Amino acid dipepetide frequency for Wenzhou picorna-like virus 42

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.512AlaAla: 3.512 ± 0.788
0.878AlaCys: 0.878 ± 0.149
0.878AlaAsp: 0.878 ± 0.149
3.512AlaGlu: 3.512 ± 0.788
3.951AlaPhe: 3.951 ± 0.326
3.073AlaGly: 3.073 ± 0.869
1.317AlaHis: 1.317 ± 0.122
3.073AlaIle: 3.073 ± 0.176
1.756AlaLys: 1.756 ± 0.992
8.341AlaLeu: 8.341 ± 1.006
1.317AlaMet: 1.317 ± 0.122
2.634AlaAsn: 2.634 ± 0.938
7.463AlaPro: 7.463 ± 2.309
0.439AlaGln: 0.439 ± 0.272
2.634AlaArg: 2.634 ± 0.448
4.39AlaSer: 4.39 ± 0.054
3.073AlaThr: 3.073 ± 1.562
4.39AlaVal: 4.39 ± 0.054
2.195AlaTrp: 2.195 ± 0.666
1.317AlaTyr: 1.317 ± 0.571
0.0AlaXaa: 0.0 ± 0.0
Cys
0.878CysAla: 0.878 ± 0.544
0.0CysCys: 0.0 ± 0.0
1.317CysAsp: 1.317 ± 0.571
0.439CysGlu: 0.439 ± 0.421
0.439CysPhe: 0.439 ± 0.272
2.195CysGly: 2.195 ± 0.666
0.439CysHis: 0.439 ± 0.272
0.878CysIle: 0.878 ± 0.842
0.878CysLys: 0.878 ± 0.842
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.439CysAsn: 0.439 ± 0.272
0.439CysPro: 0.439 ± 0.421
0.439CysGln: 0.439 ± 0.272
0.439CysArg: 0.439 ± 0.272
0.439CysSer: 0.439 ± 0.421
0.439CysThr: 0.439 ± 0.421
2.195CysVal: 2.195 ± 0.666
0.0CysTrp: 0.0 ± 0.0
0.878CysTyr: 0.878 ± 0.149
0.0CysXaa: 0.0 ± 0.0
Asp
4.39AspAla: 4.39 ± 0.747
0.439AspCys: 0.439 ± 0.272
4.39AspAsp: 4.39 ± 1.332
2.195AspGlu: 2.195 ± 0.027
3.073AspPhe: 3.073 ± 1.21
3.951AspGly: 3.951 ± 0.326
0.878AspHis: 0.878 ± 0.149
3.951AspIle: 3.951 ± 1.753
3.951AspLys: 3.951 ± 1.06
7.463AspLeu: 7.463 ± 1.156
0.878AspMet: 0.878 ± 0.149
2.634AspAsn: 2.634 ± 1.141
1.317AspPro: 1.317 ± 0.571
0.439AspGln: 0.439 ± 0.421
1.317AspArg: 1.317 ± 0.815
3.512AspSer: 3.512 ± 0.597
7.024AspThr: 7.024 ± 1.577
3.951AspVal: 3.951 ± 1.753
0.439AspTrp: 0.439 ± 0.421
3.073AspTyr: 3.073 ± 0.176
0.0AspXaa: 0.0 ± 0.0
Glu
3.512GluAla: 3.512 ± 0.788
0.439GluCys: 0.439 ± 0.421
3.073GluAsp: 3.073 ± 1.903
1.756GluGlu: 1.756 ± 0.394
2.634GluPhe: 2.634 ± 1.141
3.073GluGly: 3.073 ± 0.176
0.0GluHis: 0.0 ± 0.0
3.073GluIle: 3.073 ± 0.176
1.756GluLys: 1.756 ± 0.394
5.707GluLeu: 5.707 ± 2.84
0.0GluMet: 0.0 ± 0.0
3.073GluAsn: 3.073 ± 1.903
1.317GluPro: 1.317 ± 0.815
0.878GluGln: 0.878 ± 0.149
1.756GluArg: 1.756 ± 1.087
3.512GluSer: 3.512 ± 0.096
2.195GluThr: 2.195 ± 0.666
5.268GluVal: 5.268 ± 0.896
2.195GluTrp: 2.195 ± 0.027
0.878GluTyr: 0.878 ± 0.149
0.0GluXaa: 0.0 ± 0.0
Phe
1.756PheAla: 1.756 ± 0.299
0.439PheCys: 0.439 ± 0.272
0.878PheAsp: 0.878 ± 0.544
3.512PheGlu: 3.512 ± 0.096
0.878PhePhe: 0.878 ± 0.149
1.756PheGly: 1.756 ± 0.992
0.878PheHis: 0.878 ± 0.149
1.756PheIle: 1.756 ± 0.394
5.268PheLys: 5.268 ± 1.183
3.951PheLeu: 3.951 ± 0.326
1.317PheMet: 1.317 ± 0.122
1.756PheAsn: 1.756 ± 0.992
2.634PhePro: 2.634 ± 0.448
1.756PheGln: 1.756 ± 0.992
3.073PheArg: 3.073 ± 1.21
3.073PheSer: 3.073 ± 0.176
3.951PheThr: 3.951 ± 1.712
2.195PheVal: 2.195 ± 1.413
0.878PheTrp: 0.878 ± 0.544
2.634PheTyr: 2.634 ± 0.448
0.0PheXaa: 0.0 ± 0.0
Gly
1.756GlyAla: 1.756 ± 0.299
1.317GlyCys: 1.317 ± 0.815
4.829GlyAsp: 4.829 ± 0.475
1.317GlyGlu: 1.317 ± 0.122
1.317GlyPhe: 1.317 ± 0.571
3.951GlyGly: 3.951 ± 1.712
0.878GlyHis: 0.878 ± 0.544
2.634GlyIle: 2.634 ± 0.245
2.634GlyLys: 2.634 ± 0.448
5.707GlyLeu: 5.707 ± 0.069
2.195GlyMet: 2.195 ± 0.72
2.195GlyAsn: 2.195 ± 1.359
1.756GlyPro: 1.756 ± 0.394
0.878GlyGln: 0.878 ± 0.544
0.878GlyArg: 0.878 ± 0.149
5.268GlySer: 5.268 ± 1.589
5.707GlyThr: 5.707 ± 2.703
6.585GlyVal: 6.585 ± 0.774
0.439GlyTrp: 0.439 ± 0.272
2.634GlyTyr: 2.634 ± 0.448
0.0GlyXaa: 0.0 ± 0.0
His
0.439HisAla: 0.439 ± 0.272
0.439HisCys: 0.439 ± 0.421
0.439HisAsp: 0.439 ± 0.272
0.0HisGlu: 0.0 ± 0.0
1.317HisPhe: 1.317 ± 0.122
1.317HisGly: 1.317 ± 0.571
0.878HisHis: 0.878 ± 0.544
1.317HisIle: 1.317 ± 0.571
0.878HisLys: 0.878 ± 0.149
2.195HisLeu: 2.195 ± 0.72
0.878HisMet: 0.878 ± 0.145
0.0HisAsn: 0.0 ± 0.0
0.439HisPro: 0.439 ± 0.272
1.317HisGln: 1.317 ± 1.263
0.878HisArg: 0.878 ± 0.544
3.951HisSer: 3.951 ± 0.326
1.317HisThr: 1.317 ± 0.571
3.512HisVal: 3.512 ± 1.481
0.439HisTrp: 0.439 ± 0.421
2.195HisTyr: 2.195 ± 0.666
0.0HisXaa: 0.0 ± 0.0
Ile
4.829IleAla: 4.829 ± 0.911
2.634IleCys: 2.634 ± 0.448
4.829IleAsp: 4.829 ± 0.475
3.073IleGlu: 3.073 ± 0.517
1.317IlePhe: 1.317 ± 0.571
1.756IleGly: 1.756 ± 0.299
1.317IleHis: 1.317 ± 0.122
3.951IleIle: 3.951 ± 1.06
2.634IleLys: 2.634 ± 1.631
3.951IleLeu: 3.951 ± 1.753
1.317IleMet: 1.317 ± 0.122
3.951IleAsn: 3.951 ± 1.019
1.756IlePro: 1.756 ± 0.394
3.512IleGln: 3.512 ± 1.983
4.39IleArg: 4.39 ± 0.747
4.39IleSer: 4.39 ± 0.054
5.268IleThr: 5.268 ± 0.49
3.073IleVal: 3.073 ± 1.21
0.0IleTrp: 0.0 ± 0.0
1.317IleTyr: 1.317 ± 0.122
0.0IleXaa: 0.0 ± 0.0
Lys
3.512LysAla: 3.512 ± 0.788
0.878LysCys: 0.878 ± 0.544
5.268LysAsp: 5.268 ± 2.569
2.634LysGlu: 2.634 ± 1.631
2.634LysPhe: 2.634 ± 0.245
3.073LysGly: 3.073 ± 1.21
1.756LysHis: 1.756 ± 0.394
3.512LysIle: 3.512 ± 0.096
6.146LysLys: 6.146 ± 1.033
4.829LysLeu: 4.829 ± 0.911
0.878LysMet: 0.878 ± 0.544
3.951LysAsn: 3.951 ± 1.06
2.195LysPro: 2.195 ± 1.413
2.195LysGln: 2.195 ± 0.666
1.756LysArg: 1.756 ± 1.087
2.195LysSer: 2.195 ± 0.72
3.951LysThr: 3.951 ± 3.097
4.829LysVal: 4.829 ± 0.218
0.439LysTrp: 0.439 ± 0.272
2.195LysTyr: 2.195 ± 0.666
0.0LysXaa: 0.0 ± 0.0
Leu
7.463LeuAla: 7.463 ± 1.156
0.878LeuCys: 0.878 ± 0.149
7.902LeuAsp: 7.902 ± 0.042
6.146LeuGlu: 6.146 ± 0.34
4.829LeuPhe: 4.829 ± 0.218
4.39LeuGly: 4.39 ± 1.332
2.195LeuHis: 2.195 ± 0.72
6.146LeuIle: 6.146 ± 2.419
6.585LeuLys: 6.585 ± 1.998
9.219LeuLeu: 9.219 ± 2.243
2.195LeuMet: 2.195 ± 1.359
6.146LeuAsn: 6.146 ± 0.34
3.073LeuPro: 3.073 ± 1.562
3.512LeuGln: 3.512 ± 0.096
1.756LeuArg: 1.756 ± 1.087
6.146LeuSer: 6.146 ± 0.34
3.512LeuThr: 3.512 ± 0.788
4.39LeuVal: 4.39 ± 0.639
0.439LeuTrp: 0.439 ± 0.272
4.829LeuTyr: 4.829 ± 0.475
0.0LeuXaa: 0.0 ± 0.0
Met
0.878MetAla: 0.878 ± 0.149
0.878MetCys: 0.878 ± 0.149
1.756MetAsp: 1.756 ± 0.299
1.317MetGlu: 1.317 ± 0.815
1.317MetPhe: 1.317 ± 0.122
0.878MetGly: 0.878 ± 0.149
1.756MetHis: 1.756 ± 0.299
0.878MetIle: 0.878 ± 0.149
0.439MetLys: 0.439 ± 0.272
3.073MetLeu: 3.073 ± 1.21
0.0MetMet: 0.0 ± 0.0
0.439MetAsn: 0.439 ± 0.421
0.878MetPro: 0.878 ± 0.149
0.439MetGln: 0.439 ± 0.421
1.317MetArg: 1.317 ± 0.815
2.195MetSer: 2.195 ± 0.027
1.317MetThr: 1.317 ± 1.263
1.756MetVal: 1.756 ± 1.087
0.878MetTrp: 0.878 ± 0.149
0.439MetTyr: 0.439 ± 0.421
0.0MetXaa: 0.0 ± 0.0
Asn
2.195AsnAla: 2.195 ± 0.027
1.317AsnCys: 1.317 ± 0.571
3.073AsnAsp: 3.073 ± 1.21
0.439AsnGlu: 0.439 ± 0.272
3.073AsnPhe: 3.073 ± 0.517
3.512AsnGly: 3.512 ± 0.788
0.439AsnHis: 0.439 ± 0.272
7.024AsnIle: 7.024 ± 0.884
3.073AsnLys: 3.073 ± 0.176
2.634AsnLeu: 2.634 ± 0.938
0.439AsnMet: 0.439 ± 0.272
4.39AsnAsn: 4.39 ± 1.332
4.829AsnPro: 4.829 ± 1.168
0.439AsnGln: 0.439 ± 0.421
1.756AsnArg: 1.756 ± 1.087
3.512AsnSer: 3.512 ± 0.597
4.829AsnThr: 4.829 ± 0.911
4.829AsnVal: 4.829 ± 0.475
0.0AsnTrp: 0.0 ± 0.0
2.195AsnTyr: 2.195 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
0.439ProAla: 0.439 ± 0.272
0.0ProCys: 0.0 ± 0.0
1.317ProAsp: 1.317 ± 0.122
2.634ProGlu: 2.634 ± 0.938
3.073ProPhe: 3.073 ± 2.255
1.756ProGly: 1.756 ± 0.299
1.756ProHis: 1.756 ± 0.299
3.073ProIle: 3.073 ± 0.869
3.512ProLys: 3.512 ± 1.29
4.829ProLeu: 4.829 ± 1.168
2.195ProMet: 2.195 ± 0.535
0.878ProAsn: 0.878 ± 0.149
3.951ProPro: 3.951 ± 2.405
2.195ProGln: 2.195 ± 0.027
2.195ProArg: 2.195 ± 0.027
3.951ProSer: 3.951 ± 1.019
3.951ProThr: 3.951 ± 2.405
5.268ProVal: 5.268 ± 0.896
0.0ProTrp: 0.0 ± 0.0
3.073ProTyr: 3.073 ± 0.869
0.0ProXaa: 0.0 ± 0.0
Gln
3.073GlnAla: 3.073 ± 2.255
0.0GlnCys: 0.0 ± 0.0
1.317GlnAsp: 1.317 ± 0.815
1.317GlnGlu: 1.317 ± 0.571
0.439GlnPhe: 0.439 ± 0.421
2.195GlnGly: 2.195 ± 0.027
1.317GlnHis: 1.317 ± 0.571
0.878GlnIle: 0.878 ± 0.149
0.0GlnLys: 0.0 ± 0.0
2.195GlnLeu: 2.195 ± 0.666
0.439GlnMet: 0.439 ± 0.421
1.756GlnAsn: 1.756 ± 0.299
2.634GlnPro: 2.634 ± 1.141
0.439GlnGln: 0.439 ± 0.272
0.0GlnArg: 0.0 ± 0.0
2.634GlnSer: 2.634 ± 1.141
2.195GlnThr: 2.195 ± 0.027
2.195GlnVal: 2.195 ± 0.027
0.878GlnTrp: 0.878 ± 0.544
1.317GlnTyr: 1.317 ± 0.815
0.0GlnXaa: 0.0 ± 0.0
Arg
3.073ArgAla: 3.073 ± 0.176
0.0ArgCys: 0.0 ± 0.0
2.634ArgAsp: 2.634 ± 0.245
2.195ArgGlu: 2.195 ± 0.666
1.756ArgPhe: 1.756 ± 0.394
2.195ArgGly: 2.195 ± 0.72
0.878ArgHis: 0.878 ± 0.544
2.195ArgIle: 2.195 ± 0.72
0.878ArgLys: 0.878 ± 0.544
3.073ArgLeu: 3.073 ± 0.517
2.634ArgMet: 2.634 ± 0.448
2.634ArgAsn: 2.634 ± 0.938
3.073ArgPro: 3.073 ± 0.517
1.317ArgGln: 1.317 ± 0.122
4.39ArgArg: 4.39 ± 2.025
1.317ArgSer: 1.317 ± 0.815
2.634ArgThr: 2.634 ± 0.448
3.951ArgVal: 3.951 ± 1.753
0.439ArgTrp: 0.439 ± 0.272
2.195ArgTyr: 2.195 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
5.268SerAla: 5.268 ± 2.282
0.878SerCys: 0.878 ± 0.842
5.268SerAsp: 5.268 ± 0.896
4.39SerGlu: 4.39 ± 0.639
3.073SerPhe: 3.073 ± 0.869
7.024SerGly: 7.024 ± 0.502
2.195SerHis: 2.195 ± 0.666
3.512SerIle: 3.512 ± 0.597
3.512SerLys: 3.512 ± 0.788
5.707SerLeu: 5.707 ± 0.762
2.634SerMet: 2.634 ± 0.448
3.073SerAsn: 3.073 ± 0.176
4.39SerPro: 4.39 ± 1.44
1.756SerGln: 1.756 ± 0.299
2.634SerArg: 2.634 ± 1.141
5.268SerSer: 5.268 ± 1.589
5.268SerThr: 5.268 ± 0.203
6.146SerVal: 6.146 ± 0.353
1.317SerTrp: 1.317 ± 0.815
1.756SerTyr: 1.756 ± 0.299
0.0SerXaa: 0.0 ± 0.0
Thr
4.39ThrAla: 4.39 ± 0.747
1.317ThrCys: 1.317 ± 0.815
3.951ThrAsp: 3.951 ± 1.019
1.756ThrGlu: 1.756 ± 0.394
3.951ThrPhe: 3.951 ± 1.019
3.951ThrGly: 3.951 ± 3.097
2.195ThrHis: 2.195 ± 0.72
4.39ThrIle: 4.39 ± 0.639
6.146ThrLys: 6.146 ± 1.033
5.268ThrLeu: 5.268 ± 0.896
1.756ThrMet: 1.756 ± 0.299
5.707ThrAsn: 5.707 ± 2.01
3.073ThrPro: 3.073 ± 0.869
1.756ThrGln: 1.756 ± 0.394
3.073ThrArg: 3.073 ± 1.562
6.146ThrSer: 6.146 ± 1.738
9.219ThrThr: 9.219 ± 5.38
3.951ThrVal: 3.951 ± 0.367
0.878ThrTrp: 0.878 ± 0.149
3.073ThrTyr: 3.073 ± 0.869
0.0ThrXaa: 0.0 ± 0.0
Val
6.585ValAla: 6.585 ± 0.774
0.439ValCys: 0.439 ± 0.421
3.951ValAsp: 3.951 ± 1.753
3.951ValGlu: 3.951 ± 0.326
3.073ValPhe: 3.073 ± 1.21
3.512ValGly: 3.512 ± 0.096
1.756ValHis: 1.756 ± 0.992
3.951ValIle: 3.951 ± 1.019
6.585ValLys: 6.585 ± 2.691
8.341ValLeu: 8.341 ± 2.392
0.439ValMet: 0.439 ± 0.272
5.268ValAsn: 5.268 ± 1.876
2.195ValPro: 2.195 ± 1.413
2.195ValGln: 2.195 ± 0.72
4.39ValArg: 4.39 ± 0.639
7.463ValSer: 7.463 ± 1.156
5.707ValThr: 5.707 ± 0.069
9.219ValVal: 9.219 ± 2.936
1.317ValTrp: 1.317 ± 0.122
3.073ValTyr: 3.073 ± 2.255
0.0ValXaa: 0.0 ± 0.0
Trp
0.878TrpAla: 0.878 ± 0.149
0.0TrpCys: 0.0 ± 0.0
1.317TrpAsp: 1.317 ± 0.122
0.439TrpGlu: 0.439 ± 0.272
0.439TrpPhe: 0.439 ± 0.272
0.439TrpGly: 0.439 ± 0.272
0.0TrpHis: 0.0 ± 0.0
0.878TrpIle: 0.878 ± 0.544
0.439TrpLys: 0.439 ± 0.421
1.756TrpLeu: 1.756 ± 0.299
0.439TrpMet: 0.439 ± 0.272
0.0TrpAsn: 0.0 ± 0.0
0.878TrpPro: 0.878 ± 0.149
0.0TrpGln: 0.0 ± 0.0
2.634TrpArg: 2.634 ± 0.938
0.439TrpSer: 0.439 ± 0.272
0.439TrpThr: 0.439 ± 0.421
0.878TrpVal: 0.878 ± 0.544
0.0TrpTrp: 0.0 ± 0.0
1.317TrpTyr: 1.317 ± 0.815
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.317TyrAla: 1.317 ± 0.571
0.0TyrCys: 0.0 ± 0.0
0.878TyrAsp: 0.878 ± 0.842
3.073TyrGlu: 3.073 ± 1.21
1.756TyrPhe: 1.756 ± 0.992
0.878TyrGly: 0.878 ± 0.149
1.756TyrHis: 1.756 ± 0.299
2.195TyrIle: 2.195 ± 0.027
1.756TyrLys: 1.756 ± 0.394
3.512TyrLeu: 3.512 ± 1.29
0.439TyrMet: 0.439 ± 0.272
3.073TyrAsn: 3.073 ± 1.21
1.756TyrPro: 1.756 ± 0.299
1.317TyrGln: 1.317 ± 0.122
2.195TyrArg: 2.195 ± 0.72
5.268TyrSer: 5.268 ± 0.896
3.951TyrThr: 3.951 ± 1.019
4.829TyrVal: 4.829 ± 0.475
0.439TyrTrp: 0.439 ± 0.272
2.195TyrTyr: 2.195 ± 0.666
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski