Amino acid dipepetide frequency for Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.728AlaAla: 1.728 ± 0.216
1.024AlaCys: 1.024 ± 0.145
2.176AlaAsp: 2.176 ± 0.217
1.472AlaGlu: 1.472 ± 0.195
1.685AlaPhe: 1.685 ± 0.186
1.664AlaGly: 1.664 ± 0.226
0.619AlaHis: 0.619 ± 0.109
3.136AlaIle: 3.136 ± 0.215
2.283AlaLys: 2.283 ± 0.225
4.16AlaLeu: 4.16 ± 0.314
0.917AlaMet: 0.917 ± 0.162
2.261AlaAsn: 2.261 ± 0.195
1.045AlaPro: 1.045 ± 0.137
0.597AlaGln: 0.597 ± 0.111
1.579AlaArg: 1.579 ± 0.185
3.157AlaSer: 3.157 ± 0.297
2.773AlaThr: 2.773 ± 0.267
3.072AlaVal: 3.072 ± 0.269
0.299AlaTrp: 0.299 ± 0.066
2.155AlaTyr: 2.155 ± 0.218
0.0AlaXaa: 0.0 ± 0.0
Cys
0.789CysAla: 0.789 ± 0.103
0.597CysCys: 0.597 ± 0.107
1.237CysAsp: 1.237 ± 0.154
0.981CysGlu: 0.981 ± 0.16
0.896CysPhe: 0.896 ± 0.158
0.832CysGly: 0.832 ± 0.137
0.32CysHis: 0.32 ± 0.077
2.197CysIle: 2.197 ± 0.232
1.493CysLys: 1.493 ± 0.157
1.685CysLeu: 1.685 ± 0.207
0.512CysMet: 0.512 ± 0.094
1.408CysAsn: 1.408 ± 0.182
0.768CysPro: 0.768 ± 0.135
0.277CysGln: 0.277 ± 0.069
0.853CysArg: 0.853 ± 0.145
1.835CysSer: 1.835 ± 0.225
1.429CysThr: 1.429 ± 0.209
2.069CysVal: 2.069 ± 0.233
0.192CysTrp: 0.192 ± 0.074
1.323CysTyr: 1.323 ± 0.175
0.0CysXaa: 0.0 ± 0.0
Asp
2.667AspAla: 2.667 ± 0.249
0.896AspCys: 0.896 ± 0.124
5.227AspAsp: 5.227 ± 0.447
4.373AspGlu: 4.373 ± 0.287
2.581AspPhe: 2.581 ± 0.204
2.688AspGly: 2.688 ± 0.21
0.747AspHis: 0.747 ± 0.154
5.781AspIle: 5.781 ± 0.329
4.117AspLys: 4.117 ± 0.32
4.821AspLeu: 4.821 ± 0.273
1.579AspMet: 1.579 ± 0.2
2.923AspAsn: 2.923 ± 0.234
1.728AspPro: 1.728 ± 0.2
0.917AspGln: 0.917 ± 0.131
2.155AspArg: 2.155 ± 0.293
3.669AspSer: 3.669 ± 0.266
3.947AspThr: 3.947 ± 0.29
6.357AspVal: 6.357 ± 0.426
0.405AspTrp: 0.405 ± 0.081
3.115AspTyr: 3.115 ± 0.257
0.0AspXaa: 0.0 ± 0.0
Glu
1.941GluAla: 1.941 ± 0.199
1.216GluCys: 1.216 ± 0.188
3.883GluAsp: 3.883 ± 0.322
4.267GluGlu: 4.267 ± 0.474
2.219GluPhe: 2.219 ± 0.208
1.728GluGly: 1.728 ± 0.191
1.387GluHis: 1.387 ± 0.165
4.139GluIle: 4.139 ± 0.318
4.096GluLys: 4.096 ± 0.241
5.803GluLeu: 5.803 ± 0.404
1.131GluMet: 1.131 ± 0.161
3.157GluAsn: 3.157 ± 0.285
2.069GluPro: 2.069 ± 0.221
1.323GluGln: 1.323 ± 0.164
2.624GluArg: 2.624 ± 0.269
3.925GluSer: 3.925 ± 0.279
3.627GluThr: 3.627 ± 0.285
2.816GluVal: 2.816 ± 0.225
0.491GluTrp: 0.491 ± 0.107
3.627GluTyr: 3.627 ± 0.258
0.0GluXaa: 0.0 ± 0.0
Phe
1.493PheAla: 1.493 ± 0.197
0.96PheCys: 0.96 ± 0.166
2.837PheAsp: 2.837 ± 0.254
2.304PheGlu: 2.304 ± 0.185
2.624PhePhe: 2.624 ± 0.247
2.133PheGly: 2.133 ± 0.233
0.853PheHis: 0.853 ± 0.12
4.672PheIle: 4.672 ± 0.338
3.52PheLys: 3.52 ± 0.307
4.715PheLeu: 4.715 ± 0.301
1.344PheMet: 1.344 ± 0.188
3.136PheAsn: 3.136 ± 0.321
1.621PhePro: 1.621 ± 0.196
0.896PheGln: 0.896 ± 0.136
1.515PheArg: 1.515 ± 0.156
3.648PheSer: 3.648 ± 0.279
3.285PheThr: 3.285 ± 0.27
3.883PheVal: 3.883 ± 0.316
0.363PheTrp: 0.363 ± 0.082
2.325PheTyr: 2.325 ± 0.194
0.0PheXaa: 0.0 ± 0.0
Gly
1.707GlyAla: 1.707 ± 0.228
1.088GlyCys: 1.088 ± 0.159
2.688GlyAsp: 2.688 ± 0.243
1.6GlyGlu: 1.6 ± 0.154
1.877GlyPhe: 1.877 ± 0.189
2.624GlyGly: 2.624 ± 0.369
0.811GlyHis: 0.811 ± 0.201
3.584GlyIle: 3.584 ± 0.241
3.072GlyLys: 3.072 ± 0.313
2.624GlyLeu: 2.624 ± 0.235
0.875GlyMet: 0.875 ± 0.126
2.325GlyAsn: 2.325 ± 0.234
0.939GlyPro: 0.939 ± 0.158
0.747GlyGln: 0.747 ± 0.115
1.899GlyArg: 1.899 ± 0.236
2.517GlySer: 2.517 ± 0.277
2.923GlyThr: 2.923 ± 0.226
3.627GlyVal: 3.627 ± 0.255
0.341GlyTrp: 0.341 ± 0.094
2.624GlyTyr: 2.624 ± 0.237
0.0GlyXaa: 0.0 ± 0.0
His
0.725HisAla: 0.725 ± 0.108
0.448HisCys: 0.448 ± 0.113
1.131HisAsp: 1.131 ± 0.124
1.237HisGlu: 1.237 ± 0.151
0.896HisPhe: 0.896 ± 0.12
1.216HisGly: 1.216 ± 0.177
0.448HisHis: 0.448 ± 0.117
1.941HisIle: 1.941 ± 0.197
1.707HisLys: 1.707 ± 0.183
1.941HisLeu: 1.941 ± 0.213
0.875HisMet: 0.875 ± 0.146
1.643HisAsn: 1.643 ± 0.213
1.024HisPro: 1.024 ± 0.154
0.555HisGln: 0.555 ± 0.098
0.917HisArg: 0.917 ± 0.141
1.493HisSer: 1.493 ± 0.159
1.408HisThr: 1.408 ± 0.201
2.069HisVal: 2.069 ± 0.224
0.235HisTrp: 0.235 ± 0.071
0.917HisTyr: 0.917 ± 0.138
0.0HisXaa: 0.0 ± 0.0
Ile
3.456IleAla: 3.456 ± 0.286
1.387IleCys: 1.387 ± 0.15
4.907IleAsp: 4.907 ± 0.304
4.48IleGlu: 4.48 ± 0.332
3.285IlePhe: 3.285 ± 0.331
2.88IleGly: 2.88 ± 0.239
2.475IleHis: 2.475 ± 0.243
6.72IleIle: 6.72 ± 0.379
7.104IleLys: 7.104 ± 0.432
7.979IleLeu: 7.979 ± 0.442
1.643IleMet: 1.643 ± 0.207
5.568IleAsn: 5.568 ± 0.409
2.667IlePro: 2.667 ± 0.283
2.304IleGln: 2.304 ± 0.209
4.117IleArg: 4.117 ± 0.335
6.4IleSer: 6.4 ± 0.379
5.675IleThr: 5.675 ± 0.357
5.611IleVal: 5.611 ± 0.384
0.555IleTrp: 0.555 ± 0.111
3.776IleTyr: 3.776 ± 0.277
0.0IleXaa: 0.0 ± 0.0
Lys
2.965LysAla: 2.965 ± 0.233
1.365LysCys: 1.365 ± 0.165
4.075LysAsp: 4.075 ± 0.279
4.309LysGlu: 4.309 ± 0.283
2.752LysPhe: 2.752 ± 0.337
2.88LysGly: 2.88 ± 0.25
2.432LysHis: 2.432 ± 0.228
6.123LysIle: 6.123 ± 0.493
7.616LysLys: 7.616 ± 0.475
7.125LysLeu: 7.125 ± 0.415
2.155LysMet: 2.155 ± 0.205
4.821LysAsn: 4.821 ± 0.329
2.133LysPro: 2.133 ± 0.192
2.539LysGln: 2.539 ± 0.222
3.691LysArg: 3.691 ± 0.237
4.949LysSer: 4.949 ± 0.373
5.269LysThr: 5.269 ± 0.301
4.245LysVal: 4.245 ± 0.295
0.491LysTrp: 0.491 ± 0.1
4.331LysTyr: 4.331 ± 0.275
0.0LysXaa: 0.0 ± 0.0
Leu
2.859LeuAla: 2.859 ± 0.227
1.963LeuCys: 1.963 ± 0.217
5.376LeuAsp: 5.376 ± 0.285
5.184LeuGlu: 5.184 ± 0.341
5.056LeuPhe: 5.056 ± 0.372
3.264LeuGly: 3.264 ± 0.262
2.005LeuHis: 2.005 ± 0.238
6.357LeuIle: 6.357 ± 0.381
6.784LeuLys: 6.784 ± 0.423
9.174LeuLeu: 9.174 ± 0.482
2.197LeuMet: 2.197 ± 0.211
5.547LeuAsn: 5.547 ± 0.369
3.072LeuPro: 3.072 ± 0.242
2.56LeuGln: 2.56 ± 0.205
4.501LeuArg: 4.501 ± 0.38
7.467LeuSer: 7.467 ± 0.359
6.549LeuThr: 6.549 ± 0.396
6.123LeuVal: 6.123 ± 0.279
0.576LeuTrp: 0.576 ± 0.148
4.928LeuTyr: 4.928 ± 0.33
0.0LeuXaa: 0.0 ± 0.0
Met
1.131MetAla: 1.131 ± 0.149
0.405MetCys: 0.405 ± 0.096
1.728MetAsp: 1.728 ± 0.222
1.643MetGlu: 1.643 ± 0.154
1.685MetPhe: 1.685 ± 0.177
0.981MetGly: 0.981 ± 0.126
0.427MetHis: 0.427 ± 0.108
2.091MetIle: 2.091 ± 0.203
1.6MetLys: 1.6 ± 0.226
2.197MetLeu: 2.197 ± 0.24
0.341MetMet: 0.341 ± 0.078
1.536MetAsn: 1.536 ± 0.159
0.683MetPro: 0.683 ± 0.129
0.448MetGln: 0.448 ± 0.096
1.131MetArg: 1.131 ± 0.149
1.984MetSer: 1.984 ± 0.177
1.451MetThr: 1.451 ± 0.183
1.28MetVal: 1.28 ± 0.128
0.107MetTrp: 0.107 ± 0.046
1.6MetTyr: 1.6 ± 0.217
0.0MetXaa: 0.0 ± 0.0
Asn
2.688AsnAla: 2.688 ± 0.219
0.96AsnCys: 0.96 ± 0.166
3.733AsnAsp: 3.733 ± 0.231
3.84AsnGlu: 3.84 ± 0.288
2.411AsnPhe: 2.411 ± 0.2
2.752AsnGly: 2.752 ± 0.249
1.216AsnHis: 1.216 ± 0.174
5.525AsnIle: 5.525 ± 0.464
5.163AsnLys: 5.163 ± 0.351
4.331AsnLeu: 4.331 ± 0.38
1.792AsnMet: 1.792 ± 0.202
4.48AsnAsn: 4.48 ± 0.428
2.624AsnPro: 2.624 ± 0.272
1.152AsnGln: 1.152 ± 0.136
1.963AsnArg: 1.963 ± 0.201
3.413AsnSer: 3.413 ± 0.267
4.224AsnThr: 4.224 ± 0.262
5.163AsnVal: 5.163 ± 0.311
0.384AsnTrp: 0.384 ± 0.081
3.328AsnTyr: 3.328 ± 0.269
0.0AsnXaa: 0.0 ± 0.0
Pro
0.747ProAla: 0.747 ± 0.102
0.853ProCys: 0.853 ± 0.138
1.941ProAsp: 1.941 ± 0.204
2.24ProGlu: 2.24 ± 0.206
1.941ProPhe: 1.941 ± 0.193
1.451ProGly: 1.451 ± 0.165
0.832ProHis: 0.832 ± 0.167
2.709ProIle: 2.709 ± 0.235
2.24ProLys: 2.24 ± 0.238
3.413ProLeu: 3.413 ± 0.306
0.64ProMet: 0.64 ± 0.104
1.984ProAsn: 1.984 ± 0.153
1.451ProPro: 1.451 ± 0.221
0.597ProGln: 0.597 ± 0.114
1.493ProArg: 1.493 ± 0.201
2.816ProSer: 2.816 ± 0.241
2.432ProThr: 2.432 ± 0.218
2.539ProVal: 2.539 ± 0.206
0.235ProTrp: 0.235 ± 0.08
1.579ProTyr: 1.579 ± 0.183
0.0ProXaa: 0.0 ± 0.0
Gln
0.789GlnAla: 0.789 ± 0.136
0.533GlnCys: 0.533 ± 0.098
1.259GlnAsp: 1.259 ± 0.146
1.195GlnGlu: 1.195 ± 0.153
0.811GlnPhe: 0.811 ± 0.122
0.917GlnGly: 0.917 ± 0.155
0.619GlnHis: 0.619 ± 0.105
1.749GlnIle: 1.749 ± 0.161
1.92GlnLys: 1.92 ± 0.239
2.432GlnLeu: 2.432 ± 0.253
0.427GlnMet: 0.427 ± 0.101
1.131GlnAsn: 1.131 ± 0.156
0.875GlnPro: 0.875 ± 0.136
0.747GlnGln: 0.747 ± 0.129
1.472GlnArg: 1.472 ± 0.182
1.557GlnSer: 1.557 ± 0.183
1.472GlnThr: 1.472 ± 0.192
1.067GlnVal: 1.067 ± 0.183
0.277GlnTrp: 0.277 ± 0.067
1.109GlnTyr: 1.109 ± 0.136
0.0GlnXaa: 0.0 ± 0.0
Arg
1.152ArgAla: 1.152 ± 0.148
1.216ArgCys: 1.216 ± 0.165
2.347ArgAsp: 2.347 ± 0.251
2.005ArgGlu: 2.005 ± 0.206
2.517ArgPhe: 2.517 ± 0.212
1.643ArgGly: 1.643 ± 0.214
1.067ArgHis: 1.067 ± 0.148
3.392ArgIle: 3.392 ± 0.236
2.816ArgLys: 2.816 ± 0.249
4.693ArgLeu: 4.693 ± 0.304
1.195ArgMet: 1.195 ± 0.166
2.368ArgAsn: 2.368 ± 0.246
1.216ArgPro: 1.216 ± 0.193
1.173ArgGln: 1.173 ± 0.152
2.859ArgArg: 2.859 ± 0.323
2.709ArgSer: 2.709 ± 0.24
2.752ArgThr: 2.752 ± 0.278
3.136ArgVal: 3.136 ± 0.253
0.491ArgTrp: 0.491 ± 0.124
2.901ArgTyr: 2.901 ± 0.314
0.0ArgXaa: 0.0 ± 0.0
Ser
2.837SerAla: 2.837 ± 0.221
1.557SerCys: 1.557 ± 0.197
4.48SerAsp: 4.48 ± 0.383
3.733SerGlu: 3.733 ± 0.259
3.712SerPhe: 3.712 ± 0.294
2.816SerGly: 2.816 ± 0.236
1.685SerHis: 1.685 ± 0.183
5.995SerIle: 5.995 ± 0.315
5.355SerLys: 5.355 ± 0.348
6.315SerLeu: 6.315 ± 0.394
1.984SerMet: 1.984 ± 0.177
4.139SerAsn: 4.139 ± 0.347
2.539SerPro: 2.539 ± 0.239
1.643SerGln: 1.643 ± 0.186
3.029SerArg: 3.029 ± 0.269
5.291SerSer: 5.291 ± 0.313
4.672SerThr: 4.672 ± 0.367
6.123SerVal: 6.123 ± 0.336
0.427SerTrp: 0.427 ± 0.082
3.605SerTyr: 3.605 ± 0.288
0.0SerXaa: 0.0 ± 0.0
Thr
2.56ThrAla: 2.56 ± 0.245
1.429ThrCys: 1.429 ± 0.188
3.925ThrAsp: 3.925 ± 0.282
3.691ThrGlu: 3.691 ± 0.268
3.776ThrPhe: 3.776 ± 0.256
2.389ThrGly: 2.389 ± 0.223
1.728ThrHis: 1.728 ± 0.184
5.397ThrIle: 5.397 ± 0.414
5.013ThrLys: 5.013 ± 0.335
5.781ThrLeu: 5.781 ± 0.319
1.643ThrMet: 1.643 ± 0.197
4.011ThrAsn: 4.011 ± 0.295
2.901ThrPro: 2.901 ± 0.259
1.301ThrGln: 1.301 ± 0.162
2.517ThrArg: 2.517 ± 0.233
5.291ThrSer: 5.291 ± 0.33
4.48ThrThr: 4.48 ± 0.329
5.419ThrVal: 5.419 ± 0.388
0.661ThrTrp: 0.661 ± 0.141
3.755ThrTyr: 3.755 ± 0.259
0.0ThrXaa: 0.0 ± 0.0
Val
3.093ValAla: 3.093 ± 0.25
2.368ValCys: 2.368 ± 0.249
4.352ValAsp: 4.352 ± 0.316
3.883ValGlu: 3.883 ± 0.329
4.139ValPhe: 4.139 ± 0.374
2.496ValGly: 2.496 ± 0.232
2.005ValHis: 2.005 ± 0.211
5.803ValIle: 5.803 ± 0.313
5.568ValLys: 5.568 ± 0.36
6.741ValLeu: 6.741 ± 0.331
1.344ValMet: 1.344 ± 0.148
4.907ValAsn: 4.907 ± 0.317
2.496ValPro: 2.496 ± 0.21
1.6ValGln: 1.6 ± 0.196
3.051ValArg: 3.051 ± 0.285
5.632ValSer: 5.632 ± 0.38
5.056ValThr: 5.056 ± 0.396
5.205ValVal: 5.205 ± 0.419
0.341ValTrp: 0.341 ± 0.074
4.715ValTyr: 4.715 ± 0.389
0.0ValXaa: 0.0 ± 0.0
Trp
0.192TrpAla: 0.192 ± 0.081
0.128TrpCys: 0.128 ± 0.051
0.213TrpAsp: 0.213 ± 0.064
0.469TrpGlu: 0.469 ± 0.105
0.533TrpPhe: 0.533 ± 0.11
0.32TrpGly: 0.32 ± 0.077
0.171TrpHis: 0.171 ± 0.055
0.96TrpIle: 0.96 ± 0.144
0.661TrpLys: 0.661 ± 0.135
0.555TrpLeu: 0.555 ± 0.117
0.299TrpMet: 0.299 ± 0.072
0.256TrpAsn: 0.256 ± 0.079
0.235TrpPro: 0.235 ± 0.064
0.149TrpGln: 0.149 ± 0.06
0.491TrpArg: 0.491 ± 0.118
0.533TrpSer: 0.533 ± 0.098
0.491TrpThr: 0.491 ± 0.104
0.427TrpVal: 0.427 ± 0.1
0.043TrpTrp: 0.043 ± 0.032
0.341TrpTyr: 0.341 ± 0.071
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.283TyrAla: 2.283 ± 0.232
1.301TyrCys: 1.301 ± 0.17
3.179TyrAsp: 3.179 ± 0.268
2.56TyrGlu: 2.56 ± 0.236
2.731TyrPhe: 2.731 ± 0.226
2.816TyrGly: 2.816 ± 0.251
0.981TyrHis: 0.981 ± 0.13
4.715TyrIle: 4.715 ± 0.337
4.139TyrLys: 4.139 ± 0.328
5.056TyrLeu: 5.056 ± 0.316
1.536TyrMet: 1.536 ± 0.178
3.541TyrAsn: 3.541 ± 0.306
2.048TyrPro: 2.048 ± 0.184
0.832TyrGln: 0.832 ± 0.116
1.792TyrArg: 1.792 ± 0.229
3.648TyrSer: 3.648 ± 0.32
3.776TyrThr: 3.776 ± 0.269
4.565TyrVal: 4.565 ± 0.282
0.555TyrTrp: 0.555 ± 0.102
2.432TyrTyr: 2.432 ± 0.233
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 153 proteins (46875 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski