Amino acid dipepetide frequency for Nocardia pseudobrasiliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.188AlaAla: 21.188 ± 0.149	0.958AlaCys: 0.958 ± 0.024	8.331AlaAsp: 8.331 ± 0.066	8.528AlaGlu: 8.528 ± 0.07	3.34AlaPhe: 3.34 ± 0.043	11.6AlaGly: 11.6 ± 0.074	2.743AlaHis: 2.743 ± 0.037	5.185AlaIle: 5.185 ± 0.056	2.547AlaLys: 2.547 ± 0.04	13.961AlaLeu: 13.961 ± 0.11	2.643AlaMet: 2.643 ± 0.034	2.402AlaAsn: 2.402 ± 0.032	6.328AlaPro: 6.328 ± 0.07	3.892AlaGln: 3.892 ± 0.047	9.808AlaArg: 9.808 ± 0.079	5.224AlaSer: 5.224 ± 0.051	7.551AlaThr: 7.551 ± 0.064	11.89AlaVal: 11.89 ± 0.093	1.698AlaTrp: 1.698 ± 0.024	2.427AlaTyr: 2.427 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.115CysAla: 1.115 ± 0.022	0.087CysCys: 0.087 ± 0.006	0.48CysAsp: 0.48 ± 0.014	0.406CysGlu: 0.406 ± 0.013	0.214CysPhe: 0.214 ± 0.009	0.927CysGly: 0.927 ± 0.02	0.198CysHis: 0.198 ± 0.01	0.203CysIle: 0.203 ± 0.009	0.109CysLys: 0.109 ± 0.006	0.712CysLeu: 0.712 ± 0.018	0.11CysMet: 0.11 ± 0.007	0.14CysAsn: 0.14 ± 0.007	0.492CysPro: 0.492 ± 0.017	0.169CysGln: 0.169 ± 0.007	0.593CysArg: 0.593 ± 0.018	0.431CysSer: 0.431 ± 0.013	0.452CysThr: 0.452 ± 0.016	0.656CysVal: 0.656 ± 0.016	0.124CysTrp: 0.124 ± 0.007	0.19CysTyr: 0.19 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.276AspAla: 7.276 ± 0.061	0.431AspCys: 0.431 ± 0.013	3.516AspAsp: 3.516 ± 0.039	3.722AspGlu: 3.722 ± 0.056	1.723AspPhe: 1.723 ± 0.023	5.569AspGly: 5.569 ± 0.056	1.504AspHis: 1.504 ± 0.028	2.593AspIle: 2.593 ± 0.032	1.192AspLys: 1.192 ± 0.029	6.303AspLeu: 6.303 ± 0.062	0.907AspMet: 0.907 ± 0.02	1.262AspAsn: 1.262 ± 0.023	4.776AspPro: 4.776 ± 0.052	1.704AspGln: 1.704 ± 0.025	5.524AspArg: 5.524 ± 0.056	3.024AspSer: 3.024 ± 0.043	3.252AspThr: 3.252 ± 0.035	4.199AspVal: 4.199 ± 0.046	1.02AspTrp: 1.02 ± 0.024	1.461AspTyr: 1.461 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	5.98GluAla: 5.98 ± 0.057	0.358GluCys: 0.358 ± 0.011	2.277GluAsp: 2.277 ± 0.038	2.372GluGlu: 2.372 ± 0.039	2.088GluPhe: 2.088 ± 0.034	3.205GluGly: 3.205 ± 0.041	1.56GluHis: 1.56 ± 0.031	2.906GluIle: 2.906 ± 0.038	1.129GluLys: 1.129 ± 0.026	7.286GluLeu: 7.286 ± 0.076	0.998GluMet: 0.998 ± 0.021	1.089GluAsn: 1.089 ± 0.022	3.324GluPro: 3.324 ± 0.041	2.37GluGln: 2.37 ± 0.032	5.21GluArg: 5.21 ± 0.058	2.884GluSer: 2.884 ± 0.039	2.86GluThr: 2.86 ± 0.035	4.287GluVal: 4.287 ± 0.048	0.805GluTrp: 0.805 ± 0.017	1.236GluTyr: 1.236 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.19PheAla: 4.19 ± 0.05	0.27PheCys: 0.27 ± 0.011	2.556PheAsp: 2.556 ± 0.042	1.639PheGlu: 1.639 ± 0.027	0.878PhePhe: 0.878 ± 0.023	3.542PheGly: 3.542 ± 0.042	0.647PheHis: 0.647 ± 0.016	0.881PheIle: 0.881 ± 0.02	0.401PheLys: 0.401 ± 0.013	2.565PheLeu: 2.565 ± 0.031	0.418PheMet: 0.418 ± 0.012	0.552PheAsn: 0.552 ± 0.016	1.454PhePro: 1.454 ± 0.025	0.71PheGln: 0.71 ± 0.018	1.897PheArg: 1.897 ± 0.025	1.446PheSer: 1.446 ± 0.024	2.089PheThr: 2.089 ± 0.031	2.581PheVal: 2.581 ± 0.033	0.417PheTrp: 0.417 ± 0.014	0.626PheTyr: 0.626 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.161GlyAla: 10.161 ± 0.079	0.846GlyCys: 0.846 ± 0.02	4.83GlyAsp: 4.83 ± 0.051	4.624GlyGlu: 4.624 ± 0.058	3.01GlyPhe: 3.01 ± 0.038	7.921GlyGly: 7.921 ± 0.088	2.14GlyHis: 2.14 ± 0.032	4.218GlyIle: 4.218 ± 0.046	2.156GlyLys: 2.156 ± 0.034	8.949GlyLeu: 8.949 ± 0.071	2.051GlyMet: 2.051 ± 0.032	1.913GlyAsn: 1.913 ± 0.034	4.778GlyPro: 4.778 ± 0.051	2.519GlyGln: 2.519 ± 0.041	6.954GlyArg: 6.954 ± 0.058	5.168GlySer: 5.168 ± 0.06	5.032GlyThr: 5.032 ± 0.051	7.358GlyVal: 7.358 ± 0.059	1.675GlyTrp: 1.675 ± 0.025	2.422GlyTyr: 2.422 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.578HisAla: 2.578 ± 0.037	0.227HisCys: 0.227 ± 0.01	1.337HisAsp: 1.337 ± 0.028	1.154HisGlu: 1.154 ± 0.023	0.68HisPhe: 0.68 ± 0.016	2.233HisGly: 2.233 ± 0.036	0.685HisHis: 0.685 ± 0.018	0.895HisIle: 0.895 ± 0.02	0.295HisLys: 0.295 ± 0.012	2.19HisLeu: 2.19 ± 0.028	0.378HisMet: 0.378 ± 0.014	0.494HisAsn: 0.494 ± 0.015	1.752HisPro: 1.752 ± 0.028	0.6HisGln: 0.6 ± 0.016	2.067HisArg: 2.067 ± 0.031	1.154HisSer: 1.154 ± 0.021	1.356HisThr: 1.356 ± 0.027	1.448HisVal: 1.448 ± 0.024	0.38HisTrp: 0.38 ± 0.011	0.555HisTyr: 0.555 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.662IleAla: 6.662 ± 0.065	0.363IleCys: 0.363 ± 0.013	3.356IleAsp: 3.356 ± 0.037	2.723IleGlu: 2.723 ± 0.035	1.021IlePhe: 1.021 ± 0.025	4.684IleGly: 4.684 ± 0.051	0.803IleHis: 0.803 ± 0.019	1.284IleIle: 1.284 ± 0.027	0.653IleLys: 0.653 ± 0.019	3.279IleLeu: 3.279 ± 0.038	0.571IleMet: 0.571 ± 0.017	0.861IleAsn: 0.861 ± 0.017	2.459IlePro: 2.459 ± 0.03	0.848IleGln: 0.848 ± 0.019	3.044IleArg: 3.044 ± 0.036	2.212IleSer: 2.212 ± 0.033	2.763IleThr: 2.763 ± 0.038	3.861IleVal: 3.861 ± 0.047	0.485IleTrp: 0.485 ± 0.014	0.733IleTyr: 0.733 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.21LysAla: 2.21 ± 0.041	0.109LysCys: 0.109 ± 0.007	0.921LysAsp: 0.921 ± 0.025	0.78LysGlu: 0.78 ± 0.021	0.584LysPhe: 0.584 ± 0.016	1.319LysGly: 1.319 ± 0.028	0.37LysHis: 0.37 ± 0.013	0.92LysIle: 0.92 ± 0.021	0.516LysLys: 0.516 ± 0.02	1.966LysLeu: 1.966 ± 0.033	0.414LysMet: 0.414 ± 0.015	0.452LysAsn: 0.452 ± 0.016	1.261LysPro: 1.261 ± 0.027	0.7LysGln: 0.7 ± 0.018	1.314LysArg: 1.314 ± 0.031	1.144LysSer: 1.144 ± 0.024	1.148LysThr: 1.148 ± 0.022	1.612LysVal: 1.612 ± 0.031	0.265LysTrp: 0.265 ± 0.01	0.473LysTyr: 0.473 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.827LeuAla: 14.827 ± 0.103	0.866LeuCys: 0.866 ± 0.02	6.879LeuAsp: 6.879 ± 0.065	4.76LeuGlu: 4.76 ± 0.054	2.833LeuPhe: 2.833 ± 0.037	9.287LeuGly: 9.287 ± 0.076	2.169LeuHis: 2.169 ± 0.034	4.417LeuIle: 4.417 ± 0.052	1.4LeuLys: 1.4 ± 0.029	10.648LeuLeu: 10.648 ± 0.09	1.591LeuMet: 1.591 ± 0.027	1.92LeuAsn: 1.92 ± 0.029	6.228LeuPro: 6.228 ± 0.062	2.207LeuGln: 2.207 ± 0.029	8.911LeuArg: 8.911 ± 0.071	5.748LeuSer: 5.748 ± 0.046	6.716LeuThr: 6.716 ± 0.06	8.418LeuVal: 8.418 ± 0.065	1.289LeuTrp: 1.289 ± 0.023	1.78LeuTyr: 1.78 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.216MetAla: 2.216 ± 0.03	0.147MetCys: 0.147 ± 0.008	0.885MetAsp: 0.885 ± 0.017	0.611MetGlu: 0.611 ± 0.015	0.621MetPhe: 0.621 ± 0.018	1.309MetGly: 1.309 ± 0.024	0.386MetHis: 0.386 ± 0.013	0.935MetIle: 0.935 ± 0.022	0.348MetLys: 0.348 ± 0.014	1.967MetLeu: 1.967 ± 0.028	0.346MetMet: 0.346 ± 0.013	0.527MetAsn: 0.527 ± 0.016	1.17MetPro: 1.17 ± 0.022	0.447MetGln: 0.447 ± 0.012	1.642MetArg: 1.642 ± 0.032	1.503MetSer: 1.503 ± 0.025	1.621MetThr: 1.621 ± 0.028	1.482MetVal: 1.482 ± 0.024	0.249MetTrp: 0.249 ± 0.01	0.352MetTyr: 0.352 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.421AsnAla: 2.421 ± 0.036	0.167AsnCys: 0.167 ± 0.008	1.062AsnAsp: 1.062 ± 0.02	0.872AsnGlu: 0.872 ± 0.017	0.637AsnPhe: 0.637 ± 0.016	1.954AsnGly: 1.954 ± 0.037	0.449AsnHis: 0.449 ± 0.014	0.902AsnIle: 0.902 ± 0.02	0.416AsnLys: 0.416 ± 0.015	1.985AsnLeu: 1.985 ± 0.026	0.398AsnMet: 0.398 ± 0.013	0.525AsnAsn: 0.525 ± 0.016	1.722AsnPro: 1.722 ± 0.028	0.631AsnGln: 0.631 ± 0.017	1.556AsnArg: 1.556 ± 0.026	1.192AsnSer: 1.192 ± 0.022	1.251AsnThr: 1.251 ± 0.026	1.483AsnVal: 1.483 ± 0.027	0.348AsnTrp: 0.348 ± 0.012	0.536AsnTyr: 0.536 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.661ProAla: 7.661 ± 0.081	0.294ProCys: 0.294 ± 0.011	4.49ProAsp: 4.49 ± 0.051	4.086ProGlu: 4.086 ± 0.051	1.562ProPhe: 1.562 ± 0.025	5.925ProGly: 5.925 ± 0.065	1.278ProHis: 1.278 ± 0.025	2.473ProIle: 2.473 ± 0.03	1.177ProLys: 1.177 ± 0.022	5.102ProLeu: 5.102 ± 0.048	1.146ProMet: 1.146 ± 0.024	1.358ProAsn: 1.358 ± 0.026	3.411ProPro: 3.411 ± 0.064	1.889ProGln: 1.889 ± 0.037	3.881ProArg: 3.881 ± 0.042	2.858ProSer: 2.858 ± 0.032	3.623ProThr: 3.623 ± 0.044	5.05ProVal: 5.05 ± 0.045	0.833ProTrp: 0.833 ± 0.017	1.158ProTyr: 1.158 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.472GlnAla: 3.472 ± 0.04	0.197GlnCys: 0.197 ± 0.009	1.157GlnAsp: 1.157 ± 0.025	1.031GlnGlu: 1.031 ± 0.022	0.879GlnPhe: 0.879 ± 0.021	1.944GlnGly: 1.944 ± 0.033	0.673GlnHis: 0.673 ± 0.018	1.379GlnIle: 1.379 ± 0.023	0.508GlnLys: 0.508 ± 0.017	3.485GlnLeu: 3.485 ± 0.038	0.562GlnMet: 0.562 ± 0.016	0.571GlnAsn: 0.571 ± 0.016	1.852GlnPro: 1.852 ± 0.035	1.326GlnGln: 1.326 ± 0.031	2.791GlnArg: 2.791 ± 0.04	1.386GlnSer: 1.386 ± 0.026	1.399GlnThr: 1.399 ± 0.022	2.418GlnVal: 2.418 ± 0.035	0.545GlnTrp: 0.545 ± 0.014	0.617GlnTyr: 0.617 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.693ArgAla: 9.693 ± 0.083	0.6ArgCys: 0.6 ± 0.019	4.478ArgAsp: 4.478 ± 0.052	4.572ArgGlu: 4.572 ± 0.06	2.593ArgPhe: 2.593 ± 0.036	5.598ArgGly: 5.598 ± 0.05	1.934ArgHis: 1.934 ± 0.03	4.114ArgIle: 4.114 ± 0.044	1.613ArgLys: 1.613 ± 0.031	8.465ArgLeu: 8.465 ± 0.077	2.03ArgMet: 2.03 ± 0.03	1.671ArgAsn: 1.671 ± 0.03	4.525ArgPro: 4.525 ± 0.054	2.295ArgGln: 2.295 ± 0.032	7.349ArgArg: 7.349 ± 0.073	4.128ArgSer: 4.128 ± 0.045	4.918ArgThr: 4.918 ± 0.045	6.035ArgVal: 6.035 ± 0.053	1.507ArgTrp: 1.507 ± 0.026	2.05ArgTyr: 2.05 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.946SerAla: 6.946 ± 0.067	0.396SerCys: 0.396 ± 0.013	3.158SerAsp: 3.158 ± 0.036	2.647SerGlu: 2.647 ± 0.039	1.573SerPhe: 1.573 ± 0.027	5.935SerGly: 5.935 ± 0.061	0.998SerHis: 0.998 ± 0.02	2.075SerIle: 2.075 ± 0.028	0.983SerLys: 0.983 ± 0.024	4.503SerLeu: 4.503 ± 0.048	1.216SerMet: 1.216 ± 0.022	1.053SerAsn: 1.053 ± 0.024	2.964SerPro: 2.964 ± 0.038	1.235SerGln: 1.235 ± 0.022	3.626SerArg: 3.626 ± 0.04	2.821SerSer: 2.821 ± 0.041	3.2SerThr: 3.2 ± 0.046	4.381SerVal: 4.381 ± 0.041	0.867SerTrp: 0.867 ± 0.02	1.205SerTyr: 1.205 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.318ThrAla: 8.318 ± 0.072	0.409ThrCys: 0.409 ± 0.014	3.81ThrAsp: 3.81 ± 0.046	3.363ThrGlu: 3.363 ± 0.042	1.691ThrPhe: 1.691 ± 0.024	6.033ThrGly: 6.033 ± 0.06	1.221ThrHis: 1.221 ± 0.026	2.488ThrIle: 2.488 ± 0.041	1.089ThrLys: 1.089 ± 0.025	5.81ThrLeu: 5.81 ± 0.057	1.046ThrMet: 1.046 ± 0.02	1.117ThrAsn: 1.117 ± 0.023	3.975ThrPro: 3.975 ± 0.052	1.385ThrGln: 1.385 ± 0.024	3.985ThrArg: 3.985 ± 0.042	2.922ThrSer: 2.922 ± 0.037	4.025ThrThr: 4.025 ± 0.058	5.919ThrVal: 5.919 ± 0.059	0.783ThrTrp: 0.783 ± 0.017	1.269ThrTyr: 1.269 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.3ValAla: 11.3 ± 0.078	0.733ValCys: 0.733 ± 0.017	5.31ValAsp: 5.31 ± 0.043	4.546ValGlu: 4.546 ± 0.046	2.565ValPhe: 2.565 ± 0.037	6.728ValGly: 6.728 ± 0.059	1.816ValHis: 1.816 ± 0.028	3.489ValIle: 3.489 ± 0.043	1.327ValLys: 1.327 ± 0.024	9.363ValLeu: 9.363 ± 0.083	1.357ValMet: 1.357 ± 0.025	1.727ValAsn: 1.727 ± 0.03	4.748ValPro: 4.748 ± 0.049	1.961ValGln: 1.961 ± 0.028	6.584ValArg: 6.584 ± 0.055	4.38ValSer: 4.38 ± 0.049	5.275ValThr: 5.275 ± 0.051	8.154ValVal: 8.154 ± 0.07	1.043ValTrp: 1.043 ± 0.019	1.517ValTyr: 1.517 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.574TrpAla: 1.574 ± 0.023	0.137TrpCys: 0.137 ± 0.008	0.778TrpAsp: 0.778 ± 0.019	0.691TrpGlu: 0.691 ± 0.017	0.539TrpPhe: 0.539 ± 0.016	0.98TrpGly: 0.98 ± 0.02	0.39TrpHis: 0.39 ± 0.014	0.648TrpIle: 0.648 ± 0.015	0.306TrpLys: 0.306 ± 0.013	1.808TrpLeu: 1.808 ± 0.032	0.315TrpMet: 0.315 ± 0.011	0.427TrpAsn: 0.427 ± 0.015	0.792TrpPro: 0.792 ± 0.016	0.625TrpGln: 0.625 ± 0.017	1.342TrpArg: 1.342 ± 0.021	0.995TrpSer: 0.995 ± 0.023	0.931TrpThr: 0.931 ± 0.018	1.097TrpVal: 1.097 ± 0.022	0.357TrpTrp: 0.357 ± 0.013	0.337TrpTyr: 0.337 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.457TyrAla: 2.457 ± 0.034	0.215TyrCys: 0.215 ± 0.009	1.347TyrAsp: 1.347 ± 0.027	1.098TyrGlu: 1.098 ± 0.02	0.726TyrPhe: 0.726 ± 0.016	2.033TyrGly: 2.033 ± 0.033	0.494TyrHis: 0.494 ± 0.013	0.658TyrIle: 0.658 ± 0.018	0.313TyrLys: 0.313 ± 0.012	2.549TyrLeu: 2.549 ± 0.032	0.266TyrMet: 0.266 ± 0.009	0.447TyrAsn: 0.447 ± 0.014	1.241TyrPro: 1.241 ± 0.025	0.677TyrGln: 0.677 ± 0.016	2.091TyrArg: 2.091 ± 0.033	1.162TyrSer: 1.162 ± 0.022	1.196TyrThr: 1.196 ± 0.024	1.594TyrVal: 1.594 ± 0.027	0.379TyrTrp: 0.379 ± 0.013	0.515TyrTyr: 0.515 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7943 proteins (2519924 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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