Amino acid dipepetide frequency for Gordonia phage Clark

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.143AlaAla: 18.143 ± 1.561
1.098AlaCys: 1.098 ± 0.319
8.135AlaAsp: 8.135 ± 0.704
8.716AlaGlu: 8.716 ± 0.81
2.712AlaPhe: 2.712 ± 0.447
9.556AlaGly: 9.556 ± 0.802
2.454AlaHis: 2.454 ± 0.47
5.424AlaIle: 5.424 ± 0.598
4.972AlaLys: 4.972 ± 0.63
8.975AlaLeu: 8.975 ± 0.742
3.293AlaMet: 3.293 ± 0.659
3.228AlaAsn: 3.228 ± 0.605
5.488AlaPro: 5.488 ± 0.785
5.811AlaGln: 5.811 ± 0.808
8.2AlaArg: 8.2 ± 0.727
5.876AlaSer: 5.876 ± 0.707
8.264AlaThr: 8.264 ± 0.915
8.329AlaVal: 8.329 ± 0.985
2.002AlaTrp: 2.002 ± 0.286
2.066AlaTyr: 2.066 ± 0.346
0.0AlaXaa: 0.0 ± 0.0
Cys
0.581CysAla: 0.581 ± 0.189
0.258CysCys: 0.258 ± 0.111
0.646CysAsp: 0.646 ± 0.222
0.517CysGlu: 0.517 ± 0.194
0.129CysPhe: 0.129 ± 0.093
1.679CysGly: 1.679 ± 0.417
0.387CysHis: 0.387 ± 0.202
0.129CysIle: 0.129 ± 0.097
0.194CysLys: 0.194 ± 0.127
0.387CysLeu: 0.387 ± 0.171
0.065CysMet: 0.065 ± 0.066
0.452CysAsn: 0.452 ± 0.2
0.323CysPro: 0.323 ± 0.143
0.194CysGln: 0.194 ± 0.123
0.904CysArg: 0.904 ± 0.315
0.452CysSer: 0.452 ± 0.191
0.517CysThr: 0.517 ± 0.261
0.387CysVal: 0.387 ± 0.182
0.194CysTrp: 0.194 ± 0.111
0.387CysTyr: 0.387 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
7.554AspAla: 7.554 ± 0.764
0.387AspCys: 0.387 ± 0.183
6.521AspAsp: 6.521 ± 0.904
5.036AspGlu: 5.036 ± 0.697
1.291AspPhe: 1.291 ± 0.295
5.294AspGly: 5.294 ± 0.716
2.002AspHis: 2.002 ± 0.494
2.647AspIle: 2.647 ± 0.497
1.679AspLys: 1.679 ± 0.273
7.231AspLeu: 7.231 ± 0.569
1.291AspMet: 1.291 ± 0.291
1.42AspAsn: 1.42 ± 0.299
5.617AspPro: 5.617 ± 0.598
2.389AspGln: 2.389 ± 0.449
4.261AspArg: 4.261 ± 0.667
2.454AspSer: 2.454 ± 0.354
3.616AspThr: 3.616 ± 0.585
4.907AspVal: 4.907 ± 0.518
1.614AspTrp: 1.614 ± 0.299
1.485AspTyr: 1.485 ± 0.244
0.0AspXaa: 0.0 ± 0.0
Glu
7.683GluAla: 7.683 ± 0.694
0.71GluCys: 0.71 ± 0.195
3.099GluAsp: 3.099 ± 0.427
2.647GluGlu: 2.647 ± 0.46
2.324GluPhe: 2.324 ± 0.386
3.357GluGly: 3.357 ± 0.45
1.098GluHis: 1.098 ± 0.317
2.647GluIle: 2.647 ± 0.511
1.937GluLys: 1.937 ± 0.355
5.682GluLeu: 5.682 ± 0.559
1.42GluMet: 1.42 ± 0.367
1.098GluAsn: 1.098 ± 0.343
2.905GluPro: 2.905 ± 0.458
3.164GluGln: 3.164 ± 0.445
5.036GluArg: 5.036 ± 0.654
3.422GluSer: 3.422 ± 0.454
3.293GluThr: 3.293 ± 0.401
3.939GluVal: 3.939 ± 0.548
1.291GluTrp: 1.291 ± 0.28
1.743GluTyr: 1.743 ± 0.381
0.0GluXaa: 0.0 ± 0.0
Phe
2.583PheAla: 2.583 ± 0.403
0.065PheCys: 0.065 ± 0.061
2.066PheAsp: 2.066 ± 0.327
1.42PheGlu: 1.42 ± 0.288
0.581PhePhe: 0.581 ± 0.177
2.712PheGly: 2.712 ± 0.343
0.581PheHis: 0.581 ± 0.195
0.968PheIle: 0.968 ± 0.281
0.387PheLys: 0.387 ± 0.178
1.291PheLeu: 1.291 ± 0.335
0.387PheMet: 0.387 ± 0.153
0.581PheAsn: 0.581 ± 0.203
1.098PhePro: 1.098 ± 0.223
0.904PheGln: 0.904 ± 0.277
1.808PheArg: 1.808 ± 0.409
1.356PheSer: 1.356 ± 0.268
2.389PheThr: 2.389 ± 0.387
2.002PheVal: 2.002 ± 0.513
0.517PheTrp: 0.517 ± 0.172
0.452PheTyr: 0.452 ± 0.18
0.0PheXaa: 0.0 ± 0.0
Gly
8.652GlyAla: 8.652 ± 0.838
0.581GlyCys: 0.581 ± 0.185
5.036GlyAsp: 5.036 ± 0.561
4.261GlyGlu: 4.261 ± 0.437
1.937GlyPhe: 1.937 ± 0.333
7.49GlyGly: 7.49 ± 0.969
1.872GlyHis: 1.872 ± 0.386
3.874GlyIle: 3.874 ± 0.435
3.293GlyLys: 3.293 ± 0.492
6.521GlyLeu: 6.521 ± 0.604
2.066GlyMet: 2.066 ± 0.467
3.099GlyAsn: 3.099 ± 0.484
4.068GlyPro: 4.068 ± 0.472
2.97GlyGln: 2.97 ± 0.511
6.586GlyArg: 6.586 ± 0.695
4.778GlySer: 4.778 ± 0.672
6.134GlyThr: 6.134 ± 0.773
6.779GlyVal: 6.779 ± 0.718
1.485GlyTrp: 1.485 ± 0.305
2.002GlyTyr: 2.002 ± 0.297
0.0GlyXaa: 0.0 ± 0.0
His
2.389HisAla: 2.389 ± 0.408
0.194HisCys: 0.194 ± 0.111
1.291HisAsp: 1.291 ± 0.325
1.42HisGlu: 1.42 ± 0.335
0.387HisPhe: 0.387 ± 0.17
1.614HisGly: 1.614 ± 0.362
0.517HisHis: 0.517 ± 0.186
1.227HisIle: 1.227 ± 0.407
0.387HisLys: 0.387 ± 0.163
1.614HisLeu: 1.614 ± 0.416
0.517HisMet: 0.517 ± 0.16
0.452HisAsn: 0.452 ± 0.168
1.743HisPro: 1.743 ± 0.349
0.71HisGln: 0.71 ± 0.192
1.356HisArg: 1.356 ± 0.291
0.581HisSer: 0.581 ± 0.2
1.872HisThr: 1.872 ± 0.386
1.614HisVal: 1.614 ± 0.259
0.517HisTrp: 0.517 ± 0.156
0.517HisTyr: 0.517 ± 0.197
0.0HisXaa: 0.0 ± 0.0
Ile
6.392IleAla: 6.392 ± 0.642
0.258IleCys: 0.258 ± 0.156
4.326IleAsp: 4.326 ± 0.529
3.164IleGlu: 3.164 ± 0.495
0.581IlePhe: 0.581 ± 0.231
3.487IleGly: 3.487 ± 0.55
0.968IleHis: 0.968 ± 0.202
1.227IleIle: 1.227 ± 0.281
0.968IleLys: 0.968 ± 0.269
2.26IleLeu: 2.26 ± 0.373
0.71IleMet: 0.71 ± 0.222
1.808IleAsn: 1.808 ± 0.355
2.712IlePro: 2.712 ± 0.425
1.485IleGln: 1.485 ± 0.313
3.099IleArg: 3.099 ± 0.42
2.324IleSer: 2.324 ± 0.342
3.357IleThr: 3.357 ± 0.585
3.616IleVal: 3.616 ± 0.527
0.452IleTrp: 0.452 ± 0.153
1.679IleTyr: 1.679 ± 0.373
0.0IleXaa: 0.0 ± 0.0
Lys
4.455LysAla: 4.455 ± 0.616
0.065LysCys: 0.065 ± 0.06
1.291LysAsp: 1.291 ± 0.297
1.679LysGlu: 1.679 ± 0.308
0.581LysPhe: 0.581 ± 0.168
2.389LysGly: 2.389 ± 0.457
0.904LysHis: 0.904 ± 0.215
1.227LysIle: 1.227 ± 0.266
1.55LysLys: 1.55 ± 0.419
3.164LysLeu: 3.164 ± 0.47
0.517LysMet: 0.517 ± 0.21
0.839LysAsn: 0.839 ± 0.18
2.389LysPro: 2.389 ± 0.394
1.098LysGln: 1.098 ± 0.371
2.066LysArg: 2.066 ± 0.306
1.872LysSer: 1.872 ± 0.47
2.324LysThr: 2.324 ± 0.395
2.26LysVal: 2.26 ± 0.386
0.581LysTrp: 0.581 ± 0.244
0.904LysTyr: 0.904 ± 0.239
0.0LysXaa: 0.0 ± 0.0
Leu
9.685LeuAla: 9.685 ± 0.865
0.775LeuCys: 0.775 ± 0.243
6.909LeuAsp: 6.909 ± 0.673
4.455LeuGlu: 4.455 ± 0.557
2.583LeuPhe: 2.583 ± 0.539
6.392LeuGly: 6.392 ± 0.709
1.291LeuHis: 1.291 ± 0.275
3.422LeuIle: 3.422 ± 0.441
2.066LeuLys: 2.066 ± 0.414
5.617LeuLeu: 5.617 ± 0.526
1.872LeuMet: 1.872 ± 0.308
2.454LeuAsn: 2.454 ± 0.377
4.003LeuPro: 4.003 ± 0.559
2.324LeuGln: 2.324 ± 0.519
6.65LeuArg: 6.65 ± 0.593
4.584LeuSer: 4.584 ± 0.546
6.779LeuThr: 6.779 ± 0.673
5.746LeuVal: 5.746 ± 0.694
1.033LeuTrp: 1.033 ± 0.245
1.033LeuTyr: 1.033 ± 0.252
0.0LeuXaa: 0.0 ± 0.0
Met
2.841MetAla: 2.841 ± 0.6
0.194MetCys: 0.194 ± 0.108
0.968MetAsp: 0.968 ± 0.265
0.452MetGlu: 0.452 ± 0.185
0.387MetPhe: 0.387 ± 0.161
1.42MetGly: 1.42 ± 0.372
0.646MetHis: 0.646 ± 0.176
0.387MetIle: 0.387 ± 0.163
0.839MetLys: 0.839 ± 0.168
1.808MetLeu: 1.808 ± 0.353
0.452MetMet: 0.452 ± 0.171
0.646MetAsn: 0.646 ± 0.188
1.679MetPro: 1.679 ± 0.274
0.71MetGln: 0.71 ± 0.22
1.872MetArg: 1.872 ± 0.326
1.55MetSer: 1.55 ± 0.294
2.712MetThr: 2.712 ± 0.32
1.291MetVal: 1.291 ± 0.253
0.646MetTrp: 0.646 ± 0.259
0.065MetTyr: 0.065 ± 0.064
0.0MetXaa: 0.0 ± 0.0
Asn
3.035AsnAla: 3.035 ± 0.597
0.065AsnCys: 0.065 ± 0.053
1.872AsnAsp: 1.872 ± 0.342
1.485AsnGlu: 1.485 ± 0.293
0.581AsnPhe: 0.581 ± 0.165
2.776AsnGly: 2.776 ± 0.511
1.098AsnHis: 1.098 ± 0.257
1.485AsnIle: 1.485 ± 0.253
1.098AsnLys: 1.098 ± 0.373
2.195AsnLeu: 2.195 ± 0.375
0.387AsnMet: 0.387 ± 0.127
0.968AsnAsn: 0.968 ± 0.254
2.647AsnPro: 2.647 ± 0.365
0.968AsnGln: 0.968 ± 0.266
2.518AsnArg: 2.518 ± 0.462
1.55AsnSer: 1.55 ± 0.307
1.743AsnThr: 1.743 ± 0.35
1.227AsnVal: 1.227 ± 0.323
0.517AsnTrp: 0.517 ± 0.163
0.71AsnTyr: 0.71 ± 0.264
0.0AsnXaa: 0.0 ± 0.0
Pro
8.006ProAla: 8.006 ± 0.57
0.646ProCys: 0.646 ± 0.242
4.972ProAsp: 4.972 ± 0.946
3.939ProGlu: 3.939 ± 0.467
1.098ProPhe: 1.098 ± 0.27
5.617ProGly: 5.617 ± 0.775
0.775ProHis: 0.775 ± 0.236
2.26ProIle: 2.26 ± 0.315
1.356ProLys: 1.356 ± 0.265
3.68ProLeu: 3.68 ± 0.401
1.227ProMet: 1.227 ± 0.276
2.066ProAsn: 2.066 ± 0.428
2.518ProPro: 2.518 ± 0.445
1.291ProGln: 1.291 ± 0.224
3.487ProArg: 3.487 ± 0.53
2.97ProSer: 2.97 ± 0.336
4.455ProThr: 4.455 ± 0.595
4.326ProVal: 4.326 ± 0.537
1.614ProTrp: 1.614 ± 0.289
0.839ProTyr: 0.839 ± 0.2
0.0ProXaa: 0.0 ± 0.0
Gln
4.778GlnAla: 4.778 ± 0.655
0.258GlnCys: 0.258 ± 0.145
1.485GlnAsp: 1.485 ± 0.322
1.485GlnGlu: 1.485 ± 0.295
1.098GlnPhe: 1.098 ± 0.246
2.26GlnGly: 2.26 ± 0.567
0.71GlnHis: 0.71 ± 0.194
2.131GlnIle: 2.131 ± 0.373
1.42GlnLys: 1.42 ± 0.381
4.326GlnLeu: 4.326 ± 0.548
1.033GlnMet: 1.033 ± 0.223
0.646GlnAsn: 0.646 ± 0.251
1.485GlnPro: 1.485 ± 0.306
1.485GlnGln: 1.485 ± 0.393
3.422GlnArg: 3.422 ± 0.513
1.743GlnSer: 1.743 ± 0.344
2.712GlnThr: 2.712 ± 0.512
2.905GlnVal: 2.905 ± 0.443
0.775GlnTrp: 0.775 ± 0.205
0.581GlnTyr: 0.581 ± 0.2
0.0GlnXaa: 0.0 ± 0.0
Arg
8.523ArgAla: 8.523 ± 0.854
0.968ArgCys: 0.968 ± 0.375
5.23ArgAsp: 5.23 ± 0.681
4.132ArgGlu: 4.132 ± 0.562
1.872ArgPhe: 1.872 ± 0.378
4.907ArgGly: 4.907 ± 0.507
1.291ArgHis: 1.291 ± 0.344
3.939ArgIle: 3.939 ± 0.554
2.647ArgLys: 2.647 ± 0.287
6.844ArgLeu: 6.844 ± 0.535
2.26ArgMet: 2.26 ± 0.381
2.647ArgAsn: 2.647 ± 0.409
4.326ArgPro: 4.326 ± 0.645
2.97ArgGln: 2.97 ± 0.353
6.65ArgArg: 6.65 ± 0.965
3.099ArgSer: 3.099 ± 0.489
4.649ArgThr: 4.649 ± 0.646
4.649ArgVal: 4.649 ± 0.597
2.389ArgTrp: 2.389 ± 0.414
1.872ArgTyr: 1.872 ± 0.347
0.0ArgXaa: 0.0 ± 0.0
Ser
5.746SerAla: 5.746 ± 0.515
0.323SerCys: 0.323 ± 0.136
3.099SerAsp: 3.099 ± 0.367
2.776SerGlu: 2.776 ± 0.35
1.291SerPhe: 1.291 ± 0.304
5.488SerGly: 5.488 ± 0.776
0.775SerHis: 0.775 ± 0.213
2.776SerIle: 2.776 ± 0.347
1.872SerLys: 1.872 ± 0.27
3.745SerLeu: 3.745 ± 0.46
1.162SerMet: 1.162 ± 0.296
1.614SerAsn: 1.614 ± 0.35
2.647SerPro: 2.647 ± 0.38
2.324SerGln: 2.324 ± 0.503
3.164SerArg: 3.164 ± 0.581
2.776SerSer: 2.776 ± 0.494
3.809SerThr: 3.809 ± 0.439
3.099SerVal: 3.099 ± 0.444
1.033SerTrp: 1.033 ± 0.28
1.356SerTyr: 1.356 ± 0.404
0.0SerXaa: 0.0 ± 0.0
Thr
9.298ThrAla: 9.298 ± 0.913
0.839ThrCys: 0.839 ± 0.21
4.132ThrAsp: 4.132 ± 0.49
3.422ThrGlu: 3.422 ± 0.456
1.808ThrPhe: 1.808 ± 0.332
7.812ThrGly: 7.812 ± 0.766
1.291ThrHis: 1.291 ± 0.257
4.584ThrIle: 4.584 ± 0.516
1.614ThrLys: 1.614 ± 0.314
6.069ThrLeu: 6.069 ± 0.575
0.904ThrMet: 0.904 ± 0.231
1.485ThrAsn: 1.485 ± 0.285
4.907ThrPro: 4.907 ± 0.631
1.808ThrGln: 1.808 ± 0.423
6.069ThrArg: 6.069 ± 0.958
3.099ThrSer: 3.099 ± 0.442
5.876ThrThr: 5.876 ± 0.799
5.553ThrVal: 5.553 ± 0.611
1.55ThrTrp: 1.55 ± 0.337
1.55ThrTyr: 1.55 ± 0.346
0.0ThrXaa: 0.0 ± 0.0
Val
7.812ValAla: 7.812 ± 0.91
0.517ValCys: 0.517 ± 0.178
5.23ValAsp: 5.23 ± 0.464
5.101ValGlu: 5.101 ± 0.526
1.743ValPhe: 1.743 ± 0.295
5.876ValGly: 5.876 ± 0.644
1.162ValHis: 1.162 ± 0.26
3.293ValIle: 3.293 ± 0.399
2.712ValLys: 2.712 ± 0.534
4.907ValLeu: 4.907 ± 0.639
1.098ValMet: 1.098 ± 0.233
2.518ValAsn: 2.518 ± 0.381
4.003ValPro: 4.003 ± 0.561
2.454ValGln: 2.454 ± 0.548
4.972ValArg: 4.972 ± 0.469
3.616ValSer: 3.616 ± 0.52
5.811ValThr: 5.811 ± 0.564
4.778ValVal: 4.778 ± 0.614
0.904ValTrp: 0.904 ± 0.242
1.356ValTyr: 1.356 ± 0.351
0.0ValXaa: 0.0 ± 0.0
Trp
1.872TrpAla: 1.872 ± 0.34
0.452TrpCys: 0.452 ± 0.166
1.098TrpAsp: 1.098 ± 0.288
0.968TrpGlu: 0.968 ± 0.252
0.581TrpPhe: 0.581 ± 0.187
1.356TrpGly: 1.356 ± 0.308
0.581TrpHis: 0.581 ± 0.2
0.775TrpIle: 0.775 ± 0.226
0.581TrpLys: 0.581 ± 0.181
1.55TrpLeu: 1.55 ± 0.325
0.387TrpMet: 0.387 ± 0.147
0.452TrpAsn: 0.452 ± 0.162
1.227TrpPro: 1.227 ± 0.253
0.775TrpGln: 0.775 ± 0.169
2.26TrpArg: 2.26 ± 0.359
1.098TrpSer: 1.098 ± 0.279
1.743TrpThr: 1.743 ± 0.351
1.098TrpVal: 1.098 ± 0.226
0.71TrpTrp: 0.71 ± 0.213
0.387TrpTyr: 0.387 ± 0.165
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.712TyrAla: 2.712 ± 0.437
0.129TyrCys: 0.129 ± 0.097
1.291TyrAsp: 1.291 ± 0.257
1.42TyrGlu: 1.42 ± 0.314
0.581TyrPhe: 0.581 ± 0.186
2.002TyrGly: 2.002 ± 0.317
0.517TyrHis: 0.517 ± 0.249
0.452TyrIle: 0.452 ± 0.201
0.581TyrLys: 0.581 ± 0.208
1.808TyrLeu: 1.808 ± 0.325
0.452TyrMet: 0.452 ± 0.16
0.452TyrAsn: 0.452 ± 0.241
1.42TyrPro: 1.42 ± 0.322
0.904TyrGln: 0.904 ± 0.209
1.485TyrArg: 1.485 ± 0.306
1.679TyrSer: 1.679 ± 0.305
1.614TyrThr: 1.614 ± 0.297
1.356TyrVal: 1.356 ± 0.265
0.129TyrTrp: 0.129 ± 0.089
0.452TyrTyr: 0.452 ± 0.135
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (15489 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski