Amino acid dipepetide frequency for Pseudoxanthomonas spadix (strain BD-a59)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.63AlaAla: 18.63 ± 0.245	1.28AlaCys: 1.28 ± 0.036	6.989AlaAsp: 6.989 ± 0.098	6.647AlaGlu: 6.647 ± 0.098	3.915AlaPhe: 3.915 ± 0.06	11.561AlaGly: 11.561 ± 0.146	2.863AlaHis: 2.863 ± 0.06	5.289AlaIle: 5.289 ± 0.084	2.813AlaLys: 2.813 ± 0.066	16.51AlaLeu: 16.51 ± 0.176	3.416AlaMet: 3.416 ± 0.071	2.63AlaAsn: 2.63 ± 0.048	6.844AlaPro: 6.844 ± 0.125	6.619AlaGln: 6.619 ± 0.106	10.979AlaArg: 10.979 ± 0.144	6.697AlaSer: 6.697 ± 0.081	6.07AlaThr: 6.07 ± 0.089	8.726AlaVal: 8.726 ± 0.099	2.091AlaTrp: 2.091 ± 0.053	2.407AlaTyr: 2.407 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.105CysAla: 1.105 ± 0.039	0.101CysCys: 0.101 ± 0.01	0.439CysAsp: 0.439 ± 0.023	0.443CysGlu: 0.443 ± 0.023	0.27CysPhe: 0.27 ± 0.015	0.888CysGly: 0.888 ± 0.036	0.254CysHis: 0.254 ± 0.023	0.335CysIle: 0.335 ± 0.018	0.206CysLys: 0.206 ± 0.013	0.835CysLeu: 0.835 ± 0.035	0.16CysMet: 0.16 ± 0.012	0.212CysAsn: 0.212 ± 0.013	0.421CysPro: 0.421 ± 0.021	0.297CysGln: 0.297 ± 0.019	0.581CysArg: 0.581 ± 0.026	0.472CysSer: 0.472 ± 0.023	0.472CysThr: 0.472 ± 0.022	0.618CysVal: 0.618 ± 0.027	0.126CysTrp: 0.126 ± 0.01	0.183CysTyr: 0.183 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.237AspAla: 8.237 ± 0.105	0.408AspCys: 0.408 ± 0.021	2.912AspAsp: 2.912 ± 0.055	2.823AspGlu: 2.823 ± 0.064	2.01AspPhe: 2.01 ± 0.052	5.312AspGly: 5.312 ± 0.096	1.212AspHis: 1.212 ± 0.036	2.283AspIle: 2.283 ± 0.054	1.454AspLys: 1.454 ± 0.049	5.735AspLeu: 5.735 ± 0.082	1.103AspMet: 1.103 ± 0.035	1.3AspAsn: 1.3 ± 0.037	3.718AspPro: 3.718 ± 0.062	2.287AspGln: 2.287 ± 0.051	3.805AspArg: 3.805 ± 0.06	2.329AspSer: 2.329 ± 0.051	2.819AspThr: 2.819 ± 0.056	3.714AspVal: 3.714 ± 0.058	1.05AspTrp: 1.05 ± 0.032	1.629AspTyr: 1.629 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.477GluAla: 6.477 ± 0.091	0.302GluCys: 0.302 ± 0.017	2.491GluAsp: 2.491 ± 0.054	2.37GluGlu: 2.37 ± 0.068	1.582GluPhe: 1.582 ± 0.042	3.908GluGly: 3.908 ± 0.061	1.45GluHis: 1.45 ± 0.043	2.246GluIle: 2.246 ± 0.058	1.492GluLys: 1.492 ± 0.046	6.137GluLeu: 6.137 ± 0.093	1.018GluMet: 1.018 ± 0.035	1.165GluAsn: 1.165 ± 0.036	2.484GluPro: 2.484 ± 0.053	2.781GluGln: 2.781 ± 0.058	4.617GluArg: 4.617 ± 0.089	2.264GluSer: 2.264 ± 0.056	2.431GluThr: 2.431 ± 0.06	3.996GluVal: 3.996 ± 0.076	0.596GluTrp: 0.596 ± 0.023	1.064GluTyr: 1.064 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.086PheAla: 4.086 ± 0.067	0.303PheCys: 0.303 ± 0.016	2.541PheAsp: 2.541 ± 0.055	1.892PheGlu: 1.892 ± 0.045	1.22PhePhe: 1.22 ± 0.042	3.322PheGly: 3.322 ± 0.065	0.741PheHis: 0.741 ± 0.027	1.298PheIle: 1.298 ± 0.04	0.911PheLys: 0.911 ± 0.031	2.986PheLeu: 2.986 ± 0.064	0.652PheMet: 0.652 ± 0.026	1.076PheAsn: 1.076 ± 0.035	1.436PhePro: 1.436 ± 0.038	1.088PheGln: 1.088 ± 0.038	1.998PheArg: 1.998 ± 0.055	1.891PheSer: 1.891 ± 0.046	1.762PheThr: 1.762 ± 0.04	2.411PheVal: 2.411 ± 0.051	0.495PheTrp: 0.495 ± 0.02	0.803PheTyr: 0.803 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.487GlyAla: 9.487 ± 0.108	0.785GlyCys: 0.785 ± 0.029	4.456GlyAsp: 4.456 ± 0.067	4.427GlyGlu: 4.427 ± 0.057	3.291GlyPhe: 3.291 ± 0.057	6.848GlyGly: 6.848 ± 0.116	2.172GlyHis: 2.172 ± 0.046	3.784GlyIle: 3.784 ± 0.073	2.96GlyLys: 2.96 ± 0.055	9.277GlyLeu: 9.277 ± 0.129	2.256GlyMet: 2.256 ± 0.047	2.263GlyAsn: 2.263 ± 0.056	3.331GlyPro: 3.331 ± 0.061	4.257GlyGln: 4.257 ± 0.072	6.364GlyArg: 6.364 ± 0.081	4.505GlySer: 4.505 ± 0.072	4.331GlyThr: 4.331 ± 0.073	6.359GlyVal: 6.359 ± 0.092	1.643GlyTrp: 1.643 ± 0.042	2.33GlyTyr: 2.33 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	3.203HisAla: 3.203 ± 0.058	0.252HisCys: 0.252 ± 0.017	1.346HisAsp: 1.346 ± 0.038	1.113HisGlu: 1.113 ± 0.034	0.828HisPhe: 0.828 ± 0.03	2.45HisGly: 2.45 ± 0.058	0.635HisHis: 0.635 ± 0.031	0.792HisIle: 0.792 ± 0.029	0.5HisLys: 0.5 ± 0.022	2.333HisLeu: 2.333 ± 0.054	0.467HisMet: 0.467 ± 0.023	0.497HisAsn: 0.497 ± 0.022	1.49HisPro: 1.49 ± 0.039	0.796HisGln: 0.796 ± 0.027	1.764HisArg: 1.764 ± 0.05	0.985HisSer: 0.985 ± 0.033	1.024HisThr: 1.024 ± 0.032	1.622HisVal: 1.622 ± 0.042	0.453HisTrp: 0.453 ± 0.022	0.671HisTyr: 0.671 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.387IleAla: 6.387 ± 0.085	0.345IleCys: 0.345 ± 0.021	3.061IleAsp: 3.061 ± 0.062	2.899IleGlu: 2.899 ± 0.064	1.117IlePhe: 1.117 ± 0.038	4.316IleGly: 4.316 ± 0.066	0.81IleHis: 0.81 ± 0.027	1.447IleIle: 1.447 ± 0.048	1.186IleLys: 1.186 ± 0.041	3.155IleLeu: 3.155 ± 0.067	0.543IleMet: 0.543 ± 0.023	1.24IleAsn: 1.24 ± 0.037	1.978IlePro: 1.978 ± 0.046	1.296IleGln: 1.296 ± 0.039	2.484IleArg: 2.484 ± 0.056	2.065IleSer: 2.065 ± 0.05	2.236IleThr: 2.236 ± 0.052	3.323IleVal: 3.323 ± 0.069	0.429IleTrp: 0.429 ± 0.021	0.827IleTyr: 0.827 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.419LysAla: 3.419 ± 0.07	0.126LysCys: 0.126 ± 0.01	1.416LysAsp: 1.416 ± 0.046	1.081LysGlu: 1.081 ± 0.049	0.707LysPhe: 0.707 ± 0.029	1.988LysGly: 1.988 ± 0.05	0.538LysHis: 0.538 ± 0.024	1.083LysIle: 1.083 ± 0.037	0.831LysLys: 0.831 ± 0.037	2.923LysLeu: 2.923 ± 0.058	0.581LysMet: 0.581 ± 0.024	0.609LysAsn: 0.609 ± 0.027	1.823LysPro: 1.823 ± 0.05	1.115LysGln: 1.115 ± 0.038	1.978LysArg: 1.978 ± 0.048	1.344LysSer: 1.344 ± 0.042	1.488LysThr: 1.488 ± 0.039	2.187LysVal: 2.187 ± 0.054	0.288LysTrp: 0.288 ± 0.018	0.597LysTyr: 0.597 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.848LeuAla: 15.848 ± 0.193	0.978LeuCys: 0.978 ± 0.034	6.924LeuAsp: 6.924 ± 0.103	5.824LeuGlu: 5.824 ± 0.095	3.392LeuPhe: 3.392 ± 0.086	8.938LeuGly: 8.938 ± 0.117	2.622LeuHis: 2.622 ± 0.043	4.197LeuIle: 4.197 ± 0.076	3.162LeuLys: 3.162 ± 0.065	12.251LeuLeu: 12.251 ± 0.175	2.166LeuMet: 2.166 ± 0.05	2.294LeuAsn: 2.294 ± 0.049	6.66LeuPro: 6.66 ± 0.082	4.55LeuGln: 4.55 ± 0.072	8.909LeuArg: 8.909 ± 0.112	6.016LeuSer: 6.016 ± 0.071	5.016LeuThr: 5.016 ± 0.07	8.169LeuVal: 8.169 ± 0.097	1.42LeuTrp: 1.42 ± 0.048	2.142LeuTyr: 2.142 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.911MetAla: 2.911 ± 0.058	0.148MetCys: 0.148 ± 0.012	1.101MetAsp: 1.101 ± 0.036	0.952MetGlu: 0.952 ± 0.035	0.621MetPhe: 0.621 ± 0.024	1.544MetGly: 1.544 ± 0.041	0.458MetHis: 0.458 ± 0.019	0.9MetIle: 0.9 ± 0.032	0.734MetLys: 0.734 ± 0.029	2.441MetLeu: 2.441 ± 0.053	0.435MetMet: 0.435 ± 0.024	0.638MetAsn: 0.638 ± 0.027	1.437MetPro: 1.437 ± 0.041	0.93MetGln: 0.93 ± 0.033	1.659MetArg: 1.659 ± 0.041	1.514MetSer: 1.514 ± 0.039	1.369MetThr: 1.369 ± 0.04	1.457MetVal: 1.457 ± 0.044	0.189MetTrp: 0.189 ± 0.014	0.33MetTyr: 0.33 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.154AsnAla: 3.154 ± 0.058	0.193AsnCys: 0.193 ± 0.014	1.275AsnAsp: 1.275 ± 0.039	0.996AsnGlu: 0.996 ± 0.037	0.833AsnPhe: 0.833 ± 0.031	2.092AsnGly: 2.092 ± 0.044	0.479AsnHis: 0.479 ± 0.019	1.03AsnIle: 1.03 ± 0.033	0.596AsnLys: 0.596 ± 0.029	2.448AsnLeu: 2.448 ± 0.055	0.405AsnMet: 0.405 ± 0.023	0.552AsnAsn: 0.552 ± 0.027	1.751AsnPro: 1.751 ± 0.051	0.834AsnGln: 0.834 ± 0.031	1.657AsnArg: 1.657 ± 0.043	1.017AsnSer: 1.017 ± 0.04	1.277AsnThr: 1.277 ± 0.036	1.813AsnVal: 1.813 ± 0.043	0.333AsnTrp: 0.333 ± 0.019	0.609AsnTyr: 0.609 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.95ProAla: 7.95 ± 0.119	0.348ProCys: 0.348 ± 0.019	3.578ProAsp: 3.578 ± 0.057	3.193ProGlu: 3.193 ± 0.051	1.613ProPhe: 1.613 ± 0.037	5.281ProGly: 5.281 ± 0.08	1.176ProHis: 1.176 ± 0.035	1.988ProIle: 1.988 ± 0.043	1.239ProLys: 1.239 ± 0.036	5.716ProLeu: 5.716 ± 0.084	1.287ProMet: 1.287 ± 0.039	1.124ProAsn: 1.124 ± 0.028	3.026ProPro: 3.026 ± 0.08	2.484ProGln: 2.484 ± 0.052	3.663ProArg: 3.663 ± 0.07	2.642ProSer: 2.642 ± 0.048	2.425ProThr: 2.425 ± 0.055	4.198ProVal: 4.198 ± 0.067	0.858ProTrp: 0.858 ± 0.029	1.185ProTyr: 1.185 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	7.41GlnAla: 7.41 ± 0.117	0.341GlnCys: 0.341 ± 0.02	2.081GlnAsp: 2.081 ± 0.048	1.576GlnGlu: 1.576 ± 0.043	1.285GlnPhe: 1.285 ± 0.035	3.227GlnGly: 3.227 ± 0.062	0.982GlnHis: 0.982 ± 0.031	1.85GlnIle: 1.85 ± 0.046	0.936GlnLys: 0.936 ± 0.034	4.823GlnLeu: 4.823 ± 0.081	0.921GlnMet: 0.921 ± 0.028	0.642GlnAsn: 0.642 ± 0.029	2.5GlnPro: 2.5 ± 0.055	2.171GlnGln: 2.171 ± 0.066	3.938GlnArg: 3.938 ± 0.071	1.821GlnSer: 1.821 ± 0.047	1.958GlnThr: 1.958 ± 0.051	3.871GlnVal: 3.871 ± 0.071	0.723GlnTrp: 0.723 ± 0.025	0.877GlnTyr: 0.877 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	9.05ArgAla: 9.05 ± 0.128	0.589ArgCys: 0.589 ± 0.025	4.114ArgAsp: 4.114 ± 0.068	4.21ArgGlu: 4.21 ± 0.069	2.945ArgPhe: 2.945 ± 0.05	5.393ArgGly: 5.393 ± 0.069	2.029ArgHis: 2.029 ± 0.054	3.734ArgIle: 3.734 ± 0.068	2.064ArgLys: 2.064 ± 0.058	8.799ArgLeu: 8.799 ± 0.127	1.932ArgMet: 1.932 ± 0.043	1.894ArgAsn: 1.894 ± 0.05	3.649ArgPro: 3.649 ± 0.063	3.861ArgGln: 3.861 ± 0.071	6.136ArgArg: 6.136 ± 0.101	3.792ArgSer: 3.792 ± 0.057	3.534ArgThr: 3.534 ± 0.067	5.322ArgVal: 5.322 ± 0.074	1.384ArgTrp: 1.384 ± 0.039	2.181ArgTyr: 2.181 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	6.423SerAla: 6.423 ± 0.101	0.407SerCys: 0.407 ± 0.021	2.696SerAsp: 2.696 ± 0.046	2.439SerGlu: 2.439 ± 0.047	1.775SerPhe: 1.775 ± 0.045	4.984SerGly: 4.984 ± 0.082	1.15SerHis: 1.15 ± 0.039	2.098SerIle: 2.098 ± 0.053	1.247SerLys: 1.247 ± 0.042	5.29SerLeu: 5.29 ± 0.071	1.092SerMet: 1.092 ± 0.038	1.376SerAsn: 1.376 ± 0.049	2.793SerPro: 2.793 ± 0.06	2.058SerGln: 2.058 ± 0.052	3.695SerArg: 3.695 ± 0.065	2.691SerSer: 2.691 ± 0.056	2.701SerThr: 2.701 ± 0.054	3.517SerVal: 3.517 ± 0.062	0.761SerTrp: 0.761 ± 0.027	1.281SerTyr: 1.281 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.846ThrAla: 5.846 ± 0.08	0.431ThrCys: 0.431 ± 0.024	2.472ThrAsp: 2.472 ± 0.044	2.215ThrGlu: 2.215 ± 0.051	1.566ThrPhe: 1.566 ± 0.039	4.725ThrGly: 4.725 ± 0.08	1.109ThrHis: 1.109 ± 0.034	2.004ThrIle: 2.004 ± 0.05	0.91ThrLys: 0.91 ± 0.03	6.422ThrLeu: 6.422 ± 0.087	0.873ThrMet: 0.873 ± 0.028	0.987ThrAsn: 0.987 ± 0.034	3.545ThrPro: 3.545 ± 0.067	1.691ThrGln: 1.691 ± 0.042	3.666ThrArg: 3.666 ± 0.069	2.353ThrSer: 2.353 ± 0.052	2.502ThrThr: 2.502 ± 0.062	3.824ThrVal: 3.824 ± 0.062	0.677ThrTrp: 0.677 ± 0.026	1.101ThrTyr: 1.101 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.256ValAla: 9.256 ± 0.099	0.734ValCys: 0.734 ± 0.029	4.155ValAsp: 4.155 ± 0.064	4.125ValGlu: 4.125 ± 0.069	2.534ValPhe: 2.534 ± 0.049	5.406ValGly: 5.406 ± 0.083	1.639ValHis: 1.639 ± 0.036	3.329ValIle: 3.329 ± 0.061	1.85ValLys: 1.85 ± 0.048	8.626ValLeu: 8.626 ± 0.097	1.65ValMet: 1.65 ± 0.046	1.779ValAsn: 1.779 ± 0.044	4.135ValPro: 4.135 ± 0.064	3.078ValGln: 3.078 ± 0.054	5.35ValArg: 5.35 ± 0.078	4.054ValSer: 4.054 ± 0.065	3.607ValThr: 3.607 ± 0.06	6.153ValVal: 6.153 ± 0.096	0.897ValTrp: 0.897 ± 0.03	1.478ValTyr: 1.478 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.305TrpAla: 1.305 ± 0.039	0.136TrpCys: 0.136 ± 0.011	0.729TrpAsp: 0.729 ± 0.028	0.57TrpGlu: 0.57 ± 0.025	0.572TrpPhe: 0.572 ± 0.026	0.895TrpGly: 0.895 ± 0.035	0.41TrpHis: 0.41 ± 0.021	0.713TrpIle: 0.713 ± 0.026	0.521TrpLys: 0.521 ± 0.025	2.284TrpLeu: 2.284 ± 0.061	0.411TrpMet: 0.411 ± 0.021	0.474TrpAsn: 0.474 ± 0.023	0.828TrpPro: 0.828 ± 0.029	0.768TrpGln: 0.768 ± 0.022	1.317TrpArg: 1.317 ± 0.042	0.837TrpSer: 0.837 ± 0.028	0.692TrpThr: 0.692 ± 0.023	0.967TrpVal: 0.967 ± 0.032	0.313TrpTrp: 0.313 ± 0.02	0.342TrpTyr: 0.342 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.791TyrAla: 2.791 ± 0.047	0.212TyrCys: 0.212 ± 0.017	1.365TyrAsp: 1.365 ± 0.039	1.078TyrGlu: 1.078 ± 0.029	0.832TyrPhe: 0.832 ± 0.029	2.049TyrGly: 2.049 ± 0.049	0.492TyrHis: 0.492 ± 0.021	0.745TyrIle: 0.745 ± 0.028	0.506TyrLys: 0.506 ± 0.024	2.487TyrLeu: 2.487 ± 0.054	0.399TyrMet: 0.399 ± 0.023	0.591TyrAsn: 0.591 ± 0.026	1.129TyrPro: 1.129 ± 0.036	0.975TyrGln: 0.975 ± 0.034	2.053TyrArg: 2.053 ± 0.048	1.181TyrSer: 1.181 ± 0.041	1.206TyrThr: 1.206 ± 0.04	1.586TyrVal: 1.586 ± 0.044	0.359TyrTrp: 0.359 ± 0.02	0.613TyrTyr: 0.613 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3147 proteins (1003021 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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