Amino acid dipepetide frequency for Laetiporus sulphureus 93-53

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.019AlaAla: 9.019 ± 0.058	1.232AlaCys: 1.232 ± 0.016	4.397AlaAsp: 4.397 ± 0.029	5.311AlaGlu: 5.311 ± 0.041	3.32AlaPhe: 3.32 ± 0.026	5.388AlaGly: 5.388 ± 0.037	2.371AlaHis: 2.371 ± 0.022	4.313AlaIle: 4.313 ± 0.029	3.729AlaLys: 3.729 ± 0.031	8.615AlaLeu: 8.615 ± 0.046	2.153AlaMet: 2.153 ± 0.021	2.769AlaAsn: 2.769 ± 0.023	5.046AlaPro: 5.046 ± 0.042	3.496AlaGln: 3.496 ± 0.029	5.823AlaArg: 5.823 ± 0.042	8.084AlaSer: 8.084 ± 0.048	5.149AlaThr: 5.149 ± 0.033	5.766AlaVal: 5.766 ± 0.033	1.158AlaTrp: 1.158 ± 0.016	2.305AlaTyr: 2.305 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.151CysAla: 1.151 ± 0.015	0.301CysCys: 0.301 ± 0.008	0.706CysAsp: 0.706 ± 0.011	0.68CysGlu: 0.68 ± 0.012	0.516CysPhe: 0.516 ± 0.01	0.974CysGly: 0.974 ± 0.018	0.391CysHis: 0.391 ± 0.008	0.757CysIle: 0.757 ± 0.014	0.558CysLys: 0.558 ± 0.013	1.344CysLeu: 1.344 ± 0.018	0.352CysMet: 0.352 ± 0.01	0.44CysAsn: 0.44 ± 0.009	0.781CysPro: 0.781 ± 0.011	0.445CysGln: 0.445 ± 0.009	0.9CysArg: 0.9 ± 0.015	1.138CysSer: 1.138 ± 0.017	0.846CysThr: 0.846 ± 0.013	0.906CysVal: 0.906 ± 0.013	0.212CysTrp: 0.212 ± 0.007	0.392CysTyr: 0.392 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.179AspAla: 5.179 ± 0.033	0.658AspCys: 0.658 ± 0.012	4.057AspAsp: 4.057 ± 0.039	4.517AspGlu: 4.517 ± 0.038	1.993AspPhe: 1.993 ± 0.019	3.888AspGly: 3.888 ± 0.033	1.299AspHis: 1.299 ± 0.016	2.97AspIle: 2.97 ± 0.027	2.094AspLys: 2.094 ± 0.022	4.77AspLeu: 4.77 ± 0.03	1.288AspMet: 1.288 ± 0.017	1.628AspAsn: 1.628 ± 0.018	3.201AspPro: 3.201 ± 0.026	1.599AspGln: 1.599 ± 0.019	2.95AspArg: 2.95 ± 0.027	3.888AspSer: 3.888 ± 0.033	2.825AspThr: 2.825 ± 0.026	4.183AspVal: 4.183 ± 0.032	0.869AspTrp: 0.869 ± 0.015	1.484AspTyr: 1.484 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.163GluAla: 5.163 ± 0.038	0.729GluCys: 0.729 ± 0.012	4.233GluAsp: 4.233 ± 0.034	5.778GluGlu: 5.778 ± 0.054	1.848GluPhe: 1.848 ± 0.018	3.733GluGly: 3.733 ± 0.03	1.687GluHis: 1.687 ± 0.018	2.848GluIle: 2.848 ± 0.025	3.127GluLys: 3.127 ± 0.033	5.588GluLeu: 5.588 ± 0.045	1.469GluMet: 1.469 ± 0.016	1.989GluAsn: 1.989 ± 0.02	2.741GluPro: 2.741 ± 0.028	2.524GluGln: 2.524 ± 0.027	4.429GluArg: 4.429 ± 0.042	4.08GluSer: 4.08 ± 0.031	3.103GluThr: 3.103 ± 0.023	3.782GluVal: 3.782 ± 0.03	0.959GluTrp: 0.959 ± 0.015	1.634GluTyr: 1.634 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.148PheAla: 3.148 ± 0.027	0.577PheCys: 0.577 ± 0.011	2.143PheAsp: 2.143 ± 0.021	2.01PheGlu: 2.01 ± 0.018	1.443PhePhe: 1.443 ± 0.021	2.49PheGly: 2.49 ± 0.028	0.938PheHis: 0.938 ± 0.015	1.738PheIle: 1.738 ± 0.018	1.391PheLys: 1.391 ± 0.018	3.352PheLeu: 3.352 ± 0.026	0.801PheMet: 0.801 ± 0.012	1.211PheAsn: 1.211 ± 0.016	1.938PhePro: 1.938 ± 0.021	1.168PheGln: 1.168 ± 0.014	1.997PheArg: 1.997 ± 0.02	3.024PheSer: 3.024 ± 0.025	2.074PheThr: 2.074 ± 0.023	2.459PheVal: 2.459 ± 0.024	0.545PheTrp: 0.545 ± 0.012	0.998PheTyr: 0.998 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	4.941GlyAla: 4.941 ± 0.038	0.877GlyCys: 0.877 ± 0.013	3.27GlyAsp: 3.27 ± 0.026	3.547GlyGlu: 3.547 ± 0.033	2.333GlyPhe: 2.333 ± 0.023	4.787GlyGly: 4.787 ± 0.044	1.7GlyHis: 1.7 ± 0.02	3.121GlyIle: 3.121 ± 0.03	3.153GlyLys: 3.153 ± 0.03	5.328GlyLeu: 5.328 ± 0.039	1.591GlyMet: 1.591 ± 0.021	1.973GlyAsn: 1.973 ± 0.022	3.159GlyPro: 3.159 ± 0.028	2.21GlyGln: 2.21 ± 0.023	4.169GlyArg: 4.169 ± 0.03	5.372GlySer: 5.372 ± 0.036	3.791GlyThr: 3.791 ± 0.031	4.063GlyVal: 4.063 ± 0.031	1.059GlyTrp: 1.059 ± 0.016	1.811GlyTyr: 1.811 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.469HisAla: 2.469 ± 0.021	0.422HisCys: 0.422 ± 0.01	1.444HisAsp: 1.444 ± 0.02	1.471HisGlu: 1.471 ± 0.017	1.004HisPhe: 1.004 ± 0.014	1.709HisGly: 1.709 ± 0.019	0.919HisHis: 0.919 ± 0.018	1.397HisIle: 1.397 ± 0.018	0.945HisLys: 0.945 ± 0.013	2.641HisLeu: 2.641 ± 0.027	0.572HisMet: 0.572 ± 0.012	0.81HisAsn: 0.81 ± 0.012	1.908HisPro: 1.908 ± 0.019	0.907HisGln: 0.907 ± 0.015	1.772HisArg: 1.772 ± 0.02	2.237HisSer: 2.237 ± 0.021	1.53HisThr: 1.53 ± 0.018	1.809HisVal: 1.809 ± 0.021	0.359HisTrp: 0.359 ± 0.007	0.74HisTyr: 0.74 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.352IleAla: 4.352 ± 0.027	0.795IleCys: 0.795 ± 0.014	2.762IleAsp: 2.762 ± 0.024	2.716IleGlu: 2.716 ± 0.024	1.794IlePhe: 1.794 ± 0.022	2.883IleGly: 2.883 ± 0.03	1.236IleHis: 1.236 ± 0.015	2.436IleIle: 2.436 ± 0.023	1.974IleLys: 1.974 ± 0.018	4.5IleLeu: 4.5 ± 0.035	1.053IleMet: 1.053 ± 0.015	1.522IleAsn: 1.522 ± 0.014	3.083IlePro: 3.083 ± 0.024	1.658IleGln: 1.658 ± 0.017	2.886IleArg: 2.886 ± 0.024	3.907IleSer: 3.907 ± 0.028	2.726IleThr: 2.726 ± 0.023	3.437IleVal: 3.437 ± 0.027	0.757IleTrp: 0.757 ± 0.015	1.318IleTyr: 1.318 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.071LysAla: 4.071 ± 0.035	0.537LysCys: 0.537 ± 0.011	2.378LysAsp: 2.378 ± 0.024	3.116LysGlu: 3.116 ± 0.033	1.213LysPhe: 1.213 ± 0.017	2.719LysGly: 2.719 ± 0.026	1.155LysHis: 1.155 ± 0.015	1.907LysIle: 1.907 ± 0.019	2.772LysLys: 2.772 ± 0.038	3.848LysLeu: 3.848 ± 0.029	0.997LysMet: 0.997 ± 0.013	1.317LysAsn: 1.317 ± 0.015	2.354LysPro: 2.354 ± 0.023	1.669LysGln: 1.669 ± 0.02	3.398LysArg: 3.398 ± 0.032	2.948LysSer: 2.948 ± 0.028	2.414LysThr: 2.414 ± 0.025	2.661LysVal: 2.661 ± 0.025	0.644LysTrp: 0.644 ± 0.012	1.164LysTyr: 1.164 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.274LeuAla: 8.274 ± 0.047	1.449LeuCys: 1.449 ± 0.019	5.079LeuAsp: 5.079 ± 0.039	5.474LeuGlu: 5.474 ± 0.044	3.312LeuPhe: 3.312 ± 0.032	5.284LeuGly: 5.284 ± 0.037	2.694LeuHis: 2.694 ± 0.026	3.908LeuIle: 3.908 ± 0.032	3.94LeuLys: 3.94 ± 0.034	8.961LeuLeu: 8.961 ± 0.058	1.93LeuMet: 1.93 ± 0.02	2.962LeuAsn: 2.962 ± 0.027	6.205LeuPro: 6.205 ± 0.048	3.902LeuGln: 3.902 ± 0.03	6.313LeuArg: 6.313 ± 0.04	8.047LeuSer: 8.047 ± 0.051	5.177LeuThr: 5.177 ± 0.034	5.687LeuVal: 5.687 ± 0.037	1.237LeuTrp: 1.237 ± 0.016	2.465LeuTyr: 2.465 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.005MetAla: 2.005 ± 0.018	0.281MetCys: 0.281 ± 0.009	1.296MetAsp: 1.296 ± 0.017	1.307MetGlu: 1.307 ± 0.014	0.78MetPhe: 0.78 ± 0.013	1.292MetGly: 1.292 ± 0.02	0.696MetHis: 0.696 ± 0.012	1.014MetIle: 1.014 ± 0.015	0.996MetLys: 0.996 ± 0.016	2.173MetLeu: 2.173 ± 0.02	0.58MetMet: 0.58 ± 0.011	0.83MetAsn: 0.83 ± 0.013	1.454MetPro: 1.454 ± 0.021	1.053MetGln: 1.053 ± 0.015	1.535MetArg: 1.535 ± 0.017	2.209MetSer: 2.209 ± 0.023	1.324MetThr: 1.324 ± 0.016	1.298MetVal: 1.298 ± 0.015	0.307MetTrp: 0.307 ± 0.008	0.558MetTyr: 0.558 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.246AsnAla: 3.246 ± 0.025	0.401AsnCys: 0.401 ± 0.008	1.722AsnAsp: 1.722 ± 0.018	1.794AsnGlu: 1.794 ± 0.019	1.122AsnPhe: 1.122 ± 0.016	2.418AsnGly: 2.418 ± 0.024	0.751AsnHis: 0.751 ± 0.012	1.756AsnIle: 1.756 ± 0.016	1.243AsnLys: 1.243 ± 0.017	2.855AsnLeu: 2.855 ± 0.028	0.775AsnMet: 0.775 ± 0.012	1.051AsnAsn: 1.051 ± 0.014	2.028AsnPro: 2.028 ± 0.022	0.955AsnGln: 0.955 ± 0.015	1.689AsnArg: 1.689 ± 0.018	2.279AsnSer: 2.279 ± 0.022	1.822AsnThr: 1.822 ± 0.02	2.524AsnVal: 2.524 ± 0.023	0.461AsnTrp: 0.461 ± 0.009	0.85AsnTyr: 0.85 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.604ProAla: 5.604 ± 0.04	0.602ProCys: 0.602 ± 0.011	3.143ProAsp: 3.143 ± 0.026	3.671ProGlu: 3.671 ± 0.026	2.115ProPhe: 2.115 ± 0.023	3.515ProGly: 3.515 ± 0.03	1.651ProHis: 1.651 ± 0.019	2.668ProIle: 2.668 ± 0.024	2.224ProLys: 2.224 ± 0.024	5.284ProLeu: 5.284 ± 0.039	1.184ProMet: 1.184 ± 0.015	1.906ProAsn: 1.906 ± 0.021	6.083ProPro: 6.083 ± 0.079	2.321ProGln: 2.321 ± 0.029	3.731ProArg: 3.731 ± 0.034	7.013ProSer: 7.013 ± 0.059	4.035ProThr: 4.035 ± 0.034	3.805ProVal: 3.805 ± 0.028	0.704ProTrp: 0.704 ± 0.012	1.617ProTyr: 1.617 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.435GlnAla: 3.435 ± 0.031	0.534GlnCys: 0.534 ± 0.01	1.914GlnAsp: 1.914 ± 0.019	2.288GlnGlu: 2.288 ± 0.023	1.185GlnPhe: 1.185 ± 0.016	2.07GlnGly: 2.07 ± 0.023	1.094GlnHis: 1.094 ± 0.015	1.7GlnIle: 1.7 ± 0.018	1.591GlnLys: 1.591 ± 0.021	3.515GlnLeu: 3.515 ± 0.031	0.922GlnMet: 0.922 ± 0.014	1.249GlnAsn: 1.249 ± 0.016	2.357GlnPro: 2.357 ± 0.028	1.938GlnGln: 1.938 ± 0.034	2.625GlnArg: 2.625 ± 0.023	2.985GlnSer: 2.985 ± 0.029	2.161GlnThr: 2.161 ± 0.019	2.164GlnVal: 2.164 ± 0.022	0.572GlnTrp: 0.572 ± 0.011	1.096GlnTyr: 1.096 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.582ArgAla: 5.582 ± 0.04	0.913ArgCys: 0.913 ± 0.013	3.289ArgAsp: 3.289 ± 0.025	4.081ArgGlu: 4.081 ± 0.038	2.153ArgPhe: 2.153 ± 0.02	3.676ArgGly: 3.676 ± 0.029	1.752ArgHis: 1.752 ± 0.018	3.107ArgIle: 3.107 ± 0.024	3.401ArgLys: 3.401 ± 0.033	5.937ArgLeu: 5.937 ± 0.039	1.607ArgMet: 1.607 ± 0.017	2.069ArgAsn: 2.069 ± 0.019	3.856ArgPro: 3.856 ± 0.038	2.504ArgGln: 2.504 ± 0.022	5.723ArgArg: 5.723 ± 0.049	5.5ArgSer: 5.5 ± 0.043	3.822ArgThr: 3.822 ± 0.033	3.821ArgVal: 3.821 ± 0.028	1.027ArgTrp: 1.027 ± 0.015	1.709ArgTyr: 1.709 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.609SerAla: 7.609 ± 0.046	1.04SerCys: 1.04 ± 0.016	4.379SerAsp: 4.379 ± 0.028	4.313SerGlu: 4.313 ± 0.031	3.014SerPhe: 3.014 ± 0.026	5.335SerGly: 5.335 ± 0.038	2.251SerHis: 2.251 ± 0.026	3.94SerIle: 3.94 ± 0.029	3.261SerLys: 3.261 ± 0.026	7.81SerLeu: 7.81 ± 0.05	1.964SerMet: 1.964 ± 0.022	2.59SerAsn: 2.59 ± 0.02	6.145SerPro: 6.145 ± 0.062	3.11SerGln: 3.11 ± 0.025	5.455SerArg: 5.455 ± 0.047	10.214SerSer: 10.214 ± 0.078	5.887SerThr: 5.887 ± 0.043	5.224SerVal: 5.224 ± 0.034	1.079SerTrp: 1.079 ± 0.017	2.038SerTyr: 2.038 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.265ThrAla: 5.265 ± 0.037	0.825ThrCys: 0.825 ± 0.014	2.76ThrAsp: 2.76 ± 0.022	2.966ThrGlu: 2.966 ± 0.026	2.31ThrPhe: 2.31 ± 0.022	3.623ThrGly: 3.623 ± 0.032	1.497ThrHis: 1.497 ± 0.017	2.987ThrIle: 2.987 ± 0.023	2.188ThrLys: 2.188 ± 0.022	5.587ThrLeu: 5.587 ± 0.038	1.264ThrMet: 1.264 ± 0.018	1.79ThrAsn: 1.79 ± 0.021	4.25ThrPro: 4.25 ± 0.035	1.914ThrGln: 1.914 ± 0.019	3.47ThrArg: 3.47 ± 0.029	5.651ThrSer: 5.651 ± 0.041	3.834ThrThr: 3.834 ± 0.031	3.951ThrVal: 3.951 ± 0.029	0.811ThrTrp: 0.811 ± 0.012	1.627ThrTyr: 1.627 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.455ValAla: 5.455 ± 0.035	0.962ValCys: 0.962 ± 0.015	3.907ValAsp: 3.907 ± 0.027	4.007ValGlu: 4.007 ± 0.03	2.397ValPhe: 2.397 ± 0.022	3.792ValGly: 3.792 ± 0.032	1.845ValHis: 1.845 ± 0.02	3.143ValIle: 3.143 ± 0.027	2.913ValLys: 2.913 ± 0.028	6.303ValLeu: 6.303 ± 0.037	1.466ValMet: 1.466 ± 0.018	2.103ValAsn: 2.103 ± 0.021	4.066ValPro: 4.066 ± 0.031	2.562ValGln: 2.562 ± 0.021	4.019ValArg: 4.019 ± 0.032	5.006ValSer: 5.006 ± 0.033	3.581ValThr: 3.581 ± 0.024	4.576ValVal: 4.576 ± 0.033	0.944ValTrp: 0.944 ± 0.014	1.783ValTyr: 1.783 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.108TrpAla: 1.108 ± 0.014	0.237TrpCys: 0.237 ± 0.007	0.831TrpAsp: 0.831 ± 0.014	0.891TrpGlu: 0.891 ± 0.014	0.523TrpPhe: 0.523 ± 0.01	0.812TrpGly: 0.812 ± 0.013	0.396TrpHis: 0.396 ± 0.009	0.713TrpIle: 0.713 ± 0.014	0.746TrpLys: 0.746 ± 0.013	1.385TrpLeu: 1.385 ± 0.019	0.401TrpMet: 0.401 ± 0.008	0.573TrpAsn: 0.573 ± 0.009	0.651TrpPro: 0.651 ± 0.011	0.55TrpGln: 0.55 ± 0.011	1.033TrpArg: 1.033 ± 0.018	1.074TrpSer: 1.074 ± 0.015	0.901TrpThr: 0.901 ± 0.013	0.857TrpVal: 0.857 ± 0.012	0.272TrpTrp: 0.272 ± 0.008	0.42TrpTyr: 0.42 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.367TyrAla: 2.367 ± 0.023	0.416TyrCys: 0.416 ± 0.01	1.631TyrAsp: 1.631 ± 0.019	1.505TyrGlu: 1.505 ± 0.018	1.072TyrPhe: 1.072 ± 0.016	1.87TyrGly: 1.87 ± 0.02	0.743TyrHis: 0.743 ± 0.012	1.373TyrIle: 1.373 ± 0.019	1.034TyrLys: 1.034 ± 0.014	2.505TyrLeu: 2.505 ± 0.024	0.619TyrMet: 0.619 ± 0.011	0.96TyrAsn: 0.96 ± 0.016	1.568TyrPro: 1.568 ± 0.021	0.912TyrGln: 0.912 ± 0.012	1.609TyrArg: 1.609 ± 0.017	2.0TyrSer: 2.0 ± 0.02	1.568TyrThr: 1.568 ± 0.018	1.856TyrVal: 1.856 ± 0.018	0.4TyrTrp: 0.4 ± 0.01	0.87TyrTyr: 0.87 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13712 proteins (5380101 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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