Amino acid dipepetide frequency for Mycolicibacterium cosmeticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.993AlaAla: 21.993 ± 0.166	0.982AlaCys: 0.982 ± 0.022	9.0AlaAsp: 9.0 ± 0.07	7.781AlaGlu: 7.781 ± 0.079	3.578AlaPhe: 3.578 ± 0.042	12.748AlaGly: 12.748 ± 0.099	2.819AlaHis: 2.819 ± 0.042	5.302AlaIle: 5.302 ± 0.064	2.895AlaLys: 2.895 ± 0.052	13.79AlaLeu: 13.79 ± 0.103	2.87AlaMet: 2.87 ± 0.037	2.452AlaAsn: 2.452 ± 0.043	6.876AlaPro: 6.876 ± 0.088	4.203AlaGln: 4.203 ± 0.055	8.668AlaArg: 8.668 ± 0.079	5.648AlaSer: 5.648 ± 0.052	7.685AlaThr: 7.685 ± 0.068	12.641AlaVal: 12.641 ± 0.106	1.607AlaTrp: 1.607 ± 0.029	2.385AlaTyr: 2.385 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.134CysAla: 1.134 ± 0.027	0.082CysCys: 0.082 ± 0.007	0.492CysAsp: 0.492 ± 0.017	0.347CysGlu: 0.347 ± 0.014	0.207CysPhe: 0.207 ± 0.01	0.897CysGly: 0.897 ± 0.025	0.189CysHis: 0.189 ± 0.011	0.256CysIle: 0.256 ± 0.012	0.109CysLys: 0.109 ± 0.007	0.638CysLeu: 0.638 ± 0.02	0.126CysMet: 0.126 ± 0.009	0.164CysAsn: 0.164 ± 0.009	0.492CysPro: 0.492 ± 0.02	0.195CysGln: 0.195 ± 0.011	0.579CysArg: 0.579 ± 0.018	0.449CysSer: 0.449 ± 0.016	0.503CysThr: 0.503 ± 0.016	0.631CysVal: 0.631 ± 0.018	0.119CysTrp: 0.119 ± 0.008	0.186CysTyr: 0.186 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.954AspAla: 7.954 ± 0.068	0.423AspCys: 0.423 ± 0.016	4.107AspAsp: 4.107 ± 0.055	3.803AspGlu: 3.803 ± 0.051	1.79AspPhe: 1.79 ± 0.028	6.095AspGly: 6.095 ± 0.058	1.415AspHis: 1.415 ± 0.029	2.84AspIle: 2.84 ± 0.043	1.294AspLys: 1.294 ± 0.03	5.992AspLeu: 5.992 ± 0.057	0.985AspMet: 0.985 ± 0.023	1.254AspAsn: 1.254 ± 0.027	4.396AspPro: 4.396 ± 0.047	1.664AspGln: 1.664 ± 0.029	4.623AspArg: 4.623 ± 0.048	2.536AspSer: 2.536 ± 0.037	3.55AspThr: 3.55 ± 0.044	5.164AspVal: 5.164 ± 0.054	1.003AspTrp: 1.003 ± 0.024	1.447AspTyr: 1.447 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	5.794GluAla: 5.794 ± 0.068	0.327GluCys: 0.327 ± 0.015	2.231GluAsp: 2.231 ± 0.04	2.175GluGlu: 2.175 ± 0.035	1.791GluPhe: 1.791 ± 0.033	3.033GluGly: 3.033 ± 0.045	1.55GluHis: 1.55 ± 0.027	2.487GluIle: 2.487 ± 0.04	1.201GluLys: 1.201 ± 0.029	6.377GluLeu: 6.377 ± 0.066	0.967GluMet: 0.967 ± 0.021	1.036GluAsn: 1.036 ± 0.024	2.967GluPro: 2.967 ± 0.047	2.081GluGln: 2.081 ± 0.033	4.156GluArg: 4.156 ± 0.054	2.475GluSer: 2.475 ± 0.037	2.565GluThr: 2.565 ± 0.036	4.294GluVal: 4.294 ± 0.05	0.69GluTrp: 0.69 ± 0.019	1.1GluTyr: 1.1 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.138PheAla: 4.138 ± 0.047	0.31PheCys: 0.31 ± 0.012	2.464PheAsp: 2.464 ± 0.037	1.48PheGlu: 1.48 ± 0.031	1.02PhePhe: 1.02 ± 0.029	3.601PheGly: 3.601 ± 0.049	0.669PheHis: 0.669 ± 0.018	1.118PheIle: 1.118 ± 0.027	0.527PheLys: 0.527 ± 0.016	2.615PheLeu: 2.615 ± 0.04	0.488PheMet: 0.488 ± 0.017	0.726PheAsn: 0.726 ± 0.02	1.423PhePro: 1.423 ± 0.027	0.679PheGln: 0.679 ± 0.018	1.652PheArg: 1.652 ± 0.028	1.585PheSer: 1.585 ± 0.027	2.253PheThr: 2.253 ± 0.038	2.641PheVal: 2.641 ± 0.039	0.44PheTrp: 0.44 ± 0.014	0.72PheTyr: 0.72 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.924GlyAla: 10.924 ± 0.093	0.793GlyCys: 0.793 ± 0.02	5.013GlyAsp: 5.013 ± 0.066	4.153GlyGlu: 4.153 ± 0.045	3.124GlyPhe: 3.124 ± 0.043	7.821GlyGly: 7.821 ± 0.09	2.123GlyHis: 2.123 ± 0.035	4.282GlyIle: 4.282 ± 0.051	2.213GlyLys: 2.213 ± 0.042	8.846GlyLeu: 8.846 ± 0.075	2.063GlyMet: 2.063 ± 0.035	1.964GlyAsn: 1.964 ± 0.036	4.667GlyPro: 4.667 ± 0.051	2.795GlyGln: 2.795 ± 0.042	6.328GlyArg: 6.328 ± 0.059	5.021GlySer: 5.021 ± 0.058	5.756GlyThr: 5.756 ± 0.052	7.802GlyVal: 7.802 ± 0.06	1.654GlyTrp: 1.654 ± 0.033	2.477GlyTyr: 2.477 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.556HisAla: 2.556 ± 0.029	0.226HisCys: 0.226 ± 0.011	1.413HisAsp: 1.413 ± 0.03	1.037HisGlu: 1.037 ± 0.026	0.667HisPhe: 0.667 ± 0.017	2.247HisGly: 2.247 ± 0.035	0.72HisHis: 0.72 ± 0.021	0.891HisIle: 0.891 ± 0.022	0.348HisLys: 0.348 ± 0.013	2.248HisLeu: 2.248 ± 0.033	0.347HisMet: 0.347 ± 0.013	0.477HisAsn: 0.477 ± 0.015	1.713HisPro: 1.713 ± 0.03	0.631HisGln: 0.631 ± 0.019	1.969HisArg: 1.969 ± 0.03	1.049HisSer: 1.049 ± 0.021	1.352HisThr: 1.352 ± 0.029	1.722HisVal: 1.722 ± 0.032	0.386HisTrp: 0.386 ± 0.015	0.55HisTyr: 0.55 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.713IleAla: 6.713 ± 0.069	0.393IleCys: 0.393 ± 0.014	3.301IleAsp: 3.301 ± 0.048	2.454IleGlu: 2.454 ± 0.036	1.073IlePhe: 1.073 ± 0.021	4.768IleGly: 4.768 ± 0.049	0.753IleHis: 0.753 ± 0.021	1.519IleIle: 1.519 ± 0.031	0.894IleLys: 0.894 ± 0.024	3.103IleLeu: 3.103 ± 0.049	0.576IleMet: 0.576 ± 0.017	1.108IleAsn: 1.108 ± 0.028	2.386IlePro: 2.386 ± 0.039	0.9IleGln: 0.9 ± 0.023	2.654IleArg: 2.654 ± 0.037	2.184IleSer: 2.184 ± 0.03	2.999IleThr: 2.999 ± 0.037	3.771IleVal: 3.771 ± 0.049	0.479IleTrp: 0.479 ± 0.014	0.765IleTyr: 0.765 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.704LysAla: 2.704 ± 0.048	0.104LysCys: 0.104 ± 0.007	1.096LysAsp: 1.096 ± 0.029	0.903LysGlu: 0.903 ± 0.027	0.616LysPhe: 0.616 ± 0.022	1.528LysGly: 1.528 ± 0.03	0.465LysHis: 0.465 ± 0.015	0.996LysIle: 0.996 ± 0.024	0.63LysLys: 0.63 ± 0.024	2.164LysLeu: 2.164 ± 0.037	0.455LysMet: 0.455 ± 0.017	0.491LysAsn: 0.491 ± 0.016	1.447LysPro: 1.447 ± 0.033	0.698LysGln: 0.698 ± 0.021	1.507LysArg: 1.507 ± 0.028	1.129LysSer: 1.129 ± 0.024	1.332LysThr: 1.332 ± 0.027	1.889LysVal: 1.889 ± 0.038	0.283LysTrp: 0.283 ± 0.013	0.455LysTyr: 0.455 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.669LeuAla: 14.669 ± 0.101	0.793LeuCys: 0.793 ± 0.022	6.632LeuAsp: 6.632 ± 0.064	4.111LeuGlu: 4.111 ± 0.054	2.76LeuPhe: 2.76 ± 0.041	8.928LeuGly: 8.928 ± 0.075	2.149LeuHis: 2.149 ± 0.033	4.174LeuIle: 4.174 ± 0.053	1.801LeuLys: 1.801 ± 0.035	9.929LeuLeu: 9.929 ± 0.098	1.697LeuMet: 1.697 ± 0.031	2.066LeuAsn: 2.066 ± 0.034	5.861LeuPro: 5.861 ± 0.059	2.582LeuGln: 2.582 ± 0.042	7.524LeuArg: 7.524 ± 0.075	5.568LeuSer: 5.568 ± 0.058	6.696LeuThr: 6.696 ± 0.056	8.566LeuVal: 8.566 ± 0.076	1.194LeuTrp: 1.194 ± 0.025	1.713LeuTyr: 1.713 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.496MetAla: 2.496 ± 0.037	0.181MetCys: 0.181 ± 0.01	0.845MetAsp: 0.845 ± 0.021	0.641MetGlu: 0.641 ± 0.02	0.611MetPhe: 0.611 ± 0.016	1.416MetGly: 1.416 ± 0.025	0.403MetHis: 0.403 ± 0.014	0.895MetIle: 0.895 ± 0.023	0.448MetLys: 0.448 ± 0.015	1.964MetLeu: 1.964 ± 0.034	0.389MetMet: 0.389 ± 0.015	0.494MetAsn: 0.494 ± 0.015	1.132MetPro: 1.132 ± 0.024	0.531MetGln: 0.531 ± 0.017	1.467MetArg: 1.467 ± 0.025	1.535MetSer: 1.535 ± 0.026	1.878MetThr: 1.878 ± 0.029	1.618MetVal: 1.618 ± 0.032	0.234MetTrp: 0.234 ± 0.013	0.347MetTyr: 0.347 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.656AsnAla: 2.656 ± 0.04	0.188AsnCys: 0.188 ± 0.01	1.14AsnAsp: 1.14 ± 0.024	0.903AsnGlu: 0.903 ± 0.021	0.643AsnPhe: 0.643 ± 0.021	2.071AsnGly: 2.071 ± 0.044	0.469AsnHis: 0.469 ± 0.016	0.956AsnIle: 0.956 ± 0.022	0.457AsnLys: 0.457 ± 0.016	2.044AsnLeu: 2.044 ± 0.03	0.41AsnMet: 0.41 ± 0.014	0.551AsnAsn: 0.551 ± 0.017	1.733AsnPro: 1.733 ± 0.031	0.652AsnGln: 0.652 ± 0.017	1.453AsnArg: 1.453 ± 0.032	1.084AsnSer: 1.084 ± 0.025	1.338AsnThr: 1.338 ± 0.03	1.772AsnVal: 1.772 ± 0.03	0.371AsnTrp: 0.371 ± 0.014	0.545AsnTyr: 0.545 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.146ProAla: 8.146 ± 0.089	0.303ProCys: 0.303 ± 0.015	4.49ProAsp: 4.49 ± 0.047	3.55ProGlu: 3.55 ± 0.043	1.626ProPhe: 1.626 ± 0.026	5.812ProGly: 5.812 ± 0.066	1.277ProHis: 1.277 ± 0.025	2.139ProIle: 2.139 ± 0.036	1.216ProLys: 1.216 ± 0.03	5.025ProLeu: 5.025 ± 0.049	1.174ProMet: 1.174 ± 0.025	1.216ProAsn: 1.216 ± 0.026	3.538ProPro: 3.538 ± 0.081	1.803ProGln: 1.803 ± 0.032	3.318ProArg: 3.318 ± 0.047	2.88ProSer: 2.88 ± 0.037	3.479ProThr: 3.479 ± 0.049	5.354ProVal: 5.354 ± 0.063	0.862ProTrp: 0.862 ± 0.023	1.189ProTyr: 1.189 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.715GlnAla: 3.715 ± 0.049	0.199GlnCys: 0.199 ± 0.01	1.253GlnAsp: 1.253 ± 0.026	1.089GlnGlu: 1.089 ± 0.024	1.007GlnPhe: 1.007 ± 0.021	2.003GlnGly: 2.003 ± 0.037	0.752GlnHis: 0.752 ± 0.021	1.498GlnIle: 1.498 ± 0.031	0.618GlnLys: 0.618 ± 0.02	3.347GlnLeu: 3.347 ± 0.047	0.642GlnMet: 0.642 ± 0.019	0.639GlnAsn: 0.639 ± 0.021	1.843GlnPro: 1.843 ± 0.038	1.255GlnGln: 1.255 ± 0.033	2.77GlnArg: 2.77 ± 0.039	1.392GlnSer: 1.392 ± 0.026	1.642GlnThr: 1.642 ± 0.032	2.502GlnVal: 2.502 ± 0.037	0.59GlnTrp: 0.59 ± 0.019	0.639GlnTyr: 0.639 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.574ArgAla: 8.574 ± 0.091	0.541ArgCys: 0.541 ± 0.019	4.144ArgAsp: 4.144 ± 0.048	3.574ArgGlu: 3.574 ± 0.042	2.376ArgPhe: 2.376 ± 0.037	5.029ArgGly: 5.029 ± 0.052	1.843ArgHis: 1.843 ± 0.034	3.456ArgIle: 3.456 ± 0.044	1.524ArgLys: 1.524 ± 0.032	7.373ArgLeu: 7.373 ± 0.079	1.709ArgMet: 1.709 ± 0.031	1.603ArgAsn: 1.603 ± 0.03	3.917ArgPro: 3.917 ± 0.05	2.234ArgGln: 2.234 ± 0.036	6.395ArgArg: 6.395 ± 0.071	3.872ArgSer: 3.872 ± 0.049	4.304ArgThr: 4.304 ± 0.051	5.538ArgVal: 5.538 ± 0.056	1.325ArgTrp: 1.325 ± 0.026	1.894ArgTyr: 1.894 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.973SerAla: 6.973 ± 0.069	0.392SerCys: 0.392 ± 0.015	2.892SerAsp: 2.892 ± 0.044	2.259SerGlu: 2.259 ± 0.038	1.664SerPhe: 1.664 ± 0.031	5.346SerGly: 5.346 ± 0.059	1.005SerHis: 1.005 ± 0.021	2.073SerIle: 2.073 ± 0.034	1.055SerLys: 1.055 ± 0.024	4.48SerLeu: 4.48 ± 0.047	1.271SerMet: 1.271 ± 0.024	1.067SerAsn: 1.067 ± 0.025	2.883SerPro: 2.883 ± 0.041	1.391SerGln: 1.391 ± 0.03	3.423SerArg: 3.423 ± 0.038	2.868SerSer: 2.868 ± 0.048	3.404SerThr: 3.404 ± 0.051	4.498SerVal: 4.498 ± 0.05	0.908SerTrp: 0.908 ± 0.021	1.166SerTyr: 1.166 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.761ThrAla: 8.761 ± 0.067	0.41ThrCys: 0.41 ± 0.015	3.953ThrAsp: 3.953 ± 0.047	3.229ThrGlu: 3.229 ± 0.047	1.947ThrPhe: 1.947 ± 0.032	6.315ThrGly: 6.315 ± 0.071	1.219ThrHis: 1.219 ± 0.027	2.479ThrIle: 2.479 ± 0.045	1.337ThrLys: 1.337 ± 0.034	5.784ThrLeu: 5.784 ± 0.055	1.206ThrMet: 1.206 ± 0.025	1.218ThrAsn: 1.218 ± 0.029	4.067ThrPro: 4.067 ± 0.045	1.498ThrGln: 1.498 ± 0.03	3.661ThrArg: 3.661 ± 0.042	3.192ThrSer: 3.192 ± 0.054	4.103ThrThr: 4.103 ± 0.075	6.503ThrVal: 6.503 ± 0.059	0.846ThrTrp: 0.846 ± 0.022	1.31ThrTyr: 1.31 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.911ValAla: 11.911 ± 0.099	0.766ValCys: 0.766 ± 0.018	5.695ValAsp: 5.695 ± 0.059	4.216ValGlu: 4.216 ± 0.047	2.745ValPhe: 2.745 ± 0.04	7.098ValGly: 7.098 ± 0.06	1.902ValHis: 1.902 ± 0.036	4.071ValIle: 4.071 ± 0.049	1.625ValLys: 1.625 ± 0.032	9.521ValLeu: 9.521 ± 0.082	1.546ValMet: 1.546 ± 0.031	2.012ValAsn: 2.012 ± 0.03	4.92ValPro: 4.92 ± 0.045	2.266ValGln: 2.266 ± 0.033	6.007ValArg: 6.007 ± 0.066	4.614ValSer: 4.614 ± 0.05	6.009ValThr: 6.009 ± 0.068	8.67ValVal: 8.67 ± 0.085	1.11ValTrp: 1.11 ± 0.024	1.687ValTyr: 1.687 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.585TrpAla: 1.585 ± 0.029	0.148TrpCys: 0.148 ± 0.008	0.782TrpAsp: 0.782 ± 0.022	0.611TrpGlu: 0.611 ± 0.018	0.531TrpPhe: 0.531 ± 0.018	1.0TrpGly: 1.0 ± 0.025	0.368TrpHis: 0.368 ± 0.014	0.676TrpIle: 0.676 ± 0.025	0.32TrpLys: 0.32 ± 0.012	1.733TrpLeu: 1.733 ± 0.033	0.316TrpMet: 0.316 ± 0.014	0.408TrpAsn: 0.408 ± 0.014	0.851TrpPro: 0.851 ± 0.02	0.621TrpGln: 0.621 ± 0.019	1.21TrpArg: 1.21 ± 0.026	0.894TrpSer: 0.894 ± 0.021	0.916TrpThr: 0.916 ± 0.023	1.15TrpVal: 1.15 ± 0.026	0.34TrpTrp: 0.34 ± 0.013	0.327TrpTyr: 0.327 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.527TyrAla: 2.527 ± 0.036	0.231TyrCys: 0.231 ± 0.012	1.393TyrAsp: 1.393 ± 0.027	0.98TyrGlu: 0.98 ± 0.022	0.771TyrPhe: 0.771 ± 0.02	2.064TyrGly: 2.064 ± 0.03	0.461TyrHis: 0.461 ± 0.015	0.685TyrIle: 0.685 ± 0.018	0.38TyrLys: 0.38 ± 0.014	2.438TyrLeu: 2.438 ± 0.037	0.285TyrMet: 0.285 ± 0.013	0.488TyrAsn: 0.488 ± 0.017	1.285TyrPro: 1.285 ± 0.028	0.719TyrGln: 0.719 ± 0.021	1.861TyrArg: 1.861 ± 0.032	1.043TyrSer: 1.043 ± 0.021	1.275TyrThr: 1.275 ± 0.029	1.667TyrVal: 1.667 ± 0.027	0.35TyrTrp: 0.35 ± 0.014	0.519TyrTyr: 0.519 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6271 proteins (1990871 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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