Amino acid dipepetide frequency for Formivibrio citricus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.821AlaAla: 13.821 ± 0.192	1.362AlaCys: 1.362 ± 0.043	5.617AlaAsp: 5.617 ± 0.073	7.571AlaGlu: 7.571 ± 0.119	3.681AlaPhe: 3.681 ± 0.065	9.076AlaGly: 9.076 ± 0.117	2.337AlaHis: 2.337 ± 0.056	5.884AlaIle: 5.884 ± 0.084	4.563AlaLys: 4.563 ± 0.088	12.685AlaLeu: 12.685 ± 0.135	2.942AlaMet: 2.942 ± 0.061	3.179AlaAsn: 3.179 ± 0.06	4.646AlaPro: 4.646 ± 0.08	4.841AlaGln: 4.841 ± 0.08	7.605AlaArg: 7.605 ± 0.107	5.894AlaSer: 5.894 ± 0.089	5.052AlaThr: 5.052 ± 0.081	7.469AlaVal: 7.469 ± 0.09	1.493AlaTrp: 1.493 ± 0.043	2.28AlaTyr: 2.28 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.12CysAla: 1.12 ± 0.037	0.171CysCys: 0.171 ± 0.014	0.566CysAsp: 0.566 ± 0.024	0.617CysGlu: 0.617 ± 0.025	0.372CysPhe: 0.372 ± 0.022	1.094CysGly: 1.094 ± 0.036	0.304CysHis: 0.304 ± 0.018	0.527CysIle: 0.527 ± 0.024	0.373CysLys: 0.373 ± 0.024	1.127CysLeu: 1.127 ± 0.038	0.246CysMet: 0.246 ± 0.016	0.356CysAsn: 0.356 ± 0.019	0.56CysPro: 0.56 ± 0.024	0.348CysGln: 0.348 ± 0.02	0.722CysArg: 0.722 ± 0.029	0.598CysSer: 0.598 ± 0.024	0.487CysThr: 0.487 ± 0.026	0.697CysVal: 0.697 ± 0.028	0.136CysTrp: 0.136 ± 0.011	0.265CysTyr: 0.265 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.567AspAla: 5.567 ± 0.086	0.554AspCys: 0.554 ± 0.027	2.531AspAsp: 2.531 ± 0.062	3.599AspGlu: 3.599 ± 0.068	2.324AspPhe: 2.324 ± 0.054	3.997AspGly: 3.997 ± 0.059	1.062AspHis: 1.062 ± 0.036	2.907AspIle: 2.907 ± 0.057	2.239AspLys: 2.239 ± 0.053	5.354AspLeu: 5.354 ± 0.088	1.286AspMet: 1.286 ± 0.033	1.476AspAsn: 1.476 ± 0.04	2.546AspPro: 2.546 ± 0.061	1.65AspGln: 1.65 ± 0.044	2.949AspArg: 2.949 ± 0.062	2.558AspSer: 2.558 ± 0.049	2.394AspThr: 2.394 ± 0.053	3.523AspVal: 3.523 ± 0.055	0.987AspTrp: 0.987 ± 0.033	1.708AspTyr: 1.708 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.039GluAla: 7.039 ± 0.095	0.578GluCys: 0.578 ± 0.028	2.598GluAsp: 2.598 ± 0.053	3.919GluGlu: 3.919 ± 0.089	2.14GluPhe: 2.14 ± 0.051	4.026GluGly: 4.026 ± 0.071	1.455GluHis: 1.455 ± 0.043	4.246GluIle: 4.246 ± 0.073	3.287GluLys: 3.287 ± 0.071	6.87GluLeu: 6.87 ± 0.111	1.662GluMet: 1.662 ± 0.041	2.087GluAsn: 2.087 ± 0.047	2.43GluPro: 2.43 ± 0.06	2.949GluGln: 2.949 ± 0.066	4.512GluArg: 4.512 ± 0.085	3.167GluSer: 3.167 ± 0.061	3.382GluThr: 3.382 ± 0.067	4.315GluVal: 4.315 ± 0.088	0.791GluTrp: 0.791 ± 0.033	1.507GluTyr: 1.507 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.188PheAla: 4.188 ± 0.079	0.505PheCys: 0.505 ± 0.025	2.358PheAsp: 2.358 ± 0.047	2.244PheGlu: 2.244 ± 0.052	1.645PhePhe: 1.645 ± 0.046	3.204PheGly: 3.204 ± 0.064	0.783PheHis: 0.783 ± 0.03	1.854PheIle: 1.854 ± 0.048	1.388PheLys: 1.388 ± 0.036	3.596PheLeu: 3.596 ± 0.078	0.876PheMet: 0.876 ± 0.037	1.333PheAsn: 1.333 ± 0.04	1.538PhePro: 1.538 ± 0.039	1.028PheGln: 1.028 ± 0.038	2.109PheArg: 2.109 ± 0.046	2.601PheSer: 2.601 ± 0.056	1.836PheThr: 1.836 ± 0.044	2.757PheVal: 2.757 ± 0.063	0.546PheTrp: 0.546 ± 0.029	0.981PheTyr: 0.981 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.92GlyAla: 6.92 ± 0.095	1.071GlyCys: 1.071 ± 0.033	3.641GlyAsp: 3.641 ± 0.055	5.085GlyGlu: 5.085 ± 0.08	3.253GlyPhe: 3.253 ± 0.066	5.7GlyGly: 5.7 ± 0.105	1.718GlyHis: 1.718 ± 0.046	4.723GlyIle: 4.723 ± 0.075	4.495GlyLys: 4.495 ± 0.061	8.183GlyLeu: 8.183 ± 0.109	2.402GlyMet: 2.402 ± 0.056	2.569GlyAsn: 2.569 ± 0.061	2.108GlyPro: 2.108 ± 0.06	3.069GlyGln: 3.069 ± 0.072	4.72GlyArg: 4.72 ± 0.074	4.074GlySer: 4.074 ± 0.075	3.493GlyThr: 3.493 ± 0.076	5.862GlyVal: 5.862 ± 0.086	1.211GlyTrp: 1.211 ± 0.033	2.259GlyTyr: 2.259 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.541HisAla: 2.541 ± 0.058	0.287HisCys: 0.287 ± 0.017	1.215HisAsp: 1.215 ± 0.038	1.388HisGlu: 1.388 ± 0.039	0.953HisPhe: 0.953 ± 0.031	1.946HisGly: 1.946 ± 0.053	0.655HisHis: 0.655 ± 0.028	1.105HisIle: 1.105 ± 0.033	0.78HisLys: 0.78 ± 0.029	2.321HisLeu: 2.321 ± 0.056	0.416HisMet: 0.416 ± 0.019	0.593HisAsn: 0.593 ± 0.026	1.459HisPro: 1.459 ± 0.045	0.74HisGln: 0.74 ± 0.026	1.312HisArg: 1.312 ± 0.039	1.115HisSer: 1.115 ± 0.033	0.965HisThr: 0.965 ± 0.036	1.481HisVal: 1.481 ± 0.036	0.325HisTrp: 0.325 ± 0.022	0.696HisTyr: 0.696 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.46IleAla: 6.46 ± 0.104	0.595IleCys: 0.595 ± 0.025	3.32IleAsp: 3.32 ± 0.071	3.894IleGlu: 3.894 ± 0.075	1.7IlePhe: 1.7 ± 0.045	4.813IleGly: 4.813 ± 0.083	1.129IleHis: 1.129 ± 0.035	2.302IleIle: 2.302 ± 0.055	2.189IleLys: 2.189 ± 0.056	4.881IleLeu: 4.881 ± 0.078	1.038IleMet: 1.038 ± 0.035	1.918IleAsn: 1.918 ± 0.042	2.544IlePro: 2.544 ± 0.058	1.715IleGln: 1.715 ± 0.044	3.401IleArg: 3.401 ± 0.062	3.149IleSer: 3.149 ± 0.072	2.713IleThr: 2.713 ± 0.063	4.045IleVal: 4.045 ± 0.065	0.517IleTrp: 0.517 ± 0.025	1.137IleTyr: 1.137 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.509LysAla: 4.509 ± 0.092	0.248LysCys: 0.248 ± 0.018	1.973LysAsp: 1.973 ± 0.051	2.431LysGlu: 2.431 ± 0.062	1.219LysPhe: 1.219 ± 0.03	2.941LysGly: 2.941 ± 0.055	0.907LysHis: 0.907 ± 0.031	2.479LysIle: 2.479 ± 0.062	2.328LysLys: 2.328 ± 0.058	4.884LysLeu: 4.884 ± 0.08	1.168LysMet: 1.168 ± 0.039	1.538LysAsn: 1.538 ± 0.052	2.489LysPro: 2.489 ± 0.054	1.885LysGln: 1.885 ± 0.044	2.62LysArg: 2.62 ± 0.049	2.317LysSer: 2.317 ± 0.055	2.625LysThr: 2.625 ± 0.061	2.921LysVal: 2.921 ± 0.058	0.456LysTrp: 0.456 ± 0.021	0.969LysTyr: 0.969 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	14.015LeuAla: 14.015 ± 0.152	1.087LeuCys: 1.087 ± 0.035	6.119LeuAsp: 6.119 ± 0.087	6.45LeuGlu: 6.45 ± 0.097	4.048LeuPhe: 4.048 ± 0.083	7.949LeuGly: 7.949 ± 0.103	2.332LeuHis: 2.332 ± 0.05	5.289LeuIle: 5.289 ± 0.081	4.755LeuLys: 4.755 ± 0.08	12.256LeuLeu: 12.256 ± 0.159	2.552LeuMet: 2.552 ± 0.051	3.426LeuAsn: 3.426 ± 0.066	6.236LeuPro: 6.236 ± 0.095	4.174LeuGln: 4.174 ± 0.071	6.913LeuArg: 6.913 ± 0.092	6.365LeuSer: 6.365 ± 0.093	5.41LeuThr: 5.41 ± 0.093	7.383LeuVal: 7.383 ± 0.111	1.206LeuTrp: 1.206 ± 0.042	2.339LeuTyr: 2.339 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.95MetAla: 2.95 ± 0.06	0.16MetCys: 0.16 ± 0.013	1.168MetAsp: 1.168 ± 0.033	1.31MetGlu: 1.31 ± 0.042	0.683MetPhe: 0.683 ± 0.027	1.788MetGly: 1.788 ± 0.052	0.537MetHis: 0.537 ± 0.024	1.248MetIle: 1.248 ± 0.033	1.224MetLys: 1.224 ± 0.038	2.846MetLeu: 2.846 ± 0.06	0.633MetMet: 0.633 ± 0.028	0.98MetAsn: 0.98 ± 0.032	1.436MetPro: 1.436 ± 0.039	1.237MetGln: 1.237 ± 0.034	1.637MetArg: 1.637 ± 0.041	1.517MetSer: 1.517 ± 0.042	1.493MetThr: 1.493 ± 0.039	1.667MetVal: 1.667 ± 0.042	0.158MetTrp: 0.158 ± 0.015	0.362MetTyr: 0.362 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.326AsnAla: 3.326 ± 0.057	0.338AsnCys: 0.338 ± 0.021	1.583AsnAsp: 1.583 ± 0.041	1.744AsnGlu: 1.744 ± 0.047	1.091AsnPhe: 1.091 ± 0.034	2.552AsnGly: 2.552 ± 0.07	0.66AsnHis: 0.66 ± 0.027	1.673AsnIle: 1.673 ± 0.042	1.282AsnLys: 1.282 ± 0.039	3.455AsnLeu: 3.455 ± 0.066	0.77AsnMet: 0.77 ± 0.029	1.04AsnAsn: 1.04 ± 0.047	2.062AsnPro: 2.062 ± 0.046	1.259AsnGln: 1.259 ± 0.042	2.195AsnArg: 2.195 ± 0.053	1.539AsnSer: 1.539 ± 0.047	1.563AsnThr: 1.563 ± 0.045	2.141AsnVal: 2.141 ± 0.056	0.459AsnTrp: 0.459 ± 0.024	0.806AsnTyr: 0.806 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.627ProAla: 5.627 ± 0.089	0.429ProCys: 0.429 ± 0.02	3.048ProAsp: 3.048 ± 0.068	3.752ProGlu: 3.752 ± 0.074	1.811ProPhe: 1.811 ± 0.048	3.781ProGly: 3.781 ± 0.064	1.086ProHis: 1.086 ± 0.041	1.931ProIle: 1.931 ± 0.043	1.777ProLys: 1.777 ± 0.042	4.976ProLeu: 4.976 ± 0.083	1.062ProMet: 1.062 ± 0.033	1.315ProAsn: 1.315 ± 0.039	2.136ProPro: 2.136 ± 0.059	2.16ProGln: 2.16 ± 0.05	2.397ProArg: 2.397 ± 0.051	2.303ProSer: 2.303 ± 0.05	1.925ProThr: 1.925 ± 0.048	4.177ProVal: 4.177 ± 0.071	0.623ProTrp: 0.623 ± 0.028	1.124ProTyr: 1.124 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.843GlnAla: 4.843 ± 0.078	0.337GlnCys: 0.337 ± 0.019	1.691GlnAsp: 1.691 ± 0.048	2.285GlnGlu: 2.285 ± 0.054	1.307GlnPhe: 1.307 ± 0.04	2.888GlnGly: 2.888 ± 0.054	0.984GlnHis: 0.984 ± 0.035	2.387GlnIle: 2.387 ± 0.054	1.797GlnLys: 1.797 ± 0.045	4.31GlnLeu: 4.31 ± 0.071	1.053GlnMet: 1.053 ± 0.036	1.134GlnAsn: 1.134 ± 0.039	1.97GlnPro: 1.97 ± 0.047	2.138GlnGln: 2.138 ± 0.064	2.698GlnArg: 2.698 ± 0.061	2.285GlnSer: 2.285 ± 0.046	2.177GlnThr: 2.177 ± 0.06	2.82GlnVal: 2.82 ± 0.054	0.509GlnTrp: 0.509 ± 0.019	0.952GlnTyr: 0.952 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.092ArgAla: 6.092 ± 0.092	0.576ArgCys: 0.576 ± 0.024	3.308ArgAsp: 3.308 ± 0.067	4.498ArgGlu: 4.498 ± 0.082	2.919ArgPhe: 2.919 ± 0.057	3.745ArgGly: 3.745 ± 0.064	1.708ArgHis: 1.708 ± 0.052	4.032ArgIle: 4.032 ± 0.067	2.681ArgLys: 2.681 ± 0.053	7.718ArgLeu: 7.718 ± 0.115	1.855ArgMet: 1.855 ± 0.041	2.197ArgAsn: 2.197 ± 0.049	2.648ArgPro: 2.648 ± 0.049	3.155ArgGln: 3.155 ± 0.065	4.256ArgArg: 4.256 ± 0.088	2.981ArgSer: 2.981 ± 0.071	2.734ArgThr: 2.734 ± 0.054	4.258ArgVal: 4.258 ± 0.077	0.928ArgTrp: 0.928 ± 0.032	1.97ArgTyr: 1.97 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.978SerAla: 5.978 ± 0.097	0.558SerCys: 0.558 ± 0.025	2.576SerAsp: 2.576 ± 0.047	3.031SerGlu: 3.031 ± 0.064	2.065SerPhe: 2.065 ± 0.051	5.055SerGly: 5.055 ± 0.082	1.286SerHis: 1.286 ± 0.035	2.868SerIle: 2.868 ± 0.055	2.006SerLys: 2.006 ± 0.056	6.123SerLeu: 6.123 ± 0.082	1.375SerMet: 1.375 ± 0.034	1.621SerAsn: 1.621 ± 0.043	2.613SerPro: 2.613 ± 0.054	2.148SerGln: 2.148 ± 0.051	3.713SerArg: 3.713 ± 0.074	3.123SerSer: 3.123 ± 0.075	2.627SerThr: 2.627 ± 0.063	3.696SerVal: 3.696 ± 0.075	0.675SerTrp: 0.675 ± 0.023	1.285SerTyr: 1.285 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.216ThrAla: 5.216 ± 0.09	0.494ThrCys: 0.494 ± 0.027	2.397ThrAsp: 2.397 ± 0.05	2.768ThrGlu: 2.768 ± 0.065	1.72ThrPhe: 1.72 ± 0.043	4.395ThrGly: 4.395 ± 0.073	1.06ThrHis: 1.06 ± 0.037	2.43ThrIle: 2.43 ± 0.062	1.445ThrLys: 1.445 ± 0.034	6.07ThrLeu: 6.07 ± 0.098	1.026ThrMet: 1.026 ± 0.04	1.363ThrAsn: 1.363 ± 0.042	3.097ThrPro: 3.097 ± 0.062	1.788ThrGln: 1.788 ± 0.048	3.017ThrArg: 3.017 ± 0.067	2.609ThrSer: 2.609 ± 0.061	2.427ThrThr: 2.427 ± 0.059	3.772ThrVal: 3.772 ± 0.062	0.554ThrTrp: 0.554 ± 0.026	1.01ThrTyr: 1.01 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.218ValAla: 8.218 ± 0.113	0.863ValCys: 0.863 ± 0.032	3.78ValAsp: 3.78 ± 0.06	4.589ValGlu: 4.589 ± 0.07	2.79ValPhe: 2.79 ± 0.064	4.897ValGly: 4.897 ± 0.075	1.365ValHis: 1.365 ± 0.035	3.836ValIle: 3.836 ± 0.061	2.891ValLys: 2.891 ± 0.06	7.813ValLeu: 7.813 ± 0.1	1.906ValMet: 1.906 ± 0.046	2.271ValAsn: 2.271 ± 0.05	3.054ValPro: 3.054 ± 0.063	2.41ValGln: 2.41 ± 0.053	4.464ValArg: 4.464 ± 0.074	4.197ValSer: 4.197 ± 0.07	3.759ValThr: 3.759 ± 0.069	5.651ValVal: 5.651 ± 0.101	0.83ValTrp: 0.83 ± 0.034	1.583ValTyr: 1.583 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.026TrpAla: 1.026 ± 0.035	0.139TrpCys: 0.139 ± 0.012	0.512TrpAsp: 0.512 ± 0.023	0.564TrpGlu: 0.564 ± 0.026	0.586TrpPhe: 0.586 ± 0.027	0.762TrpGly: 0.762 ± 0.032	0.373TrpHis: 0.373 ± 0.018	0.684TrpIle: 0.684 ± 0.032	0.564TrpLys: 0.564 ± 0.026	2.06TrpLeu: 2.06 ± 0.06	0.322TrpMet: 0.322 ± 0.02	0.427TrpAsn: 0.427 ± 0.024	0.553TrpPro: 0.553 ± 0.026	0.842TrpGln: 0.842 ± 0.033	1.045TrpArg: 1.045 ± 0.035	0.646TrpSer: 0.646 ± 0.028	0.478TrpThr: 0.478 ± 0.021	0.877TrpVal: 0.877 ± 0.036	0.204TrpTrp: 0.204 ± 0.015	0.297TrpTyr: 0.297 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.542TyrAla: 2.542 ± 0.055	0.336TyrCys: 0.336 ± 0.02	1.211TyrAsp: 1.211 ± 0.039	1.223TyrGlu: 1.223 ± 0.035	1.062TyrPhe: 1.062 ± 0.037	1.947TyrGly: 1.947 ± 0.046	0.555TyrHis: 0.555 ± 0.026	1.054TyrIle: 1.054 ± 0.034	0.845TyrLys: 0.845 ± 0.035	2.777TyrLeu: 2.777 ± 0.056	0.444TyrMet: 0.444 ± 0.024	0.713TyrAsn: 0.713 ± 0.03	1.312TyrPro: 1.312 ± 0.035	1.031TyrGln: 1.031 ± 0.031	1.974TyrArg: 1.974 ± 0.05	1.386TyrSer: 1.386 ± 0.041	1.114TyrThr: 1.114 ± 0.033	1.654TyrVal: 1.654 ± 0.049	0.351TyrTrp: 0.351 ± 0.02	0.684TyrTyr: 0.684 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2769 proteins (913534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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