Amino acid dipepetide frequency for Nocardioides dokdonensis FR1436

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.586AlaAla: 19.586 ± 0.202	1.035AlaCys: 1.035 ± 0.029	8.284AlaAsp: 8.284 ± 0.072	8.076AlaGlu: 8.076 ± 0.089	3.352AlaPhe: 3.352 ± 0.06	12.751AlaGly: 12.751 ± 0.128	2.731AlaHis: 2.731 ± 0.046	3.781AlaIle: 3.781 ± 0.062	2.202AlaLys: 2.202 ± 0.053	14.135AlaLeu: 14.135 ± 0.145	2.775AlaMet: 2.775 ± 0.053	1.721AlaAsn: 1.721 ± 0.039	6.682AlaPro: 6.682 ± 0.09	3.742AlaGln: 3.742 ± 0.061	10.011AlaArg: 10.011 ± 0.103	6.27AlaSer: 6.27 ± 0.061	7.591AlaThr: 7.591 ± 0.088	11.799AlaVal: 11.799 ± 0.129	2.029AlaTrp: 2.029 ± 0.038	2.538AlaTyr: 2.538 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.886CysAla: 0.886 ± 0.024	0.08CysCys: 0.08 ± 0.008	0.51CysAsp: 0.51 ± 0.021	0.413CysGlu: 0.413 ± 0.019	0.223CysPhe: 0.223 ± 0.012	0.819CysGly: 0.819 ± 0.026	0.193CysHis: 0.193 ± 0.011	0.176CysIle: 0.176 ± 0.01	0.103CysLys: 0.103 ± 0.009	0.662CysLeu: 0.662 ± 0.024	0.122CysMet: 0.122 ± 0.01	0.132CysAsn: 0.132 ± 0.009	0.435CysPro: 0.435 ± 0.017	0.174CysGln: 0.174 ± 0.011	0.572CysArg: 0.572 ± 0.022	0.437CysSer: 0.437 ± 0.02	0.494CysThr: 0.494 ± 0.022	0.606CysVal: 0.606 ± 0.02	0.109CysTrp: 0.109 ± 0.009	0.145CysTyr: 0.145 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.05AspAla: 8.05 ± 0.083	0.373AspCys: 0.373 ± 0.017	4.682AspAsp: 4.682 ± 0.071	4.551AspGlu: 4.551 ± 0.068	1.635AspPhe: 1.635 ± 0.036	6.291AspGly: 6.291 ± 0.096	1.582AspHis: 1.582 ± 0.036	1.726AspIle: 1.726 ± 0.037	1.013AspLys: 1.013 ± 0.031	7.944AspLeu: 7.944 ± 0.086	0.889AspMet: 0.889 ± 0.029	0.876AspAsn: 0.876 ± 0.027	5.0AspPro: 5.0 ± 0.061	1.973AspGln: 1.973 ± 0.04	4.866AspArg: 4.866 ± 0.066	2.581AspSer: 2.581 ± 0.049	3.009AspThr: 3.009 ± 0.053	6.18AspVal: 6.18 ± 0.071	0.952AspTrp: 0.952 ± 0.028	1.141AspTyr: 1.141 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.39GluAla: 7.39 ± 0.097	0.341GluCys: 0.341 ± 0.015	3.315GluAsp: 3.315 ± 0.053	3.454GluGlu: 3.454 ± 0.056	1.244GluPhe: 1.244 ± 0.037	4.58GluGly: 4.58 ± 0.066	1.896GluHis: 1.896 ± 0.039	2.281GluIle: 2.281 ± 0.048	1.264GluLys: 1.264 ± 0.035	6.226GluLeu: 6.226 ± 0.077	1.061GluMet: 1.061 ± 0.029	0.863GluAsn: 0.863 ± 0.029	3.447GluPro: 3.447 ± 0.063	2.688GluGln: 2.688 ± 0.047	5.402GluArg: 5.402 ± 0.066	2.73GluSer: 2.73 ± 0.047	3.059GluThr: 3.059 ± 0.059	6.033GluVal: 6.033 ± 0.072	0.805GluTrp: 0.805 ± 0.025	0.924GluTyr: 0.924 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.405PheAla: 3.405 ± 0.059	0.264PheCys: 0.264 ± 0.014	2.021PheAsp: 2.021 ± 0.04	1.589PheGlu: 1.589 ± 0.037	0.88PhePhe: 0.88 ± 0.028	2.835PheGly: 2.835 ± 0.053	0.587PheHis: 0.587 ± 0.022	0.734PheIle: 0.734 ± 0.028	0.426PheLys: 0.426 ± 0.02	2.472PheLeu: 2.472 ± 0.044	0.429PheMet: 0.429 ± 0.018	0.547PheAsn: 0.547 ± 0.021	1.254PhePro: 1.254 ± 0.032	0.603PheGln: 0.603 ± 0.022	1.621PheArg: 1.621 ± 0.032	1.517PheSer: 1.517 ± 0.039	1.761PheThr: 1.761 ± 0.043	2.529PheVal: 2.529 ± 0.041	0.4PheTrp: 0.4 ± 0.02	0.579PheTyr: 0.579 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.241GlyAla: 11.241 ± 0.099	0.823GlyCys: 0.823 ± 0.028	5.442GlyAsp: 5.442 ± 0.078	5.247GlyGlu: 5.247 ± 0.063	2.893GlyPhe: 2.893 ± 0.05	8.402GlyGly: 8.402 ± 0.127	2.145GlyHis: 2.145 ± 0.04	3.255GlyIle: 3.255 ± 0.053	1.89GlyLys: 1.89 ± 0.043	9.921GlyLeu: 9.921 ± 0.098	1.982GlyMet: 1.982 ± 0.041	1.463GlyAsn: 1.463 ± 0.045	5.022GlyPro: 5.022 ± 0.066	2.61GlyGln: 2.61 ± 0.047	7.657GlyArg: 7.657 ± 0.085	5.703GlySer: 5.703 ± 0.071	5.899GlyThr: 5.899 ± 0.079	8.251GlyVal: 8.251 ± 0.089	1.813GlyTrp: 1.813 ± 0.042	2.083GlyTyr: 2.083 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.666HisAla: 2.666 ± 0.045	0.202HisCys: 0.202 ± 0.012	1.714HisAsp: 1.714 ± 0.041	1.469HisGlu: 1.469 ± 0.034	0.52HisPhe: 0.52 ± 0.021	2.325HisGly: 2.325 ± 0.047	0.729HisHis: 0.729 ± 0.025	0.464HisIle: 0.464 ± 0.018	0.275HisLys: 0.275 ± 0.016	2.576HisLeu: 2.576 ± 0.041	0.288HisMet: 0.288 ± 0.017	0.331HisAsn: 0.331 ± 0.017	1.75HisPro: 1.75 ± 0.039	0.715HisGln: 0.715 ± 0.021	2.021HisArg: 2.021 ± 0.041	0.879HisSer: 0.879 ± 0.027	1.129HisThr: 1.129 ± 0.028	2.056HisVal: 2.056 ± 0.043	0.322HisTrp: 0.322 ± 0.016	0.426HisTyr: 0.426 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.304IleAla: 4.304 ± 0.056	0.269IleCys: 0.269 ± 0.014	2.432IleAsp: 2.432 ± 0.044	2.278IleGlu: 2.278 ± 0.046	0.734IlePhe: 0.734 ± 0.025	3.468IleGly: 3.468 ± 0.052	0.556IleHis: 0.556 ± 0.018	0.929IleIle: 0.929 ± 0.029	0.615IleLys: 0.615 ± 0.026	2.265IleLeu: 2.265 ± 0.039	0.426IleMet: 0.426 ± 0.018	0.664IleAsn: 0.664 ± 0.023	1.535IlePro: 1.535 ± 0.035	0.689IleGln: 0.689 ± 0.022	1.871IleArg: 1.871 ± 0.043	1.795IleSer: 1.795 ± 0.033	2.022IleThr: 2.022 ± 0.04	2.705IleVal: 2.705 ± 0.046	0.363IleTrp: 0.363 ± 0.017	0.545IleTyr: 0.545 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.3LysAla: 2.3 ± 0.058	0.079LysCys: 0.079 ± 0.008	1.007LysAsp: 1.007 ± 0.03	0.837LysGlu: 0.837 ± 0.028	0.408LysPhe: 0.408 ± 0.016	1.42LysGly: 1.42 ± 0.04	0.396LysHis: 0.396 ± 0.018	0.749LysIle: 0.749 ± 0.024	0.709LysLys: 0.709 ± 0.034	1.418LysLeu: 1.418 ± 0.035	0.364LysMet: 0.364 ± 0.019	0.409LysAsn: 0.409 ± 0.02	1.029LysPro: 1.029 ± 0.028	0.674LysGln: 0.674 ± 0.027	1.289LysArg: 1.289 ± 0.033	0.944LysSer: 0.944 ± 0.031	1.049LysThr: 1.049 ± 0.033	1.771LysVal: 1.771 ± 0.038	0.188LysTrp: 0.188 ± 0.011	0.357LysTyr: 0.357 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.432LeuAla: 15.432 ± 0.158	0.696LeuCys: 0.696 ± 0.022	7.479LeuAsp: 7.479 ± 0.087	5.949LeuGlu: 5.949 ± 0.068	2.364LeuPhe: 2.364 ± 0.046	10.314LeuGly: 10.314 ± 0.105	2.224LeuHis: 2.224 ± 0.043	2.581LeuIle: 2.581 ± 0.055	1.535LeuLys: 1.535 ± 0.037	11.555LeuLeu: 11.555 ± 0.145	1.699LeuMet: 1.699 ± 0.034	1.45LeuAsn: 1.45 ± 0.042	5.902LeuPro: 5.902 ± 0.068	2.428LeuGln: 2.428 ± 0.043	8.019LeuArg: 8.019 ± 0.086	5.477LeuSer: 5.477 ± 0.069	6.214LeuThr: 6.214 ± 0.071	11.509LeuVal: 11.509 ± 0.12	1.199LeuTrp: 1.199 ± 0.032	1.467LeuTyr: 1.467 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.261MetAla: 2.261 ± 0.037	0.135MetCys: 0.135 ± 0.01	0.922MetAsp: 0.922 ± 0.029	0.771MetGlu: 0.771 ± 0.024	0.482MetPhe: 0.482 ± 0.019	1.443MetGly: 1.443 ± 0.035	0.388MetHis: 0.388 ± 0.015	0.684MetIle: 0.684 ± 0.023	0.405MetLys: 0.405 ± 0.019	1.916MetLeu: 1.916 ± 0.042	0.372MetMet: 0.372 ± 0.019	0.372MetAsn: 0.372 ± 0.016	1.107MetPro: 1.107 ± 0.029	0.482MetGln: 0.482 ± 0.018	1.471MetArg: 1.471 ± 0.035	1.64MetSer: 1.64 ± 0.033	1.662MetThr: 1.662 ± 0.03	1.602MetVal: 1.602 ± 0.035	0.201MetTrp: 0.201 ± 0.012	0.254MetTyr: 0.254 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	1.969AsnAla: 1.969 ± 0.038	0.124AsnCys: 0.124 ± 0.011	0.972AsnAsp: 0.972 ± 0.032	0.802AsnGlu: 0.802 ± 0.023	0.434AsnPhe: 0.434 ± 0.019	1.457AsnGly: 1.457 ± 0.034	0.35AsnHis: 0.35 ± 0.018	0.601AsnIle: 0.601 ± 0.021	0.354AsnLys: 0.354 ± 0.019	1.671AsnLeu: 1.671 ± 0.037	0.246AsnMet: 0.246 ± 0.014	0.384AsnAsn: 0.384 ± 0.018	1.235AsnPro: 1.235 ± 0.037	0.483AsnGln: 0.483 ± 0.018	1.045AsnArg: 1.045 ± 0.031	0.664AsnSer: 0.664 ± 0.028	0.869AsnThr: 0.869 ± 0.03	1.347AsnVal: 1.347 ± 0.03	0.2AsnTrp: 0.2 ± 0.013	0.33AsnTyr: 0.33 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.551ProAla: 7.551 ± 0.09	0.296ProCys: 0.296 ± 0.014	4.684ProAsp: 4.684 ± 0.069	4.118ProGlu: 4.118 ± 0.06	1.454ProPhe: 1.454 ± 0.036	6.295ProGly: 6.295 ± 0.075	1.271ProHis: 1.271 ± 0.03	1.422ProIle: 1.422 ± 0.032	0.831ProLys: 0.831 ± 0.028	4.991ProLeu: 4.991 ± 0.072	1.07ProMet: 1.07 ± 0.028	0.704ProAsn: 0.704 ± 0.025	2.923ProPro: 2.923 ± 0.054	1.532ProGln: 1.532 ± 0.038	3.941ProArg: 3.941 ± 0.065	3.016ProSer: 3.016 ± 0.051	3.63ProThr: 3.63 ± 0.062	5.526ProVal: 5.526 ± 0.071	0.912ProTrp: 0.912 ± 0.024	1.074ProTyr: 1.074 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.626GlnAla: 3.626 ± 0.058	0.164GlnCys: 0.164 ± 0.012	1.467GlnAsp: 1.467 ± 0.033	1.465GlnGlu: 1.465 ± 0.036	0.707GlnPhe: 0.707 ± 0.023	2.29GlnGly: 2.29 ± 0.043	0.76GlnHis: 0.76 ± 0.025	0.973GlnIle: 0.973 ± 0.031	0.51GlnLys: 0.51 ± 0.022	2.925GlnLeu: 2.925 ± 0.043	0.605GlnMet: 0.605 ± 0.023	0.421GlnAsn: 0.421 ± 0.021	1.576GlnPro: 1.576 ± 0.039	1.247GlnGln: 1.247 ± 0.031	2.593GlnArg: 2.593 ± 0.046	1.226GlnSer: 1.226 ± 0.031	1.366GlnThr: 1.366 ± 0.033	3.275GlnVal: 3.275 ± 0.053	0.429GlnTrp: 0.429 ± 0.02	0.479GlnTyr: 0.479 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.399ArgAla: 9.399 ± 0.097	0.538ArgCys: 0.538 ± 0.021	4.628ArgAsp: 4.628 ± 0.061	4.618ArgGlu: 4.618 ± 0.071	2.187ArgPhe: 2.187 ± 0.042	5.949ArgGly: 5.949 ± 0.076	1.887ArgHis: 1.887 ± 0.041	2.76ArgIle: 2.76 ± 0.044	1.277ArgLys: 1.277 ± 0.033	8.675ArgLeu: 8.675 ± 0.099	1.824ArgMet: 1.824 ± 0.033	1.16ArgAsn: 1.16 ± 0.03	4.461ArgPro: 4.461 ± 0.064	2.015ArgGln: 2.015 ± 0.039	7.773ArgArg: 7.773 ± 0.105	4.446ArgSer: 4.446 ± 0.065	5.09ArgThr: 5.09 ± 0.068	6.645ArgVal: 6.645 ± 0.078	1.416ArgTrp: 1.416 ± 0.033	1.528ArgTyr: 1.528 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.504SerAla: 6.504 ± 0.067	0.365SerCys: 0.365 ± 0.017	3.118SerAsp: 3.118 ± 0.049	2.65SerGlu: 2.65 ± 0.047	1.737SerPhe: 1.737 ± 0.035	5.72SerGly: 5.72 ± 0.069	1.077SerHis: 1.077 ± 0.028	1.692SerIle: 1.692 ± 0.034	0.887SerLys: 0.887 ± 0.033	5.168SerLeu: 5.168 ± 0.067	1.336SerMet: 1.336 ± 0.034	0.868SerAsn: 0.868 ± 0.024	3.062SerPro: 3.062 ± 0.049	1.363SerGln: 1.363 ± 0.034	3.753SerArg: 3.753 ± 0.054	3.257SerSer: 3.257 ± 0.053	3.632SerThr: 3.632 ± 0.062	4.531SerVal: 4.531 ± 0.063	0.926SerTrp: 0.926 ± 0.027	1.276SerTyr: 1.276 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	7.353ThrAla: 7.353 ± 0.083	0.5ThrCys: 0.5 ± 0.02	3.776ThrAsp: 3.776 ± 0.06	2.988ThrGlu: 2.988 ± 0.044	1.771ThrPhe: 1.771 ± 0.041	6.413ThrGly: 6.413 ± 0.081	1.223ThrHis: 1.223 ± 0.029	2.007ThrIle: 2.007 ± 0.04	1.0ThrLys: 1.0 ± 0.028	5.827ThrLeu: 5.827 ± 0.071	1.096ThrMet: 1.096 ± 0.028	0.961ThrAsn: 0.961 ± 0.027	3.841ThrPro: 3.841 ± 0.063	1.443ThrGln: 1.443 ± 0.034	4.236ThrArg: 4.236 ± 0.049	3.711ThrSer: 3.711 ± 0.057	4.29ThrThr: 4.29 ± 0.071	5.423ThrVal: 5.423 ± 0.067	1.09ThrTrp: 1.09 ± 0.032	1.403ThrTyr: 1.403 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	12.93ValAla: 12.93 ± 0.134	0.687ValCys: 0.687 ± 0.023	6.433ValAsp: 6.433 ± 0.073	5.949ValGlu: 5.949 ± 0.071	2.343ValPhe: 2.343 ± 0.046	8.062ValGly: 8.062 ± 0.102	2.178ValHis: 2.178 ± 0.037	2.72ValIle: 2.72 ± 0.048	1.526ValLys: 1.526 ± 0.036	11.332ValLeu: 11.332 ± 0.129	1.454ValMet: 1.454 ± 0.037	1.582ValAsn: 1.582 ± 0.036	5.292ValPro: 5.292 ± 0.07	2.24ValGln: 2.24 ± 0.044	7.297ValArg: 7.297 ± 0.081	4.648ValSer: 4.648 ± 0.063	5.622ValThr: 5.622 ± 0.063	11.104ValVal: 11.104 ± 0.13	1.169ValTrp: 1.169 ± 0.034	1.424ValTyr: 1.424 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.677TrpAla: 1.677 ± 0.036	0.15TrpCys: 0.15 ± 0.01	0.845TrpAsp: 0.845 ± 0.027	0.728TrpGlu: 0.728 ± 0.022	0.516TrpPhe: 0.516 ± 0.023	1.136TrpGly: 1.136 ± 0.03	0.368TrpHis: 0.368 ± 0.018	0.5TrpIle: 0.5 ± 0.018	0.265TrpLys: 0.265 ± 0.016	1.739TrpLeu: 1.739 ± 0.038	0.313TrpMet: 0.313 ± 0.014	0.313TrpAsn: 0.313 ± 0.016	0.737TrpPro: 0.737 ± 0.024	0.517TrpGln: 0.517 ± 0.021	1.351TrpArg: 1.351 ± 0.038	1.075TrpSer: 1.075 ± 0.024	0.968TrpThr: 0.968 ± 0.027	1.327TrpVal: 1.327 ± 0.033	0.413TrpTrp: 0.413 ± 0.022	0.292TrpTyr: 0.292 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.561TyrAla: 2.561 ± 0.046	0.168TyrCys: 0.168 ± 0.01	1.585TyrAsp: 1.585 ± 0.037	1.051TyrGlu: 1.051 ± 0.027	0.571TyrPhe: 0.571 ± 0.023	1.771TyrGly: 1.771 ± 0.04	0.316TyrHis: 0.316 ± 0.018	0.432TyrIle: 0.432 ± 0.018	0.31TyrLys: 0.31 ± 0.015	2.075TyrLeu: 2.075 ± 0.041	0.216TyrMet: 0.216 ± 0.014	0.316TyrAsn: 0.316 ± 0.017	0.95TyrPro: 0.95 ± 0.03	0.485TyrGln: 0.485 ± 0.02	1.487TyrArg: 1.487 ± 0.032	0.905TyrSer: 0.905 ± 0.027	0.997TyrThr: 0.997 ± 0.03	1.772TyrVal: 1.772 ± 0.037	0.292TyrTrp: 0.292 ± 0.015	0.406TyrTyr: 0.406 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4089 proteins (1337234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---