Amino acid dipepetide frequency for Lake Sarah-associated circular virus-38

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.837AlaAla: 4.837 ± 2.985
1.209AlaCys: 1.209 ± 0.746
2.418AlaAsp: 2.418 ± 0.138
3.628AlaGlu: 3.628 ± 1.022
2.418AlaPhe: 2.418 ± 0.138
3.628AlaGly: 3.628 ± 2.239
2.418AlaHis: 2.418 ± 1.769
6.046AlaIle: 6.046 ± 1.16
3.628AlaLys: 3.628 ± 2.653
4.837AlaLeu: 4.837 ± 1.355
1.209AlaMet: 1.209 ± 0.746
2.418AlaAsn: 2.418 ± 0.138
3.628AlaPro: 3.628 ± 1.022
4.837AlaGln: 4.837 ± 1.355
6.046AlaArg: 6.046 ± 1.16
7.255AlaSer: 7.255 ± 0.414
2.418AlaThr: 2.418 ± 1.493
7.255AlaVal: 7.255 ± 2.847
0.0AlaTrp: 0.0 ± 0.0
3.628AlaTyr: 3.628 ± 2.239
0.0AlaXaa: 0.0 ± 0.0
Cys
1.209CysAla: 1.209 ± 0.746
0.0CysCys: 0.0 ± 0.0
1.209CysAsp: 1.209 ± 0.746
0.0CysGlu: 0.0 ± 0.0
1.209CysPhe: 1.209 ± 0.884
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.209CysLys: 1.209 ± 0.884
1.209CysLeu: 1.209 ± 0.884
1.209CysMet: 1.209 ± 0.884
1.209CysAsn: 1.209 ± 0.746
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
1.209CysVal: 1.209 ± 0.884
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.209AspAla: 1.209 ± 0.884
0.0AspCys: 0.0 ± 0.0
2.418AspAsp: 2.418 ± 1.769
0.0AspGlu: 0.0 ± 0.0
0.0AspPhe: 0.0 ± 0.0
2.418AspGly: 2.418 ± 0.138
0.0AspHis: 0.0 ± 0.0
3.628AspIle: 3.628 ± 1.022
3.628AspLys: 3.628 ± 1.022
7.255AspLeu: 7.255 ± 2.045
2.418AspMet: 2.418 ± 1.769
3.628AspAsn: 3.628 ± 2.653
1.209AspPro: 1.209 ± 0.746
3.628AspGln: 3.628 ± 1.022
2.418AspArg: 2.418 ± 1.769
2.418AspSer: 2.418 ± 0.138
2.418AspThr: 2.418 ± 0.138
2.418AspVal: 2.418 ± 1.493
0.0AspTrp: 0.0 ± 0.0
3.628AspTyr: 3.628 ± 0.608
0.0AspXaa: 0.0 ± 0.0
Glu
1.209GluAla: 1.209 ± 0.884
1.209GluCys: 1.209 ± 0.746
1.209GluAsp: 1.209 ± 0.884
9.674GluGlu: 9.674 ± 5.444
1.209GluPhe: 1.209 ± 0.746
6.046GluGly: 6.046 ± 0.47
1.209GluHis: 1.209 ± 0.884
2.418GluIle: 2.418 ± 0.138
2.418GluLys: 2.418 ± 0.138
6.046GluLeu: 6.046 ± 1.16
1.209GluMet: 1.209 ± 0.884
3.628GluAsn: 3.628 ± 2.653
1.209GluPro: 1.209 ± 0.884
3.628GluGln: 3.628 ± 1.022
1.209GluArg: 1.209 ± 0.884
2.418GluSer: 2.418 ± 1.769
3.628GluThr: 3.628 ± 2.653
3.628GluVal: 3.628 ± 2.653
1.209GluTrp: 1.209 ± 0.884
1.209GluTyr: 1.209 ± 0.746
0.0GluXaa: 0.0 ± 0.0
Phe
1.209PheAla: 1.209 ± 0.746
0.0PheCys: 0.0 ± 0.0
2.418PheAsp: 2.418 ± 0.138
6.046PheGlu: 6.046 ± 2.791
2.418PhePhe: 2.418 ± 0.138
3.628PheGly: 3.628 ± 0.608
0.0PheHis: 0.0 ± 0.0
1.209PheIle: 1.209 ± 0.884
1.209PheLys: 1.209 ± 0.884
1.209PheLeu: 1.209 ± 0.746
0.0PheMet: 0.0 ± 0.0
0.0PheAsn: 0.0 ± 0.0
6.046PhePro: 6.046 ± 0.47
1.209PheGln: 1.209 ± 0.746
2.418PheArg: 2.418 ± 1.493
3.628PheSer: 3.628 ± 0.608
2.418PheThr: 2.418 ± 1.493
2.418PheVal: 2.418 ± 1.493
0.0PheTrp: 0.0 ± 0.0
2.418PheTyr: 2.418 ± 0.138
0.0PheXaa: 0.0 ± 0.0
Gly
7.255GlyAla: 7.255 ± 4.478
0.0GlyCys: 0.0 ± 0.0
6.046GlyAsp: 6.046 ± 1.16
3.628GlyGlu: 3.628 ± 1.022
3.628GlyPhe: 3.628 ± 0.608
8.464GlyGly: 8.464 ± 5.225
1.209GlyHis: 1.209 ± 0.884
0.0GlyIle: 0.0 ± 0.0
1.209GlyLys: 1.209 ± 0.884
6.046GlyLeu: 6.046 ± 2.101
0.0GlyMet: 0.0 ± 0.0
7.255GlyAsn: 7.255 ± 4.478
4.837GlyPro: 4.837 ± 1.907
6.046GlyGln: 6.046 ± 2.101
0.0GlyArg: 0.0 ± 0.0
7.255GlySer: 7.255 ± 4.478
3.628GlyThr: 3.628 ± 0.608
4.837GlyVal: 4.837 ± 0.276
1.209GlyTrp: 1.209 ± 0.746
4.837GlyTyr: 4.837 ± 1.355
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
1.209HisAsp: 1.209 ± 0.884
0.0HisGlu: 0.0 ± 0.0
1.209HisPhe: 1.209 ± 0.884
3.628HisGly: 3.628 ± 1.022
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
1.209HisLeu: 1.209 ± 0.884
2.418HisMet: 2.418 ± 1.769
1.209HisAsn: 1.209 ± 0.884
1.209HisPro: 1.209 ± 0.884
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
1.209HisVal: 1.209 ± 0.884
0.0HisTrp: 0.0 ± 0.0
1.209HisTyr: 1.209 ± 0.746
0.0HisXaa: 0.0 ± 0.0
Ile
3.628IleAla: 3.628 ± 0.608
0.0IleCys: 0.0 ± 0.0
0.0IleAsp: 0.0 ± 0.0
6.046IleGlu: 6.046 ± 2.791
3.628IlePhe: 3.628 ± 0.608
1.209IleGly: 1.209 ± 0.746
1.209IleHis: 1.209 ± 0.884
1.209IleIle: 1.209 ± 0.746
2.418IleLys: 2.418 ± 0.138
2.418IleLeu: 2.418 ± 1.769
0.0IleMet: 0.0 ± 0.0
3.628IleAsn: 3.628 ± 1.022
2.418IlePro: 2.418 ± 0.138
2.418IleGln: 2.418 ± 1.493
3.628IleArg: 3.628 ± 0.608
3.628IleSer: 3.628 ± 1.022
6.046IleThr: 6.046 ± 3.732
1.209IleVal: 1.209 ± 0.884
3.628IleTrp: 3.628 ± 2.653
4.837IleTyr: 4.837 ± 1.907
0.0IleXaa: 0.0 ± 0.0
Lys
4.837LysAla: 4.837 ± 0.276
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
2.418LysGlu: 2.418 ± 0.138
1.209LysPhe: 1.209 ± 0.884
2.418LysGly: 2.418 ± 0.138
0.0LysHis: 0.0 ± 0.0
3.628LysIle: 3.628 ± 1.022
8.464LysLys: 8.464 ± 6.191
1.209LysLeu: 1.209 ± 0.746
3.628LysMet: 3.628 ± 2.653
2.418LysAsn: 2.418 ± 0.138
1.209LysPro: 1.209 ± 0.884
0.0LysGln: 0.0 ± 0.0
3.628LysArg: 3.628 ± 2.653
2.418LysSer: 2.418 ± 1.769
3.628LysThr: 3.628 ± 0.608
2.418LysVal: 2.418 ± 1.769
1.209LysTrp: 1.209 ± 0.884
4.837LysTyr: 4.837 ± 1.907
0.0LysXaa: 0.0 ± 0.0
Leu
3.628LeuAla: 3.628 ± 1.022
0.0LeuCys: 0.0 ± 0.0
1.209LeuAsp: 1.209 ± 0.884
3.628LeuGlu: 3.628 ± 1.022
0.0LeuPhe: 0.0 ± 0.0
9.674LeuGly: 9.674 ± 5.971
1.209LeuHis: 1.209 ± 0.884
3.628LeuIle: 3.628 ± 0.608
8.464LeuLys: 8.464 ± 2.929
6.046LeuLeu: 6.046 ± 1.16
2.418LeuMet: 2.418 ± 1.143
2.418LeuAsn: 2.418 ± 0.138
4.837LeuPro: 4.837 ± 1.355
6.046LeuGln: 6.046 ± 0.47
3.628LeuArg: 3.628 ± 1.022
2.418LeuSer: 2.418 ± 0.138
0.0LeuThr: 0.0 ± 0.0
6.046LeuVal: 6.046 ± 2.101
2.418LeuTrp: 2.418 ± 0.138
1.209LeuTyr: 1.209 ± 0.746
0.0LeuXaa: 0.0 ± 0.0
Met
3.628MetAla: 3.628 ± 1.022
0.0MetCys: 0.0 ± 0.0
4.837MetAsp: 4.837 ± 0.276
4.837MetGlu: 4.837 ± 0.276
1.209MetPhe: 1.209 ± 0.884
2.418MetGly: 2.418 ± 0.138
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.209MetLys: 1.209 ± 0.884
1.209MetLeu: 1.209 ± 0.746
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.418MetPro: 2.418 ± 0.138
1.209MetGln: 1.209 ± 0.746
1.209MetArg: 1.209 ± 0.884
3.628MetSer: 3.628 ± 1.022
1.209MetThr: 1.209 ± 0.884
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
1.209MetTyr: 1.209 ± 0.746
0.0MetXaa: 0.0 ± 0.0
Asn
7.255AsnAla: 7.255 ± 1.217
0.0AsnCys: 0.0 ± 0.0
1.209AsnAsp: 1.209 ± 0.884
0.0AsnGlu: 0.0 ± 0.0
4.837AsnPhe: 4.837 ± 0.276
1.209AsnGly: 1.209 ± 0.746
0.0AsnHis: 0.0 ± 0.0
3.628AsnIle: 3.628 ± 1.022
3.628AsnLys: 3.628 ± 2.653
2.418AsnLeu: 2.418 ± 1.493
2.418AsnMet: 2.418 ± 1.493
2.418AsnAsn: 2.418 ± 0.138
4.837AsnPro: 4.837 ± 1.355
2.418AsnGln: 2.418 ± 0.138
1.209AsnArg: 1.209 ± 0.746
8.464AsnSer: 8.464 ± 3.594
3.628AsnThr: 3.628 ± 2.239
1.209AsnVal: 1.209 ± 0.746
1.209AsnTrp: 1.209 ± 0.884
7.255AsnTyr: 7.255 ± 2.045
0.0AsnXaa: 0.0 ± 0.0
Pro
3.628ProAla: 3.628 ± 1.022
0.0ProCys: 0.0 ± 0.0
2.418ProAsp: 2.418 ± 1.769
2.418ProGlu: 2.418 ± 0.138
2.418ProPhe: 2.418 ± 1.493
1.209ProGly: 1.209 ± 0.746
2.418ProHis: 2.418 ± 0.138
3.628ProIle: 3.628 ± 0.608
2.418ProLys: 2.418 ± 0.138
2.418ProLeu: 2.418 ± 0.138
1.209ProMet: 1.209 ± 0.746
6.046ProAsn: 6.046 ± 2.101
2.418ProPro: 2.418 ± 0.138
2.418ProGln: 2.418 ± 1.769
3.628ProArg: 3.628 ± 1.022
3.628ProSer: 3.628 ± 0.608
8.464ProThr: 8.464 ± 0.332
3.628ProVal: 3.628 ± 0.608
2.418ProTrp: 2.418 ± 1.769
1.209ProTyr: 1.209 ± 0.884
0.0ProXaa: 0.0 ± 0.0
Gln
3.628GlnAla: 3.628 ± 0.608
1.209GlnCys: 1.209 ± 0.884
1.209GlnAsp: 1.209 ± 0.884
1.209GlnGlu: 1.209 ± 0.884
6.046GlnPhe: 6.046 ± 2.101
2.418GlnGly: 2.418 ± 1.493
0.0GlnHis: 0.0 ± 0.0
3.628GlnIle: 3.628 ± 0.608
0.0GlnLys: 0.0 ± 0.0
0.0GlnLeu: 0.0 ± 0.0
0.0GlnMet: 0.0 ± 0.0
3.628GlnAsn: 3.628 ± 0.608
4.837GlnPro: 4.837 ± 1.907
2.418GlnGln: 2.418 ± 0.138
2.418GlnArg: 2.418 ± 1.493
2.418GlnSer: 2.418 ± 1.493
4.837GlnThr: 4.837 ± 1.355
6.046GlnVal: 6.046 ± 2.101
0.0GlnTrp: 0.0 ± 0.0
2.418GlnTyr: 2.418 ± 0.138
0.0GlnXaa: 0.0 ± 0.0
Arg
9.674ArgAla: 9.674 ± 2.183
0.0ArgCys: 0.0 ± 0.0
1.209ArgAsp: 1.209 ± 0.884
1.209ArgGlu: 1.209 ± 0.884
2.418ArgPhe: 2.418 ± 1.769
8.464ArgGly: 8.464 ± 1.963
0.0ArgHis: 0.0 ± 0.0
2.418ArgIle: 2.418 ± 1.769
2.418ArgLys: 2.418 ± 0.138
1.209ArgLeu: 1.209 ± 0.746
2.418ArgMet: 2.418 ± 0.138
1.209ArgAsn: 1.209 ± 0.884
4.837ArgPro: 4.837 ± 0.276
0.0ArgGln: 0.0 ± 0.0
13.301ArgArg: 13.301 ± 4.948
6.046ArgSer: 6.046 ± 2.101
2.418ArgThr: 2.418 ± 1.493
0.0ArgVal: 0.0 ± 0.0
0.0ArgTrp: 0.0 ± 0.0
0.0ArgTyr: 0.0 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
3.628SerAla: 3.628 ± 0.608
2.418SerCys: 2.418 ± 0.138
7.255SerAsp: 7.255 ± 2.045
2.418SerGlu: 2.418 ± 1.769
1.209SerPhe: 1.209 ± 0.746
4.837SerGly: 4.837 ± 1.355
1.209SerHis: 1.209 ± 0.884
3.628SerIle: 3.628 ± 2.239
2.418SerLys: 2.418 ± 0.138
4.837SerLeu: 4.837 ± 1.355
1.209SerMet: 1.209 ± 0.746
7.255SerAsn: 7.255 ± 1.217
3.628SerPro: 3.628 ± 2.239
3.628SerGln: 3.628 ± 0.608
6.046SerArg: 6.046 ± 0.47
2.418SerSer: 2.418 ± 1.493
7.255SerThr: 7.255 ± 0.414
1.209SerVal: 1.209 ± 0.746
0.0SerTrp: 0.0 ± 0.0
2.418SerTyr: 2.418 ± 0.138
0.0SerXaa: 0.0 ± 0.0
Thr
4.837ThrAla: 4.837 ± 1.355
0.0ThrCys: 0.0 ± 0.0
2.418ThrAsp: 2.418 ± 1.493
0.0ThrGlu: 0.0 ± 0.0
2.418ThrPhe: 2.418 ± 1.493
7.255ThrGly: 7.255 ± 1.217
2.418ThrHis: 2.418 ± 1.769
4.837ThrIle: 4.837 ± 1.907
1.209ThrLys: 1.209 ± 0.746
8.464ThrLeu: 8.464 ± 1.963
3.628ThrMet: 3.628 ± 0.608
3.628ThrAsn: 3.628 ± 2.239
2.418ThrPro: 2.418 ± 0.138
1.209ThrGln: 1.209 ± 0.746
2.418ThrArg: 2.418 ± 1.493
6.046ThrSer: 6.046 ± 1.16
6.046ThrThr: 6.046 ± 3.732
4.837ThrVal: 4.837 ± 1.355
0.0ThrTrp: 0.0 ± 0.0
3.628ThrTyr: 3.628 ± 2.239
0.0ThrXaa: 0.0 ± 0.0
Val
4.837ValAla: 4.837 ± 1.355
0.0ValCys: 0.0 ± 0.0
0.0ValAsp: 0.0 ± 0.0
4.837ValGlu: 4.837 ± 1.907
2.418ValPhe: 2.418 ± 1.493
2.418ValGly: 2.418 ± 0.138
1.209ValHis: 1.209 ± 0.746
6.046ValIle: 6.046 ± 0.47
3.628ValLys: 3.628 ± 1.022
7.255ValLeu: 7.255 ± 2.045
1.209ValMet: 1.209 ± 0.564
2.418ValAsn: 2.418 ± 1.493
3.628ValPro: 3.628 ± 2.239
3.628ValGln: 3.628 ± 2.239
0.0ValArg: 0.0 ± 0.0
2.418ValSer: 2.418 ± 1.493
3.628ValThr: 3.628 ± 0.608
3.628ValVal: 3.628 ± 0.608
1.209ValTrp: 1.209 ± 0.746
1.209ValTyr: 1.209 ± 0.884
0.0ValXaa: 0.0 ± 0.0
Trp
1.209TrpAla: 1.209 ± 0.884
2.418TrpCys: 2.418 ± 1.769
1.209TrpAsp: 1.209 ± 0.884
1.209TrpGlu: 1.209 ± 0.884
0.0TrpPhe: 0.0 ± 0.0
1.209TrpGly: 1.209 ± 0.884
0.0TrpHis: 0.0 ± 0.0
1.209TrpIle: 1.209 ± 0.884
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
1.209TrpAsn: 1.209 ± 0.884
1.209TrpPro: 1.209 ± 0.884
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
2.418TrpThr: 2.418 ± 1.493
1.209TrpVal: 1.209 ± 0.746
1.209TrpTrp: 1.209 ± 0.884
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.418TyrAla: 2.418 ± 0.138
1.209TyrCys: 1.209 ± 0.884
4.837TyrAsp: 4.837 ± 0.276
2.418TyrGlu: 2.418 ± 0.138
0.0TyrPhe: 0.0 ± 0.0
4.837TyrGly: 4.837 ± 0.276
0.0TyrHis: 0.0 ± 0.0
2.418TyrIle: 2.418 ± 0.138
0.0TyrLys: 0.0 ± 0.0
4.837TyrLeu: 4.837 ± 1.355
2.418TyrMet: 2.418 ± 1.769
3.628TyrAsn: 3.628 ± 2.239
1.209TyrPro: 1.209 ± 0.884
3.628TyrGln: 3.628 ± 0.608
6.046TyrArg: 6.046 ± 0.47
2.418TyrSer: 2.418 ± 0.138
3.628TyrThr: 3.628 ± 0.608
1.209TyrVal: 1.209 ± 0.746
0.0TyrTrp: 0.0 ± 0.0
2.418TyrTyr: 2.418 ± 1.769
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (828 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski