Amino acid dipepetide frequency for Natronomonas moolapensis (strain DSM 18674 / CECT 7526 / JCM 14361 / 8.8.11)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.653AlaAla: 14.653 ± 0.225	0.798AlaCys: 0.798 ± 0.033	10.136AlaAsp: 10.136 ± 0.15	9.51AlaGlu: 9.51 ± 0.134	4.004AlaPhe: 4.004 ± 0.076	10.278AlaGly: 10.278 ± 0.15	1.834AlaHis: 1.834 ± 0.053	4.878AlaIle: 4.878 ± 0.086	1.877AlaLys: 1.877 ± 0.052	10.362AlaLeu: 10.362 ± 0.142	2.024AlaMet: 2.024 ± 0.059	2.294AlaAsn: 2.294 ± 0.054	4.011AlaPro: 4.011 ± 0.08	1.845AlaGln: 1.845 ± 0.051	6.285AlaArg: 6.285 ± 0.112	5.63AlaSer: 5.63 ± 0.114	6.886AlaThr: 6.886 ± 0.104	10.849AlaVal: 10.849 ± 0.167	1.017AlaTrp: 1.017 ± 0.038	2.85AlaTyr: 2.85 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.624CysAla: 0.624 ± 0.032	0.106CysCys: 0.106 ± 0.012	0.569CysAsp: 0.569 ± 0.032	0.62CysGlu: 0.62 ± 0.033	0.241CysPhe: 0.241 ± 0.017	0.963CysGly: 0.963 ± 0.037	0.199CysHis: 0.199 ± 0.015	0.283CysIle: 0.283 ± 0.018	0.119CysLys: 0.119 ± 0.013	0.621CysLeu: 0.621 ± 0.031	0.103CysMet: 0.103 ± 0.012	0.198CysAsn: 0.198 ± 0.015	0.588CysPro: 0.588 ± 0.037	0.145CysGln: 0.145 ± 0.014	0.561CysArg: 0.561 ± 0.03	0.508CysSer: 0.508 ± 0.024	0.398CysThr: 0.398 ± 0.021	0.566CysVal: 0.566 ± 0.024	0.086CysTrp: 0.086 ± 0.009	0.174CysTyr: 0.174 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	10.132AspAla: 10.132 ± 0.137	0.674AspCys: 0.674 ± 0.032	7.406AspAsp: 7.406 ± 0.116	7.032AspGlu: 7.032 ± 0.124	1.729AspPhe: 1.729 ± 0.044	8.657AspGly: 8.657 ± 0.16	1.682AspHis: 1.682 ± 0.048	3.324AspIle: 3.324 ± 0.078	0.968AspLys: 0.968 ± 0.036	6.397AspLeu: 6.397 ± 0.101	1.028AspMet: 1.028 ± 0.037	1.361AspAsn: 1.361 ± 0.048	5.105AspPro: 5.105 ± 0.09	1.308AspGln: 1.308 ± 0.049	7.018AspArg: 7.018 ± 0.109	4.149AspSer: 4.149 ± 0.1	4.424AspThr: 4.424 ± 0.089	7.65AspVal: 7.65 ± 0.117	0.705AspTrp: 0.705 ± 0.032	1.532AspTyr: 1.532 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	10.373GluAla: 10.373 ± 0.151	0.618GluCys: 0.618 ± 0.028	5.313GluAsp: 5.313 ± 0.108	6.419GluGlu: 6.419 ± 0.129	2.846GluPhe: 2.846 ± 0.058	5.94GluGly: 5.94 ± 0.088	2.07GluHis: 2.07 ± 0.054	4.074GluIle: 4.074 ± 0.086	1.816GluLys: 1.816 ± 0.059	8.219GluLeu: 8.219 ± 0.127	1.895GluMet: 1.895 ± 0.06	2.195GluAsn: 2.195 ± 0.055	3.899GluPro: 3.899 ± 0.083	2.473GluGln: 2.473 ± 0.075	8.251GluArg: 8.251 ± 0.141	5.529GluSer: 5.529 ± 0.085	7.265GluThr: 7.265 ± 0.109	5.322GluVal: 5.322 ± 0.097	1.096GluTrp: 1.096 ± 0.037	2.777GluTyr: 2.777 ± 0.073	0.0GluXaa: 0.0 ± 0.0
Phe	3.384PheAla: 3.384 ± 0.074	0.271PheCys: 0.271 ± 0.018	3.149PheAsp: 3.149 ± 0.07	3.667PheGlu: 3.667 ± 0.07	0.978PhePhe: 0.978 ± 0.04	3.361PheGly: 3.361 ± 0.074	0.536PheHis: 0.536 ± 0.026	0.966PheIle: 0.966 ± 0.042	0.464PheLys: 0.464 ± 0.026	2.659PheLeu: 2.659 ± 0.07	0.474PheMet: 0.474 ± 0.023	0.673PheAsn: 0.673 ± 0.031	1.212PhePro: 1.212 ± 0.042	0.66PheGln: 0.66 ± 0.028	1.876PheArg: 1.876 ± 0.049	1.731PheSer: 1.731 ± 0.054	1.556PheThr: 1.556 ± 0.053	3.197PheVal: 3.197 ± 0.066	0.315PheTrp: 0.315 ± 0.023	0.835PheTyr: 0.835 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.786GlyAla: 8.786 ± 0.13	0.718GlyCys: 0.718 ± 0.03	7.109GlyAsp: 7.109 ± 0.118	7.374GlyGlu: 7.374 ± 0.091	3.14GlyPhe: 3.14 ± 0.076	8.373GlyGly: 8.373 ± 0.175	1.689GlyHis: 1.689 ± 0.047	4.31GlyIle: 4.31 ± 0.076	1.764GlyLys: 1.764 ± 0.048	7.388GlyLeu: 7.388 ± 0.113	1.707GlyMet: 1.707 ± 0.048	1.99GlyAsn: 1.99 ± 0.064	3.358GlyPro: 3.358 ± 0.073	1.859GlyGln: 1.859 ± 0.052	5.694GlyArg: 5.694 ± 0.092	5.677GlySer: 5.677 ± 0.095	6.435GlyThr: 6.435 ± 0.137	7.884GlyVal: 7.884 ± 0.109	1.063GlyTrp: 1.063 ± 0.04	2.664GlyTyr: 2.664 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.991HisAla: 1.991 ± 0.053	0.194HisCys: 0.194 ± 0.016	1.821HisAsp: 1.821 ± 0.048	1.558HisGlu: 1.558 ± 0.056	0.489HisPhe: 0.489 ± 0.025	1.986HisGly: 1.986 ± 0.059	0.482HisHis: 0.482 ± 0.026	0.72HisIle: 0.72 ± 0.03	0.309HisLys: 0.309 ± 0.018	1.588HisLeu: 1.588 ± 0.044	0.262HisMet: 0.262 ± 0.016	0.474HisAsn: 0.474 ± 0.028	1.165HisPro: 1.165 ± 0.038	0.41HisGln: 0.41 ± 0.021	1.343HisArg: 1.343 ± 0.044	0.954HisSer: 0.954 ± 0.036	1.083HisThr: 1.083 ± 0.039	1.838HisVal: 1.838 ± 0.048	0.187HisTrp: 0.187 ± 0.014	0.557HisTyr: 0.557 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.758IleAla: 4.758 ± 0.086	0.275IleCys: 0.275 ± 0.02	4.358IleAsp: 4.358 ± 0.087	5.179IleGlu: 5.179 ± 0.098	0.818IlePhe: 0.818 ± 0.036	3.816IleGly: 3.816 ± 0.073	0.784IleHis: 0.784 ± 0.032	1.192IleIle: 1.192 ± 0.044	0.9IleLys: 0.9 ± 0.041	2.654IleLeu: 2.654 ± 0.067	0.453IleMet: 0.453 ± 0.023	1.045IleAsn: 1.045 ± 0.043	1.852IlePro: 1.852 ± 0.05	1.124IleGln: 1.124 ± 0.04	2.667IleArg: 2.667 ± 0.063	2.005IleSer: 2.005 ± 0.072	2.423IleThr: 2.423 ± 0.081	3.559IleVal: 3.559 ± 0.077	0.275IleTrp: 0.275 ± 0.019	0.871IleTyr: 0.871 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	1.807LysAla: 1.807 ± 0.048	0.114LysCys: 0.114 ± 0.012	0.976LysAsp: 0.976 ± 0.043	1.333LysGlu: 1.333 ± 0.048	0.473LysPhe: 0.473 ± 0.024	1.306LysGly: 1.306 ± 0.047	0.561LysHis: 0.561 ± 0.03	0.85LysIle: 0.85 ± 0.041	0.603LysLys: 0.603 ± 0.036	1.735LysLeu: 1.735 ± 0.053	0.315LysMet: 0.315 ± 0.019	0.624LysAsn: 0.624 ± 0.035	0.9LysPro: 0.9 ± 0.036	0.863LysGln: 0.863 ± 0.036	1.805LysArg: 1.805 ± 0.058	1.173LysSer: 1.173 ± 0.045	1.329LysThr: 1.329 ± 0.045	1.08LysVal: 1.08 ± 0.037	0.222LysTrp: 0.222 ± 0.018	0.564LysTyr: 0.564 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	10.481LeuAla: 10.481 ± 0.15	0.7LeuCys: 0.7 ± 0.034	7.258LeuAsp: 7.258 ± 0.106	8.114LeuGlu: 8.114 ± 0.129	3.003LeuPhe: 3.003 ± 0.075	7.521LeuGly: 7.521 ± 0.118	1.523LeuHis: 1.523 ± 0.043	2.741LeuIle: 2.741 ± 0.06	1.681LeuLys: 1.681 ± 0.054	8.081LeuLeu: 8.081 ± 0.14	1.219LeuMet: 1.219 ± 0.041	1.874LeuAsn: 1.874 ± 0.051	3.983LeuPro: 3.983 ± 0.071	1.869LeuGln: 1.869 ± 0.053	5.852LeuArg: 5.852 ± 0.085	5.857LeuSer: 5.857 ± 0.089	4.554LeuThr: 4.554 ± 0.101	7.68LeuVal: 7.68 ± 0.112	0.805LeuTrp: 0.805 ± 0.033	2.191LeuTyr: 2.191 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.748MetAla: 1.748 ± 0.051	0.126MetCys: 0.126 ± 0.012	1.213MetAsp: 1.213 ± 0.046	1.072MetGlu: 1.072 ± 0.038	0.442MetPhe: 0.442 ± 0.026	1.302MetGly: 1.302 ± 0.042	0.319MetHis: 0.319 ± 0.019	0.639MetIle: 0.639 ± 0.029	0.466MetLys: 0.466 ± 0.026	1.417MetLeu: 1.417 ± 0.046	0.308MetMet: 0.308 ± 0.022	0.644MetAsn: 0.644 ± 0.025	0.786MetPro: 0.786 ± 0.036	0.406MetGln: 0.406 ± 0.025	1.129MetArg: 1.129 ± 0.038	1.537MetSer: 1.537 ± 0.046	1.402MetThr: 1.402 ± 0.04	1.044MetVal: 1.044 ± 0.039	0.137MetTrp: 0.137 ± 0.014	0.403MetTyr: 0.403 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.654AsnAla: 2.654 ± 0.061	0.232AsnCys: 0.232 ± 0.019	1.812AsnAsp: 1.812 ± 0.052	1.817AsnGlu: 1.817 ± 0.056	0.641AsnPhe: 0.641 ± 0.031	1.979AsnGly: 1.979 ± 0.074	0.503AsnHis: 0.503 ± 0.026	0.912AsnIle: 0.912 ± 0.037	0.492AsnLys: 0.492 ± 0.028	1.839AsnLeu: 1.839 ± 0.052	0.357AsnMet: 0.357 ± 0.021	0.581AsnAsn: 0.581 ± 0.034	1.383AsnPro: 1.383 ± 0.045	0.582AsnGln: 0.582 ± 0.029	1.67AsnArg: 1.67 ± 0.045	1.068AsnSer: 1.068 ± 0.047	1.455AsnThr: 1.455 ± 0.064	2.195AsnVal: 2.195 ± 0.066	0.293AsnTrp: 0.293 ± 0.021	0.605AsnTyr: 0.605 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.736ProAla: 4.736 ± 0.085	0.251ProCys: 0.251 ± 0.019	4.796ProAsp: 4.796 ± 0.091	5.024ProGlu: 5.024 ± 0.085	1.481ProPhe: 1.481 ± 0.044	4.129ProGly: 4.129 ± 0.079	0.786ProHis: 0.786 ± 0.033	2.048ProIle: 2.048 ± 0.052	0.883ProLys: 0.883 ± 0.033	3.47ProLeu: 3.47 ± 0.072	0.797ProMet: 0.797 ± 0.037	1.096ProAsn: 1.096 ± 0.042	2.299ProPro: 2.299 ± 0.057	0.855ProGln: 0.855 ± 0.032	2.273ProArg: 2.273 ± 0.049	2.544ProSer: 2.544 ± 0.063	3.313ProThr: 3.313 ± 0.067	3.927ProVal: 3.927 ± 0.073	0.447ProTrp: 0.447 ± 0.026	1.113ProTyr: 1.113 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.196GlnAla: 2.196 ± 0.06	0.152GlnCys: 0.152 ± 0.015	1.126GlnAsp: 1.126 ± 0.041	1.487GlnGlu: 1.487 ± 0.05	0.915GlnPhe: 0.915 ± 0.034	1.474GlnGly: 1.474 ± 0.043	0.463GlnHis: 0.463 ± 0.027	0.993GlnIle: 0.993 ± 0.04	0.583GlnLys: 0.583 ± 0.029	2.284GlnLeu: 2.284 ± 0.059	0.459GlnMet: 0.459 ± 0.023	0.719GlnAsn: 0.719 ± 0.036	1.025GlnPro: 1.025 ± 0.031	0.829GlnGln: 0.829 ± 0.047	2.015GlnArg: 2.015 ± 0.053	1.432GlnSer: 1.432 ± 0.041	1.477GlnThr: 1.477 ± 0.055	1.433GlnVal: 1.433 ± 0.044	0.252GlnTrp: 0.252 ± 0.019	0.816GlnTyr: 0.816 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	7.092ArgAla: 7.092 ± 0.115	0.553ArgCys: 0.553 ± 0.029	4.546ArgAsp: 4.546 ± 0.082	6.696ArgGlu: 6.696 ± 0.114	2.52ArgPhe: 2.52 ± 0.062	4.933ArgGly: 4.933 ± 0.089	1.371ArgHis: 1.371 ± 0.043	3.482ArgIle: 3.482 ± 0.076	1.444ArgLys: 1.444 ± 0.051	6.708ArgLeu: 6.708 ± 0.11	1.346ArgMet: 1.346 ± 0.038	1.684ArgAsn: 1.684 ± 0.051	2.852ArgPro: 2.852 ± 0.071	1.71ArgGln: 1.71 ± 0.045	5.603ArgArg: 5.603 ± 0.109	4.124ArgSer: 4.124 ± 0.07	4.36ArgThr: 4.36 ± 0.077	5.273ArgVal: 5.273 ± 0.08	0.708ArgTrp: 0.708 ± 0.032	2.083ArgTyr: 2.083 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.693SerAla: 5.693 ± 0.1	0.342SerCys: 0.342 ± 0.02	4.353SerAsp: 4.353 ± 0.097	4.943SerGlu: 4.943 ± 0.084	1.984SerPhe: 1.984 ± 0.056	5.867SerGly: 5.867 ± 0.121	0.997SerHis: 0.997 ± 0.038	2.645SerIle: 2.645 ± 0.08	1.309SerLys: 1.309 ± 0.053	4.769SerLeu: 4.769 ± 0.083	1.087SerMet: 1.087 ± 0.04	1.429SerAsn: 1.429 ± 0.05	2.63SerPro: 2.63 ± 0.067	1.25SerGln: 1.25 ± 0.044	3.316SerArg: 3.316 ± 0.07	3.032SerSer: 3.032 ± 0.097	3.476SerThr: 3.476 ± 0.082	5.671SerVal: 5.671 ± 0.094	0.568SerTrp: 0.568 ± 0.028	1.381SerTyr: 1.381 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	7.199ThrAla: 7.199 ± 0.113	0.419ThrCys: 0.419 ± 0.025	5.739ThrAsp: 5.739 ± 0.095	5.051ThrGlu: 5.051 ± 0.086	2.079ThrPhe: 2.079 ± 0.053	5.697ThrGly: 5.697 ± 0.108	1.241ThrHis: 1.241 ± 0.036	2.817ThrIle: 2.817 ± 0.078	1.05ThrLys: 1.05 ± 0.039	5.677ThrLeu: 5.677 ± 0.119	0.934ThrMet: 0.934 ± 0.033	1.521ThrAsn: 1.521 ± 0.057	3.428ThrPro: 3.428 ± 0.068	1.294ThrGln: 1.294 ± 0.045	3.394ThrArg: 3.394 ± 0.074	2.712ThrSer: 2.712 ± 0.078	4.24ThrThr: 4.24 ± 0.098	7.073ThrVal: 7.073 ± 0.129	0.546ThrTrp: 0.546 ± 0.029	1.768ThrTyr: 1.768 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	10.059ValAla: 10.059 ± 0.154	0.779ValCys: 0.779 ± 0.034	7.358ValAsp: 7.358 ± 0.099	8.397ValGlu: 8.397 ± 0.112	2.982ValPhe: 2.982 ± 0.068	8.266ValGly: 8.266 ± 0.144	1.528ValHis: 1.528 ± 0.051	2.892ValIle: 2.892 ± 0.065	1.252ValLys: 1.252 ± 0.043	7.673ValLeu: 7.673 ± 0.128	1.238ValMet: 1.238 ± 0.04	1.71ValAsn: 1.71 ± 0.054	4.227ValPro: 4.227 ± 0.072	1.685ValGln: 1.685 ± 0.043	5.487ValArg: 5.487 ± 0.077	5.366ValSer: 5.366 ± 0.103	5.632ValThr: 5.632 ± 0.122	9.207ValVal: 9.207 ± 0.163	0.742ValTrp: 0.742 ± 0.031	2.126ValTyr: 2.126 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.903TrpAla: 0.903 ± 0.032	0.098TrpCys: 0.098 ± 0.011	0.692TrpAsp: 0.692 ± 0.032	0.71TrpGlu: 0.71 ± 0.034	0.394TrpPhe: 0.394 ± 0.023	0.762TrpGly: 0.762 ± 0.03	0.214TrpHis: 0.214 ± 0.017	0.455TrpIle: 0.455 ± 0.027	0.214TrpLys: 0.214 ± 0.017	1.103TrpLeu: 1.103 ± 0.036	0.17TrpMet: 0.17 ± 0.015	0.315TrpAsn: 0.315 ± 0.022	0.363TrpPro: 0.363 ± 0.026	0.298TrpGln: 0.298 ± 0.019	0.818TrpArg: 0.818 ± 0.036	0.541TrpSer: 0.541 ± 0.026	0.625TrpThr: 0.625 ± 0.026	0.789TrpVal: 0.789 ± 0.039	0.148TrpTrp: 0.148 ± 0.014	0.317TrpTyr: 0.317 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.751TyrAla: 2.751 ± 0.07	0.251TyrCys: 0.251 ± 0.019	2.556TyrAsp: 2.556 ± 0.066	2.386TyrGlu: 2.386 ± 0.066	0.807TyrPhe: 0.807 ± 0.035	2.372TyrGly: 2.372 ± 0.058	0.629TyrHis: 0.629 ± 0.029	0.791TyrIle: 0.791 ± 0.032	0.438TyrLys: 0.438 ± 0.027	2.343TyrLeu: 2.343 ± 0.064	0.359TyrMet: 0.359 ± 0.022	0.646TyrAsn: 0.646 ± 0.029	1.199TyrPro: 1.199 ± 0.042	0.667TyrGln: 0.667 ± 0.031	2.032TyrArg: 2.032 ± 0.057	1.173TyrSer: 1.173 ± 0.036	1.542TyrThr: 1.542 ± 0.048	2.37TyrVal: 2.37 ± 0.053	0.315TyrTrp: 0.315 ± 0.021	0.779TyrTyr: 0.779 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2723 proteins (809592 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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