Amino acid dipepetide frequency for Thermovirga lienii (strain ATCC BAA-1197 / DSM 17291 / Cas60314)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.226AlaAla: 7.226 ± 0.172
1.038AlaCys: 1.038 ± 0.041
3.162AlaAsp: 3.162 ± 0.075
5.445AlaGlu: 5.445 ± 0.1
3.713AlaPhe: 3.713 ± 0.085
5.937AlaGly: 5.937 ± 0.129
1.286AlaHis: 1.286 ± 0.051
5.547AlaIle: 5.547 ± 0.113
5.191AlaLys: 5.191 ± 0.104
10.115AlaLeu: 10.115 ± 0.134
2.369AlaMet: 2.369 ± 0.076
2.265AlaAsn: 2.265 ± 0.066
2.682AlaPro: 2.682 ± 0.074
2.427AlaGln: 2.427 ± 0.063
4.185AlaArg: 4.185 ± 0.092
5.224AlaSer: 5.224 ± 0.113
3.226AlaThr: 3.226 ± 0.073
6.428AlaVal: 6.428 ± 0.114
0.912AlaTrp: 0.912 ± 0.047
2.181AlaTyr: 2.181 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.819CysAla: 0.819 ± 0.039
0.194CysCys: 0.194 ± 0.021
0.728CysAsp: 0.728 ± 0.037
0.665CysGlu: 0.665 ± 0.037
0.547CysPhe: 0.547 ± 0.03
1.291CysGly: 1.291 ± 0.057
0.254CysHis: 0.254 ± 0.021
0.728CysIle: 0.728 ± 0.037
0.654CysLys: 0.654 ± 0.036
1.127CysLeu: 1.127 ± 0.042
0.28CysMet: 0.28 ± 0.019
0.362CysAsn: 0.362 ± 0.027
0.805CysPro: 0.805 ± 0.041
0.238CysGln: 0.238 ± 0.02
0.663CysArg: 0.663 ± 0.033
0.901CysSer: 0.901 ± 0.039
0.474CysThr: 0.474 ± 0.027
0.825CysVal: 0.825 ± 0.041
0.156CysTrp: 0.156 ± 0.019
0.375CysTyr: 0.375 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.503AspAla: 3.503 ± 0.084
0.546AspCys: 0.546 ± 0.033
2.193AspAsp: 2.193 ± 0.105
4.012AspGlu: 4.012 ± 0.086
2.357AspPhe: 2.357 ± 0.065
3.619AspGly: 3.619 ± 0.095
0.875AspHis: 0.875 ± 0.041
3.646AspIle: 3.646 ± 0.087
3.072AspLys: 3.072 ± 0.067
5.515AspLeu: 5.515 ± 0.104
1.374AspMet: 1.374 ± 0.044
1.413AspAsn: 1.413 ± 0.044
2.65AspPro: 2.65 ± 0.068
1.08AspGln: 1.08 ± 0.046
2.442AspArg: 2.442 ± 0.068
2.435AspSer: 2.435 ± 0.067
1.979AspThr: 1.979 ± 0.064
4.36AspVal: 4.36 ± 0.094
0.581AspTrp: 0.581 ± 0.037
1.438AspTyr: 1.438 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
6.806GluAla: 6.806 ± 0.114
0.584GluCys: 0.584 ± 0.032
4.108GluAsp: 4.108 ± 0.085
8.036GluGlu: 8.036 ± 0.16
2.049GluPhe: 2.049 ± 0.059
6.095GluGly: 6.095 ± 0.113
1.212GluHis: 1.212 ± 0.044
5.336GluIle: 5.336 ± 0.106
6.647GluLys: 6.647 ± 0.125
6.993GluLeu: 6.993 ± 0.124
2.102GluMet: 2.102 ± 0.063
2.7GluAsn: 2.7 ± 0.071
2.335GluPro: 2.335 ± 0.068
1.93GluGln: 1.93 ± 0.064
4.938GluArg: 4.938 ± 0.103
3.428GluSer: 3.428 ± 0.076
3.142GluThr: 3.142 ± 0.069
5.89GluVal: 5.89 ± 0.098
0.803GluTrp: 0.803 ± 0.041
1.831GluTyr: 1.831 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.19PheAla: 3.19 ± 0.089
0.606PheCys: 0.606 ± 0.032
2.042PheAsp: 2.042 ± 0.061
2.482PheGlu: 2.482 ± 0.069
1.977PhePhe: 1.977 ± 0.069
3.149PheGly: 3.149 ± 0.084
0.758PheHis: 0.758 ± 0.039
2.541PheIle: 2.541 ± 0.072
2.139PheLys: 2.139 ± 0.062
4.69PheLeu: 4.69 ± 0.096
1.175PheMet: 1.175 ± 0.044
1.209PheAsn: 1.209 ± 0.044
2.002PhePro: 2.002 ± 0.067
1.029PheGln: 1.029 ± 0.04
1.833PheArg: 1.833 ± 0.056
3.048PheSer: 3.048 ± 0.061
1.766PheThr: 1.766 ± 0.048
3.137PheVal: 3.137 ± 0.073
0.608PheTrp: 0.608 ± 0.031
1.259PheTyr: 1.259 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
6.429GlyAla: 6.429 ± 0.112
1.11GlyCys: 1.11 ± 0.049
3.584GlyAsp: 3.584 ± 0.092
5.028GlyGlu: 5.028 ± 0.102
3.428GlyPhe: 3.428 ± 0.08
6.073GlyGly: 6.073 ± 0.115
1.485GlyHis: 1.485 ± 0.051
6.011GlyIle: 6.011 ± 0.097
6.011GlyLys: 6.011 ± 0.103
7.842GlyLeu: 7.842 ± 0.127
2.238GlyMet: 2.238 ± 0.068
2.588GlyAsn: 2.588 ± 0.06
2.63GlyPro: 2.63 ± 0.074
1.855GlyGln: 1.855 ± 0.061
4.195GlyArg: 4.195 ± 0.089
4.484GlySer: 4.484 ± 0.094
4.002GlyThr: 4.002 ± 0.086
6.615GlyVal: 6.615 ± 0.126
1.036GlyTrp: 1.036 ± 0.043
2.655GlyTyr: 2.655 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.187HisAla: 1.187 ± 0.045
0.218HisCys: 0.218 ± 0.019
0.79HisAsp: 0.79 ± 0.037
1.018HisGlu: 1.018 ± 0.041
0.842HisPhe: 0.842 ± 0.041
1.401HisGly: 1.401 ± 0.052
0.432HisHis: 0.432 ± 0.029
1.269HisIle: 1.269 ± 0.05
1.058HisLys: 1.058 ± 0.046
1.878HisLeu: 1.878 ± 0.059
0.485HisMet: 0.485 ± 0.029
0.549HisAsn: 0.549 ± 0.029
1.14HisPro: 1.14 ± 0.043
0.434HisGln: 0.434 ± 0.026
0.952HisArg: 0.952 ± 0.042
0.852HisSer: 0.852 ± 0.036
0.767HisThr: 0.767 ± 0.031
1.292HisVal: 1.292 ± 0.048
0.244HisTrp: 0.244 ± 0.023
0.569HisTyr: 0.569 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.664IleAla: 5.664 ± 0.115
0.884IleCys: 0.884 ± 0.035
3.467IleAsp: 3.467 ± 0.08
4.863IleGlu: 4.863 ± 0.09
2.548IlePhe: 2.548 ± 0.074
5.068IleGly: 5.068 ± 0.116
1.07IleHis: 1.07 ± 0.042
4.126IleIle: 4.126 ± 0.102
4.504IleLys: 4.504 ± 0.084
6.988IleLeu: 6.988 ± 0.112
1.635IleMet: 1.635 ± 0.057
2.258IleAsn: 2.258 ± 0.055
3.212IlePro: 3.212 ± 0.08
1.565IleGln: 1.565 ± 0.05
3.51IleArg: 3.51 ± 0.07
4.392IleSer: 4.392 ± 0.084
3.39IleThr: 3.39 ± 0.076
4.916IleVal: 4.916 ± 0.091
0.668IleTrp: 0.668 ± 0.031
1.858IleTyr: 1.858 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
6.083LysAla: 6.083 ± 0.097
0.524LysCys: 0.524 ± 0.028
4.243LysAsp: 4.243 ± 0.087
6.948LysGlu: 6.948 ± 0.125
1.734LysPhe: 1.734 ± 0.053
5.793LysGly: 5.793 ± 0.084
1.026LysHis: 1.026 ± 0.041
4.436LysIle: 4.436 ± 0.086
5.107LysLys: 5.107 ± 0.105
5.848LysLeu: 5.848 ± 0.113
1.676LysMet: 1.676 ± 0.054
2.435LysAsn: 2.435 ± 0.078
2.519LysPro: 2.519 ± 0.072
1.363LysGln: 1.363 ± 0.045
3.927LysArg: 3.927 ± 0.092
3.303LysSer: 3.303 ± 0.066
3.247LysThr: 3.247 ± 0.085
5.564LysVal: 5.564 ± 0.098
0.758LysTrp: 0.758 ± 0.033
1.706LysTyr: 1.706 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
8.969LeuAla: 8.969 ± 0.136
1.374LeuCys: 1.374 ± 0.049
5.276LeuAsp: 5.276 ± 0.104
8.296LeuGlu: 8.296 ± 0.147
4.221LeuPhe: 4.221 ± 0.095
8.41LeuGly: 8.41 ± 0.119
1.697LeuHis: 1.697 ± 0.054
5.52LeuIle: 5.52 ± 0.109
7.318LeuLys: 7.318 ± 0.126
10.639LeuLeu: 10.639 ± 0.164
2.643LeuMet: 2.643 ± 0.075
3.137LeuAsn: 3.137 ± 0.07
4.971LeuPro: 4.971 ± 0.099
2.62LeuGln: 2.62 ± 0.069
5.582LeuArg: 5.582 ± 0.11
7.355LeuSer: 7.355 ± 0.125
4.238LeuThr: 4.238 ± 0.103
7.732LeuVal: 7.732 ± 0.132
1.431LeuTrp: 1.431 ± 0.056
2.702LeuTyr: 2.702 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.663MetAla: 2.663 ± 0.074
0.224MetCys: 0.224 ± 0.017
1.495MetAsp: 1.495 ± 0.052
2.395MetGlu: 2.395 ± 0.066
0.798MetPhe: 0.798 ± 0.039
2.323MetGly: 2.323 ± 0.073
0.377MetHis: 0.377 ± 0.026
1.533MetIle: 1.533 ± 0.049
1.937MetLys: 1.937 ± 0.052
2.435MetLeu: 2.435 ± 0.067
0.634MetMet: 0.634 ± 0.037
0.986MetAsn: 0.986 ± 0.043
1.177MetPro: 1.177 ± 0.047
0.613MetGln: 0.613 ± 0.028
1.456MetArg: 1.456 ± 0.046
1.483MetSer: 1.483 ± 0.045
1.322MetThr: 1.322 ± 0.049
2.173MetVal: 2.173 ± 0.062
0.248MetTrp: 0.248 ± 0.022
0.557MetTyr: 0.557 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.297AsnAla: 2.297 ± 0.064
0.405AsnCys: 0.405 ± 0.027
1.322AsnAsp: 1.322 ± 0.049
1.91AsnGlu: 1.91 ± 0.059
1.274AsnPhe: 1.274 ± 0.043
2.338AsnGly: 2.338 ± 0.068
0.567AsnHis: 0.567 ± 0.029
2.628AsnIle: 2.628 ± 0.067
2.015AsnLys: 2.015 ± 0.069
3.828AsnLeu: 3.828 ± 0.074
1.1AsnMet: 1.1 ± 0.043
1.033AsnAsn: 1.033 ± 0.044
2.054AsnPro: 2.054 ± 0.06
0.812AsnGln: 0.812 ± 0.04
1.582AsnArg: 1.582 ± 0.051
1.59AsnSer: 1.59 ± 0.054
1.332AsnThr: 1.332 ± 0.045
2.554AsnVal: 2.554 ± 0.065
0.402AsnTrp: 0.402 ± 0.026
0.996AsnTyr: 0.996 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
2.666ProAla: 2.666 ± 0.073
0.524ProCys: 0.524 ± 0.031
2.238ProAsp: 2.238 ± 0.06
3.887ProGlu: 3.887 ± 0.088
2.066ProPhe: 2.066 ± 0.068
3.503ProGly: 3.503 ± 0.072
0.988ProHis: 0.988 ± 0.043
2.653ProIle: 2.653 ± 0.073
2.889ProLys: 2.889 ± 0.084
4.401ProLeu: 4.401 ± 0.091
1.018ProMet: 1.018 ± 0.04
1.354ProAsn: 1.354 ± 0.049
1.773ProPro: 1.773 ± 0.063
1.383ProGln: 1.383 ± 0.051
1.846ProArg: 1.846 ± 0.059
2.899ProSer: 2.899 ± 0.07
1.989ProThr: 1.989 ± 0.051
3.537ProVal: 3.537 ± 0.085
0.654ProTrp: 0.654 ± 0.036
1.455ProTyr: 1.455 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.0GlnAla: 2.0 ± 0.064
0.268GlnCys: 0.268 ± 0.024
1.249GlnAsp: 1.249 ± 0.048
2.357GlnGlu: 2.357 ± 0.06
0.783GlnPhe: 0.783 ± 0.037
1.928GlnGly: 1.928 ± 0.049
0.382GlnHis: 0.382 ± 0.025
1.796GlnIle: 1.796 ± 0.054
2.146GlnLys: 2.146 ± 0.069
2.226GlnLeu: 2.226 ± 0.063
0.815GlnMet: 0.815 ± 0.041
0.934GlnAsn: 0.934 ± 0.037
0.77GlnPro: 0.77 ± 0.037
0.778GlnGln: 0.778 ± 0.038
1.594GlnArg: 1.594 ± 0.054
1.23GlnSer: 1.23 ± 0.046
1.06GlnThr: 1.06 ± 0.047
2.045GlnVal: 2.045 ± 0.056
0.375GlnTrp: 0.375 ± 0.025
0.636GlnTyr: 0.636 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.85ArgAla: 3.85 ± 0.078
0.685ArgCys: 0.685 ± 0.035
2.462ArgAsp: 2.462 ± 0.068
4.283ArgGlu: 4.283 ± 0.084
2.181ArgPhe: 2.181 ± 0.063
3.92ArgGly: 3.92 ± 0.08
0.986ArgHis: 0.986 ± 0.04
3.634ArgIle: 3.634 ± 0.085
4.039ArgLys: 4.039 ± 0.089
5.554ArgLeu: 5.554 ± 0.109
1.548ArgMet: 1.548 ± 0.053
1.942ArgAsn: 1.942 ± 0.055
2.05ArgPro: 2.05 ± 0.057
1.463ArgGln: 1.463 ± 0.052
3.113ArgArg: 3.113 ± 0.087
2.872ArgSer: 2.872 ± 0.074
2.377ArgThr: 2.377 ± 0.065
3.711ArgVal: 3.711 ± 0.086
0.72ArgTrp: 0.72 ± 0.037
1.748ArgTyr: 1.748 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.114SerAla: 4.114 ± 0.092
0.869SerCys: 0.869 ± 0.039
2.656SerAsp: 2.656 ± 0.071
3.756SerGlu: 3.756 ± 0.088
2.995SerPhe: 2.995 ± 0.074
5.077SerGly: 5.077 ± 0.102
1.091SerHis: 1.091 ± 0.051
4.081SerIle: 4.081 ± 0.088
3.639SerLys: 3.639 ± 0.071
6.615SerLeu: 6.615 ± 0.118
1.746SerMet: 1.746 ± 0.057
1.821SerAsn: 1.821 ± 0.067
2.76SerPro: 2.76 ± 0.065
1.687SerGln: 1.687 ± 0.057
3.298SerArg: 3.298 ± 0.077
4.161SerSer: 4.161 ± 0.105
2.531SerThr: 2.531 ± 0.069
4.396SerVal: 4.396 ± 0.107
0.911SerTrp: 0.911 ± 0.036
1.813SerTyr: 1.813 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.458ThrAla: 3.458 ± 0.079
0.546ThrCys: 0.546 ± 0.032
1.806ThrAsp: 1.806 ± 0.058
2.708ThrGlu: 2.708 ± 0.071
2.027ThrPhe: 2.027 ± 0.064
4.017ThrGly: 4.017 ± 0.08
0.817ThrHis: 0.817 ± 0.037
3.088ThrIle: 3.088 ± 0.068
2.543ThrLys: 2.543 ± 0.067
5.053ThrLeu: 5.053 ± 0.096
1.038ThrMet: 1.038 ± 0.042
1.396ThrAsn: 1.396 ± 0.051
2.516ThrPro: 2.516 ± 0.059
1.128ThrGln: 1.128 ± 0.044
1.953ThrArg: 1.953 ± 0.052
2.804ThrSer: 2.804 ± 0.066
2.228ThrThr: 2.228 ± 0.074
3.485ThrVal: 3.485 ± 0.083
0.514ThrTrp: 0.514 ± 0.031
1.316ThrTyr: 1.316 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
6.654ValAla: 6.654 ± 0.127
0.961ValCys: 0.961 ± 0.049
4.106ValAsp: 4.106 ± 0.079
5.805ValGlu: 5.805 ± 0.108
3.329ValPhe: 3.329 ± 0.08
5.731ValGly: 5.731 ± 0.124
1.289ValHis: 1.289 ± 0.049
5.43ValIle: 5.43 ± 0.107
4.846ValLys: 4.846 ± 0.095
8.311ValLeu: 8.311 ± 0.123
1.925ValMet: 1.925 ± 0.053
2.28ValAsn: 2.28 ± 0.058
3.8ValPro: 3.8 ± 0.083
1.759ValGln: 1.759 ± 0.063
3.708ValArg: 3.708 ± 0.081
5.137ValSer: 5.137 ± 0.1
3.751ValThr: 3.751 ± 0.082
7.124ValVal: 7.124 ± 0.13
0.81ValTrp: 0.81 ± 0.036
1.979ValTyr: 1.979 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.914TrpAla: 0.914 ± 0.04
0.144TrpCys: 0.144 ± 0.017
0.671TrpAsp: 0.671 ± 0.033
1.091TrpGlu: 1.091 ± 0.047
0.47TrpPhe: 0.47 ± 0.028
1.204TrpGly: 1.204 ± 0.051
0.231TrpHis: 0.231 ± 0.02
0.793TrpIle: 0.793 ± 0.038
0.805TrpLys: 0.805 ± 0.036
1.193TrpLeu: 1.193 ± 0.058
0.306TrpMet: 0.306 ± 0.025
0.495TrpAsn: 0.495 ± 0.027
0.44TrpPro: 0.44 ± 0.03
0.395TrpGln: 0.395 ± 0.025
0.685TrpArg: 0.685 ± 0.034
0.721TrpSer: 0.721 ± 0.039
0.432TrpThr: 0.432 ± 0.028
0.894TrpVal: 0.894 ± 0.037
0.189TrpTrp: 0.189 ± 0.019
0.318TrpTyr: 0.318 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.064TyrAla: 2.064 ± 0.067
0.382TyrCys: 0.382 ± 0.025
1.491TyrAsp: 1.491 ± 0.055
1.98TyrGlu: 1.98 ± 0.06
1.301TyrPhe: 1.301 ± 0.049
2.422TyrGly: 2.422 ± 0.071
0.554TyrHis: 0.554 ± 0.029
1.789TyrIle: 1.789 ± 0.053
1.681TyrLys: 1.681 ± 0.058
2.877TyrLeu: 2.877 ± 0.08
0.721TyrMet: 0.721 ± 0.032
0.884TyrAsn: 0.884 ± 0.041
1.436TyrPro: 1.436 ± 0.052
0.815TyrGln: 0.815 ± 0.034
1.677TyrArg: 1.677 ± 0.053
1.696TyrSer: 1.696 ± 0.054
1.19TyrThr: 1.19 ± 0.045
2.056TyrVal: 2.056 ± 0.059
0.373TyrTrp: 0.373 ± 0.023
0.956TyrTyr: 0.956 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1853 proteins (597420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski