Amino acid dipepetide frequency for Bacteroides phage B124-14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.94AlaAla: 3.94 ± 0.774
0.968AlaCys: 0.968 ± 0.299
3.664AlaAsp: 3.664 ± 0.425
4.147AlaGlu: 4.147 ± 0.6
3.318AlaPhe: 3.318 ± 0.503
3.871AlaGly: 3.871 ± 0.632
0.484AlaHis: 0.484 ± 0.156
4.147AlaIle: 4.147 ± 0.536
5.322AlaLys: 5.322 ± 0.733
4.424AlaLeu: 4.424 ± 0.434
1.452AlaMet: 1.452 ± 0.381
4.355AlaAsn: 4.355 ± 0.818
0.968AlaPro: 0.968 ± 0.35
2.005AlaGln: 2.005 ± 0.44
2.005AlaArg: 2.005 ± 0.371
3.18AlaSer: 3.18 ± 0.542
3.249AlaThr: 3.249 ± 0.657
4.009AlaVal: 4.009 ± 0.967
0.76AlaTrp: 0.76 ± 0.223
2.212AlaTyr: 2.212 ± 0.38
0.0AlaXaa: 0.0 ± 0.0
Cys
0.829CysAla: 0.829 ± 0.283
0.622CysCys: 0.622 ± 0.259
1.313CysAsp: 1.313 ± 0.291
1.521CysGlu: 1.521 ± 0.492
0.691CysPhe: 0.691 ± 0.249
1.382CysGly: 1.382 ± 0.372
0.415CysHis: 0.415 ± 0.201
0.968CysIle: 0.968 ± 0.3
1.244CysLys: 1.244 ± 0.289
1.244CysLeu: 1.244 ± 0.393
0.276CysMet: 0.276 ± 0.17
0.968CysAsn: 0.968 ± 0.28
0.691CysPro: 0.691 ± 0.256
0.415CysGln: 0.415 ± 0.189
0.76CysArg: 0.76 ± 0.196
0.691CysSer: 0.691 ± 0.221
0.415CysThr: 0.415 ± 0.164
1.313CysVal: 1.313 ± 0.359
0.138CysTrp: 0.138 ± 0.119
0.968CysTyr: 0.968 ± 0.288
0.0CysXaa: 0.0 ± 0.0
Asp
2.281AspAla: 2.281 ± 0.493
1.106AspCys: 1.106 ± 0.296
2.834AspAsp: 2.834 ± 0.598
3.94AspGlu: 3.94 ± 0.585
2.488AspPhe: 2.488 ± 0.325
3.871AspGly: 3.871 ± 0.507
0.553AspHis: 0.553 ± 0.176
4.355AspIle: 4.355 ± 0.505
5.046AspLys: 5.046 ± 0.701
6.221AspLeu: 6.221 ± 0.761
1.244AspMet: 1.244 ± 0.292
3.594AspAsn: 3.594 ± 0.51
1.659AspPro: 1.659 ± 0.326
1.313AspGln: 1.313 ± 0.295
2.627AspArg: 2.627 ± 0.472
5.668AspSer: 5.668 ± 0.668
2.903AspThr: 2.903 ± 0.405
3.733AspVal: 3.733 ± 0.494
0.829AspTrp: 0.829 ± 0.198
2.419AspTyr: 2.419 ± 0.353
0.0AspXaa: 0.0 ± 0.0
Glu
5.253GluAla: 5.253 ± 0.708
0.968GluCys: 0.968 ± 0.279
3.318GluAsp: 3.318 ± 0.446
6.428GluGlu: 6.428 ± 0.886
3.456GluPhe: 3.456 ± 0.533
4.009GluGly: 4.009 ± 0.487
1.106GluHis: 1.106 ± 0.281
5.737GluIle: 5.737 ± 0.631
6.498GluLys: 6.498 ± 0.841
8.018GluLeu: 8.018 ± 0.838
2.35GluMet: 2.35 ± 0.454
4.216GluAsn: 4.216 ± 0.524
1.797GluPro: 1.797 ± 0.379
2.696GluGln: 2.696 ± 0.579
5.392GluArg: 5.392 ± 0.996
4.216GluSer: 4.216 ± 0.472
3.94GluThr: 3.94 ± 0.389
4.355GluVal: 4.355 ± 0.515
0.76GluTrp: 0.76 ± 0.208
3.871GluTyr: 3.871 ± 0.479
0.0GluXaa: 0.0 ± 0.0
Phe
3.802PheAla: 3.802 ± 0.486
0.691PheCys: 0.691 ± 0.232
2.488PheAsp: 2.488 ± 0.41
3.594PheGlu: 3.594 ± 0.522
1.382PhePhe: 1.382 ± 0.317
2.558PheGly: 2.558 ± 0.388
0.76PheHis: 0.76 ± 0.291
2.765PheIle: 2.765 ± 0.394
3.525PheLys: 3.525 ± 0.416
3.318PheLeu: 3.318 ± 0.47
1.175PheMet: 1.175 ± 0.34
3.456PheAsn: 3.456 ± 0.403
1.659PhePro: 1.659 ± 0.424
1.59PheGln: 1.59 ± 0.302
2.143PheArg: 2.143 ± 0.433
3.041PheSer: 3.041 ± 0.374
2.419PheThr: 2.419 ± 0.432
2.419PheVal: 2.419 ± 0.431
0.484PheTrp: 0.484 ± 0.208
1.521PheTyr: 1.521 ± 0.339
0.0PheXaa: 0.0 ± 0.0
Gly
3.111GlyAla: 3.111 ± 0.657
0.899GlyCys: 0.899 ± 0.262
4.7GlyAsp: 4.7 ± 0.511
4.977GlyGlu: 4.977 ± 0.578
3.387GlyPhe: 3.387 ± 0.502
4.355GlyGly: 4.355 ± 0.835
0.622GlyHis: 0.622 ± 0.225
3.802GlyIle: 3.802 ± 0.442
6.428GlyLys: 6.428 ± 0.626
3.456GlyLeu: 3.456 ± 0.422
1.382GlyMet: 1.382 ± 0.313
3.733GlyAsn: 3.733 ± 0.598
0.0GlyPro: 0.0 ± 0.0
1.935GlyGln: 1.935 ± 0.359
2.627GlyArg: 2.627 ± 0.522
4.424GlySer: 4.424 ± 0.489
3.318GlyThr: 3.318 ± 0.498
4.009GlyVal: 4.009 ± 0.616
0.76GlyTrp: 0.76 ± 0.215
2.972GlyTyr: 2.972 ± 0.416
0.0GlyXaa: 0.0 ± 0.0
His
0.346HisAla: 0.346 ± 0.133
0.415HisCys: 0.415 ± 0.186
1.313HisAsp: 1.313 ± 0.26
1.175HisGlu: 1.175 ± 0.279
0.622HisPhe: 0.622 ± 0.211
1.244HisGly: 1.244 ± 0.396
0.0HisHis: 0.0 ± 0.0
1.452HisIle: 1.452 ± 0.24
0.829HisLys: 0.829 ± 0.27
0.899HisLeu: 0.899 ± 0.214
0.415HisMet: 0.415 ± 0.161
1.037HisAsn: 1.037 ± 0.289
0.691HisPro: 0.691 ± 0.163
0.138HisGln: 0.138 ± 0.097
0.346HisArg: 0.346 ± 0.16
0.415HisSer: 0.415 ± 0.187
0.691HisThr: 0.691 ± 0.212
0.829HisVal: 0.829 ± 0.242
0.0HisTrp: 0.0 ± 0.0
0.622HisTyr: 0.622 ± 0.224
0.0HisXaa: 0.0 ± 0.0
Ile
4.216IleAla: 4.216 ± 0.465
1.659IleCys: 1.659 ± 0.333
5.875IleAsp: 5.875 ± 0.589
6.359IleGlu: 6.359 ± 0.581
2.35IlePhe: 2.35 ± 0.417
3.525IleGly: 3.525 ± 0.597
0.968IleHis: 0.968 ± 0.22
3.18IleIle: 3.18 ± 0.438
5.253IleLys: 5.253 ± 0.822
4.769IleLeu: 4.769 ± 0.561
1.59IleMet: 1.59 ± 0.313
4.009IleAsn: 4.009 ± 0.452
2.903IlePro: 2.903 ± 0.595
2.419IleGln: 2.419 ± 0.433
2.903IleArg: 2.903 ± 0.447
5.806IleSer: 5.806 ± 0.657
4.286IleThr: 4.286 ± 0.603
3.525IleVal: 3.525 ± 0.61
0.76IleTrp: 0.76 ± 0.199
2.488IleTyr: 2.488 ± 0.478
0.0IleXaa: 0.0 ± 0.0
Lys
5.806LysAla: 5.806 ± 0.765
1.175LysCys: 1.175 ± 0.358
4.424LysAsp: 4.424 ± 0.683
8.364LysGlu: 8.364 ± 1.152
3.387LysPhe: 3.387 ± 0.411
4.769LysGly: 4.769 ± 0.675
1.797LysHis: 1.797 ± 0.487
5.945LysIle: 5.945 ± 0.516
6.912LysLys: 6.912 ± 0.951
7.258LysLeu: 7.258 ± 0.824
2.35LysMet: 2.35 ± 0.525
3.94LysAsn: 3.94 ± 0.438
2.419LysPro: 2.419 ± 0.439
3.249LysGln: 3.249 ± 0.661
4.631LysArg: 4.631 ± 0.697
4.009LysSer: 4.009 ± 0.51
5.046LysThr: 5.046 ± 0.537
6.152LysVal: 6.152 ± 0.598
0.829LysTrp: 0.829 ± 0.294
4.631LysTyr: 4.631 ± 0.585
0.0LysXaa: 0.0 ± 0.0
Leu
4.355LeuAla: 4.355 ± 0.725
1.382LeuCys: 1.382 ± 0.377
4.562LeuAsp: 4.562 ± 0.619
4.216LeuGlu: 4.216 ± 0.723
2.972LeuPhe: 2.972 ± 0.541
3.733LeuGly: 3.733 ± 0.563
0.691LeuHis: 0.691 ± 0.218
5.737LeuIle: 5.737 ± 0.52
7.465LeuLys: 7.465 ± 0.995
6.014LeuLeu: 6.014 ± 0.631
2.005LeuMet: 2.005 ± 0.361
5.461LeuAsn: 5.461 ± 0.498
3.111LeuPro: 3.111 ± 0.505
2.419LeuGln: 2.419 ± 0.519
4.493LeuArg: 4.493 ± 0.563
7.88LeuSer: 7.88 ± 0.656
5.737LeuThr: 5.737 ± 0.683
4.562LeuVal: 4.562 ± 0.471
0.691LeuTrp: 0.691 ± 0.188
3.041LeuTyr: 3.041 ± 0.408
0.0LeuXaa: 0.0 ± 0.0
Met
1.106MetAla: 1.106 ± 0.285
0.553MetCys: 0.553 ± 0.208
0.899MetAsp: 0.899 ± 0.213
1.866MetGlu: 1.866 ± 0.387
0.76MetPhe: 0.76 ± 0.236
1.452MetGly: 1.452 ± 0.301
0.415MetHis: 0.415 ± 0.179
1.382MetIle: 1.382 ± 0.35
3.18MetLys: 3.18 ± 0.622
2.005MetLeu: 2.005 ± 0.315
0.415MetMet: 0.415 ± 0.14
2.005MetAsn: 2.005 ± 0.38
0.899MetPro: 0.899 ± 0.226
1.106MetGln: 1.106 ± 0.258
0.553MetArg: 0.553 ± 0.207
1.175MetSer: 1.175 ± 0.273
1.106MetThr: 1.106 ± 0.333
0.899MetVal: 0.899 ± 0.241
0.207MetTrp: 0.207 ± 0.116
1.521MetTyr: 1.521 ± 0.306
0.0MetXaa: 0.0 ± 0.0
Asn
3.594AsnAla: 3.594 ± 0.572
0.76AsnCys: 0.76 ± 0.213
3.387AsnAsp: 3.387 ± 0.468
5.115AsnGlu: 5.115 ± 0.647
2.696AsnPhe: 2.696 ± 0.465
4.078AsnGly: 4.078 ± 0.551
1.106AsnHis: 1.106 ± 0.289
3.802AsnIle: 3.802 ± 0.425
4.977AsnLys: 4.977 ± 0.621
4.562AsnLeu: 4.562 ± 0.487
1.244AsnMet: 1.244 ± 0.295
3.387AsnAsn: 3.387 ± 0.628
2.005AsnPro: 2.005 ± 0.371
1.866AsnGln: 1.866 ± 0.368
2.143AsnArg: 2.143 ± 0.357
3.664AsnSer: 3.664 ± 0.684
3.041AsnThr: 3.041 ± 0.452
3.871AsnVal: 3.871 ± 0.554
0.691AsnTrp: 0.691 ± 0.183
2.488AsnTyr: 2.488 ± 0.43
0.0AsnXaa: 0.0 ± 0.0
Pro
1.797ProAla: 1.797 ± 0.347
0.276ProCys: 0.276 ± 0.141
2.212ProAsp: 2.212 ± 0.37
2.972ProGlu: 2.972 ± 0.414
1.452ProPhe: 1.452 ± 0.291
1.797ProGly: 1.797 ± 0.447
0.346ProHis: 0.346 ± 0.163
2.35ProIle: 2.35 ± 0.469
2.419ProLys: 2.419 ± 0.423
2.143ProLeu: 2.143 ± 0.512
0.484ProMet: 0.484 ± 0.156
1.313ProAsn: 1.313 ± 0.263
0.76ProPro: 0.76 ± 0.341
0.899ProGln: 0.899 ± 0.279
0.691ProArg: 0.691 ± 0.257
1.797ProSer: 1.797 ± 0.337
2.005ProThr: 2.005 ± 0.547
2.005ProVal: 2.005 ± 0.345
0.069ProTrp: 0.069 ± 0.088
1.659ProTyr: 1.659 ± 0.335
0.0ProXaa: 0.0 ± 0.0
Gln
2.074GlnAla: 2.074 ± 0.627
0.276GlnCys: 0.276 ± 0.166
0.968GlnAsp: 0.968 ± 0.239
1.866GlnGlu: 1.866 ± 0.39
2.005GlnPhe: 2.005 ± 0.27
1.521GlnGly: 1.521 ± 0.391
0.138GlnHis: 0.138 ± 0.094
2.419GlnIle: 2.419 ± 0.484
4.009GlnLys: 4.009 ± 0.673
3.387GlnLeu: 3.387 ± 0.613
0.968GlnMet: 0.968 ± 0.265
2.005GlnAsn: 2.005 ± 0.264
1.106GlnPro: 1.106 ± 0.315
2.074GlnGln: 2.074 ± 0.531
1.521GlnArg: 1.521 ± 0.27
1.59GlnSer: 1.59 ± 0.367
2.143GlnThr: 2.143 ± 0.553
1.935GlnVal: 1.935 ± 0.427
0.415GlnTrp: 0.415 ± 0.142
1.59GlnTyr: 1.59 ± 0.317
0.0GlnXaa: 0.0 ± 0.0
Arg
2.212ArgAla: 2.212 ± 0.483
0.829ArgCys: 0.829 ± 0.254
2.834ArgAsp: 2.834 ± 0.506
3.664ArgGlu: 3.664 ± 0.606
2.972ArgPhe: 2.972 ± 0.507
2.488ArgGly: 2.488 ± 0.358
0.415ArgHis: 0.415 ± 0.13
3.94ArgIle: 3.94 ± 0.448
4.562ArgLys: 4.562 ± 0.724
4.424ArgLeu: 4.424 ± 0.529
0.829ArgMet: 0.829 ± 0.217
2.558ArgAsn: 2.558 ± 0.523
0.899ArgPro: 0.899 ± 0.233
1.244ArgGln: 1.244 ± 0.237
2.143ArgArg: 2.143 ± 0.423
3.111ArgSer: 3.111 ± 0.628
2.005ArgThr: 2.005 ± 0.329
3.111ArgVal: 3.111 ± 0.311
0.415ArgTrp: 0.415 ± 0.155
1.935ArgTyr: 1.935 ± 0.339
0.0ArgXaa: 0.0 ± 0.0
Ser
4.147SerAla: 4.147 ± 0.741
0.899SerCys: 0.899 ± 0.342
3.733SerAsp: 3.733 ± 0.435
5.599SerGlu: 5.599 ± 0.794
2.696SerPhe: 2.696 ± 0.488
4.977SerGly: 4.977 ± 0.856
0.691SerHis: 0.691 ± 0.197
4.769SerIle: 4.769 ± 0.494
4.7SerLys: 4.7 ± 0.565
5.115SerLeu: 5.115 ± 0.504
1.313SerMet: 1.313 ± 0.284
3.318SerAsn: 3.318 ± 0.494
2.35SerPro: 2.35 ± 0.537
2.281SerGln: 2.281 ± 0.47
2.627SerArg: 2.627 ± 0.429
3.041SerSer: 3.041 ± 0.489
3.456SerThr: 3.456 ± 0.426
4.839SerVal: 4.839 ± 0.575
0.484SerTrp: 0.484 ± 0.165
2.903SerTyr: 2.903 ± 0.412
0.0SerXaa: 0.0 ± 0.0
Thr
3.733ThrAla: 3.733 ± 0.919
0.899ThrCys: 0.899 ± 0.246
3.802ThrAsp: 3.802 ± 0.566
3.594ThrGlu: 3.594 ± 0.541
2.834ThrPhe: 2.834 ± 0.458
4.839ThrGly: 4.839 ± 0.801
1.106ThrHis: 1.106 ± 0.239
4.562ThrIle: 4.562 ± 0.607
4.769ThrLys: 4.769 ± 0.56
3.594ThrLeu: 3.594 ± 0.448
0.968ThrMet: 0.968 ± 0.23
2.212ThrAsn: 2.212 ± 0.347
2.143ThrPro: 2.143 ± 0.438
2.419ThrGln: 2.419 ± 0.388
2.212ThrArg: 2.212 ± 0.401
2.765ThrSer: 2.765 ± 0.542
2.972ThrThr: 2.972 ± 0.353
4.562ThrVal: 4.562 ± 0.65
0.553ThrTrp: 0.553 ± 0.226
2.005ThrTyr: 2.005 ± 0.329
0.0ThrXaa: 0.0 ± 0.0
Val
2.558ValAla: 2.558 ± 0.46
1.244ValCys: 1.244 ± 0.302
4.078ValAsp: 4.078 ± 0.712
5.253ValGlu: 5.253 ± 0.593
2.558ValPhe: 2.558 ± 0.513
3.456ValGly: 3.456 ± 0.558
0.968ValHis: 0.968 ± 0.209
3.594ValIle: 3.594 ± 0.501
6.29ValLys: 6.29 ± 0.517
5.115ValLeu: 5.115 ± 0.72
1.244ValMet: 1.244 ± 0.266
3.111ValAsn: 3.111 ± 0.436
2.143ValPro: 2.143 ± 0.354
1.59ValGln: 1.59 ± 0.321
3.525ValArg: 3.525 ± 0.363
4.839ValSer: 4.839 ± 0.448
4.216ValThr: 4.216 ± 0.54
3.594ValVal: 3.594 ± 0.476
0.484ValTrp: 0.484 ± 0.182
4.147ValTyr: 4.147 ± 0.59
0.0ValXaa: 0.0 ± 0.0
Trp
0.76TrpAla: 0.76 ± 0.232
0.276TrpCys: 0.276 ± 0.152
0.415TrpAsp: 0.415 ± 0.135
0.899TrpGlu: 0.899 ± 0.275
0.76TrpPhe: 0.76 ± 0.204
0.484TrpGly: 0.484 ± 0.154
0.138TrpHis: 0.138 ± 0.087
0.622TrpIle: 0.622 ± 0.187
0.76TrpLys: 0.76 ± 0.182
0.691TrpLeu: 0.691 ± 0.2
0.276TrpMet: 0.276 ± 0.152
0.691TrpAsn: 0.691 ± 0.182
0.0TrpPro: 0.0 ± 0.0
0.276TrpGln: 0.276 ± 0.122
0.691TrpArg: 0.691 ± 0.219
0.622TrpSer: 0.622 ± 0.227
0.276TrpThr: 0.276 ± 0.121
0.829TrpVal: 0.829 ± 0.318
0.0TrpTrp: 0.0 ± 0.0
0.415TrpTyr: 0.415 ± 0.122
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.558TyrAla: 2.558 ± 0.381
0.968TyrCys: 0.968 ± 0.313
1.866TyrAsp: 1.866 ± 0.334
2.834TyrGlu: 2.834 ± 0.342
2.005TyrPhe: 2.005 ± 0.364
2.488TyrGly: 2.488 ± 0.313
0.76TyrHis: 0.76 ± 0.227
3.318TyrIle: 3.318 ± 0.398
2.972TyrLys: 2.972 ± 0.444
3.871TyrLeu: 3.871 ± 0.486
1.452TyrMet: 1.452 ± 0.408
3.111TyrAsn: 3.111 ± 0.307
1.244TyrPro: 1.244 ± 0.242
2.074TyrGln: 2.074 ± 0.279
2.558TyrArg: 2.558 ± 0.54
2.005TyrSer: 2.005 ± 0.382
3.318TyrThr: 3.318 ± 0.573
3.456TyrVal: 3.456 ± 0.601
0.553TyrTrp: 0.553 ± 0.195
2.143TyrTyr: 2.143 ± 0.392
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (14468 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski