Amino acid dipepetide frequency for Klebsiella phage kpssk3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.001AlaAla: 9.001 ± 1.039
0.594AlaCys: 0.594 ± 0.206
6.199AlaAsp: 6.199 ± 0.82
5.35AlaGlu: 5.35 ± 0.711
3.736AlaPhe: 3.736 ± 0.489
7.133AlaGly: 7.133 ± 1.105
1.359AlaHis: 1.359 ± 0.263
4.331AlaIle: 4.331 ± 0.608
6.539AlaLys: 6.539 ± 0.638
8.492AlaLeu: 8.492 ± 1.079
2.802AlaMet: 2.802 ± 0.578
4.501AlaAsn: 4.501 ± 0.454
2.632AlaPro: 2.632 ± 0.518
3.482AlaGln: 3.482 ± 0.61
5.35AlaArg: 5.35 ± 0.73
5.35AlaSer: 5.35 ± 0.637
3.821AlaThr: 3.821 ± 0.409
5.69AlaVal: 5.69 ± 0.722
1.019AlaTrp: 1.019 ± 0.337
3.227AlaTyr: 3.227 ± 0.411
0.0AlaXaa: 0.0 ± 0.0
Cys
0.594CysAla: 0.594 ± 0.274
0.085CysCys: 0.085 ± 0.107
0.51CysAsp: 0.51 ± 0.352
0.764CysGlu: 0.764 ± 0.298
0.34CysPhe: 0.34 ± 0.19
0.679CysGly: 0.679 ± 0.261
0.51CysHis: 0.51 ± 0.231
0.51CysIle: 0.51 ± 0.202
0.679CysLys: 0.679 ± 0.34
0.679CysLeu: 0.679 ± 0.202
0.085CysMet: 0.085 ± 0.084
0.34CysAsn: 0.34 ± 0.207
0.425CysPro: 0.425 ± 0.171
0.425CysGln: 0.425 ± 0.198
0.594CysArg: 0.594 ± 0.298
0.51CysSer: 0.51 ± 0.244
0.34CysThr: 0.34 ± 0.211
1.019CysVal: 1.019 ± 0.284
0.17CysTrp: 0.17 ± 0.139
0.255CysTyr: 0.255 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
5.859AspAla: 5.859 ± 0.474
0.679AspCys: 0.679 ± 0.356
4.246AspAsp: 4.246 ± 0.677
3.651AspGlu: 3.651 ± 0.435
2.887AspPhe: 2.887 ± 0.444
6.029AspGly: 6.029 ± 0.431
1.104AspHis: 1.104 ± 0.278
2.972AspIle: 2.972 ± 0.538
4.671AspLys: 4.671 ± 0.649
4.076AspLeu: 4.076 ± 0.63
2.293AspMet: 2.293 ± 0.431
2.378AspAsn: 2.378 ± 0.373
3.057AspPro: 3.057 ± 0.422
2.293AspGln: 2.293 ± 0.469
2.717AspArg: 2.717 ± 0.613
3.651AspSer: 3.651 ± 0.442
4.161AspThr: 4.161 ± 0.496
4.84AspVal: 4.84 ± 0.577
0.934AspTrp: 0.934 ± 0.37
1.868AspTyr: 1.868 ± 0.337
0.0AspXaa: 0.0 ± 0.0
Glu
7.388GluAla: 7.388 ± 0.905
0.594GluCys: 0.594 ± 0.242
4.161GluAsp: 4.161 ± 0.711
6.369GluGlu: 6.369 ± 1.205
2.887GluPhe: 2.887 ± 0.435
5.095GluGly: 5.095 ± 0.684
1.359GluHis: 1.359 ± 0.429
2.293GluIle: 2.293 ± 0.374
3.227GluLys: 3.227 ± 0.683
6.539GluLeu: 6.539 ± 0.936
1.529GluMet: 1.529 ± 0.49
2.208GluAsn: 2.208 ± 0.345
2.038GluPro: 2.038 ± 0.641
3.142GluGln: 3.142 ± 0.737
4.161GluArg: 4.161 ± 0.68
4.076GluSer: 4.076 ± 0.532
3.397GluThr: 3.397 ± 0.579
5.18GluVal: 5.18 ± 0.827
0.51GluTrp: 0.51 ± 0.187
3.057GluTyr: 3.057 ± 0.486
0.0GluXaa: 0.0 ± 0.0
Phe
2.548PheAla: 2.548 ± 0.457
0.255PheCys: 0.255 ± 0.157
3.057PheAsp: 3.057 ± 0.559
2.123PheGlu: 2.123 ± 0.368
0.934PhePhe: 0.934 ± 0.24
3.227PheGly: 3.227 ± 0.59
0.679PheHis: 0.679 ± 0.29
1.868PheIle: 1.868 ± 0.487
2.632PheLys: 2.632 ± 0.397
2.887PheLeu: 2.887 ± 0.473
1.019PheMet: 1.019 ± 0.289
2.632PheAsn: 2.632 ± 0.469
1.529PhePro: 1.529 ± 0.482
1.104PheGln: 1.104 ± 0.313
1.613PheArg: 1.613 ± 0.349
2.378PheSer: 2.378 ± 0.567
2.378PheThr: 2.378 ± 0.412
2.208PheVal: 2.208 ± 0.36
0.34PheTrp: 0.34 ± 0.151
0.849PheTyr: 0.849 ± 0.271
0.0PheXaa: 0.0 ± 0.0
Gly
6.793GlyAla: 6.793 ± 0.96
0.594GlyCys: 0.594 ± 0.204
5.265GlyAsp: 5.265 ± 0.493
5.35GlyGlu: 5.35 ± 0.679
2.972GlyPhe: 2.972 ± 0.366
6.284GlyGly: 6.284 ± 0.912
1.274GlyHis: 1.274 ± 0.299
5.01GlyIle: 5.01 ± 0.842
5.774GlyLys: 5.774 ± 0.761
6.709GlyLeu: 6.709 ± 0.854
1.868GlyMet: 1.868 ± 0.415
2.632GlyAsn: 2.632 ± 0.422
1.698GlyPro: 1.698 ± 0.563
2.717GlyGln: 2.717 ± 0.509
4.416GlyArg: 4.416 ± 0.341
5.52GlySer: 5.52 ± 0.677
3.991GlyThr: 3.991 ± 0.583
5.265GlyVal: 5.265 ± 0.815
1.868GlyTrp: 1.868 ± 0.462
3.651GlyTyr: 3.651 ± 0.581
0.0GlyXaa: 0.0 ± 0.0
His
1.274HisAla: 1.274 ± 0.342
0.594HisCys: 0.594 ± 0.21
1.444HisAsp: 1.444 ± 0.3
1.698HisGlu: 1.698 ± 0.367
0.679HisPhe: 0.679 ± 0.221
1.274HisGly: 1.274 ± 0.326
0.425HisHis: 0.425 ± 0.203
0.594HisIle: 0.594 ± 0.223
1.189HisLys: 1.189 ± 0.299
1.104HisLeu: 1.104 ± 0.315
0.51HisMet: 0.51 ± 0.205
0.425HisAsn: 0.425 ± 0.175
0.934HisPro: 0.934 ± 0.216
0.425HisGln: 0.425 ± 0.159
0.51HisArg: 0.51 ± 0.18
0.849HisSer: 0.849 ± 0.226
0.764HisThr: 0.764 ± 0.243
1.529HisVal: 1.529 ± 0.348
0.17HisTrp: 0.17 ± 0.103
1.104HisTyr: 1.104 ± 0.266
0.0HisXaa: 0.0 ± 0.0
Ile
3.991IleAla: 3.991 ± 0.495
0.934IleCys: 0.934 ± 0.297
3.057IleAsp: 3.057 ± 0.51
2.632IleGlu: 2.632 ± 0.481
0.934IlePhe: 0.934 ± 0.276
3.651IleGly: 3.651 ± 0.513
0.849IleHis: 0.849 ± 0.291
2.632IleIle: 2.632 ± 0.507
2.972IleLys: 2.972 ± 0.403
3.397IleLeu: 3.397 ± 0.544
1.104IleMet: 1.104 ± 0.274
2.038IleAsn: 2.038 ± 0.529
2.972IlePro: 2.972 ± 0.502
2.038IleGln: 2.038 ± 0.456
3.736IleArg: 3.736 ± 0.524
3.397IleSer: 3.397 ± 0.521
2.548IleThr: 2.548 ± 0.659
3.142IleVal: 3.142 ± 0.589
0.425IleTrp: 0.425 ± 0.219
1.613IleTyr: 1.613 ± 0.42
0.0IleXaa: 0.0 ± 0.0
Lys
8.322LysAla: 8.322 ± 1.045
0.51LysCys: 0.51 ± 0.213
3.651LysAsp: 3.651 ± 0.68
4.925LysGlu: 4.925 ± 0.656
2.632LysPhe: 2.632 ± 0.407
5.52LysGly: 5.52 ± 0.987
1.613LysHis: 1.613 ± 0.349
2.548LysIle: 2.548 ± 0.538
3.651LysLys: 3.651 ± 1.047
6.029LysLeu: 6.029 ± 0.627
1.613LysMet: 1.613 ± 0.393
3.057LysAsn: 3.057 ± 0.35
2.463LysPro: 2.463 ± 0.728
2.378LysGln: 2.378 ± 0.465
3.821LysArg: 3.821 ± 0.716
2.972LysSer: 2.972 ± 0.542
2.972LysThr: 2.972 ± 0.447
5.095LysVal: 5.095 ± 0.664
0.849LysTrp: 0.849 ± 0.361
1.868LysTyr: 1.868 ± 0.428
0.0LysXaa: 0.0 ± 0.0
Leu
7.218LeuAla: 7.218 ± 1.164
0.425LeuCys: 0.425 ± 0.207
4.671LeuAsp: 4.671 ± 0.539
7.133LeuGlu: 7.133 ± 1.075
2.293LeuPhe: 2.293 ± 0.378
5.774LeuGly: 5.774 ± 0.651
1.104LeuHis: 1.104 ± 0.259
3.227LeuIle: 3.227 ± 0.628
6.284LeuLys: 6.284 ± 0.453
6.114LeuLeu: 6.114 ± 0.798
2.293LeuMet: 2.293 ± 0.384
4.671LeuAsn: 4.671 ± 0.928
3.312LeuPro: 3.312 ± 0.525
3.821LeuGln: 3.821 ± 0.476
5.01LeuArg: 5.01 ± 0.624
4.501LeuSer: 4.501 ± 0.664
4.755LeuThr: 4.755 ± 0.68
5.01LeuVal: 5.01 ± 0.846
1.529LeuTrp: 1.529 ± 0.448
2.972LeuTyr: 2.972 ± 0.505
0.0LeuXaa: 0.0 ± 0.0
Met
3.482MetAla: 3.482 ± 0.519
0.255MetCys: 0.255 ± 0.181
1.783MetAsp: 1.783 ± 0.375
1.444MetGlu: 1.444 ± 0.301
0.849MetPhe: 0.849 ± 0.254
1.868MetGly: 1.868 ± 0.421
0.764MetHis: 0.764 ± 0.225
1.189MetIle: 1.189 ± 0.267
1.359MetLys: 1.359 ± 0.317
2.717MetLeu: 2.717 ± 0.482
0.51MetMet: 0.51 ± 0.214
0.849MetAsn: 0.849 ± 0.266
0.679MetPro: 0.679 ± 0.215
2.208MetGln: 2.208 ± 0.445
1.019MetArg: 1.019 ± 0.252
1.274MetSer: 1.274 ± 0.32
1.529MetThr: 1.529 ± 0.477
1.783MetVal: 1.783 ± 0.393
0.0MetTrp: 0.0 ± 0.0
0.764MetTyr: 0.764 ± 0.209
0.0MetXaa: 0.0 ± 0.0
Asn
4.076AsnAla: 4.076 ± 0.774
0.425AsnCys: 0.425 ± 0.192
2.293AsnAsp: 2.293 ± 0.412
2.548AsnGlu: 2.548 ± 0.551
1.953AsnPhe: 1.953 ± 0.487
4.076AsnGly: 4.076 ± 0.686
0.17AsnHis: 0.17 ± 0.115
2.802AsnIle: 2.802 ± 0.447
1.953AsnLys: 1.953 ± 0.397
3.312AsnLeu: 3.312 ± 0.569
0.849AsnMet: 0.849 ± 0.278
1.444AsnAsn: 1.444 ± 0.287
2.548AsnPro: 2.548 ± 0.348
1.104AsnGln: 1.104 ± 0.234
2.123AsnArg: 2.123 ± 0.514
3.142AsnSer: 3.142 ± 0.627
2.123AsnThr: 2.123 ± 0.413
3.142AsnVal: 3.142 ± 0.593
0.764AsnTrp: 0.764 ± 0.278
1.698AsnTyr: 1.698 ± 0.453
0.0AsnXaa: 0.0 ± 0.0
Pro
2.972ProAla: 2.972 ± 0.49
0.425ProCys: 0.425 ± 0.183
2.123ProAsp: 2.123 ± 0.376
4.84ProGlu: 4.84 ± 0.705
1.529ProPhe: 1.529 ± 0.29
2.038ProGly: 2.038 ± 0.401
0.594ProHis: 0.594 ± 0.196
1.104ProIle: 1.104 ± 0.347
2.378ProLys: 2.378 ± 0.407
2.717ProLeu: 2.717 ± 0.409
0.679ProMet: 0.679 ± 0.236
2.038ProAsn: 2.038 ± 0.411
0.934ProPro: 0.934 ± 0.34
1.189ProGln: 1.189 ± 0.266
1.698ProArg: 1.698 ± 0.407
1.868ProSer: 1.868 ± 0.314
2.293ProThr: 2.293 ± 0.521
3.227ProVal: 3.227 ± 0.431
0.849ProTrp: 0.849 ± 0.207
2.038ProTyr: 2.038 ± 0.445
0.0ProXaa: 0.0 ± 0.0
Gln
3.651GlnAla: 3.651 ± 0.603
0.255GlnCys: 0.255 ± 0.153
2.632GlnAsp: 2.632 ± 0.269
2.802GlnGlu: 2.802 ± 0.455
1.529GlnPhe: 1.529 ± 0.288
2.802GlnGly: 2.802 ± 0.439
0.34GlnHis: 0.34 ± 0.178
1.698GlnIle: 1.698 ± 0.365
3.227GlnLys: 3.227 ± 0.547
3.991GlnLeu: 3.991 ± 0.534
1.529GlnMet: 1.529 ± 0.498
1.189GlnAsn: 1.189 ± 0.239
1.698GlnPro: 1.698 ± 0.238
3.397GlnGln: 3.397 ± 0.611
2.293GlnArg: 2.293 ± 0.51
2.378GlnSer: 2.378 ± 0.445
1.783GlnThr: 1.783 ± 0.47
2.802GlnVal: 2.802 ± 0.512
0.764GlnTrp: 0.764 ± 0.27
1.613GlnTyr: 1.613 ± 0.475
0.0GlnXaa: 0.0 ± 0.0
Arg
4.84ArgAla: 4.84 ± 0.721
0.764ArgCys: 0.764 ± 0.268
3.567ArgAsp: 3.567 ± 0.556
3.906ArgGlu: 3.906 ± 0.548
1.868ArgPhe: 1.868 ± 0.349
4.246ArgGly: 4.246 ± 0.632
0.849ArgHis: 0.849 ± 0.262
3.227ArgIle: 3.227 ± 0.571
3.482ArgLys: 3.482 ± 0.485
4.076ArgLeu: 4.076 ± 0.659
1.359ArgMet: 1.359 ± 0.314
2.293ArgAsn: 2.293 ± 0.453
2.038ArgPro: 2.038 ± 0.41
2.887ArgGln: 2.887 ± 0.609
2.632ArgArg: 2.632 ± 0.399
3.736ArgSer: 3.736 ± 0.425
3.057ArgThr: 3.057 ± 0.544
3.821ArgVal: 3.821 ± 0.721
0.934ArgTrp: 0.934 ± 0.307
1.274ArgTyr: 1.274 ± 0.271
0.0ArgXaa: 0.0 ± 0.0
Ser
4.84SerAla: 4.84 ± 0.735
0.425SerCys: 0.425 ± 0.157
3.991SerAsp: 3.991 ± 0.519
3.397SerGlu: 3.397 ± 0.57
2.802SerPhe: 2.802 ± 0.465
5.52SerGly: 5.52 ± 0.912
1.274SerHis: 1.274 ± 0.32
2.972SerIle: 2.972 ± 0.577
4.246SerLys: 4.246 ± 0.466
4.925SerLeu: 4.925 ± 0.772
1.444SerMet: 1.444 ± 0.394
1.529SerAsn: 1.529 ± 0.424
2.038SerPro: 2.038 ± 0.387
2.632SerGln: 2.632 ± 0.422
3.227SerArg: 3.227 ± 0.548
2.293SerSer: 2.293 ± 0.491
3.821SerThr: 3.821 ± 0.791
3.651SerVal: 3.651 ± 0.475
0.679SerTrp: 0.679 ± 0.186
2.293SerTyr: 2.293 ± 0.513
0.0SerXaa: 0.0 ± 0.0
Thr
4.586ThrAla: 4.586 ± 0.74
0.51ThrCys: 0.51 ± 0.282
3.567ThrAsp: 3.567 ± 0.487
3.227ThrGlu: 3.227 ± 0.513
2.038ThrPhe: 2.038 ± 0.393
5.01ThrGly: 5.01 ± 0.77
0.934ThrHis: 0.934 ± 0.201
3.651ThrIle: 3.651 ± 0.498
4.671ThrLys: 4.671 ± 0.615
4.84ThrLeu: 4.84 ± 0.673
1.444ThrMet: 1.444 ± 0.338
1.953ThrAsn: 1.953 ± 0.41
2.717ThrPro: 2.717 ± 0.408
2.378ThrGln: 2.378 ± 0.38
2.548ThrArg: 2.548 ± 0.431
2.972ThrSer: 2.972 ± 0.512
2.463ThrThr: 2.463 ± 0.588
3.736ThrVal: 3.736 ± 0.567
0.594ThrTrp: 0.594 ± 0.258
1.529ThrTyr: 1.529 ± 0.563
0.0ThrXaa: 0.0 ± 0.0
Val
6.114ValAla: 6.114 ± 0.705
0.51ValCys: 0.51 ± 0.21
4.416ValAsp: 4.416 ± 0.597
4.076ValGlu: 4.076 ± 0.616
1.868ValPhe: 1.868 ± 0.543
5.01ValGly: 5.01 ± 0.599
0.934ValHis: 0.934 ± 0.32
3.312ValIle: 3.312 ± 0.537
4.671ValLys: 4.671 ± 0.568
5.774ValLeu: 5.774 ± 0.663
1.613ValMet: 1.613 ± 0.375
3.736ValAsn: 3.736 ± 0.627
2.463ValPro: 2.463 ± 0.46
2.463ValGln: 2.463 ± 0.365
4.076ValArg: 4.076 ± 0.695
4.501ValSer: 4.501 ± 0.775
6.029ValThr: 6.029 ± 0.813
4.755ValVal: 4.755 ± 0.603
0.849ValTrp: 0.849 ± 0.317
2.378ValTyr: 2.378 ± 0.547
0.0ValXaa: 0.0 ± 0.0
Trp
0.764TrpAla: 0.764 ± 0.202
0.425TrpCys: 0.425 ± 0.202
0.594TrpAsp: 0.594 ± 0.232
0.934TrpGlu: 0.934 ± 0.279
0.425TrpPhe: 0.425 ± 0.212
1.019TrpGly: 1.019 ± 0.346
0.425TrpHis: 0.425 ± 0.302
0.594TrpIle: 0.594 ± 0.362
1.274TrpLys: 1.274 ± 0.408
1.274TrpLeu: 1.274 ± 0.337
0.255TrpMet: 0.255 ± 0.131
0.594TrpAsn: 0.594 ± 0.208
0.34TrpPro: 0.34 ± 0.155
0.679TrpGln: 0.679 ± 0.207
0.849TrpArg: 0.849 ± 0.25
0.849TrpSer: 0.849 ± 0.269
0.849TrpThr: 0.849 ± 0.29
1.359TrpVal: 1.359 ± 0.359
0.425TrpTrp: 0.425 ± 0.173
0.255TrpTyr: 0.255 ± 0.139
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.293TyrAla: 2.293 ± 0.472
0.255TyrCys: 0.255 ± 0.139
3.142TyrAsp: 3.142 ± 0.572
2.123TyrGlu: 2.123 ± 0.481
1.104TyrPhe: 1.104 ± 0.237
3.397TyrGly: 3.397 ± 0.418
0.934TyrHis: 0.934 ± 0.355
1.529TyrIle: 1.529 ± 0.319
1.613TyrLys: 1.613 ± 0.337
2.463TyrLeu: 2.463 ± 0.447
1.444TyrMet: 1.444 ± 0.331
2.038TyrAsn: 2.038 ± 0.413
1.019TyrPro: 1.019 ± 0.284
1.613TyrGln: 1.613 ± 0.44
2.463TyrArg: 2.463 ± 0.492
1.783TyrSer: 1.783 ± 0.517
2.293TyrThr: 2.293 ± 0.538
2.293TyrVal: 2.293 ± 0.515
0.51TyrTrp: 0.51 ± 0.209
1.189TyrTyr: 1.189 ± 0.365
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (11777 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski