Amino acid dipepetide frequency for Cardiobacterium hominis (strain ATCC 15826 / DSM 8339 / NCTC 10426 / 6573)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.468AlaAla: 17.468 ± 0.289	1.265AlaCys: 1.265 ± 0.047	7.379AlaAsp: 7.379 ± 0.103	7.187AlaGlu: 7.187 ± 0.13	3.95AlaPhe: 3.95 ± 0.077	8.156AlaGly: 8.156 ± 0.12	2.829AlaHis: 2.829 ± 0.067	6.284AlaIle: 6.284 ± 0.098	4.543AlaLys: 4.543 ± 0.112	14.257AlaLeu: 14.257 ± 0.213	2.509AlaMet: 2.509 ± 0.064	3.446AlaAsn: 3.446 ± 0.085	5.347AlaPro: 5.347 ± 0.113	5.682AlaGln: 5.682 ± 0.144	7.481AlaArg: 7.481 ± 0.136	5.267AlaSer: 5.267 ± 0.097	6.014AlaThr: 6.014 ± 0.125	7.627AlaVal: 7.627 ± 0.122	1.608AlaTrp: 1.608 ± 0.051	3.263AlaTyr: 3.263 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	1.032CysAla: 1.032 ± 0.041	0.141CysCys: 0.141 ± 0.014	0.515CysAsp: 0.515 ± 0.026	0.479CysGlu: 0.479 ± 0.029	0.314CysPhe: 0.314 ± 0.021	0.934CysGly: 0.934 ± 0.04	0.278CysHis: 0.278 ± 0.02	0.449CysIle: 0.449 ± 0.025	0.266CysLys: 0.266 ± 0.019	0.889CysLeu: 0.889 ± 0.036	0.163CysMet: 0.163 ± 0.014	0.267CysAsn: 0.267 ± 0.02	0.462CysPro: 0.462 ± 0.028	0.346CysGln: 0.346 ± 0.022	0.633CysArg: 0.633 ± 0.033	0.435CysSer: 0.435 ± 0.026	0.44CysThr: 0.44 ± 0.024	0.467CysVal: 0.467 ± 0.024	0.148CysTrp: 0.148 ± 0.014	0.293CysTyr: 0.293 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	6.837AspAla: 6.837 ± 0.117	0.462AspCys: 0.462 ± 0.024	3.71AspAsp: 3.71 ± 0.091	3.361AspGlu: 3.361 ± 0.072	2.188AspPhe: 2.188 ± 0.058	5.342AspGly: 5.342 ± 0.127	1.196AspHis: 1.196 ± 0.042	3.686AspIle: 3.686 ± 0.076	2.666AspLys: 2.666 ± 0.061	4.946AspLeu: 4.946 ± 0.089	1.099AspMet: 1.099 ± 0.043	2.382AspAsn: 2.382 ± 0.066	2.687AspPro: 2.687 ± 0.071	1.379AspGln: 1.379 ± 0.045	2.918AspArg: 2.918 ± 0.057	3.074AspSer: 3.074 ± 0.079	2.845AspThr: 2.845 ± 0.075	3.134AspVal: 3.134 ± 0.074	0.989AspTrp: 0.989 ± 0.038	2.394AspTyr: 2.394 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	6.61GluAla: 6.61 ± 0.113	0.337GluCys: 0.337 ± 0.023	2.583GluAsp: 2.583 ± 0.059	2.847GluGlu: 2.847 ± 0.086	1.351GluPhe: 1.351 ± 0.047	3.285GluGly: 3.285 ± 0.08	1.723GluHis: 1.723 ± 0.046	3.484GluIle: 3.484 ± 0.08	3.253GluLys: 3.253 ± 0.081	5.123GluLeu: 5.123 ± 0.088	1.334GluMet: 1.334 ± 0.04	2.664GluAsn: 2.664 ± 0.067	2.151GluPro: 2.151 ± 0.057	2.8GluGln: 2.8 ± 0.077	4.027GluArg: 4.027 ± 0.088	2.459GluSer: 2.459 ± 0.058	3.278GluThr: 3.278 ± 0.077	2.845GluVal: 2.845 ± 0.076	0.634GluTrp: 0.634 ± 0.031	1.597GluTyr: 1.597 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	4.617PheAla: 4.617 ± 0.084	0.442PheCys: 0.442 ± 0.027	2.108PheAsp: 2.108 ± 0.061	1.453PheGlu: 1.453 ± 0.047	1.592PhePhe: 1.592 ± 0.058	2.734PheGly: 2.734 ± 0.068	0.766PheHis: 0.766 ± 0.035	2.107PheIle: 2.107 ± 0.06	1.085PheLys: 1.085 ± 0.039	3.266PheLeu: 3.266 ± 0.081	0.79PheMet: 0.79 ± 0.033	1.335PheAsn: 1.335 ± 0.051	1.407PhePro: 1.407 ± 0.048	0.938PheGln: 0.938 ± 0.034	1.717PheArg: 1.717 ± 0.053	2.286PheSer: 2.286 ± 0.06	2.125PheThr: 2.125 ± 0.053	2.14PheVal: 2.14 ± 0.065	0.551PheTrp: 0.551 ± 0.032	1.192PheTyr: 1.192 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.492GlyAla: 7.492 ± 0.131	0.667GlyCys: 0.667 ± 0.033	4.579GlyAsp: 4.579 ± 0.085	4.907GlyGlu: 4.907 ± 0.091	2.814GlyPhe: 2.814 ± 0.063	6.216GlyGly: 6.216 ± 0.129	1.772GlyHis: 1.772 ± 0.053	5.01GlyIle: 5.01 ± 0.097	4.761GlyLys: 4.761 ± 0.087	6.639GlyLeu: 6.639 ± 0.102	1.901GlyMet: 1.901 ± 0.052	2.888GlyAsn: 2.888 ± 0.091	1.248GlyPro: 1.248 ± 0.046	2.89GlyGln: 2.89 ± 0.065	3.821GlyArg: 3.821 ± 0.087	4.247GlySer: 4.247 ± 0.094	3.673GlyThr: 3.673 ± 0.09	5.086GlyVal: 5.086 ± 0.088	1.148GlyTrp: 1.148 ± 0.045	2.673GlyTyr: 2.673 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.6HisAla: 2.6 ± 0.064	0.274HisCys: 0.274 ± 0.019	1.719HisAsp: 1.719 ± 0.052	1.425HisGlu: 1.425 ± 0.045	0.912HisPhe: 0.912 ± 0.035	2.334HisGly: 2.334 ± 0.066	0.897HisHis: 0.897 ± 0.042	1.841HisIle: 1.841 ± 0.051	0.924HisLys: 0.924 ± 0.037	2.678HisLeu: 2.678 ± 0.069	0.462HisMet: 0.462 ± 0.026	1.002HisAsn: 1.002 ± 0.04	1.522HisPro: 1.522 ± 0.049	0.881HisGln: 0.881 ± 0.037	1.4HisArg: 1.4 ± 0.049	1.286HisSer: 1.286 ± 0.044	1.273HisThr: 1.273 ± 0.042	1.17HisVal: 1.17 ± 0.037	0.406HisTrp: 0.406 ± 0.024	1.247HisTyr: 1.247 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	7.715IleAla: 7.715 ± 0.116	0.544IleCys: 0.544 ± 0.028	3.554IleAsp: 3.554 ± 0.083	3.399IleGlu: 3.399 ± 0.069	1.957IlePhe: 1.957 ± 0.057	4.575IleGly: 4.575 ± 0.101	1.483IleHis: 1.483 ± 0.045	3.568IleIle: 3.568 ± 0.075	2.094IleLys: 2.094 ± 0.055	5.481IleLeu: 5.481 ± 0.101	1.028IleMet: 1.028 ± 0.038	2.219IleAsn: 2.219 ± 0.067	2.621IlePro: 2.621 ± 0.063	1.583IleGln: 1.583 ± 0.04	3.436IleArg: 3.436 ± 0.072	3.332IleSer: 3.332 ± 0.077	3.703IleThr: 3.703 ± 0.088	3.302IleVal: 3.302 ± 0.075	0.588IleTrp: 0.588 ± 0.028	1.683IleTyr: 1.683 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.678LysAla: 4.678 ± 0.12	0.163LysCys: 0.163 ± 0.016	2.295LysAsp: 2.295 ± 0.073	2.232LysGlu: 2.232 ± 0.063	0.908LysPhe: 0.908 ± 0.039	2.681LysGly: 2.681 ± 0.061	1.019LysHis: 1.019 ± 0.035	2.565LysIle: 2.565 ± 0.066	2.285LysLys: 2.285 ± 0.069	3.64LysLeu: 3.64 ± 0.084	1.035LysMet: 1.035 ± 0.036	2.179LysAsn: 2.179 ± 0.064	2.278LysPro: 2.278 ± 0.054	1.793LysGln: 1.793 ± 0.049	2.439LysArg: 2.439 ± 0.061	2.05LysSer: 2.05 ± 0.054	3.346LysThr: 3.346 ± 0.08	2.155LysVal: 2.155 ± 0.067	0.402LysTrp: 0.402 ± 0.026	1.198LysTyr: 1.198 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	14.275LeuAla: 14.275 ± 0.234	1.111LeuCys: 1.111 ± 0.043	5.896LeuAsp: 5.896 ± 0.097	5.032LeuGlu: 5.032 ± 0.093	3.507LeuPhe: 3.507 ± 0.084	7.327LeuGly: 7.327 ± 0.129	2.869LeuHis: 2.869 ± 0.064	5.706LeuIle: 5.706 ± 0.118	4.022LeuLys: 4.022 ± 0.083	11.61LeuLeu: 11.61 ± 0.22	2.264LeuMet: 2.264 ± 0.058	3.584LeuAsn: 3.584 ± 0.072	6.059LeuPro: 6.059 ± 0.117	4.559LeuGln: 4.559 ± 0.087	6.795LeuArg: 6.795 ± 0.132	5.121LeuSer: 5.121 ± 0.081	5.731LeuThr: 5.731 ± 0.097	5.595LeuVal: 5.595 ± 0.111	1.466LeuTrp: 1.466 ± 0.056	3.067LeuTyr: 3.067 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	2.067MetAla: 2.067 ± 0.052	0.139MetCys: 0.139 ± 0.014	0.998MetAsp: 0.998 ± 0.037	0.934MetGlu: 0.934 ± 0.038	0.606MetPhe: 0.606 ± 0.031	1.399MetGly: 1.399 ± 0.045	0.498MetHis: 0.498 ± 0.025	1.074MetIle: 1.074 ± 0.043	1.176MetLys: 1.176 ± 0.041	2.364MetLeu: 2.364 ± 0.062	0.558MetMet: 0.558 ± 0.027	1.05MetAsn: 1.05 ± 0.036	1.231MetPro: 1.231 ± 0.044	1.155MetGln: 1.155 ± 0.041	1.436MetArg: 1.436 ± 0.047	1.349MetSer: 1.349 ± 0.047	1.442MetThr: 1.442 ± 0.044	1.182MetVal: 1.182 ± 0.04	0.165MetTrp: 0.165 ± 0.015	0.406MetTyr: 0.406 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.876AsnAla: 3.876 ± 0.088	0.274AsnCys: 0.274 ± 0.023	1.941AsnAsp: 1.941 ± 0.063	1.719AsnGlu: 1.719 ± 0.052	1.041AsnPhe: 1.041 ± 0.035	3.084AsnGly: 3.084 ± 0.082	1.165AsnHis: 1.165 ± 0.056	2.48AsnIle: 2.48 ± 0.071	1.387AsnLys: 1.387 ± 0.049	3.577AsnLeu: 3.577 ± 0.07	0.664AsnMet: 0.664 ± 0.032	1.504AsnAsn: 1.504 ± 0.072	2.762AsnPro: 2.762 ± 0.118	1.251AsnGln: 1.251 ± 0.039	2.259AsnArg: 2.259 ± 0.055	1.881AsnSer: 1.881 ± 0.062	2.012AsnThr: 2.012 ± 0.059	1.903AsnVal: 1.903 ± 0.061	0.479AsnTrp: 0.479 ± 0.029	1.266AsnTyr: 1.266 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	6.501ProAla: 6.501 ± 0.114	0.38ProCys: 0.38 ± 0.025	3.201ProAsp: 3.201 ± 0.07	3.314ProGlu: 3.314 ± 0.075	1.744ProPhe: 1.744 ± 0.051	3.008ProGly: 3.008 ± 0.069	1.172ProHis: 1.172 ± 0.036	1.814ProIle: 1.814 ± 0.051	1.543ProLys: 1.543 ± 0.054	5.221ProLeu: 5.221 ± 0.094	1.055ProMet: 1.055 ± 0.04	1.77ProAsn: 1.77 ± 0.103	3.041ProPro: 3.041 ± 0.09	2.663ProGln: 2.663 ± 0.084	2.306ProArg: 2.306 ± 0.057	1.906ProSer: 1.906 ± 0.059	2.243ProThr: 2.243 ± 0.059	3.433ProVal: 3.433 ± 0.065	0.603ProTrp: 0.603 ± 0.031	1.536ProTyr: 1.536 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	4.787GlnAla: 4.787 ± 0.096	0.263GlnCys: 0.263 ± 0.019	1.823GlnAsp: 1.823 ± 0.055	2.193GlnGlu: 2.193 ± 0.063	1.285GlnPhe: 1.285 ± 0.041	2.799GlnGly: 2.799 ± 0.061	1.427GlnHis: 1.427 ± 0.054	2.355GlnIle: 2.355 ± 0.066	1.893GlnLys: 1.893 ± 0.05	3.963GlnLeu: 3.963 ± 0.08	0.964GlnMet: 0.964 ± 0.038	1.667GlnAsn: 1.667 ± 0.05	2.426GlnPro: 2.426 ± 0.09	2.365GlnGln: 2.365 ± 0.074	2.888GlnArg: 2.888 ± 0.071	2.024GlnSer: 2.024 ± 0.054	2.79GlnThr: 2.79 ± 0.066	1.964GlnVal: 1.964 ± 0.057	0.679GlnTrp: 0.679 ± 0.033	1.404GlnTyr: 1.404 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	6.615ArgAla: 6.615 ± 0.127	0.553ArgCys: 0.553 ± 0.028	3.931ArgAsp: 3.931 ± 0.086	4.072ArgGlu: 4.072 ± 0.085	2.507ArgPhe: 2.507 ± 0.063	4.03ArgGly: 4.03 ± 0.08	1.829ArgHis: 1.829 ± 0.053	3.62ArgIle: 3.62 ± 0.074	2.234ArgLys: 2.234 ± 0.061	7.203ArgLeu: 7.203 ± 0.142	1.209ArgMet: 1.209 ± 0.044	1.809ArgAsn: 1.809 ± 0.062	2.624ArgPro: 2.624 ± 0.07	2.839ArgGln: 2.839 ± 0.069	4.213ArgArg: 4.213 ± 0.092	2.755ArgSer: 2.755 ± 0.071	2.316ArgThr: 2.316 ± 0.053	3.362ArgVal: 3.362 ± 0.069	0.933ArgTrp: 0.933 ± 0.036	2.513ArgTyr: 2.513 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	6.113SerAla: 6.113 ± 0.095	0.367SerCys: 0.367 ± 0.024	2.999SerAsp: 2.999 ± 0.066	2.646SerGlu: 2.646 ± 0.062	1.761SerPhe: 1.761 ± 0.052	5.346SerGly: 5.346 ± 0.096	1.248SerHis: 1.248 ± 0.038	2.722SerIle: 2.722 ± 0.059	1.839SerLys: 1.839 ± 0.054	5.139SerLeu: 5.139 ± 0.094	1.037SerMet: 1.037 ± 0.036	1.538SerAsn: 1.538 ± 0.052	2.317SerPro: 2.317 ± 0.062	1.811SerGln: 1.811 ± 0.059	2.999SerArg: 2.999 ± 0.059	2.574SerSer: 2.574 ± 0.073	2.428SerThr: 2.428 ± 0.065	3.141SerVal: 3.141 ± 0.066	0.625SerTrp: 0.625 ± 0.032	1.512SerTyr: 1.512 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.883ThrAla: 6.883 ± 0.112	0.414ThrCys: 0.414 ± 0.024	2.73ThrAsp: 2.73 ± 0.077	2.153ThrGlu: 2.153 ± 0.057	2.058ThrPhe: 2.058 ± 0.059	3.903ThrGly: 3.903 ± 0.081	1.281ThrHis: 1.281 ± 0.042	3.185ThrIle: 3.185 ± 0.07	1.292ThrLys: 1.292 ± 0.048	7.633ThrLeu: 7.633 ± 0.126	0.93ThrMet: 0.93 ± 0.032	1.61ThrAsn: 1.61 ± 0.063	3.483ThrPro: 3.483 ± 0.069	1.702ThrGln: 1.702 ± 0.045	3.082ThrArg: 3.082 ± 0.066	2.317ThrSer: 2.317 ± 0.06	3.01ThrThr: 3.01 ± 0.077	3.869ThrVal: 3.869 ± 0.105	0.611ThrTrp: 0.611 ± 0.026	1.715ThrTyr: 1.715 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	7.239ValAla: 7.239 ± 0.128	0.646ValCys: 0.646 ± 0.03	2.827ValAsp: 2.827 ± 0.068	3.105ValGlu: 3.105 ± 0.066	2.297ValPhe: 2.297 ± 0.066	3.973ValGly: 3.973 ± 0.089	1.251ValHis: 1.251 ± 0.035	3.634ValIle: 3.634 ± 0.072	2.524ValLys: 2.524 ± 0.073	6.131ValLeu: 6.131 ± 0.109	1.422ValMet: 1.422 ± 0.049	2.041ValAsn: 2.041 ± 0.061	2.701ValPro: 2.701 ± 0.057	2.206ValGln: 2.206 ± 0.053	3.582ValArg: 3.582 ± 0.068	3.523ValSer: 3.523 ± 0.084	2.861ValThr: 2.861 ± 0.081	3.963ValVal: 3.963 ± 0.107	0.781ValTrp: 0.781 ± 0.033	1.687ValTyr: 1.687 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.06TrpAla: 1.06 ± 0.037	0.134TrpCys: 0.134 ± 0.013	0.524TrpAsp: 0.524 ± 0.028	0.502TrpGlu: 0.502 ± 0.025	0.592TrpPhe: 0.592 ± 0.034	0.697TrpGly: 0.697 ± 0.035	0.505TrpHis: 0.505 ± 0.025	0.667TrpIle: 0.667 ± 0.028	0.48TrpLys: 0.48 ± 0.027	2.315TrpLeu: 2.315 ± 0.075	0.302TrpMet: 0.302 ± 0.018	0.418TrpAsn: 0.418 ± 0.025	0.423TrpPro: 0.423 ± 0.023	1.339TrpGln: 1.339 ± 0.046	1.108TrpArg: 1.108 ± 0.042	0.563TrpSer: 0.563 ± 0.029	0.579TrpThr: 0.579 ± 0.03	0.68TrpVal: 0.68 ± 0.032	0.237TrpTrp: 0.237 ± 0.021	0.45TrpTyr: 0.45 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.1TyrAla: 3.1 ± 0.071	0.375TyrCys: 0.375 ± 0.02	1.981TyrAsp: 1.981 ± 0.057	1.427TyrGlu: 1.427 ± 0.048	1.27TyrPhe: 1.27 ± 0.042	2.611TyrGly: 2.611 ± 0.065	1.046TyrHis: 1.046 ± 0.04	1.612TyrIle: 1.612 ± 0.045	1.076TyrLys: 1.076 ± 0.038	3.524TyrLeu: 3.524 ± 0.077	0.5TyrMet: 0.5 ± 0.025	1.155TyrAsn: 1.155 ± 0.042	1.661TyrPro: 1.661 ± 0.051	1.778TyrGln: 1.778 ± 0.057	2.625TyrArg: 2.625 ± 0.067	1.711TyrSer: 1.711 ± 0.05	1.753TyrThr: 1.753 ± 0.058	1.374TyrVal: 1.374 ± 0.045	0.52TyrTrp: 0.52 ± 0.026	1.243TyrTyr: 1.243 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2580 proteins (770704 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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