Amino acid dipepetide frequency for Torque teno virus 8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.428AlaAla: 13.428 ± 4.508
0.707AlaCys: 0.707 ± 0.422
4.947AlaAsp: 4.947 ± 1.489
5.654AlaGlu: 5.654 ± 2.858
0.0AlaPhe: 0.0 ± 0.0
3.534AlaGly: 3.534 ± 0.619
0.707AlaHis: 0.707 ± 0.842
0.707AlaIle: 0.707 ± 0.422
2.827AlaLys: 2.827 ± 0.994
5.654AlaLeu: 5.654 ± 2.858
0.0AlaMet: 0.0 ± 0.0
1.413AlaAsn: 1.413 ± 0.844
7.774AlaPro: 7.774 ± 5.52
3.534AlaGln: 3.534 ± 0.619
3.534AlaArg: 3.534 ± 1.063
3.534AlaSer: 3.534 ± 1.548
1.413AlaThr: 1.413 ± 0.646
4.24AlaVal: 4.24 ± 2.763
1.413AlaTrp: 1.413 ± 0.844
1.413AlaTyr: 1.413 ± 0.668
0.0AlaXaa: 0.0 ± 0.0
Cys
0.707CysAla: 0.707 ± 0.842
0.0CysCys: 0.0 ± 0.0
0.707CysAsp: 0.707 ± 0.422
0.707CysGlu: 0.707 ± 0.804
2.12CysPhe: 2.12 ± 1.381
7.774CysGly: 7.774 ± 3.342
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.707CysLeu: 0.707 ± 0.804
0.707CysMet: 0.707 ± 0.422
0.707CysAsn: 0.707 ± 0.422
1.413CysPro: 1.413 ± 0.646
0.707CysGln: 0.707 ± 0.422
1.413CysArg: 1.413 ± 0.668
3.534CysSer: 3.534 ± 0.619
2.12CysThr: 2.12 ± 1.266
1.413CysVal: 1.413 ± 0.844
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.534AspAla: 3.534 ± 1.548
0.707AspCys: 0.707 ± 0.804
0.707AspAsp: 0.707 ± 0.422
2.12AspGlu: 2.12 ± 1.266
2.12AspPhe: 2.12 ± 1.266
2.827AspGly: 2.827 ± 0.983
0.0AspHis: 0.0 ± 0.0
1.413AspIle: 1.413 ± 0.844
2.12AspLys: 2.12 ± 1.266
2.12AspLeu: 2.12 ± 0.739
0.707AspMet: 0.707 ± 0.422
2.12AspAsn: 2.12 ± 1.266
9.187AspPro: 9.187 ± 1.0
0.707AspGln: 0.707 ± 0.842
4.947AspArg: 4.947 ± 3.266
2.827AspSer: 2.827 ± 1.015
2.12AspThr: 2.12 ± 0.739
4.24AspVal: 4.24 ± 1.213
5.654AspTrp: 5.654 ± 2.858
3.534AspTyr: 3.534 ± 2.11
0.0AspXaa: 0.0 ± 0.0
Glu
1.413GluAla: 1.413 ± 0.844
1.413GluCys: 1.413 ± 0.646
4.947GluAsp: 4.947 ± 2.361
4.24GluGlu: 4.24 ± 0.393
0.707GluPhe: 0.707 ± 0.422
2.827GluGly: 2.827 ± 0.983
2.12GluHis: 2.12 ± 1.266
0.0GluIle: 0.0 ± 0.0
2.12GluLys: 2.12 ± 1.266
3.534GluLeu: 3.534 ± 1.548
1.413GluMet: 1.413 ± 0.694
2.12GluAsn: 2.12 ± 0.665
2.827GluPro: 2.827 ± 1.952
3.534GluGln: 3.534 ± 1.339
1.413GluArg: 1.413 ± 1.607
4.947GluSer: 4.947 ± 2.489
3.534GluThr: 3.534 ± 1.338
1.413GluVal: 1.413 ± 0.844
0.707GluTrp: 0.707 ± 0.422
1.413GluTyr: 1.413 ± 0.668
0.0GluXaa: 0.0 ± 0.0
Phe
1.413PheAla: 1.413 ± 0.844
2.827PheCys: 2.827 ± 0.983
0.707PheAsp: 0.707 ± 0.422
2.12PheGlu: 2.12 ± 1.266
0.707PhePhe: 0.707 ± 0.422
2.12PheGly: 2.12 ± 1.266
0.707PheHis: 0.707 ± 0.422
2.12PheIle: 2.12 ± 1.266
4.24PheLys: 4.24 ± 2.003
2.827PheLeu: 2.827 ± 1.015
0.707PheMet: 0.707 ± 0.422
3.534PheAsn: 3.534 ± 2.11
2.12PhePro: 2.12 ± 0.734
2.12PheGln: 2.12 ± 0.734
3.534PheArg: 3.534 ± 0.619
0.0PheSer: 0.0 ± 0.0
1.413PheThr: 1.413 ± 0.844
1.413PheVal: 1.413 ± 0.844
0.0PheTrp: 0.0 ± 0.0
1.413PheTyr: 1.413 ± 0.668
0.0PheXaa: 0.0 ± 0.0
Gly
2.12GlyAla: 2.12 ± 0.734
2.12GlyCys: 2.12 ± 1.381
7.774GlyAsp: 7.774 ± 3.342
2.827GlyGlu: 2.827 ± 0.983
2.12GlyPhe: 2.12 ± 0.734
9.187GlyGly: 9.187 ± 2.568
0.0GlyHis: 0.0 ± 0.0
2.827GlyIle: 2.827 ± 1.292
0.0GlyLys: 0.0 ± 0.0
4.947GlyLeu: 4.947 ± 0.531
0.0GlyMet: 0.0 ± 0.0
3.534GlyAsn: 3.534 ± 2.11
4.24GlyPro: 4.24 ± 0.855
0.0GlyGln: 0.0 ± 0.0
4.24GlyArg: 4.24 ± 1.171
9.894GlySer: 9.894 ± 3.983
10.601GlyThr: 10.601 ± 2.613
0.707GlyVal: 0.707 ± 0.422
0.0GlyTrp: 0.0 ± 0.0
4.947GlyTyr: 4.947 ± 0.531
0.0GlyXaa: 0.0 ± 0.0
His
0.707HisAla: 0.707 ± 0.422
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.413HisGlu: 1.413 ± 0.668
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
2.827HisLys: 2.827 ± 0.983
4.24HisLeu: 4.24 ± 0.393
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
2.12HisPro: 2.12 ± 1.266
2.12HisGln: 2.12 ± 0.734
1.413HisArg: 1.413 ± 0.646
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
0.707HisVal: 0.707 ± 0.422
0.707HisTrp: 0.707 ± 0.422
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
0.707IleAla: 0.707 ± 0.422
2.12IleCys: 2.12 ± 1.266
0.707IleAsp: 0.707 ± 0.422
1.413IleGlu: 1.413 ± 0.844
1.413IlePhe: 1.413 ± 0.844
0.707IleGly: 0.707 ± 0.422
0.0IleHis: 0.0 ± 0.0
1.413IleIle: 1.413 ± 0.844
4.24IleLys: 4.24 ± 2.533
2.12IleLeu: 2.12 ± 0.734
0.0IleMet: 0.0 ± 0.0
0.707IleAsn: 0.707 ± 0.422
6.36IlePro: 6.36 ± 1.268
0.0IleGln: 0.0 ± 0.0
4.947IleArg: 4.947 ± 2.501
3.534IleSer: 3.534 ± 1.569
1.413IleThr: 1.413 ± 0.844
1.413IleVal: 1.413 ± 0.844
0.707IleTrp: 0.707 ± 0.422
0.707IleTyr: 0.707 ± 0.422
0.0IleXaa: 0.0 ± 0.0
Lys
0.707LysAla: 0.707 ± 0.422
4.947LysCys: 4.947 ± 1.489
2.827LysAsp: 2.827 ± 1.688
4.947LysGlu: 4.947 ± 1.151
1.413LysPhe: 1.413 ± 0.844
3.534LysGly: 3.534 ± 1.339
0.707LysHis: 0.707 ± 0.422
2.12LysIle: 2.12 ± 1.266
7.067LysLys: 7.067 ± 1.66
2.12LysLeu: 2.12 ± 0.665
0.707LysMet: 0.707 ± 0.842
4.947LysAsn: 4.947 ± 2.15
2.12LysPro: 2.12 ± 0.739
1.413LysGln: 1.413 ± 0.668
5.654LysArg: 5.654 ± 0.717
4.947LysSer: 4.947 ± 0.799
2.827LysThr: 2.827 ± 1.688
1.413LysVal: 1.413 ± 0.668
2.12LysTrp: 2.12 ± 1.266
2.827LysTyr: 2.827 ± 1.688
0.0LysXaa: 0.0 ± 0.0
Leu
4.947LeuAla: 4.947 ± 3.285
0.0LeuCys: 0.0 ± 0.0
1.413LeuAsp: 1.413 ± 0.668
3.534LeuGlu: 3.534 ± 0.619
2.12LeuPhe: 2.12 ± 0.734
2.12LeuGly: 2.12 ± 0.734
2.12LeuHis: 2.12 ± 1.266
3.534LeuIle: 3.534 ± 0.619
1.413LeuLys: 1.413 ± 0.844
5.654LeuLeu: 5.654 ± 0.747
1.413LeuMet: 1.413 ± 0.844
1.413LeuAsn: 1.413 ± 0.646
6.36LeuPro: 6.36 ± 2.46
2.827LeuGln: 2.827 ± 1.316
8.481LeuArg: 8.481 ± 0.63
4.24LeuSer: 4.24 ± 0.755
4.24LeuThr: 4.24 ± 1.719
2.12LeuVal: 2.12 ± 0.734
1.413LeuTrp: 1.413 ± 0.844
4.24LeuTyr: 4.24 ± 2.533
0.0LeuXaa: 0.0 ± 0.0
Met
1.413MetAla: 1.413 ± 1.055
0.0MetCys: 0.0 ± 0.0
0.707MetAsp: 0.707 ± 0.422
0.0MetGlu: 0.0 ± 0.0
0.707MetPhe: 0.707 ± 0.422
0.707MetGly: 0.707 ± 0.422
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.413MetLys: 1.413 ± 0.844
0.707MetLeu: 0.707 ± 0.422
0.0MetMet: 0.0 ± 0.0
0.707MetAsn: 0.707 ± 0.422
1.413MetPro: 1.413 ± 0.844
0.707MetGln: 0.707 ± 0.422
0.707MetArg: 0.707 ± 0.422
3.534MetSer: 3.534 ± 1.569
0.707MetThr: 0.707 ± 0.422
0.0MetVal: 0.0 ± 0.0
0.707MetTrp: 0.707 ± 0.422
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.413AsnAla: 1.413 ± 0.844
0.0AsnCys: 0.0 ± 0.0
2.827AsnAsp: 2.827 ± 1.688
0.707AsnGlu: 0.707 ± 0.422
4.24AsnPhe: 4.24 ± 1.751
1.413AsnGly: 1.413 ± 0.646
0.707AsnHis: 0.707 ± 0.422
1.413AsnIle: 1.413 ± 0.844
2.827AsnLys: 2.827 ± 1.688
1.413AsnLeu: 1.413 ± 0.668
0.0AsnMet: 0.0 ± 0.0
2.12AsnAsn: 2.12 ± 1.396
2.827AsnPro: 2.827 ± 1.015
2.827AsnGln: 2.827 ± 0.983
2.827AsnArg: 2.827 ± 1.015
2.827AsnSer: 2.827 ± 1.292
4.947AsnThr: 4.947 ± 2.115
3.534AsnVal: 3.534 ± 0.619
0.0AsnTrp: 0.0 ± 0.0
2.827AsnTyr: 2.827 ± 1.688
0.0AsnXaa: 0.0 ± 0.0
Pro
7.774ProAla: 7.774 ± 3.818
1.413ProCys: 1.413 ± 0.844
4.24ProAsp: 4.24 ± 1.467
2.827ProGlu: 2.827 ± 0.994
3.534ProPhe: 3.534 ± 1.339
7.774ProGly: 7.774 ± 1.75
0.0ProHis: 0.0 ± 0.0
3.534ProIle: 3.534 ± 2.11
2.827ProLys: 2.827 ± 0.994
7.067ProLeu: 7.067 ± 0.91
0.707ProMet: 0.707 ± 0.658
0.707ProAsn: 0.707 ± 0.422
15.548ProPro: 15.548 ± 6.032
4.947ProGln: 4.947 ± 1.646
7.067ProArg: 7.067 ± 3.229
4.947ProSer: 4.947 ± 0.915
5.654ProThr: 5.654 ± 1.676
4.947ProVal: 4.947 ± 3.054
1.413ProTrp: 1.413 ± 0.668
4.947ProTyr: 4.947 ± 0.531
0.0ProXaa: 0.0 ± 0.0
Gln
2.827GlnAla: 2.827 ± 1.944
2.12GlnCys: 2.12 ± 1.381
1.413GlnAsp: 1.413 ± 1.055
0.707GlnGlu: 0.707 ± 0.422
1.413GlnPhe: 1.413 ± 0.668
0.707GlnGly: 0.707 ± 0.422
0.707GlnHis: 0.707 ± 0.422
3.534GlnIle: 3.534 ± 1.338
3.534GlnLys: 3.534 ± 1.368
2.12GlnLeu: 2.12 ± 1.266
0.707GlnMet: 0.707 ± 0.804
3.534GlnAsn: 3.534 ± 0.619
4.947GlnPro: 4.947 ± 0.837
3.534GlnGln: 3.534 ± 0.619
0.707GlnArg: 0.707 ± 0.804
2.12GlnSer: 2.12 ± 0.734
3.534GlnThr: 3.534 ± 0.414
2.12GlnVal: 2.12 ± 1.46
0.707GlnTrp: 0.707 ± 0.422
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
10.601ArgAla: 10.601 ± 4.593
0.707ArgCys: 0.707 ± 0.422
2.12ArgAsp: 2.12 ± 0.739
4.947ArgGlu: 4.947 ± 0.915
2.827ArgPhe: 2.827 ± 1.688
9.187ArgGly: 9.187 ± 3.621
3.534ArgHis: 3.534 ± 1.548
0.0ArgIle: 0.0 ± 0.0
7.774ArgLys: 7.774 ± 1.771
5.654ArgLeu: 5.654 ± 1.491
1.413ArgMet: 1.413 ± 0.844
0.707ArgAsn: 0.707 ± 0.804
3.534ArgPro: 3.534 ± 1.339
2.12ArgGln: 2.12 ± 1.381
21.201ArgArg: 21.201 ± 8.087
6.36ArgSer: 6.36 ± 4.621
3.534ArgThr: 3.534 ± 1.712
1.413ArgVal: 1.413 ± 0.844
3.534ArgTrp: 3.534 ± 2.11
3.534ArgTyr: 3.534 ± 1.368
0.0ArgXaa: 0.0 ± 0.0
Ser
3.534SerAla: 3.534 ± 0.619
0.707SerCys: 0.707 ± 0.422
6.36SerAsp: 6.36 ± 2.493
4.24SerGlu: 4.24 ± 3.389
3.534SerPhe: 3.534 ± 1.338
5.654SerGly: 5.654 ± 2.858
3.534SerHis: 3.534 ± 0.619
3.534SerIle: 3.534 ± 0.619
4.24SerLys: 4.24 ± 1.784
2.827SerLeu: 2.827 ± 1.015
1.413SerMet: 1.413 ± 1.414
4.947SerAsn: 4.947 ± 0.915
7.067SerPro: 7.067 ± 2.147
1.413SerGln: 1.413 ± 0.646
7.774SerArg: 7.774 ± 3.022
14.841SerSer: 14.841 ± 9.691
3.534SerThr: 3.534 ± 2.021
2.12SerVal: 2.12 ± 0.734
0.0SerTrp: 0.0 ± 0.0
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
4.947ThrAla: 4.947 ± 2.361
1.413ThrCys: 1.413 ± 0.668
2.827ThrAsp: 2.827 ± 1.688
1.413ThrGlu: 1.413 ± 0.668
1.413ThrPhe: 1.413 ± 0.844
6.36ThrGly: 6.36 ± 0.655
0.707ThrHis: 0.707 ± 0.804
2.12ThrIle: 2.12 ± 0.734
4.24ThrLys: 4.24 ± 1.467
3.534ThrLeu: 3.534 ± 2.11
1.413ThrMet: 1.413 ± 0.844
1.413ThrAsn: 1.413 ± 0.668
5.654ThrPro: 5.654 ± 0.747
2.827ThrGln: 2.827 ± 1.688
4.24ThrArg: 4.24 ± 1.784
3.534ThrSer: 3.534 ± 2.076
4.24ThrThr: 4.24 ± 1.938
2.827ThrVal: 2.827 ± 1.015
1.413ThrTrp: 1.413 ± 0.844
2.827ThrTyr: 2.827 ± 1.015
0.0ThrXaa: 0.0 ± 0.0
Val
3.534ValAla: 3.534 ± 1.548
0.0ValCys: 0.0 ± 0.0
2.827ValAsp: 2.827 ± 1.015
2.12ValGlu: 2.12 ± 1.381
0.707ValPhe: 0.707 ± 0.422
2.827ValGly: 2.827 ± 1.944
0.0ValHis: 0.0 ± 0.0
0.707ValIle: 0.707 ± 0.422
1.413ValLys: 1.413 ± 0.844
2.827ValLeu: 2.827 ± 1.688
1.413ValMet: 1.413 ± 0.844
2.12ValAsn: 2.12 ± 0.739
2.827ValPro: 2.827 ± 0.359
2.12ValGln: 2.12 ± 0.739
4.947ValArg: 4.947 ± 0.531
2.12ValSer: 2.12 ± 0.665
1.413ValThr: 1.413 ± 0.844
4.24ValVal: 4.24 ± 1.751
0.707ValTrp: 0.707 ± 0.842
2.12ValTyr: 2.12 ± 1.381
0.0ValXaa: 0.0 ± 0.0
Trp
0.707TrpAla: 0.707 ± 0.422
0.707TrpCys: 0.707 ± 0.422
0.707TrpAsp: 0.707 ± 0.422
0.707TrpGlu: 0.707 ± 0.842
2.12TrpPhe: 2.12 ± 1.381
1.413TrpGly: 1.413 ± 0.844
0.707TrpHis: 0.707 ± 0.422
2.12TrpIle: 2.12 ± 1.381
0.707TrpLys: 0.707 ± 0.422
0.707TrpLeu: 0.707 ± 0.842
0.707TrpMet: 0.707 ± 0.422
2.12TrpAsn: 2.12 ± 1.266
0.707TrpPro: 0.707 ± 0.422
0.0TrpGln: 0.0 ± 0.0
3.534TrpArg: 3.534 ± 2.11
0.707TrpSer: 0.707 ± 0.422
0.707TrpThr: 0.707 ± 0.842
0.707TrpVal: 0.707 ± 0.422
0.707TrpTrp: 0.707 ± 0.422
1.413TrpTyr: 1.413 ± 0.844
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
2.827TyrCys: 2.827 ± 0.983
4.947TyrAsp: 4.947 ± 0.531
0.0TyrGlu: 0.0 ± 0.0
2.827TyrPhe: 2.827 ± 1.688
1.413TyrGly: 1.413 ± 0.844
0.0TyrHis: 0.0 ± 0.0
3.534TyrIle: 3.534 ± 2.11
3.534TyrLys: 3.534 ± 1.368
2.827TyrLeu: 2.827 ± 0.994
0.0TyrMet: 0.0 ± 0.0
2.827TyrAsn: 2.827 ± 1.688
3.534TyrPro: 3.534 ± 0.414
3.534TyrGln: 3.534 ± 1.548
2.12TyrArg: 2.12 ± 1.266
2.827TyrSer: 2.827 ± 1.688
1.413TyrThr: 1.413 ± 0.844
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
1.413TyrTyr: 1.413 ± 0.844
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1416 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski