Amino acid dipepetide frequency for Shimia thalassica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.868AlaAla: 12.868 ± 0.135	0.981AlaCys: 0.981 ± 0.03	6.703AlaAsp: 6.703 ± 0.101	7.128AlaGlu: 7.128 ± 0.089	4.277AlaPhe: 4.277 ± 0.067	9.388AlaGly: 9.388 ± 0.154	2.186AlaHis: 2.186 ± 0.039	5.645AlaIle: 5.645 ± 0.077	4.209AlaLys: 4.209 ± 0.069	11.667AlaLeu: 11.667 ± 0.135	3.462AlaMet: 3.462 ± 0.054	3.093AlaAsn: 3.093 ± 0.061	4.936AlaPro: 4.936 ± 0.081	4.041AlaGln: 4.041 ± 0.063	6.641AlaArg: 6.641 ± 0.092	5.778AlaSer: 5.778 ± 0.09	5.741AlaThr: 5.741 ± 0.076	7.554AlaVal: 7.554 ± 0.094	1.243AlaTrp: 1.243 ± 0.031	2.467AlaTyr: 2.467 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.003CysAla: 1.003 ± 0.032	0.11CysCys: 0.11 ± 0.01	0.612CysAsp: 0.612 ± 0.022	0.482CysGlu: 0.482 ± 0.018	0.368CysPhe: 0.368 ± 0.016	0.909CysGly: 0.909 ± 0.029	0.282CysHis: 0.282 ± 0.018	0.405CysIle: 0.405 ± 0.02	0.268CysLys: 0.268 ± 0.016	0.852CysLeu: 0.852 ± 0.03	0.181CysMet: 0.181 ± 0.012	0.269CysAsn: 0.269 ± 0.014	0.476CysPro: 0.476 ± 0.019	0.256CysGln: 0.256 ± 0.013	0.479CysArg: 0.479 ± 0.021	0.505CysSer: 0.505 ± 0.018	0.437CysThr: 0.437 ± 0.02	0.634CysVal: 0.634 ± 0.024	0.107CysTrp: 0.107 ± 0.009	0.231CysTyr: 0.231 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.055AspAla: 7.055 ± 0.088	0.538AspCys: 0.538 ± 0.019	4.015AspAsp: 4.015 ± 0.128	3.726AspGlu: 3.726 ± 0.062	2.574AspPhe: 2.574 ± 0.05	5.948AspGly: 5.948 ± 0.151	1.426AspHis: 1.426 ± 0.035	3.635AspIle: 3.635 ± 0.055	1.944AspLys: 1.944 ± 0.04	6.793AspLeu: 6.793 ± 0.116	1.873AspMet: 1.873 ± 0.037	1.696AspAsn: 1.696 ± 0.046	3.28AspPro: 3.28 ± 0.061	2.124AspGln: 2.124 ± 0.042	3.661AspArg: 3.661 ± 0.054	2.607AspSer: 2.607 ± 0.063	3.83AspThr: 3.83 ± 0.136	4.959AspVal: 4.959 ± 0.081	1.136AspTrp: 1.136 ± 0.029	1.637AspTyr: 1.637 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.284GluAla: 7.284 ± 0.092	0.402GluCys: 0.402 ± 0.02	3.859GluAsp: 3.859 ± 0.054	3.727GluGlu: 3.727 ± 0.078	1.994GluPhe: 1.994 ± 0.046	4.966GluGly: 4.966 ± 0.073	1.186GluHis: 1.186 ± 0.032	3.835GluIle: 3.835 ± 0.056	2.576GluLys: 2.576 ± 0.057	5.139GluLeu: 5.139 ± 0.067	1.963GluMet: 1.963 ± 0.045	2.28GluAsn: 2.28 ± 0.049	2.24GluPro: 2.24 ± 0.042	2.144GluGln: 2.144 ± 0.044	3.794GluArg: 3.794 ± 0.057	2.494GluSer: 2.494 ± 0.048	4.234GluThr: 4.234 ± 0.068	4.264GluVal: 4.264 ± 0.066	0.739GluTrp: 0.739 ± 0.023	1.188GluTyr: 1.188 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.398PheAla: 4.398 ± 0.064	0.491PheCys: 0.491 ± 0.022	3.135PheAsp: 3.135 ± 0.059	2.538PheGlu: 2.538 ± 0.05	1.639PhePhe: 1.639 ± 0.043	4.136PheGly: 4.136 ± 0.079	0.848PheHis: 0.848 ± 0.026	1.693PheIle: 1.693 ± 0.039	1.179PheLys: 1.179 ± 0.03	3.644PheLeu: 3.644 ± 0.068	0.959PheMet: 0.959 ± 0.029	1.181PheAsn: 1.181 ± 0.033	1.591PhePro: 1.591 ± 0.041	1.209PheGln: 1.209 ± 0.027	2.006PheArg: 2.006 ± 0.042	2.518PheSer: 2.518 ± 0.043	2.106PheThr: 2.106 ± 0.044	3.042PheVal: 3.042 ± 0.049	0.602PheTrp: 0.602 ± 0.024	1.035PheTyr: 1.035 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.157GlyAla: 9.157 ± 0.165	0.822GlyCys: 0.822 ± 0.029	5.571GlyAsp: 5.571 ± 0.189	4.722GlyGlu: 4.722 ± 0.064	3.869GlyPhe: 3.869 ± 0.063	8.023GlyGly: 8.023 ± 0.249	1.942GlyHis: 1.942 ± 0.041	4.559GlyIle: 4.559 ± 0.062	3.403GlyLys: 3.403 ± 0.065	8.544GlyLeu: 8.544 ± 0.086	2.638GlyMet: 2.638 ± 0.051	2.845GlyAsn: 2.845 ± 0.122	3.316GlyPro: 3.316 ± 0.059	3.095GlyGln: 3.095 ± 0.05	4.785GlyArg: 4.785 ± 0.061	4.614GlySer: 4.614 ± 0.121	4.882GlyThr: 4.882 ± 0.093	6.559GlyVal: 6.559 ± 0.076	1.427GlyTrp: 1.427 ± 0.033	2.388GlyTyr: 2.388 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.158HisAla: 2.158 ± 0.042	0.238HisCys: 0.238 ± 0.014	1.368HisAsp: 1.368 ± 0.032	1.067HisGlu: 1.067 ± 0.031	0.932HisPhe: 0.932 ± 0.028	1.873HisGly: 1.873 ± 0.04	0.549HisHis: 0.549 ± 0.022	1.092HisIle: 1.092 ± 0.028	0.68HisLys: 0.68 ± 0.023	2.121HisLeu: 2.121 ± 0.043	0.632HisMet: 0.632 ± 0.022	0.575HisAsn: 0.575 ± 0.019	1.295HisPro: 1.295 ± 0.038	0.638HisGln: 0.638 ± 0.02	1.185HisArg: 1.185 ± 0.034	1.084HisSer: 1.084 ± 0.029	0.953HisThr: 0.953 ± 0.026	1.585HisVal: 1.585 ± 0.034	0.346HisTrp: 0.346 ± 0.016	0.57HisTyr: 0.57 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.466IleAla: 6.466 ± 0.076	0.612IleCys: 0.612 ± 0.022	3.531IleAsp: 3.531 ± 0.064	3.784IleGlu: 3.784 ± 0.048	1.929IlePhe: 1.929 ± 0.042	4.94IleGly: 4.94 ± 0.076	1.027IleHis: 1.027 ± 0.027	2.362IleIle: 2.362 ± 0.051	1.743IleLys: 1.743 ± 0.041	4.937IleLeu: 4.937 ± 0.067	1.152IleMet: 1.152 ± 0.031	1.597IleAsn: 1.597 ± 0.039	2.288IlePro: 2.288 ± 0.05	1.427IleGln: 1.427 ± 0.03	2.964IleArg: 2.964 ± 0.046	3.447IleSer: 3.447 ± 0.043	3.026IleThr: 3.026 ± 0.059	3.887IleVal: 3.887 ± 0.057	0.776IleTrp: 0.776 ± 0.026	1.2IleTyr: 1.2 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.176LysAla: 4.176 ± 0.074	0.233LysCys: 0.233 ± 0.014	2.2LysAsp: 2.2 ± 0.043	2.031LysGlu: 2.031 ± 0.049	1.168LysPhe: 1.168 ± 0.032	3.147LysGly: 3.147 ± 0.056	0.74LysHis: 0.74 ± 0.025	1.932LysIle: 1.932 ± 0.045	1.542LysLys: 1.542 ± 0.048	3.279LysLeu: 3.279 ± 0.061	1.073LysMet: 1.073 ± 0.033	1.101LysAsn: 1.101 ± 0.03	1.919LysPro: 1.919 ± 0.042	1.19LysGln: 1.19 ± 0.035	2.403LysArg: 2.403 ± 0.047	2.156LysSer: 2.156 ± 0.041	2.316LysThr: 2.316 ± 0.044	2.677LysVal: 2.677 ± 0.052	0.449LysTrp: 0.449 ± 0.018	0.776LysTyr: 0.776 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	10.863LeuAla: 10.863 ± 0.122	0.906LeuCys: 0.906 ± 0.028	5.96LeuAsp: 5.96 ± 0.076	5.786LeuGlu: 5.786 ± 0.062	3.781LeuPhe: 3.781 ± 0.063	8.244LeuGly: 8.244 ± 0.087	1.871LeuHis: 1.871 ± 0.041	5.111LeuIle: 5.111 ± 0.082	3.682LeuLys: 3.682 ± 0.065	8.44LeuLeu: 8.44 ± 0.112	2.666LeuMet: 2.666 ± 0.053	3.153LeuAsn: 3.153 ± 0.05	4.993LeuPro: 4.993 ± 0.089	2.954LeuGln: 2.954 ± 0.046	6.035LeuArg: 6.035 ± 0.078	6.989LeuSer: 6.989 ± 0.076	5.826LeuThr: 5.826 ± 0.065	6.957LeuVal: 6.957 ± 0.081	1.221LeuTrp: 1.221 ± 0.032	1.935LeuTyr: 1.935 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.267MetAla: 3.267 ± 0.051	0.208MetCys: 0.208 ± 0.011	1.514MetAsp: 1.514 ± 0.034	1.421MetGlu: 1.421 ± 0.036	0.928MetPhe: 0.928 ± 0.026	2.288MetGly: 2.288 ± 0.043	0.523MetHis: 0.523 ± 0.022	1.6MetIle: 1.6 ± 0.034	1.212MetLys: 1.212 ± 0.033	2.573MetLeu: 2.573 ± 0.046	0.826MetMet: 0.826 ± 0.024	0.963MetAsn: 0.963 ± 0.029	1.458MetPro: 1.458 ± 0.033	1.054MetGln: 1.054 ± 0.026	1.808MetArg: 1.808 ± 0.037	1.956MetSer: 1.956 ± 0.042	2.178MetThr: 2.178 ± 0.04	1.904MetVal: 1.904 ± 0.037	0.284MetTrp: 0.284 ± 0.016	0.424MetTyr: 0.424 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.487AsnAla: 3.487 ± 0.065	0.297AsnCys: 0.297 ± 0.015	2.234AsnAsp: 2.234 ± 0.113	1.547AsnGlu: 1.547 ± 0.04	1.1AsnPhe: 1.1 ± 0.03	2.934AsnGly: 2.934 ± 0.062	0.572AsnHis: 0.572 ± 0.021	1.62AsnIle: 1.62 ± 0.036	0.901AsnLys: 0.901 ± 0.028	2.967AsnLeu: 2.967 ± 0.044	0.8AsnMet: 0.8 ± 0.023	0.832AsnAsn: 0.832 ± 0.036	1.92AsnPro: 1.92 ± 0.044	0.917AsnGln: 0.917 ± 0.028	1.808AsnArg: 1.808 ± 0.037	1.566AsnSer: 1.566 ± 0.045	1.768AsnThr: 1.768 ± 0.044	2.203AsnVal: 2.203 ± 0.053	0.547AsnTrp: 0.547 ± 0.021	0.754AsnTyr: 0.754 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.699ProAla: 4.699 ± 0.068	0.33ProCys: 0.33 ± 0.015	3.733ProAsp: 3.733 ± 0.063	3.998ProGlu: 3.998 ± 0.064	1.988ProPhe: 1.988 ± 0.04	3.416ProGly: 3.416 ± 0.053	1.041ProHis: 1.041 ± 0.036	2.238ProIle: 2.238 ± 0.049	1.938ProLys: 1.938 ± 0.046	4.235ProLeu: 4.235 ± 0.054	1.318ProMet: 1.318 ± 0.033	1.514ProAsn: 1.514 ± 0.029	1.803ProPro: 1.803 ± 0.051	1.544ProGln: 1.544 ± 0.034	2.199ProArg: 2.199 ± 0.053	2.632ProSer: 2.632 ± 0.047	2.463ProThr: 2.463 ± 0.057	3.957ProVal: 3.957 ± 0.059	0.6ProTrp: 0.6 ± 0.021	1.142ProTyr: 1.142 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.741GlnAla: 3.741 ± 0.057	0.239GlnCys: 0.239 ± 0.013	1.973GlnAsp: 1.973 ± 0.038	1.801GlnGlu: 1.801 ± 0.041	1.232GlnPhe: 1.232 ± 0.033	2.696GlnGly: 2.696 ± 0.049	0.635GlnHis: 0.635 ± 0.027	2.087GlnIle: 2.087 ± 0.043	1.362GlnLys: 1.362 ± 0.035	2.88GlnLeu: 2.88 ± 0.054	1.142GlnMet: 1.142 ± 0.028	1.148GlnAsn: 1.148 ± 0.029	1.541GlnPro: 1.541 ± 0.039	1.151GlnGln: 1.151 ± 0.032	1.953GlnArg: 1.953 ± 0.042	2.13GlnSer: 2.13 ± 0.045	1.96GlnThr: 1.96 ± 0.042	2.327GlnVal: 2.327 ± 0.04	0.425GlnTrp: 0.425 ± 0.019	0.646GlnTyr: 0.646 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.094ArgAla: 6.094 ± 0.081	0.407ArgCys: 0.407 ± 0.02	3.87ArgAsp: 3.87 ± 0.053	3.506ArgGlu: 3.506 ± 0.062	2.526ArgPhe: 2.526 ± 0.042	3.903ArgGly: 3.903 ± 0.058	1.369ArgHis: 1.369 ± 0.037	3.359ArgIle: 3.359 ± 0.054	2.386ArgLys: 2.386 ± 0.054	6.158ArgLeu: 6.158 ± 0.085	1.773ArgMet: 1.773 ± 0.038	1.808ArgAsn: 1.808 ± 0.037	2.727ArgPro: 2.727 ± 0.048	2.059ArgGln: 2.059 ± 0.041	3.798ArgArg: 3.798 ± 0.074	3.051ArgSer: 3.051 ± 0.061	2.687ArgThr: 2.687 ± 0.045	4.171ArgVal: 4.171 ± 0.064	0.811ArgTrp: 0.811 ± 0.028	1.401ArgTyr: 1.401 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.739SerAla: 5.739 ± 0.073	0.471SerCys: 0.471 ± 0.019	3.828SerAsp: 3.828 ± 0.067	3.38SerGlu: 3.38 ± 0.057	2.583SerPhe: 2.583 ± 0.043	5.968SerGly: 5.968 ± 0.13	1.207SerHis: 1.207 ± 0.033	2.902SerIle: 2.902 ± 0.06	2.045SerLys: 2.045 ± 0.041	5.522SerLeu: 5.522 ± 0.067	1.567SerMet: 1.567 ± 0.033	1.747SerAsn: 1.747 ± 0.046	2.557SerPro: 2.557 ± 0.046	1.97SerGln: 1.97 ± 0.041	3.075SerArg: 3.075 ± 0.059	3.118SerSer: 3.118 ± 0.071	2.85SerThr: 2.85 ± 0.064	4.251SerVal: 4.251 ± 0.072	0.725SerTrp: 0.725 ± 0.025	1.458SerTyr: 1.458 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.797ThrAla: 5.797 ± 0.077	0.526ThrCys: 0.526 ± 0.021	3.402ThrAsp: 3.402 ± 0.073	3.078ThrGlu: 3.078 ± 0.045	2.251ThrPhe: 2.251 ± 0.045	5.453ThrGly: 5.453 ± 0.098	1.222ThrHis: 1.222 ± 0.033	2.963ThrIle: 2.963 ± 0.058	1.802ThrLys: 1.802 ± 0.044	6.353ThrLeu: 6.353 ± 0.109	1.353ThrMet: 1.353 ± 0.033	1.559ThrAsn: 1.559 ± 0.041	3.349ThrPro: 3.349 ± 0.067	1.755ThrGln: 1.755 ± 0.036	3.094ThrArg: 3.094 ± 0.055	3.328ThrSer: 3.328 ± 0.066	3.044ThrThr: 3.044 ± 0.077	4.345ThrVal: 4.345 ± 0.083	0.704ThrTrp: 0.704 ± 0.024	1.484ThrTyr: 1.484 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.025ValAla: 8.025 ± 0.093	0.672ValCys: 0.672 ± 0.021	4.441ValAsp: 4.441 ± 0.075	4.522ValGlu: 4.522 ± 0.065	3.22ValPhe: 3.22 ± 0.057	5.631ValGly: 5.631 ± 0.067	1.401ValHis: 1.401 ± 0.035	4.317ValIle: 4.317 ± 0.062	2.393ValLys: 2.393 ± 0.052	7.428ValLeu: 7.428 ± 0.09	2.102ValMet: 2.102 ± 0.041	2.265ValAsn: 2.265 ± 0.052	3.4ValPro: 3.4 ± 0.054	2.174ValGln: 2.174 ± 0.044	3.821ValArg: 3.821 ± 0.053	4.86ValSer: 4.86 ± 0.082	4.643ValThr: 4.643 ± 0.082	5.752ValVal: 5.752 ± 0.078	1.002ValTrp: 1.002 ± 0.031	1.588ValTyr: 1.588 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.287TrpAla: 1.287 ± 0.03	0.141TrpCys: 0.141 ± 0.01	0.796TrpAsp: 0.796 ± 0.025	0.675TrpGlu: 0.675 ± 0.021	0.584TrpPhe: 0.584 ± 0.021	1.081TrpGly: 1.081 ± 0.027	0.333TrpHis: 0.333 ± 0.018	0.739TrpIle: 0.739 ± 0.027	0.535TrpLys: 0.535 ± 0.02	1.524TrpLeu: 1.524 ± 0.035	0.428TrpMet: 0.428 ± 0.018	0.458TrpAsn: 0.458 ± 0.02	0.653TrpPro: 0.653 ± 0.022	0.584TrpGln: 0.584 ± 0.023	0.913TrpArg: 0.913 ± 0.031	0.793TrpSer: 0.793 ± 0.025	0.736TrpThr: 0.736 ± 0.025	0.972TrpVal: 0.972 ± 0.032	0.215TrpTrp: 0.215 ± 0.013	0.288TrpTyr: 0.288 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.443TyrAla: 2.443 ± 0.04	0.241TyrCys: 0.241 ± 0.014	1.714TyrAsp: 1.714 ± 0.04	1.389TyrGlu: 1.389 ± 0.035	1.01TyrPhe: 1.01 ± 0.026	2.218TyrGly: 2.218 ± 0.047	0.581TyrHis: 0.581 ± 0.023	0.999TyrIle: 0.999 ± 0.024	0.708TyrLys: 0.708 ± 0.023	2.318TyrLeu: 2.318 ± 0.047	0.478TyrMet: 0.478 ± 0.017	0.691TyrAsn: 0.691 ± 0.022	1.042TyrPro: 1.042 ± 0.037	0.783TyrGln: 0.783 ± 0.022	1.443TyrArg: 1.443 ± 0.035	1.336TyrSer: 1.336 ± 0.034	1.181TyrThr: 1.181 ± 0.031	1.658TyrVal: 1.658 ± 0.035	0.38TyrTrp: 0.38 ± 0.02	0.621TyrTyr: 0.621 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4063 proteins (1322757 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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