Amino acid dipepetide frequency for Middle East respiratory syndrome-related coronavirus (MERS-CoV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.072AlaAla: 6.072 ± 0.676
2.512AlaCys: 2.512 ± 0.476
3.21AlaAsp: 3.21 ± 0.651
1.326AlaGlu: 1.326 ± 0.234
5.025AlaPhe: 5.025 ± 0.612
4.397AlaGly: 4.397 ± 0.498
0.837AlaHis: 0.837 ± 0.321
4.397AlaIle: 4.397 ± 0.401
3.28AlaLys: 3.28 ± 0.656
5.513AlaLeu: 5.513 ± 0.61
2.443AlaMet: 2.443 ± 0.483
5.025AlaAsn: 5.025 ± 0.888
3.001AlaPro: 3.001 ± 1.029
2.652AlaGln: 2.652 ± 0.697
2.861AlaArg: 2.861 ± 0.648
5.164AlaSer: 5.164 ± 0.463
4.118AlaThr: 4.118 ± 0.463
5.304AlaVal: 5.304 ± 0.908
0.977AlaTrp: 0.977 ± 0.16
4.536AlaTyr: 4.536 ± 1.252
0.0AlaXaa: 0.0 ± 0.0
Cys
1.605CysAla: 1.605 ± 0.23
0.977CysCys: 0.977 ± 0.273
1.535CysAsp: 1.535 ± 0.338
0.907CysGlu: 0.907 ± 0.21
1.396CysPhe: 1.396 ± 0.404
2.582CysGly: 2.582 ± 0.601
0.489CysHis: 0.489 ± 0.184
1.745CysIle: 1.745 ± 0.336
1.675CysLys: 1.675 ± 0.423
2.163CysLeu: 2.163 ± 0.863
0.768CysMet: 0.768 ± 0.511
2.094CysAsn: 2.094 ± 0.502
0.907CysPro: 0.907 ± 0.216
0.698CysGln: 0.698 ± 0.272
1.117CysArg: 1.117 ± 0.339
2.163CysSer: 2.163 ± 0.631
2.303CysThr: 2.303 ± 0.334
2.443CysVal: 2.443 ± 0.558
0.209CysTrp: 0.209 ± 0.135
2.233CysTyr: 2.233 ± 0.718
0.0CysXaa: 0.0 ± 0.0
Asp
3.28AspAla: 3.28 ± 0.46
1.256AspCys: 1.256 ± 0.495
2.094AspAsp: 2.094 ± 0.268
2.024AspGlu: 2.024 ± 0.327
3.28AspPhe: 3.28 ± 0.479
4.187AspGly: 4.187 ± 0.509
0.628AspHis: 0.628 ± 0.133
3.21AspIle: 3.21 ± 0.816
2.722AspLys: 2.722 ± 0.648
5.095AspLeu: 5.095 ± 0.514
0.698AspMet: 0.698 ± 0.332
2.722AspAsn: 2.722 ± 0.91
2.373AspPro: 2.373 ± 0.374
1.256AspGln: 1.256 ± 0.249
1.466AspArg: 1.466 ± 0.739
4.606AspSer: 4.606 ± 0.715
2.861AspThr: 2.861 ± 0.391
6.072AspVal: 6.072 ± 1.006
0.977AspTrp: 0.977 ± 0.231
2.163AspTyr: 2.163 ± 0.462
0.0AspXaa: 0.0 ± 0.0
Glu
3.629GluAla: 3.629 ± 0.724
1.396GluCys: 1.396 ± 0.21
2.582GluAsp: 2.582 ± 0.297
1.745GluGlu: 1.745 ± 0.587
2.303GluPhe: 2.303 ± 0.533
1.815GluGly: 1.815 ± 0.343
0.977GluHis: 0.977 ± 0.373
1.186GluIle: 1.186 ± 0.242
1.745GluLys: 1.745 ± 0.445
2.931GluLeu: 2.931 ± 0.465
0.349GluMet: 0.349 ± 0.218
1.466GluAsn: 1.466 ± 0.47
1.675GluPro: 1.675 ± 0.36
1.745GluGln: 1.745 ± 0.331
1.675GluArg: 1.675 ± 0.562
3.21GluSer: 3.21 ± 0.578
2.512GluThr: 2.512 ± 0.727
3.21GluVal: 3.21 ± 0.788
0.907GluTrp: 0.907 ± 0.248
1.745GluTyr: 1.745 ± 0.469
0.0GluXaa: 0.0 ± 0.0
Phe
3.908PheAla: 3.908 ± 0.403
1.396PheCys: 1.396 ± 0.272
2.861PheAsp: 2.861 ± 0.573
2.024PheGlu: 2.024 ± 0.555
1.535PhePhe: 1.535 ± 0.42
2.582PheGly: 2.582 ± 0.837
0.489PheHis: 0.489 ± 0.378
2.722PheIle: 2.722 ± 0.622
2.233PheLys: 2.233 ± 0.409
3.559PheLeu: 3.559 ± 0.82
1.954PheMet: 1.954 ± 0.21
3.28PheAsn: 3.28 ± 0.575
1.675PhePro: 1.675 ± 0.41
1.256PheGln: 1.256 ± 0.415
1.675PheArg: 1.675 ± 0.315
3.769PheSer: 3.769 ± 1.583
3.908PheThr: 3.908 ± 0.759
6.281PheVal: 6.281 ± 0.739
0.558PheTrp: 0.558 ± 0.236
2.792PheTyr: 2.792 ± 0.256
0.0PheXaa: 0.0 ± 0.0
Gly
3.838GlyAla: 3.838 ± 0.643
2.233GlyCys: 2.233 ± 0.362
3.629GlyAsp: 3.629 ± 0.464
1.675GlyGlu: 1.675 ± 0.512
2.652GlyPhe: 2.652 ± 0.703
4.257GlyGly: 4.257 ± 0.464
1.605GlyHis: 1.605 ± 0.297
3.35GlyIle: 3.35 ± 0.41
2.652GlyLys: 2.652 ± 0.551
4.536GlyLeu: 4.536 ± 0.467
0.977GlyMet: 0.977 ± 0.45
3.001GlyAsn: 3.001 ± 1.187
2.233GlyPro: 2.233 ± 0.513
1.535GlyGln: 1.535 ± 0.179
1.256GlyArg: 1.256 ± 0.663
5.234GlySer: 5.234 ± 0.467
4.885GlyThr: 4.885 ± 0.911
6.141GlyVal: 6.141 ± 0.895
0.279GlyTrp: 0.279 ± 0.243
2.303GlyTyr: 2.303 ± 0.75
0.0GlyXaa: 0.0 ± 0.0
His
1.466HisAla: 1.466 ± 0.314
0.349HisCys: 0.349 ± 0.327
0.558HisAsp: 0.558 ± 0.221
0.768HisGlu: 0.768 ± 0.215
0.698HisPhe: 0.698 ± 0.369
0.907HisGly: 0.907 ± 0.668
0.349HisHis: 0.349 ± 0.304
1.326HisIle: 1.326 ± 0.419
1.117HisLys: 1.117 ± 0.21
1.954HisLeu: 1.954 ± 0.353
0.349HisMet: 0.349 ± 0.194
0.628HisAsn: 0.628 ± 0.257
0.768HisPro: 0.768 ± 0.235
0.628HisGln: 0.628 ± 0.187
1.047HisArg: 1.047 ± 0.371
2.373HisSer: 2.373 ± 0.873
1.745HisThr: 1.745 ± 0.258
1.954HisVal: 1.954 ± 0.377
0.279HisTrp: 0.279 ± 0.111
1.396HisTyr: 1.396 ± 0.396
0.0HisXaa: 0.0 ± 0.0
Ile
4.118IleAla: 4.118 ± 0.56
0.907IleCys: 0.907 ± 0.245
2.094IleAsp: 2.094 ± 0.465
2.163IleGlu: 2.163 ± 0.511
2.931IlePhe: 2.931 ± 0.706
2.443IleGly: 2.443 ± 0.398
0.558IleHis: 0.558 ± 0.42
2.512IleIle: 2.512 ± 1.053
2.443IleLys: 2.443 ± 0.314
4.257IleLeu: 4.257 ± 0.561
0.837IleMet: 0.837 ± 0.314
2.233IleAsn: 2.233 ± 0.377
3.28IlePro: 3.28 ± 1.085
1.396IleGln: 1.396 ± 0.696
1.884IleArg: 1.884 ± 1.331
3.559IleSer: 3.559 ± 0.518
4.187IleThr: 4.187 ± 0.63
4.536IleVal: 4.536 ± 0.935
0.419IleTrp: 0.419 ± 0.168
1.256IleTyr: 1.256 ± 0.246
0.0IleXaa: 0.0 ± 0.0
Lys
3.489LysAla: 3.489 ± 0.435
1.675LysCys: 1.675 ± 0.379
3.28LysAsp: 3.28 ± 0.69
3.28LysGlu: 3.28 ± 0.607
2.652LysPhe: 2.652 ± 0.763
3.071LysGly: 3.071 ± 1.148
2.163LysHis: 2.163 ± 0.818
1.466LysIle: 1.466 ± 0.332
2.443LysLys: 2.443 ± 0.639
6.49LysLeu: 6.49 ± 0.693
1.675LysMet: 1.675 ± 0.481
1.605LysAsn: 1.605 ± 0.42
2.931LysPro: 2.931 ± 0.901
2.652LysGln: 2.652 ± 0.383
1.675LysArg: 1.675 ± 0.298
2.443LysSer: 2.443 ± 0.485
2.163LysThr: 2.163 ± 0.322
3.978LysVal: 3.978 ± 0.595
0.628LysTrp: 0.628 ± 0.129
2.792LysTyr: 2.792 ± 0.676
0.0LysXaa: 0.0 ± 0.0
Leu
7.258LeuAla: 7.258 ± 0.838
3.14LeuCys: 3.14 ± 0.665
4.048LeuAsp: 4.048 ± 0.521
2.861LeuGlu: 2.861 ± 0.706
4.676LeuPhe: 4.676 ± 0.863
3.978LeuGly: 3.978 ± 0.848
2.652LeuHis: 2.652 ± 1.307
3.489LeuIle: 3.489 ± 1.138
5.444LeuLys: 5.444 ± 1.156
10.887LeuLeu: 10.887 ± 2.257
1.815LeuMet: 1.815 ± 0.328
4.815LeuAsn: 4.815 ± 0.67
3.21LeuPro: 3.21 ± 0.654
4.118LeuGln: 4.118 ± 0.575
5.304LeuArg: 5.304 ± 1.033
7.258LeuSer: 7.258 ± 1.085
6.769LeuThr: 6.769 ± 0.809
6.56LeuVal: 6.56 ± 1.477
1.466LeuTrp: 1.466 ± 0.416
4.885LeuTyr: 4.885 ± 0.867
0.0LeuXaa: 0.0 ± 0.0
Met
1.605MetAla: 1.605 ± 0.658
1.186MetCys: 1.186 ± 0.472
1.326MetAsp: 1.326 ± 0.296
0.837MetGlu: 0.837 ± 0.26
1.326MetPhe: 1.326 ± 0.188
0.837MetGly: 0.837 ± 0.299
0.768MetHis: 0.768 ± 0.149
1.047MetIle: 1.047 ± 0.174
0.349MetLys: 0.349 ± 0.101
2.931MetLeu: 2.931 ± 0.476
0.279MetMet: 0.279 ± 0.159
0.489MetAsn: 0.489 ± 0.218
0.768MetPro: 0.768 ± 0.263
1.186MetGln: 1.186 ± 0.29
0.837MetArg: 0.837 ± 0.545
1.326MetSer: 1.326 ± 0.348
2.163MetThr: 2.163 ± 0.466
1.815MetVal: 1.815 ± 0.603
0.279MetTrp: 0.279 ± 0.207
1.117MetTyr: 1.117 ± 0.256
0.0MetXaa: 0.0 ± 0.0
Asn
3.978AsnAla: 3.978 ± 0.595
2.094AsnCys: 2.094 ± 0.609
2.024AsnAsp: 2.024 ± 0.369
1.884AsnGlu: 1.884 ± 0.353
2.861AsnPhe: 2.861 ± 0.632
3.629AsnGly: 3.629 ± 0.371
0.558AsnHis: 0.558 ± 0.591
2.233AsnIle: 2.233 ± 0.311
3.629AsnLys: 3.629 ± 0.605
4.118AsnLeu: 4.118 ± 0.623
1.605AsnMet: 1.605 ± 0.44
2.443AsnAsn: 2.443 ± 0.498
1.675AsnPro: 1.675 ± 0.631
1.466AsnGln: 1.466 ± 0.338
1.466AsnArg: 1.466 ± 0.294
4.466AsnSer: 4.466 ± 0.593
2.722AsnThr: 2.722 ± 0.77
3.978AsnVal: 3.978 ± 0.803
0.698AsnTrp: 0.698 ± 0.247
2.443AsnTyr: 2.443 ± 0.494
0.0AsnXaa: 0.0 ± 0.0
Pro
2.931ProAla: 2.931 ± 0.935
0.907ProCys: 0.907 ± 0.163
2.373ProAsp: 2.373 ± 0.417
1.675ProGlu: 1.675 ± 0.295
1.675ProPhe: 1.675 ± 0.369
2.443ProGly: 2.443 ± 0.729
0.907ProHis: 0.907 ± 0.424
2.931ProIle: 2.931 ± 0.442
2.163ProLys: 2.163 ± 1.075
5.095ProLeu: 5.095 ± 1.76
0.489ProMet: 0.489 ± 0.163
1.605ProAsn: 1.605 ± 0.625
1.884ProPro: 1.884 ± 0.808
1.466ProGln: 1.466 ± 0.327
1.396ProArg: 1.396 ± 0.609
2.861ProSer: 2.861 ± 0.728
3.559ProThr: 3.559 ± 0.712
3.629ProVal: 3.629 ± 0.942
0.349ProTrp: 0.349 ± 0.101
1.815ProTyr: 1.815 ± 0.42
0.0ProXaa: 0.0 ± 0.0
Gln
2.024GlnAla: 2.024 ± 0.267
0.698GlnCys: 0.698 ± 0.237
2.094GlnAsp: 2.094 ± 0.542
1.815GlnGlu: 1.815 ± 0.373
0.837GlnPhe: 0.837 ± 0.528
2.931GlnGly: 2.931 ± 0.669
0.628GlnHis: 0.628 ± 0.191
2.094GlnIle: 2.094 ± 0.341
1.815GlnLys: 1.815 ± 0.263
4.048GlnLeu: 4.048 ± 0.712
0.698GlnMet: 0.698 ± 0.182
1.466GlnAsn: 1.466 ± 0.451
1.815GlnPro: 1.815 ± 0.427
1.605GlnGln: 1.605 ± 0.554
0.558GlnArg: 0.558 ± 0.844
2.443GlnSer: 2.443 ± 0.607
2.443GlnThr: 2.443 ± 0.55
3.001GlnVal: 3.001 ± 0.636
0.279GlnTrp: 0.279 ± 0.118
1.605GlnTyr: 1.605 ± 0.455
0.0GlnXaa: 0.0 ± 0.0
Arg
3.559ArgAla: 3.559 ± 0.584
0.698ArgCys: 0.698 ± 0.653
2.094ArgAsp: 2.094 ± 0.33
0.907ArgGlu: 0.907 ± 0.211
1.815ArgPhe: 1.815 ± 0.824
1.884ArgGly: 1.884 ± 0.565
1.186ArgHis: 1.186 ± 0.338
1.884ArgIle: 1.884 ± 0.753
2.443ArgLys: 2.443 ± 0.404
3.489ArgLeu: 3.489 ± 0.585
0.907ArgMet: 0.907 ± 0.276
2.233ArgAsn: 2.233 ± 0.57
1.466ArgPro: 1.466 ± 0.386
1.466ArgGln: 1.466 ± 0.3
1.605ArgArg: 1.605 ± 0.275
3.071ArgSer: 3.071 ± 1.555
2.233ArgThr: 2.233 ± 0.595
2.443ArgVal: 2.443 ± 0.632
0.14ArgTrp: 0.14 ± 0.366
0.907ArgTyr: 0.907 ± 0.299
0.0ArgXaa: 0.0 ± 0.0
Ser
5.164SerAla: 5.164 ± 0.57
1.745SerCys: 1.745 ± 0.592
5.164SerAsp: 5.164 ± 1.188
3.21SerGlu: 3.21 ± 0.496
4.118SerPhe: 4.118 ± 0.787
5.234SerGly: 5.234 ± 0.691
1.605SerHis: 1.605 ± 0.662
3.001SerIle: 3.001 ± 1.366
3.28SerLys: 3.28 ± 0.314
7.467SerLeu: 7.467 ± 1.415
2.024SerMet: 2.024 ± 0.383
2.861SerAsn: 2.861 ± 0.406
2.233SerPro: 2.233 ± 0.861
2.373SerGln: 2.373 ± 0.844
2.443SerArg: 2.443 ± 1.365
6.072SerSer: 6.072 ± 1.27
6.072SerThr: 6.072 ± 1.949
9.003SerVal: 9.003 ± 0.925
1.396SerTrp: 1.396 ± 0.397
2.582SerTyr: 2.582 ± 0.775
0.0SerXaa: 0.0 ± 0.0
Thr
5.025ThrAla: 5.025 ± 0.743
1.815ThrCys: 1.815 ± 0.323
2.652ThrAsp: 2.652 ± 0.678
2.722ThrGlu: 2.722 ± 0.358
3.489ThrPhe: 3.489 ± 0.498
4.536ThrGly: 4.536 ± 0.872
1.396ThrHis: 1.396 ± 0.226
3.14ThrIle: 3.14 ± 0.508
2.861ThrLys: 2.861 ± 0.485
6.7ThrLeu: 6.7 ± 0.941
2.024ThrMet: 2.024 ± 0.364
3.908ThrAsn: 3.908 ± 0.626
3.978ThrPro: 3.978 ± 0.558
2.373ThrGln: 2.373 ± 0.486
2.373ThrArg: 2.373 ± 0.75
4.815ThrSer: 4.815 ± 0.584
4.955ThrThr: 4.955 ± 0.888
6.141ThrVal: 6.141 ± 0.686
0.349ThrTrp: 0.349 ± 0.101
4.118ThrTyr: 4.118 ± 0.729
0.0ThrXaa: 0.0 ± 0.0
Val
5.723ValAla: 5.723 ± 0.812
3.001ValCys: 3.001 ± 0.563
6.002ValAsp: 6.002 ± 1.012
5.025ValGlu: 5.025 ± 1.254
3.14ValPhe: 3.14 ± 0.446
4.048ValGly: 4.048 ± 0.567
1.326ValHis: 1.326 ± 0.561
3.978ValIle: 3.978 ± 0.703
6.56ValLys: 6.56 ± 1.297
7.956ValLeu: 7.956 ± 1.225
1.326ValMet: 1.326 ± 0.382
4.815ValAsn: 4.815 ± 0.767
3.699ValPro: 3.699 ± 1.399
3.838ValGln: 3.838 ± 0.9
3.699ValArg: 3.699 ± 0.56
7.956ValSer: 7.956 ± 1.115
5.513ValThr: 5.513 ± 0.749
8.375ValVal: 8.375 ± 2.09
0.768ValTrp: 0.768 ± 0.141
3.42ValTyr: 3.42 ± 0.398
0.0ValXaa: 0.0 ± 0.0
Trp
0.977TrpAla: 0.977 ± 0.271
0.558TrpCys: 0.558 ± 0.209
0.489TrpAsp: 0.489 ± 0.246
0.349TrpGlu: 0.349 ± 0.107
0.768TrpPhe: 0.768 ± 0.248
0.14TrpGly: 0.14 ± 0.09
0.349TrpHis: 0.349 ± 0.13
0.279TrpIle: 0.279 ± 0.126
0.489TrpLys: 0.489 ± 0.184
2.163TrpLeu: 2.163 ± 0.425
0.279TrpMet: 0.279 ± 0.111
0.907TrpAsn: 0.907 ± 0.258
0.558TrpPro: 0.558 ± 0.337
0.07TrpGln: 0.07 ± 0.186
0.419TrpArg: 0.419 ± 0.157
0.837TrpSer: 0.837 ± 0.24
0.279TrpThr: 0.279 ± 0.144
0.698TrpVal: 0.698 ± 0.292
0.14TrpTrp: 0.14 ± 0.138
0.628TrpTyr: 0.628 ± 0.374
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.001TyrAla: 3.001 ± 1.015
1.466TyrCys: 1.466 ± 0.266
2.931TyrAsp: 2.931 ± 0.611
1.605TyrGlu: 1.605 ± 0.361
3.28TyrPhe: 3.28 ± 0.243
2.373TyrGly: 2.373 ± 0.479
1.186TyrHis: 1.186 ± 0.249
2.024TyrIle: 2.024 ± 1.457
3.21TyrLys: 3.21 ± 0.747
3.28TyrLeu: 3.28 ± 0.809
0.907TyrMet: 0.907 ± 0.236
2.373TyrAsn: 2.373 ± 0.406
2.024TyrPro: 2.024 ± 0.541
1.117TyrGln: 1.117 ± 0.383
1.675TyrArg: 1.675 ± 0.226
3.42TyrSer: 3.42 ± 0.979
3.978TyrThr: 3.978 ± 0.545
4.606TyrVal: 4.606 ± 0.366
0.279TyrTrp: 0.279 ± 0.154
2.373TyrTyr: 2.373 ± 0.498
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (14330 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski