Amino acid dipepetide frequency for Haemophilus paracuniculus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.834AlaAla: 5.834 ± 0.176
1.148AlaCys: 1.148 ± 0.047
4.907AlaAsp: 4.907 ± 0.092
7.326AlaGlu: 7.326 ± 0.161
3.633AlaPhe: 3.633 ± 0.088
6.048AlaGly: 6.048 ± 0.132
1.36AlaHis: 1.36 ± 0.05
6.192AlaIle: 6.192 ± 0.125
6.692AlaLys: 6.692 ± 0.133
9.594AlaLeu: 9.594 ± 0.146
2.446AlaMet: 2.446 ± 0.069
4.181AlaAsn: 4.181 ± 0.102
2.631AlaPro: 2.631 ± 0.066
4.233AlaGln: 4.233 ± 0.098
3.665AlaArg: 3.665 ± 0.086
4.476AlaSer: 4.476 ± 0.095
4.85AlaThr: 4.85 ± 0.147
6.743AlaVal: 6.743 ± 0.125
0.797AlaTrp: 0.797 ± 0.034
2.389AlaTyr: 2.389 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.708CysAla: 0.708 ± 0.039
0.164CysCys: 0.164 ± 0.016
0.573CysAsp: 0.573 ± 0.033
0.728CysGlu: 0.728 ± 0.04
0.443CysPhe: 0.443 ± 0.029
0.897CysGly: 0.897 ± 0.046
0.261CysHis: 0.261 ± 0.023
0.507CysIle: 0.507 ± 0.029
0.457CysLys: 0.457 ± 0.027
1.057CysLeu: 1.057 ± 0.047
0.14CysMet: 0.14 ± 0.017
0.373CysAsn: 0.373 ± 0.026
0.442CysPro: 0.442 ± 0.028
0.512CysGln: 0.512 ± 0.03
0.421CysArg: 0.421 ± 0.028
0.609CysSer: 0.609 ± 0.032
0.459CysThr: 0.459 ± 0.028
0.691CysVal: 0.691 ± 0.031
0.138CysTrp: 0.138 ± 0.016
0.367CysTyr: 0.367 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.088AspAla: 3.088 ± 0.082
0.521AspCys: 0.521 ± 0.031
2.289AspAsp: 2.289 ± 0.072
3.614AspGlu: 3.614 ± 0.088
2.692AspPhe: 2.692 ± 0.072
2.928AspGly: 2.928 ± 0.077
0.951AspHis: 0.951 ± 0.044
3.117AspIle: 3.117 ± 0.077
3.228AspLys: 3.228 ± 0.092
5.715AspLeu: 5.715 ± 0.102
0.993AspMet: 0.993 ± 0.037
2.208AspAsn: 2.208 ± 0.061
2.345AspPro: 2.345 ± 0.069
2.222AspGln: 2.222 ± 0.063
2.409AspArg: 2.409 ± 0.067
2.458AspSer: 2.458 ± 0.061
2.104AspThr: 2.104 ± 0.064
3.164AspVal: 3.164 ± 0.074
0.693AspTrp: 0.693 ± 0.035
2.227AspTyr: 2.227 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.153GluAla: 5.153 ± 0.117
0.472GluCys: 0.472 ± 0.028
2.561GluAsp: 2.561 ± 0.063
3.478GluGlu: 3.478 ± 0.099
2.394GluPhe: 2.394 ± 0.069
3.549GluGly: 3.549 ± 0.088
1.094GluHis: 1.094 ± 0.05
4.828GluIle: 4.828 ± 0.092
5.349GluLys: 5.349 ± 0.112
6.44GluLeu: 6.44 ± 0.122
1.95GluMet: 1.95 ± 0.059
3.763GluAsn: 3.763 ± 0.078
2.095GluPro: 2.095 ± 0.067
4.87GluGln: 4.87 ± 0.117
3.528GluArg: 3.528 ± 0.091
3.039GluSer: 3.039 ± 0.082
3.248GluThr: 3.248 ± 0.075
4.073GluVal: 4.073 ± 0.107
0.88GluTrp: 0.88 ± 0.039
1.558GluTyr: 1.558 ± 0.061
0.002GluXaa: 0.002 ± 0.001
Phe
4.068PheAla: 4.068 ± 0.093
0.659PheCys: 0.659 ± 0.039
2.797PheAsp: 2.797 ± 0.067
2.893PheGlu: 2.893 ± 0.077
1.986PhePhe: 1.986 ± 0.071
3.628PheGly: 3.628 ± 0.096
0.792PheHis: 0.792 ± 0.038
2.928PheIle: 2.928 ± 0.088
2.156PheLys: 2.156 ± 0.063
4.142PheLeu: 4.142 ± 0.103
0.959PheMet: 0.959 ± 0.046
2.171PheAsn: 2.171 ± 0.061
1.642PhePro: 1.642 ± 0.053
1.596PheGln: 1.596 ± 0.057
1.623PheArg: 1.623 ± 0.048
3.324PheSer: 3.324 ± 0.094
2.149PheThr: 2.149 ± 0.058
3.026PheVal: 3.026 ± 0.083
0.544PheTrp: 0.544 ± 0.032
1.586PheTyr: 1.586 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.04GlyAla: 5.04 ± 0.12
0.76GlyCys: 0.76 ± 0.036
3.243GlyAsp: 3.243 ± 0.072
4.675GlyGlu: 4.675 ± 0.09
3.188GlyPhe: 3.188 ± 0.08
4.705GlyGly: 4.705 ± 0.116
1.116GlyHis: 1.116 ± 0.048
4.944GlyIle: 4.944 ± 0.102
5.135GlyLys: 5.135 ± 0.099
6.92GlyLeu: 6.92 ± 0.153
1.751GlyMet: 1.751 ± 0.053
2.874GlyAsn: 2.874 ± 0.095
0.984GlyPro: 0.984 ± 0.042
2.675GlyGln: 2.675 ± 0.076
2.896GlyArg: 2.896 ± 0.079
3.847GlySer: 3.847 ± 0.095
3.345GlyThr: 3.345 ± 0.077
5.492GlyVal: 5.492 ± 0.094
0.946GlyTrp: 0.946 ± 0.044
2.551GlyTyr: 2.551 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.215HisAla: 1.215 ± 0.047
0.325HisCys: 0.325 ± 0.023
0.74HisAsp: 0.74 ± 0.043
0.742HisGlu: 0.742 ± 0.042
1.148HisPhe: 1.148 ± 0.048
1.099HisGly: 1.099 ± 0.047
0.534HisHis: 0.534 ± 0.032
1.381HisIle: 1.381 ± 0.046
1.005HisLys: 1.005 ± 0.041
2.183HisLeu: 2.183 ± 0.058
0.244HisMet: 0.244 ± 0.021
0.922HisAsn: 0.922 ± 0.042
0.947HisPro: 0.947 ± 0.045
1.163HisGln: 1.163 ± 0.049
1.01HisArg: 1.01 ± 0.042
1.276HisSer: 1.276 ± 0.04
0.956HisThr: 0.956 ± 0.045
0.679HisVal: 0.679 ± 0.037
0.219HisTrp: 0.219 ± 0.021
0.821HisTyr: 0.821 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.785IleAla: 6.785 ± 0.133
0.767IleCys: 0.767 ± 0.044
3.715IleAsp: 3.715 ± 0.08
4.889IleGlu: 4.889 ± 0.095
2.857IlePhe: 2.857 ± 0.082
4.882IleGly: 4.882 ± 0.104
1.153IleHis: 1.153 ± 0.042
3.928IleIle: 3.928 ± 0.106
3.656IleLys: 3.656 ± 0.083
6.104IleLeu: 6.104 ± 0.135
1.178IleMet: 1.178 ± 0.043
2.888IleAsn: 2.888 ± 0.075
2.64IlePro: 2.64 ± 0.085
2.598IleGln: 2.598 ± 0.07
2.844IleArg: 2.844 ± 0.067
4.599IleSer: 4.599 ± 0.1
3.447IleThr: 3.447 ± 0.069
4.359IleVal: 4.359 ± 0.099
0.62IleTrp: 0.62 ± 0.034
1.993IleTyr: 1.993 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
5.922LysAla: 5.922 ± 0.151
0.349LysCys: 0.349 ± 0.023
2.647LysAsp: 2.647 ± 0.081
3.717LysGlu: 3.717 ± 0.094
2.252LysPhe: 2.252 ± 0.068
3.914LysGly: 3.914 ± 0.085
1.003LysHis: 1.003 ± 0.043
4.278LysIle: 4.278 ± 0.09
3.776LysLys: 3.776 ± 0.119
6.155LysLeu: 6.155 ± 0.105
1.928LysMet: 1.928 ± 0.059
3.27LysAsn: 3.27 ± 0.085
2.581LysPro: 2.581 ± 0.077
3.336LysGln: 3.336 ± 0.088
3.039LysArg: 3.039 ± 0.077
3.292LysSer: 3.292 ± 0.077
3.318LysThr: 3.318 ± 0.078
4.203LysVal: 4.203 ± 0.096
0.759LysTrp: 0.759 ± 0.04
1.61LysTyr: 1.61 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
11.177LeuAla: 11.177 ± 0.166
1.023LeuCys: 1.023 ± 0.044
5.698LeuAsp: 5.698 ± 0.1
5.77LeuGlu: 5.77 ± 0.125
4.912LeuPhe: 4.912 ± 0.111
7.203LeuGly: 7.203 ± 0.148
1.88LeuHis: 1.88 ± 0.053
6.536LeuIle: 6.536 ± 0.131
6.028LeuLys: 6.028 ± 0.093
10.479LeuLeu: 10.479 ± 0.196
2.399LeuMet: 2.399 ± 0.067
5.458LeuAsn: 5.458 ± 0.104
4.739LeuPro: 4.739 ± 0.09
4.093LeuGln: 4.093 ± 0.091
4.599LeuArg: 4.599 ± 0.105
6.969LeuSer: 6.969 ± 0.116
5.932LeuThr: 5.932 ± 0.096
6.617LeuVal: 6.617 ± 0.116
1.07LeuTrp: 1.07 ± 0.044
2.702LeuTyr: 2.702 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
2.539MetAla: 2.539 ± 0.062
0.153MetCys: 0.153 ± 0.015
0.932MetAsp: 0.932 ± 0.037
1.094MetGlu: 1.094 ± 0.044
0.914MetPhe: 0.914 ± 0.043
1.536MetGly: 1.536 ± 0.055
0.369MetHis: 0.369 ± 0.023
1.568MetIle: 1.568 ± 0.057
1.672MetLys: 1.672 ± 0.055
2.498MetLeu: 2.498 ± 0.074
0.689MetMet: 0.689 ± 0.041
1.173MetAsn: 1.173 ± 0.048
0.937MetPro: 0.937 ± 0.04
1.2MetGln: 1.2 ± 0.045
1.025MetArg: 1.025 ± 0.039
1.472MetSer: 1.472 ± 0.053
1.207MetThr: 1.207 ± 0.047
1.418MetVal: 1.418 ± 0.051
0.217MetTrp: 0.217 ± 0.019
0.421MetTyr: 0.421 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
4.363AsnAla: 4.363 ± 0.117
0.401AsnCys: 0.401 ± 0.028
2.212AsnAsp: 2.212 ± 0.063
2.819AsnGlu: 2.819 ± 0.065
1.903AsnPhe: 1.903 ± 0.055
3.668AsnGly: 3.668 ± 0.103
0.925AsnHis: 0.925 ± 0.036
2.871AsnIle: 2.871 ± 0.077
2.608AsnLys: 2.608 ± 0.086
5.142AsnLeu: 5.142 ± 0.097
0.872AsnMet: 0.872 ± 0.039
2.2AsnAsn: 2.2 ± 0.087
2.744AsnPro: 2.744 ± 0.07
2.682AsnGln: 2.682 ± 0.077
2.267AsnArg: 2.267 ± 0.067
2.52AsnSer: 2.52 ± 0.071
2.151AsnThr: 2.151 ± 0.079
3.233AsnVal: 3.233 ± 0.083
0.571AsnTrp: 0.571 ± 0.029
1.564AsnTyr: 1.564 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
3.227ProAla: 3.227 ± 0.082
0.334ProCys: 0.334 ± 0.025
1.907ProAsp: 1.907 ± 0.06
3.135ProGlu: 3.135 ± 0.077
2.001ProPhe: 2.001 ± 0.07
1.168ProGly: 1.168 ± 0.055
0.942ProHis: 0.942 ± 0.038
2.69ProIle: 2.69 ± 0.066
2.352ProLys: 2.352 ± 0.064
4.177ProLeu: 4.177 ± 0.094
0.875ProMet: 0.875 ± 0.037
2.448ProAsn: 2.448 ± 0.061
1.246ProPro: 1.246 ± 0.056
2.262ProGln: 2.262 ± 0.062
1.401ProArg: 1.401 ± 0.051
2.117ProSer: 2.117 ± 0.059
2.63ProThr: 2.63 ± 0.07
2.542ProVal: 2.542 ± 0.07
0.322ProTrp: 0.322 ± 0.023
1.354ProTyr: 1.354 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
5.406GlnAla: 5.406 ± 0.135
0.416GlnCys: 0.416 ± 0.032
1.907GlnAsp: 1.907 ± 0.059
2.434GlnGlu: 2.434 ± 0.074
2.355GlnPhe: 2.355 ± 0.062
3.321GlnGly: 3.321 ± 0.087
1.037GlnHis: 1.037 ± 0.038
3.7GlnIle: 3.7 ± 0.084
3.134GlnLys: 3.134 ± 0.083
5.185GlnLeu: 5.185 ± 0.121
1.077GlnMet: 1.077 ± 0.045
2.5GlnAsn: 2.5 ± 0.077
2.117GlnPro: 2.117 ± 0.071
3.827GlnGln: 3.827 ± 0.095
2.589GlnArg: 2.589 ± 0.07
2.724GlnSer: 2.724 ± 0.073
2.658GlnThr: 2.658 ± 0.073
2.881GlnVal: 2.881 ± 0.071
0.713GlnTrp: 0.713 ± 0.037
1.322GlnTyr: 1.322 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
3.404ArgAla: 3.404 ± 0.084
0.411ArgCys: 0.411 ± 0.026
2.052ArgAsp: 2.052 ± 0.059
3.26ArgGlu: 3.26 ± 0.084
2.345ArgPhe: 2.345 ± 0.066
2.675ArgGly: 2.675 ± 0.075
1.059ArgHis: 1.059 ± 0.044
2.91ArgIle: 2.91 ± 0.073
2.707ArgLys: 2.707 ± 0.074
5.241ArgLeu: 5.241 ± 0.102
0.978ArgMet: 0.978 ± 0.042
2.036ArgAsn: 2.036 ± 0.047
1.706ArgPro: 1.706 ± 0.052
2.647ArgGln: 2.647 ± 0.067
2.028ArgArg: 2.028 ± 0.066
2.436ArgSer: 2.436 ± 0.07
2.173ArgThr: 2.173 ± 0.061
2.849ArgVal: 2.849 ± 0.082
0.543ArgTrp: 0.543 ± 0.032
1.829ArgTyr: 1.829 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
5.113SerAla: 5.113 ± 0.172
0.509SerCys: 0.509 ± 0.032
2.79SerAsp: 2.79 ± 0.078
3.785SerGlu: 3.785 ± 0.083
2.655SerPhe: 2.655 ± 0.076
4.428SerGly: 4.428 ± 0.113
1.237SerHis: 1.237 ± 0.049
3.414SerIle: 3.414 ± 0.085
2.91SerLys: 2.91 ± 0.066
6.413SerLeu: 6.413 ± 0.118
1.182SerMet: 1.182 ± 0.053
2.532SerAsn: 2.532 ± 0.082
2.517SerPro: 2.517 ± 0.073
3.142SerGln: 3.142 ± 0.088
2.411SerArg: 2.411 ± 0.058
3.385SerSer: 3.385 ± 0.09
2.889SerThr: 2.889 ± 0.082
3.943SerVal: 3.943 ± 0.083
0.669SerTrp: 0.669 ± 0.032
1.778SerTyr: 1.778 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
5.737ThrAla: 5.737 ± 0.127
0.394ThrCys: 0.394 ± 0.025
2.559ThrAsp: 2.559 ± 0.064
3.189ThrGlu: 3.189 ± 0.081
2.336ThrPhe: 2.336 ± 0.066
3.658ThrGly: 3.658 ± 0.089
0.924ThrHis: 0.924 ± 0.042
3.189ThrIle: 3.189 ± 0.077
2.498ThrLys: 2.498 ± 0.067
5.952ThrLeu: 5.952 ± 0.101
1.005ThrMet: 1.005 ± 0.043
2.077ThrAsn: 2.077 ± 0.076
2.598ThrPro: 2.598 ± 0.065
2.288ThrGln: 2.288 ± 0.061
1.979ThrArg: 1.979 ± 0.06
2.758ThrSer: 2.758 ± 0.094
2.84ThrThr: 2.84 ± 0.089
3.516ThrVal: 3.516 ± 0.102
0.443ThrTrp: 0.443 ± 0.029
1.386ThrTyr: 1.386 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
6.95ValAla: 6.95 ± 0.122
0.632ValCys: 0.632 ± 0.034
3.439ValAsp: 3.439 ± 0.083
4.791ValGlu: 4.791 ± 0.099
2.561ValPhe: 2.561 ± 0.064
4.83ValGly: 4.83 ± 0.113
0.976ValHis: 0.976 ± 0.041
4.54ValIle: 4.54 ± 0.103
3.988ValLys: 3.988 ± 0.089
6.591ValLeu: 6.591 ± 0.104
1.687ValMet: 1.687 ± 0.059
2.898ValAsn: 2.898 ± 0.099
2.621ValPro: 2.621 ± 0.068
2.711ValGln: 2.711 ± 0.077
3.122ValArg: 3.122 ± 0.075
4.224ValSer: 4.224 ± 0.089
3.066ValThr: 3.066 ± 0.095
5.297ValVal: 5.297 ± 0.113
0.674ValTrp: 0.674 ± 0.035
1.713ValTyr: 1.713 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.865TrpAla: 0.865 ± 0.037
0.121TrpCys: 0.121 ± 0.015
0.534TrpAsp: 0.534 ± 0.035
0.519TrpGlu: 0.519 ± 0.031
0.526TrpPhe: 0.526 ± 0.032
0.748TrpGly: 0.748 ± 0.036
0.255TrpHis: 0.255 ± 0.023
0.725TrpIle: 0.725 ± 0.038
0.668TrpLys: 0.668 ± 0.035
1.753TrpLeu: 1.753 ± 0.062
0.182TrpMet: 0.182 ± 0.017
0.526TrpAsn: 0.526 ± 0.03
0.103TrpPro: 0.103 ± 0.013
1.042TrpGln: 1.042 ± 0.045
0.607TrpArg: 0.607 ± 0.035
0.425TrpSer: 0.425 ± 0.027
0.511TrpThr: 0.511 ± 0.03
0.775TrpVal: 0.775 ± 0.036
0.162TrpTrp: 0.162 ± 0.015
0.33TrpTyr: 0.33 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.552TyrAla: 2.552 ± 0.068
0.386TyrCys: 0.386 ± 0.024
1.467TyrAsp: 1.467 ± 0.048
1.465TyrGlu: 1.465 ± 0.048
1.569TyrPhe: 1.569 ± 0.05
2.202TyrGly: 2.202 ± 0.065
0.742TyrHis: 0.742 ± 0.036
1.657TyrIle: 1.657 ± 0.067
1.33TyrLys: 1.33 ± 0.048
3.543TyrLeu: 3.543 ± 0.092
0.497TyrMet: 0.497 ± 0.031
1.219TyrAsn: 1.219 ± 0.046
1.494TyrPro: 1.494 ± 0.052
2.205TyrGln: 2.205 ± 0.075
1.824TyrArg: 1.824 ± 0.061
1.75TyrSer: 1.75 ± 0.055
1.394TyrThr: 1.394 ± 0.049
1.81TyrVal: 1.81 ± 0.053
0.394TyrTrp: 0.394 ± 0.026
1.018TyrTyr: 1.018 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.002XaaSer: 0.002 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1927 proteins (593209 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski