GlnIle: 1.548 ± 0.04	0.801GlnLys: 0.801 ± 0.033	2.781GlnLeu: 2.781 ± 0.059	0.77GlnMet: 0.77 ± 0.03	0.633GlnAsn: 0.633 ± 0.021	1.547GlnPro: 1.547 ± 0.043	1.041GlnGln: 1.041 ± 0.041	2.296GlnArg: 2.296 ± 0.048	1.522GlnSer: 1.522 ± 0.047	1.285GlnThr: 1.285 ± 0.042	2.273GlnVal: 2.273 ± 0.059	0.397GlnTrp: 0.397 ± 0.022	0.601GlnTyr: 0.601 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.982ArgAla: 8.982 ± 0.118	0.49ArgCys: 0.49 ± 0.022	4.278ArgAsp: 4.278 ± 0.07	5.669ArgGlu: 5.669 ± 0.072	3.159ArgPhe: 3.159 ± 0.058	5.498ArgGly: 5.498 ± 0.087	1.499ArgHis: 1.499 ± 0.042	4.252ArgIle: 4.252 ± 0.073	2.1ArgLys: 2.1 ± 0.049	7.945ArgLeu: 7.945 ± 0.117	1.995ArgMet: 1.995 ± 0.043	1.751ArgAsn: 1.751 ± 0.046	3.463ArgPro: 3.463 ± 0.062	2.215ArgGln: 2.215 ± 0.049	5.86ArgArg: 5.86 ± 0.094	3.706ArgSer: 3.706 ± 0.064	3.51ArgThr: 3.51 ± 0.052	4.83ArgVal: 4.83 ± 0.071	1.161ArgTrp: 1.161 ± 0.036	1.711ArgTyr: 1.711 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.232SerAla: 6.232 ± 0.091	0.417SerCys: 0.417 ± 0.02	3.209SerAsp: 3.209 ± 0.058	3.458SerGlu: 3.458 ± 0.065	2.059SerPhe: 2.059 ± 0.051	5.561SerGly: 5.561 ± 0.087	0.942SerHis: 0.942 ± 0.03	2.369SerIle: 2.369 ± 0.056	1.297SerLys: 1.297 ± 0.036	4.963SerLeu: 4.963 ± 0.072	1.191SerMet: 1.191 ± 0.039	1.269SerAsn: 1.269 ± 0.039	2.84SerPro: 2.84 ± 0.055	1.532SerGln: 1.532 ± 0.044	3.493SerArg: 3.493 ± 0.061	2.587SerSer: 2.587 ± 0.066	2.308SerThr: 2.308 ± 0.049	3.394SerVal: 3.394 ± 0.066	0.721SerTrp: 0.721 ± 0.027	1.194SerTyr: 1.194 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.72ThrAla: 5.72 ± 0.082	0.398ThrCys: 0.398 ± 0.022	2.813ThrAsp: 2.813 ± 0.06	2.657ThrGlu: 2.657 ± 0.053	1.896ThrPhe: 1.896 ± 0.049	5.3ThrGly: 5.3 ± 0.084	0.929ThrHis: 0.929 ± 0.033	2.805ThrIle: 2.805 ± 0.053	1.261ThrLys: 1.261 ± 0.04	5.221ThrLeu: 5.221 ± 0.083	1.155ThrMet: 1.155 ± 0.033	1.179ThrAsn: 1.179 ± 0.041	3.038ThrPro: 3.038 ± 0.05	1.322ThrGln: 1.322 ± 0.039	3.489ThrArg: 3.489 ± 0.059	2.506ThrSer: 2.506 ± 0.054	2.306ThrThr: 2.306 ± 0.051	3.761ThrVal: 3.761 ± 0.065	0.606ThrTrp: 0.606 ± 0.028	1.161ThrTyr: 1.161 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.516ValAla: 8.516 ± 0.114	0.54ValCys: 0.54 ± 0.026	4.055ValAsp: 4.055 ± 0.065	4.987ValGlu: 4.987 ± 0.072	2.52ValPhe: 2.52 ± 0.061	5.313ValGly: 5.313 ± 0.095	1.304ValHis: 1.304 ± 0.038	3.894ValIle: 3.894 ± 0.069	1.901ValLys: 1.901 ± 0.053	7.018ValLeu: 7.018 ± 0.095	1.709ValMet: 1.709 ± 0.045	1.926ValAsn: 1.926 ± 0.044	4.022ValPro: 4.022 ± 0.06	1.819ValGln: 1.819 ± 0.044	4.879ValArg: 4.879 ± 0.076	3.777ValSer: 3.777 ± 0.059	4.294ValThr: 4.294 ± 0.073	5.048ValVal: 5.048 ± 0.092	0.899ValTrp: 0.899 ± 0.032	1.215ValTyr: 1.215 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.303TrpAla: 1.303 ± 0.04	0.106TrpCys: 0.106 ± 0.012	0.761TrpAsp: 0.761 ± 0.032	0.736TrpGlu: 0.736 ± 0.03	0.591TrpPhe: 0.591 ± 0.026	0.981TrpGly: 0.981 ± 0.033	0.348TrpHis: 0.348 ± 0.02	0.67TrpIle: 0.67 ± 0.028	0.447TrpLys: 0.447 ± 0.023	1.78TrpLeu: 1.78 ± 0.05	0.342TrpMet: 0.342 ± 0.02	0.396TrpAsn: 0.396 ± 0.02	0.679TrpPro: 0.679 ± 0.026	0.583TrpGln: 0.583 ± 0.024	1.267TrpArg: 1.267 ± 0.041	0.855TrpSer: 0.855 ± 0.031	0.709TrpThr: 0.709 ± 0.026	0.801TrpVal: 0.801 ± 0.029	0.223TrpTrp: 0.223 ± 0.015	0.259TrpTyr: 0.259 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.506TyrAla: 2.506 ± 0.053	0.241TyrCys: 0.241 ± 0.018	1.528TyrAsp: 1.528 ± 0.037	1.433TyrGlu: 1.433 ± 0.042	0.86TyrPhe: 0.86 ± 0.03	2.077TyrGly: 2.077 ± 0.048	0.457TyrHis: 0.457 ± 0.021	0.804TyrIle: 0.804 ± 0.029	0.458TyrLys: 0.458 ± 0.027	1.945TyrLeu: 1.945 ± 0.046	0.379TyrMet: 0.379 ± 0.019	0.529TyrAsn: 0.529 ± 0.024	0.977TyrPro: 0.977 ± 0.035	0.583TyrGln: 0.583 ± 0.028	1.849TyrArg: 1.849 ± 0.051	1.186TyrSer: 1.186 ± 0.037	1.002TyrThr: 1.002 ± 0.034	1.486TyrVal: 1.486 ± 0.042	0.333TyrTrp: 0.333 ± 0.017	0.559TyrTyr: 0.559 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2981 proteins (948914 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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