Amino acid dipepetide frequency for Phenylobacterium zucineum (strain HLK1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.99AlaAla: 23.99 ± 0.254	1.275AlaCys: 1.275 ± 0.037	7.705AlaAsp: 7.705 ± 0.081	9.609AlaGlu: 9.609 ± 0.122	5.009AlaPhe: 5.009 ± 0.066	13.521AlaGly: 13.521 ± 0.149	2.426AlaHis: 2.426 ± 0.049	5.154AlaIle: 5.154 ± 0.072	3.759AlaLys: 3.759 ± 0.072	14.877AlaLeu: 14.877 ± 0.156	3.374AlaMet: 3.374 ± 0.052	2.58AlaAsn: 2.58 ± 0.055	8.075AlaPro: 8.075 ± 0.106	4.691AlaGln: 4.691 ± 0.069	11.864AlaArg: 11.864 ± 0.144	6.041AlaSer: 6.041 ± 0.076	5.501AlaThr: 5.501 ± 0.077	10.088AlaVal: 10.088 ± 0.125	2.171AlaTrp: 2.171 ± 0.042	2.892AlaTyr: 2.892 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.123CysAla: 1.123 ± 0.033	0.096CysCys: 0.096 ± 0.009	0.497CysAsp: 0.497 ± 0.018	0.458CysGlu: 0.458 ± 0.018	0.274CysPhe: 0.274 ± 0.014	0.842CysGly: 0.842 ± 0.028	0.179CysHis: 0.179 ± 0.012	0.269CysIle: 0.269 ± 0.015	0.133CysLys: 0.133 ± 0.01	0.646CysLeu: 0.646 ± 0.022	0.117CysMet: 0.117 ± 0.009	0.151CysAsn: 0.151 ± 0.011	0.437CysPro: 0.437 ± 0.022	0.228CysGln: 0.228 ± 0.014	0.622CysArg: 0.622 ± 0.022	0.345CysSer: 0.345 ± 0.017	0.324CysThr: 0.324 ± 0.019	0.576CysVal: 0.576 ± 0.022	0.094CysTrp: 0.094 ± 0.008	0.159CysTyr: 0.159 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.378AspAla: 7.378 ± 0.085	0.405AspCys: 0.405 ± 0.018	2.886AspAsp: 2.886 ± 0.063	3.627AspGlu: 3.627 ± 0.052	2.061AspPhe: 2.061 ± 0.044	5.386AspGly: 5.386 ± 0.085	1.119AspHis: 1.119 ± 0.035	2.092AspIle: 2.092 ± 0.041	1.231AspLys: 1.231 ± 0.042	6.356AspLeu: 6.356 ± 0.079	1.037AspMet: 1.037 ± 0.034	0.942AspAsn: 0.942 ± 0.03	4.226AspPro: 4.226 ± 0.055	1.581AspGln: 1.581 ± 0.039	4.853AspArg: 4.853 ± 0.07	1.748AspSer: 1.748 ± 0.04	2.028AspThr: 2.028 ± 0.056	4.384AspVal: 4.384 ± 0.06	1.007AspTrp: 1.007 ± 0.031	1.42AspTyr: 1.42 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	10.37GluAla: 10.37 ± 0.14	0.253GluCys: 0.253 ± 0.014	2.98GluAsp: 2.98 ± 0.053	3.054GluGlu: 3.054 ± 0.066	1.613GluPhe: 1.613 ± 0.037	5.411GluGly: 5.411 ± 0.068	1.143GluHis: 1.143 ± 0.032	3.004GluIle: 3.004 ± 0.05	1.838GluLys: 1.838 ± 0.047	5.79GluLeu: 5.79 ± 0.079	1.282GluMet: 1.282 ± 0.034	1.149GluAsn: 1.149 ± 0.034	3.37GluPro: 3.37 ± 0.059	1.965GluGln: 1.965 ± 0.046	5.746GluArg: 5.746 ± 0.074	2.038GluSer: 2.038 ± 0.041	3.518GluThr: 3.518 ± 0.053	4.503GluVal: 4.503 ± 0.063	0.698GluTrp: 0.698 ± 0.023	0.924GluTyr: 0.924 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.654PheAla: 4.654 ± 0.059	0.349PheCys: 0.349 ± 0.016	2.506PheAsp: 2.506 ± 0.052	2.411PheGlu: 2.411 ± 0.048	1.216PhePhe: 1.216 ± 0.039	3.6PheGly: 3.6 ± 0.059	0.692PheHis: 0.692 ± 0.023	1.208PheIle: 1.208 ± 0.03	0.844PheLys: 0.844 ± 0.03	3.012PheLeu: 3.012 ± 0.058	0.699PheMet: 0.699 ± 0.024	0.892PheAsn: 0.892 ± 0.028	1.491PhePro: 1.491 ± 0.036	1.078PheGln: 1.078 ± 0.031	2.467PheArg: 2.467 ± 0.041	1.783PheSer: 1.783 ± 0.034	1.817PheThr: 1.817 ± 0.039	2.74PheVal: 2.74 ± 0.045	0.517PheTrp: 0.517 ± 0.02	0.83PheTyr: 0.83 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	12.072GlyAla: 12.072 ± 0.118	0.822GlyCys: 0.822 ± 0.029	4.754GlyAsp: 4.754 ± 0.092	5.968GlyGlu: 5.968 ± 0.075	3.737GlyPhe: 3.737 ± 0.061	9.081GlyGly: 9.081 ± 0.161	1.737GlyHis: 1.737 ± 0.042	2.761GlyIle: 2.761 ± 0.049	2.625GlyLys: 2.625 ± 0.052	9.88GlyLeu: 9.88 ± 0.11	2.044GlyMet: 2.044 ± 0.041	1.565GlyAsn: 1.565 ± 0.066	4.771GlyPro: 4.771 ± 0.08	3.193GlyGln: 3.193 ± 0.061	8.105GlyArg: 8.105 ± 0.094	4.077GlySer: 4.077 ± 0.067	3.359GlyThr: 3.359 ± 0.066	8.046GlyVal: 8.046 ± 0.1	1.614GlyTrp: 1.614 ± 0.035	2.301GlyTyr: 2.301 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.442HisAla: 2.442 ± 0.055	0.172HisCys: 0.172 ± 0.012	1.003HisAsp: 1.003 ± 0.031	1.053HisGlu: 1.053 ± 0.03	0.607HisPhe: 0.607 ± 0.023	1.822HisGly: 1.822 ± 0.041	0.474HisHis: 0.474 ± 0.023	0.61HisIle: 0.61 ± 0.021	0.392HisLys: 0.392 ± 0.018	1.865HisLeu: 1.865 ± 0.048	0.431HisMet: 0.431 ± 0.021	0.367HisAsn: 0.367 ± 0.017	1.347HisPro: 1.347 ± 0.033	0.526HisGln: 0.526 ± 0.019	1.468HisArg: 1.468 ± 0.046	0.667HisSer: 0.667 ± 0.021	0.677HisThr: 0.677 ± 0.024	1.486HisVal: 1.486 ± 0.04	0.293HisTrp: 0.293 ± 0.017	0.432HisTyr: 0.432 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.778IleAla: 5.778 ± 0.078	0.365IleCys: 0.365 ± 0.017	2.659IleAsp: 2.659 ± 0.046	2.845IleGlu: 2.845 ± 0.052	1.212IlePhe: 1.212 ± 0.037	3.748IleGly: 3.748 ± 0.06	0.662IleHis: 0.662 ± 0.026	1.244IleIle: 1.244 ± 0.04	0.874IleLys: 0.874 ± 0.03	3.602IleLeu: 3.602 ± 0.059	0.596IleMet: 0.596 ± 0.022	0.891IleAsn: 0.891 ± 0.028	1.952IlePro: 1.952 ± 0.043	1.059IleGln: 1.059 ± 0.032	2.896IleArg: 2.896 ± 0.044	1.966IleSer: 1.966 ± 0.041	1.976IleThr: 1.976 ± 0.046	3.486IleVal: 3.486 ± 0.052	0.485IleTrp: 0.485 ± 0.021	0.84IleTyr: 0.84 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.258LysAla: 4.258 ± 0.076	0.107LysCys: 0.107 ± 0.009	1.553LysAsp: 1.553 ± 0.038	1.221LysGlu: 1.221 ± 0.034	0.693LysPhe: 0.693 ± 0.026	2.464LysGly: 2.464 ± 0.05	0.455LysHis: 0.455 ± 0.02	1.212LysIle: 1.212 ± 0.037	0.85LysLys: 0.85 ± 0.033	2.707LysLeu: 2.707 ± 0.053	0.526LysMet: 0.526 ± 0.02	0.6LysAsn: 0.6 ± 0.025	1.911LysPro: 1.911 ± 0.045	0.693LysGln: 0.693 ± 0.028	2.042LysArg: 2.042 ± 0.04	1.252LysSer: 1.252 ± 0.033	1.667LysThr: 1.667 ± 0.042	2.295LysVal: 2.295 ± 0.046	0.3LysTrp: 0.3 ± 0.017	0.465LysTyr: 0.465 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.871LeuAla: 15.871 ± 0.149	0.739LeuCys: 0.739 ± 0.023	5.914LeuAsp: 5.914 ± 0.074	5.905LeuGlu: 5.905 ± 0.081	3.396LeuPhe: 3.396 ± 0.064	8.748LeuGly: 8.748 ± 0.092	1.766LeuHis: 1.766 ± 0.037	4.029LeuIle: 4.029 ± 0.063	3.56LeuLys: 3.56 ± 0.059	8.746LeuLeu: 8.746 ± 0.116	2.152LeuMet: 2.152 ± 0.049	2.271LeuAsn: 2.271 ± 0.044	5.462LeuPro: 5.462 ± 0.063	2.993LeuGln: 2.993 ± 0.059	7.312LeuArg: 7.312 ± 0.085	5.759LeuSer: 5.759 ± 0.066	5.506LeuThr: 5.506 ± 0.07	7.524LeuVal: 7.524 ± 0.087	1.199LeuTrp: 1.199 ± 0.034	1.928LeuTyr: 1.928 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.043MetAla: 3.043 ± 0.057	0.14MetCys: 0.14 ± 0.01	1.093MetAsp: 1.093 ± 0.038	1.003MetGlu: 1.003 ± 0.028	0.591MetPhe: 0.591 ± 0.024	1.8MetGly: 1.8 ± 0.04	0.345MetHis: 0.345 ± 0.02	0.978MetIle: 0.978 ± 0.027	0.759MetLys: 0.759 ± 0.026	1.999MetLeu: 1.999 ± 0.041	0.466MetMet: 0.466 ± 0.023	0.579MetAsn: 0.579 ± 0.021	1.189MetPro: 1.189 ± 0.033	0.617MetGln: 0.617 ± 0.02	1.713MetArg: 1.713 ± 0.038	1.417MetSer: 1.417 ± 0.037	1.565MetThr: 1.565 ± 0.042	1.369MetVal: 1.369 ± 0.035	0.186MetTrp: 0.186 ± 0.011	0.246MetTyr: 0.246 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.673AsnAla: 2.673 ± 0.053	0.164AsnCys: 0.164 ± 0.012	1.091AsnAsp: 1.091 ± 0.035	0.943AsnGlu: 0.943 ± 0.026	0.742AsnPhe: 0.742 ± 0.032	1.828AsnGly: 1.828 ± 0.052	0.384AsnHis: 0.384 ± 0.018	0.947AsnIle: 0.947 ± 0.028	0.409AsnLys: 0.409 ± 0.02	2.315AsnLeu: 2.315 ± 0.047	0.434AsnMet: 0.434 ± 0.019	0.499AsnAsn: 0.499 ± 0.023	1.56AsnPro: 1.56 ± 0.038	0.552AsnGln: 0.552 ± 0.023	1.489AsnArg: 1.489 ± 0.033	0.87AsnSer: 0.87 ± 0.031	1.043AsnThr: 1.043 ± 0.032	1.767AsnVal: 1.767 ± 0.044	0.322AsnTrp: 0.322 ± 0.017	0.581AsnTyr: 0.581 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	8.687ProAla: 8.687 ± 0.105	0.376ProCys: 0.376 ± 0.019	3.927ProAsp: 3.927 ± 0.065	4.286ProGlu: 4.286 ± 0.064	1.995ProPhe: 1.995 ± 0.045	5.725ProGly: 5.725 ± 0.075	1.056ProHis: 1.056 ± 0.03	2.054ProIle: 2.054 ± 0.04	1.705ProLys: 1.705 ± 0.041	5.139ProLeu: 5.139 ± 0.063	1.18ProMet: 1.18 ± 0.028	1.181ProAsn: 1.181 ± 0.036	3.931ProPro: 3.931 ± 0.072	1.937ProGln: 1.937 ± 0.04	3.784ProArg: 3.784 ± 0.063	2.602ProSer: 2.602 ± 0.051	2.648ProThr: 2.648 ± 0.043	4.385ProVal: 4.385 ± 0.073	0.797ProTrp: 0.797 ± 0.025	1.126ProTyr: 1.126 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.247GlnAla: 5.247 ± 0.075	0.154GlnCys: 0.154 ± 0.011	1.452GlnAsp: 1.452 ± 0.036	1.436GlnGlu: 1.436 ± 0.034	0.829GlnPhe: 0.829 ± 0.028	2.781GlnGly: 2.781 ± 0.052	0.554GlnHis: 0.554 ± 0.025	1.42GlnIle: 1.42 ± 0.037	0.846GlnLys: 0.846 ± 0.026	2.778GlnLeu: 2.778 ± 0.049	0.688GlnMet: 0.688 ± 0.022	0.634GlnAsn: 0.634 ± 0.025	1.94GlnPro: 1.94 ± 0.041	1.04GlnGln: 1.04 ± 0.039	2.432GlnArg: 2.432 ± 0.046	1.311GlnSer: 1.311 ± 0.038	1.629GlnThr: 1.629 ± 0.033	2.729GlnVal: 2.729 ± 0.058	0.317GlnTrp: 0.317 ± 0.018	0.482GlnTyr: 0.482 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.399ArgAla: 10.399 ± 0.123	0.508ArgCys: 0.508 ± 0.023	4.254ArgAsp: 4.254 ± 0.058	4.91ArgGlu: 4.91 ± 0.076	3.093ArgPhe: 3.093 ± 0.05	6.137ArgGly: 6.137 ± 0.07	1.578ArgHis: 1.578 ± 0.033	3.677ArgIle: 3.677 ± 0.062	2.102ArgLys: 2.102 ± 0.044	9.684ArgLeu: 9.684 ± 0.097	1.886ArgMet: 1.886 ± 0.038	1.611ArgAsn: 1.611 ± 0.037	5.135ArgPro: 5.135 ± 0.081	2.643ArgGln: 2.643 ± 0.053	8.085ArgArg: 8.085 ± 0.109	3.519ArgSer: 3.519 ± 0.054	3.978ArgThr: 3.978 ± 0.058	5.366ArgVal: 5.366 ± 0.073	1.263ArgTrp: 1.263 ± 0.035	1.847ArgTyr: 1.847 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.895SerAla: 5.895 ± 0.072	0.327SerCys: 0.327 ± 0.017	2.569SerAsp: 2.569 ± 0.056	2.438SerGlu: 2.438 ± 0.047	1.786SerPhe: 1.786 ± 0.042	4.923SerGly: 4.923 ± 0.075	0.83SerHis: 0.83 ± 0.025	1.774SerIle: 1.774 ± 0.047	1.202SerLys: 1.202 ± 0.031	4.709SerLeu: 4.709 ± 0.066	0.975SerMet: 0.975 ± 0.03	1.023SerAsn: 1.023 ± 0.033	2.92SerPro: 2.92 ± 0.049	1.353SerGln: 1.353 ± 0.037	3.447SerArg: 3.447 ± 0.051	2.07SerSer: 2.07 ± 0.052	2.13SerThr: 2.13 ± 0.039	3.408SerVal: 3.408 ± 0.053	0.716SerTrp: 0.716 ± 0.027	1.059SerTyr: 1.059 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.253ThrAla: 6.253 ± 0.074	0.339ThrCys: 0.339 ± 0.017	2.507ThrAsp: 2.507 ± 0.047	2.295ThrGlu: 2.295 ± 0.047	1.839ThrPhe: 1.839 ± 0.042	4.967ThrGly: 4.967 ± 0.072	0.822ThrHis: 0.822 ± 0.027	1.978ThrIle: 1.978 ± 0.04	1.085ThrLys: 1.085 ± 0.03	5.267ThrLeu: 5.267 ± 0.076	0.825ThrMet: 0.825 ± 0.031	0.996ThrAsn: 0.996 ± 0.035	3.699ThrPro: 3.699 ± 0.058	1.241ThrGln: 1.241 ± 0.033	3.294ThrArg: 3.294 ± 0.054	2.259ThrSer: 2.259 ± 0.048	2.407ThrThr: 2.407 ± 0.054	3.963ThrVal: 3.963 ± 0.06	0.681ThrTrp: 0.681 ± 0.026	1.22ThrTyr: 1.22 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.145ValAla: 10.145 ± 0.136	0.678ValCys: 0.678 ± 0.024	4.259ValAsp: 4.259 ± 0.06	5.178ValGlu: 5.178 ± 0.071	2.821ValPhe: 2.821 ± 0.049	6.446ValGly: 6.446 ± 0.084	1.3ValHis: 1.3 ± 0.035	3.36ValIle: 3.36 ± 0.052	2.124ValLys: 2.124 ± 0.049	7.751ValLeu: 7.751 ± 0.104	1.66ValMet: 1.66 ± 0.036	1.802ValAsn: 1.802 ± 0.045	3.388ValPro: 3.388 ± 0.057	2.309ValGln: 2.309 ± 0.04	6.614ValArg: 6.614 ± 0.079	3.996ValSer: 3.996 ± 0.061	4.336ValThr: 4.336 ± 0.07	6.61ValVal: 6.61 ± 0.11	1.07ValTrp: 1.07 ± 0.027	1.466ValTyr: 1.466 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.618TrpAla: 1.618 ± 0.042	0.107TrpCys: 0.107 ± 0.009	0.689TrpAsp: 0.689 ± 0.024	0.643TrpGlu: 0.643 ± 0.022	0.526TrpPhe: 0.526 ± 0.02	1.041TrpGly: 1.041 ± 0.03	0.239TrpHis: 0.239 ± 0.014	0.685TrpIle: 0.685 ± 0.022	0.456TrpLys: 0.456 ± 0.02	1.65TrpLeu: 1.65 ± 0.04	0.359TrpMet: 0.359 ± 0.018	0.387TrpAsn: 0.387 ± 0.017	0.749TrpPro: 0.749 ± 0.027	0.368TrpGln: 0.368 ± 0.018	1.615TrpArg: 1.615 ± 0.039	0.882TrpSer: 0.882 ± 0.026	0.922TrpThr: 0.922 ± 0.027	0.858TrpVal: 0.858 ± 0.027	0.259TrpTrp: 0.259 ± 0.015	0.279TrpTyr: 0.279 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.707TyrAla: 2.707 ± 0.045	0.195TyrCys: 0.195 ± 0.013	1.47TyrAsp: 1.47 ± 0.038	1.366TyrGlu: 1.366 ± 0.036	0.766TyrPhe: 0.766 ± 0.022	2.244TyrGly: 2.244 ± 0.048	0.376TyrHis: 0.376 ± 0.018	0.675TyrIle: 0.675 ± 0.023	0.476TyrLys: 0.476 ± 0.02	2.007TyrLeu: 2.007 ± 0.046	0.366TyrMet: 0.366 ± 0.016	0.492TyrAsn: 0.492 ± 0.023	0.964TyrPro: 0.964 ± 0.031	0.631TyrGln: 0.631 ± 0.02	1.828TyrArg: 1.828 ± 0.042	0.95TyrSer: 0.95 ± 0.032	0.907TyrThr: 0.907 ± 0.033	1.732TyrVal: 1.732 ± 0.044	0.345TyrTrp: 0.345 ± 0.018	0.535TyrTyr: 0.535 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3838 proteins (1282678 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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