Amino acid dipepetide frequency for Desulfobulbus oralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.625AlaAla: 15.625 ± 0.264	1.857AlaCys: 1.857 ± 0.061	5.638AlaAsp: 5.638 ± 0.087	7.122AlaGlu: 7.122 ± 0.127	4.101AlaPhe: 4.101 ± 0.073	10.686AlaGly: 10.686 ± 0.17	2.107AlaHis: 2.107 ± 0.061	4.97AlaIle: 4.97 ± 0.087	3.476AlaLys: 3.476 ± 0.074	14.016AlaLeu: 14.016 ± 0.191	3.09AlaMet: 3.09 ± 0.073	2.561AlaAsn: 2.561 ± 0.072	4.869AlaPro: 4.869 ± 0.099	4.246AlaGln: 4.246 ± 0.091	8.012AlaArg: 8.012 ± 0.136	5.38AlaSer: 5.38 ± 0.09	4.57AlaThr: 4.57 ± 0.084	7.347AlaVal: 7.347 ± 0.104	1.271AlaTrp: 1.271 ± 0.047	2.35AlaTyr: 2.35 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.454CysAla: 1.454 ± 0.05	0.396CysCys: 0.396 ± 0.021	0.581CysAsp: 0.581 ± 0.03	0.609CysGlu: 0.609 ± 0.028	0.627CysPhe: 0.627 ± 0.031	1.57CysGly: 1.57 ± 0.047	0.384CysHis: 0.384 ± 0.025	0.794CysIle: 0.794 ± 0.037	0.413CysLys: 0.413 ± 0.025	1.66CysLeu: 1.66 ± 0.057	0.404CysMet: 0.404 ± 0.022	0.426CysAsn: 0.426 ± 0.024	0.964CysPro: 0.964 ± 0.045	0.417CysGln: 0.417 ± 0.024	1.324CysArg: 1.324 ± 0.045	0.885CysSer: 0.885 ± 0.036	0.825CysThr: 0.825 ± 0.035	0.882CysVal: 0.882 ± 0.033	0.173CysTrp: 0.173 ± 0.015	0.358CysTyr: 0.358 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	5.38AspAla: 5.38 ± 0.095	0.808AspCys: 0.808 ± 0.036	2.227AspAsp: 2.227 ± 0.074	3.335AspGlu: 3.335 ± 0.077	2.274AspPhe: 2.274 ± 0.054	3.917AspGly: 3.917 ± 0.113	0.895AspHis: 0.895 ± 0.032	3.007AspIle: 3.007 ± 0.073	1.913AspLys: 1.913 ± 0.054	5.17AspLeu: 5.17 ± 0.088	1.441AspMet: 1.441 ± 0.044	1.435AspAsn: 1.435 ± 0.046	2.586AspPro: 2.586 ± 0.065	1.483AspGln: 1.483 ± 0.046	3.336AspArg: 3.336 ± 0.079	2.716AspSer: 2.716 ± 0.082	2.387AspThr: 2.387 ± 0.064	2.923AspVal: 2.923 ± 0.076	0.769AspTrp: 0.769 ± 0.036	1.624AspTyr: 1.624 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	7.181GluAla: 7.181 ± 0.115	0.614GluCys: 0.614 ± 0.033	2.712GluAsp: 2.712 ± 0.062	4.067GluGlu: 4.067 ± 0.093	1.655GluPhe: 1.655 ± 0.049	4.053GluGly: 4.053 ± 0.088	1.409GluHis: 1.409 ± 0.049	3.263GluIle: 3.263 ± 0.076	3.126GluLys: 3.126 ± 0.074	7.039GluLeu: 7.039 ± 0.115	1.535GluMet: 1.535 ± 0.05	1.888GluAsn: 1.888 ± 0.054	2.447GluPro: 2.447 ± 0.058	3.177GluGln: 3.177 ± 0.068	4.897GluArg: 4.897 ± 0.093	2.913GluSer: 2.913 ± 0.054	2.724GluThr: 2.724 ± 0.059	3.413GluVal: 3.413 ± 0.075	0.62GluTrp: 0.62 ± 0.031	1.441GluTyr: 1.441 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.315PheAla: 4.315 ± 0.095	0.796PheCys: 0.796 ± 0.037	2.197PheAsp: 2.197 ± 0.061	1.68PheGlu: 1.68 ± 0.046	2.122PhePhe: 2.122 ± 0.066	3.225PheGly: 3.225 ± 0.071	0.825PheHis: 0.825 ± 0.03	1.767PheIle: 1.767 ± 0.06	1.11PheLys: 1.11 ± 0.046	4.261PheLeu: 4.261 ± 0.094	0.936PheMet: 0.936 ± 0.038	1.087PheAsn: 1.087 ± 0.04	1.888PhePro: 1.888 ± 0.054	1.239PheGln: 1.239 ± 0.036	2.596PheArg: 2.596 ± 0.063	2.604PheSer: 2.604 ± 0.076	2.119PheThr: 2.119 ± 0.056	2.665PheVal: 2.665 ± 0.069	0.609PheTrp: 0.609 ± 0.033	1.161PheTyr: 1.161 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	7.86GlyAla: 7.86 ± 0.133	1.331GlyCys: 1.331 ± 0.047	3.701GlyAsp: 3.701 ± 0.092	4.676GlyGlu: 4.676 ± 0.088	3.216GlyPhe: 3.216 ± 0.071	6.455GlyGly: 6.455 ± 0.124	1.929GlyHis: 1.929 ± 0.045	4.699GlyIle: 4.699 ± 0.086	3.804GlyLys: 3.804 ± 0.086	9.134GlyLeu: 9.134 ± 0.125	2.356GlyMet: 2.356 ± 0.064	2.382GlyAsn: 2.382 ± 0.085	3.163GlyPro: 3.163 ± 0.07	3.585GlyGln: 3.585 ± 0.077	6.787GlyArg: 6.787 ± 0.114	4.619GlySer: 4.619 ± 0.112	3.877GlyThr: 3.877 ± 0.083	5.046GlyVal: 5.046 ± 0.081	1.069GlyTrp: 1.069 ± 0.044	2.258GlyTyr: 2.258 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.144HisAla: 2.144 ± 0.059	0.456HisCys: 0.456 ± 0.026	1.045HisAsp: 1.045 ± 0.035	1.344HisGlu: 1.344 ± 0.04	1.043HisPhe: 1.043 ± 0.038	1.965HisGly: 1.965 ± 0.055	0.533HisHis: 0.533 ± 0.03	1.22HisIle: 1.22 ± 0.041	0.713HisLys: 0.713 ± 0.033	2.5HisLeu: 2.5 ± 0.057	0.538HisMet: 0.538 ± 0.025	0.641HisAsn: 0.641 ± 0.028	1.272HisPro: 1.272 ± 0.037	0.726HisGln: 0.726 ± 0.031	1.452HisArg: 1.452 ± 0.044	1.203HisSer: 1.203 ± 0.039	0.964HisThr: 0.964 ± 0.041	1.338HisVal: 1.338 ± 0.045	0.3HisTrp: 0.3 ± 0.02	0.708HisTyr: 0.708 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.292IleAla: 5.292 ± 0.095	0.818IleCys: 0.818 ± 0.033	2.806IleAsp: 2.806 ± 0.063	2.797IleGlu: 2.797 ± 0.07	2.088IlePhe: 2.088 ± 0.062	4.036IleGly: 4.036 ± 0.081	1.048IleHis: 1.048 ± 0.039	2.526IleIle: 2.526 ± 0.082	1.81IleLys: 1.81 ± 0.057	5.158IleLeu: 5.158 ± 0.1	1.316IleMet: 1.316 ± 0.042	1.589IleAsn: 1.589 ± 0.047	2.402IlePro: 2.402 ± 0.061	1.566IleGln: 1.566 ± 0.049	3.8IleArg: 3.8 ± 0.077	2.936IleSer: 2.936 ± 0.073	2.566IleThr: 2.566 ± 0.062	3.431IleVal: 3.431 ± 0.076	0.5IleTrp: 0.5 ± 0.028	1.226IleTyr: 1.226 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.039LysAla: 4.039 ± 0.087	0.328LysCys: 0.328 ± 0.02	1.848LysAsp: 1.848 ± 0.054	2.29LysGlu: 2.29 ± 0.068	0.941LysPhe: 0.941 ± 0.038	2.893LysGly: 2.893 ± 0.068	0.702LysHis: 0.702 ± 0.032	2.103LysIle: 2.103 ± 0.061	2.523LysLys: 2.523 ± 0.069	3.353LysLeu: 3.353 ± 0.083	1.131LysMet: 1.131 ± 0.045	1.616LysAsn: 1.616 ± 0.056	1.69LysPro: 1.69 ± 0.054	1.37LysGln: 1.37 ± 0.043	2.646LysArg: 2.646 ± 0.062	2.152LysSer: 2.152 ± 0.059	2.401LysThr: 2.401 ± 0.062	2.441LysVal: 2.441 ± 0.067	0.387LysTrp: 0.387 ± 0.026	0.985LysTyr: 0.985 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	14.613LeuAla: 14.613 ± 0.194	1.9LeuCys: 1.9 ± 0.054	5.696LeuAsp: 5.696 ± 0.093	6.198LeuGlu: 6.198 ± 0.094	4.583LeuPhe: 4.583 ± 0.089	8.622LeuGly: 8.622 ± 0.112	2.862LeuHis: 2.862 ± 0.065	4.821LeuIle: 4.821 ± 0.099	4.015LeuLys: 4.015 ± 0.074	13.268LeuLeu: 13.268 ± 0.227	2.543LeuMet: 2.543 ± 0.058	2.973LeuAsn: 2.973 ± 0.064	6.413LeuPro: 6.413 ± 0.102	4.215LeuGln: 4.215 ± 0.089	7.633LeuArg: 7.633 ± 0.133	6.924LeuSer: 6.924 ± 0.139	4.805LeuThr: 4.805 ± 0.083	7.572LeuVal: 7.572 ± 0.115	1.229LeuTrp: 1.229 ± 0.051	2.741LeuTyr: 2.741 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	3.155MetAla: 3.155 ± 0.064	0.259MetCys: 0.259 ± 0.021	1.316MetAsp: 1.316 ± 0.047	1.4MetGlu: 1.4 ± 0.045	0.709MetPhe: 0.709 ± 0.035	1.834MetGly: 1.834 ± 0.052	0.541MetHis: 0.541 ± 0.029	1.026MetIle: 1.026 ± 0.041	1.1MetLys: 1.1 ± 0.045	2.883MetLeu: 2.883 ± 0.063	0.558MetMet: 0.558 ± 0.027	0.887MetAsn: 0.887 ± 0.034	1.497MetPro: 1.497 ± 0.042	1.321MetGln: 1.321 ± 0.042	1.865MetArg: 1.865 ± 0.054	1.496MetSer: 1.496 ± 0.043	1.299MetThr: 1.299 ± 0.045	1.566MetVal: 1.566 ± 0.051	0.192MetTrp: 0.192 ± 0.014	0.537MetTyr: 0.537 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.831AsnAla: 2.831 ± 0.059	0.365AsnCys: 0.365 ± 0.024	1.333AsnAsp: 1.333 ± 0.065	1.434AsnGlu: 1.434 ± 0.042	1.16AsnPhe: 1.16 ± 0.039	2.316AsnGly: 2.316 ± 0.061	0.579AsnHis: 0.579 ± 0.032	1.77AsnIle: 1.77 ± 0.055	1.083AsnLys: 1.083 ± 0.044	3.034AsnLeu: 3.034 ± 0.061	0.779AsnMet: 0.779 ± 0.033	0.885AsnAsn: 0.885 ± 0.041	1.857AsnPro: 1.857 ± 0.048	0.966AsnGln: 0.966 ± 0.039	2.156AsnArg: 2.156 ± 0.054	1.45AsnSer: 1.45 ± 0.051	1.38AsnThr: 1.38 ± 0.043	1.732AsnVal: 1.732 ± 0.047	0.482AsnTrp: 0.482 ± 0.028	0.844AsnTyr: 0.844 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	6.044ProAla: 6.044 ± 0.116	0.631ProCys: 0.631 ± 0.031	3.143ProAsp: 3.143 ± 0.066	4.698ProGlu: 4.698 ± 0.088	1.965ProPhe: 1.965 ± 0.053	4.629ProGly: 4.629 ± 0.083	0.987ProHis: 0.987 ± 0.034	1.748ProIle: 1.748 ± 0.051	1.664ProLys: 1.664 ± 0.055	5.514ProLeu: 5.514 ± 0.104	1.129ProMet: 1.129 ± 0.041	1.159ProAsn: 1.159 ± 0.041	2.399ProPro: 2.399 ± 0.067	1.736ProGln: 1.736 ± 0.055	2.494ProArg: 2.494 ± 0.055	2.025ProSer: 2.025 ± 0.054	1.671ProThr: 1.671 ± 0.045	3.933ProVal: 3.933 ± 0.075	0.678ProTrp: 0.678 ± 0.03	1.19ProTyr: 1.19 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	5.163GlnAla: 5.163 ± 0.099	0.408GlnCys: 0.408 ± 0.023	1.97GlnAsp: 1.97 ± 0.051	2.795GlnGlu: 2.795 ± 0.073	1.109GlnPhe: 1.109 ± 0.039	3.281GlnGly: 3.281 ± 0.072	0.915GlnHis: 0.915 ± 0.038	1.904GlnIle: 1.904 ± 0.052	1.874GlnLys: 1.874 ± 0.053	3.871GlnLeu: 3.871 ± 0.078	0.942GlnMet: 0.942 ± 0.034	1.175GlnAsn: 1.175 ± 0.049	1.869GlnPro: 1.869 ± 0.054	1.719GlnGln: 1.719 ± 0.057	2.596GlnArg: 2.596 ± 0.07	2.071GlnSer: 2.071 ± 0.053	1.727GlnThr: 1.727 ± 0.054	2.726GlnVal: 2.726 ± 0.063	0.43GlnTrp: 0.43 ± 0.023	0.984GlnTyr: 0.984 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	6.718ArgAla: 6.718 ± 0.123	0.963ArgCys: 0.963 ± 0.039	3.391ArgAsp: 3.391 ± 0.078	4.952ArgGlu: 4.952 ± 0.089	2.93ArgPhe: 2.93 ± 0.062	4.586ArgGly: 4.586 ± 0.087	1.956ArgHis: 1.956 ± 0.056	4.139ArgIle: 4.139 ± 0.073	2.844ArgLys: 2.844 ± 0.065	8.834ArgLeu: 8.834 ± 0.137	1.838ArgMet: 1.838 ± 0.048	2.003ArgAsn: 2.003 ± 0.054	3.562ArgPro: 3.562 ± 0.079	3.682ArgGln: 3.682 ± 0.085	5.406ArgArg: 5.406 ± 0.093	3.349ArgSer: 3.349 ± 0.078	2.705ArgThr: 2.705 ± 0.058	4.444ArgVal: 4.444 ± 0.078	0.826ArgTrp: 0.826 ± 0.033	2.187ArgTyr: 2.187 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.651SerAla: 5.651 ± 0.095	0.95SerCys: 0.95 ± 0.04	2.321SerAsp: 2.321 ± 0.074	2.692SerGlu: 2.692 ± 0.063	2.47SerPhe: 2.47 ± 0.062	6.04SerGly: 6.04 ± 0.137	1.101SerHis: 1.101 ± 0.045	2.596SerIle: 2.596 ± 0.063	1.609SerLys: 1.609 ± 0.049	5.939SerLeu: 5.939 ± 0.097	1.423SerMet: 1.423 ± 0.046	1.215SerAsn: 1.215 ± 0.041	2.711SerPro: 2.711 ± 0.059	1.796SerGln: 1.796 ± 0.054	3.851SerArg: 3.851 ± 0.076	2.986SerSer: 2.986 ± 0.069	2.516SerThr: 2.516 ± 0.062	3.467SerVal: 3.467 ± 0.072	0.812SerTrp: 0.812 ± 0.037	1.604SerTyr: 1.604 ± 0.075	0.0SerXaa: 0.0 ± 0.0
Thr	5.171ThrAla: 5.171 ± 0.093	0.636ThrCys: 0.636 ± 0.028	2.118ThrAsp: 2.118 ± 0.058	2.459ThrGlu: 2.459 ± 0.072	1.654ThrPhe: 1.654 ± 0.043	4.544ThrGly: 4.544 ± 0.086	0.887ThrHis: 0.887 ± 0.038	2.331ThrIle: 2.331 ± 0.072	1.34ThrLys: 1.34 ± 0.042	5.537ThrLeu: 5.537 ± 0.068	1.118ThrMet: 1.118 ± 0.037	1.147ThrAsn: 1.147 ± 0.038	2.549ThrPro: 2.549 ± 0.062	1.328ThrGln: 1.328 ± 0.044	2.924ThrArg: 2.924 ± 0.065	2.199ThrSer: 2.199 ± 0.051	2.209ThrThr: 2.209 ± 0.072	3.903ThrVal: 3.903 ± 0.067	0.515ThrTrp: 0.515 ± 0.029	1.01ThrTyr: 1.01 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.178ValAla: 7.178 ± 0.109	1.062ValCys: 1.062 ± 0.037	3.536ValAsp: 3.536 ± 0.072	3.585ValGlu: 3.585 ± 0.077	2.857ValPhe: 2.857 ± 0.057	4.366ValGly: 4.366 ± 0.083	1.48ValHis: 1.48 ± 0.048	3.252ValIle: 3.252 ± 0.078	2.141ValLys: 2.141 ± 0.059	7.965ValLeu: 7.965 ± 0.124	1.527ValMet: 1.527 ± 0.052	2.128ValAsn: 2.128 ± 0.053	3.322ValPro: 3.322 ± 0.07	2.98ValGln: 2.98 ± 0.06	4.483ValArg: 4.483 ± 0.083	3.73ValSer: 3.73 ± 0.084	2.996ValThr: 2.996 ± 0.067	4.753ValVal: 4.753 ± 0.087	0.713ValTrp: 0.713 ± 0.031	1.671ValTyr: 1.671 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.972TrpAla: 0.972 ± 0.033	0.152TrpCys: 0.152 ± 0.014	0.553TrpAsp: 0.553 ± 0.031	0.613TrpGlu: 0.613 ± 0.028	0.503TrpPhe: 0.503 ± 0.03	0.721TrpGly: 0.721 ± 0.033	0.353TrpHis: 0.353 ± 0.019	0.566TrpIle: 0.566 ± 0.032	0.456TrpLys: 0.456 ± 0.028	1.718TrpLeu: 1.718 ± 0.059	0.328TrpMet: 0.328 ± 0.02	0.384TrpAsn: 0.384 ± 0.025	0.674TrpPro: 0.674 ± 0.033	0.928TrpGln: 0.928 ± 0.037	0.959TrpArg: 0.959 ± 0.037	0.554TrpSer: 0.554 ± 0.029	0.517TrpThr: 0.517 ± 0.029	0.628TrpVal: 0.628 ± 0.031	0.179TrpTrp: 0.179 ± 0.015	0.336TrpTyr: 0.336 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.51TyrAla: 2.51 ± 0.057	0.417TyrCys: 0.417 ± 0.024	1.493TyrAsp: 1.493 ± 0.062	1.431TyrGlu: 1.431 ± 0.04	1.198TyrPhe: 1.198 ± 0.042	2.206TyrGly: 2.206 ± 0.067	0.61TyrHis: 0.61 ± 0.031	1.212TyrIle: 1.212 ± 0.045	0.824TyrLys: 0.824 ± 0.036	2.771TyrLeu: 2.771 ± 0.057	0.507TyrMet: 0.507 ± 0.023	0.854TyrAsn: 0.854 ± 0.04	1.302TyrPro: 1.302 ± 0.042	1.05TyrGln: 1.05 ± 0.038	2.097TyrArg: 2.097 ± 0.054	1.56TyrSer: 1.56 ± 0.059	1.32TyrThr: 1.32 ± 0.037	1.513TyrVal: 1.513 ± 0.049	0.341TyrTrp: 0.341 ± 0.021	0.807TyrTyr: 0.807 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2278 proteins (767338 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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