Amino acid dipepetide frequency for Enterobacter lignolyticus (strain SCF1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.32AlaAla: 11.32 ± 0.164	1.216AlaCys: 1.216 ± 0.029	5.246AlaAsp: 5.246 ± 0.067	5.482AlaGlu: 5.482 ± 0.071	3.776AlaPhe: 3.776 ± 0.054	7.94AlaGly: 7.94 ± 0.094	2.049AlaHis: 2.049 ± 0.038	6.065AlaIle: 6.065 ± 0.08	3.678AlaLys: 3.678 ± 0.058	12.69AlaLeu: 12.69 ± 0.128	3.198AlaMet: 3.198 ± 0.042	3.052AlaAsn: 3.052 ± 0.048	3.986AlaPro: 3.986 ± 0.064	4.924AlaGln: 4.924 ± 0.064	6.036AlaArg: 6.036 ± 0.082	5.687AlaSer: 5.687 ± 0.064	4.877AlaThr: 4.877 ± 0.06	7.286AlaVal: 7.286 ± 0.08	1.764AlaTrp: 1.764 ± 0.034	1.909AlaTyr: 1.909 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.088CysAla: 1.088 ± 0.028	0.178CysCys: 0.178 ± 0.011	0.658CysAsp: 0.658 ± 0.023	0.62CysGlu: 0.62 ± 0.022	0.44CysPhe: 0.44 ± 0.017	1.134CysGly: 1.134 ± 0.031	0.308CysHis: 0.308 ± 0.014	0.586CysIle: 0.586 ± 0.019	0.315CysLys: 0.315 ± 0.015	1.075CysLeu: 1.075 ± 0.03	0.247CysMet: 0.247 ± 0.013	0.345CysAsn: 0.345 ± 0.017	0.529CysPro: 0.529 ± 0.021	0.485CysGln: 0.485 ± 0.02	0.689CysArg: 0.689 ± 0.024	0.675CysSer: 0.675 ± 0.024	0.503CysThr: 0.503 ± 0.019	0.792CysVal: 0.792 ± 0.026	0.196CysTrp: 0.196 ± 0.013	0.329CysTyr: 0.329 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.66AspAla: 5.66 ± 0.08	0.515AspCys: 0.515 ± 0.02	3.16AspAsp: 3.16 ± 0.057	3.427AspGlu: 3.427 ± 0.053	2.059AspPhe: 2.059 ± 0.043	4.017AspGly: 4.017 ± 0.064	0.92AspHis: 0.92 ± 0.027	3.406AspIle: 3.406 ± 0.053	2.458AspLys: 2.458 ± 0.045	4.486AspLeu: 4.486 ± 0.065	1.349AspMet: 1.349 ± 0.034	2.159AspAsn: 2.159 ± 0.039	2.289AspPro: 2.289 ± 0.04	1.401AspGln: 1.401 ± 0.031	2.722AspArg: 2.722 ± 0.042	2.852AspSer: 2.852 ± 0.048	2.628AspThr: 2.628 ± 0.045	3.915AspVal: 3.915 ± 0.059	0.808AspTrp: 0.808 ± 0.026	1.825AspTyr: 1.825 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.13GluAla: 5.13 ± 0.076	0.494GluCys: 0.494 ± 0.022	2.199GluAsp: 2.199 ± 0.045	3.097GluGlu: 3.097 ± 0.057	1.74GluPhe: 1.74 ± 0.03	3.453GluGly: 3.453 ± 0.054	1.402GluHis: 1.402 ± 0.033	3.127GluIle: 3.127 ± 0.056	3.018GluLys: 3.018 ± 0.054	5.629GluLeu: 5.629 ± 0.071	1.787GluMet: 1.787 ± 0.04	2.244GluAsn: 2.244 ± 0.044	2.027GluPro: 2.027 ± 0.04	3.225GluGln: 3.225 ± 0.048	3.582GluArg: 3.582 ± 0.057	2.803GluSer: 2.803 ± 0.05	2.771GluThr: 2.771 ± 0.042	3.635GluVal: 3.635 ± 0.054	0.725GluTrp: 0.725 ± 0.023	1.425GluTyr: 1.425 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.867PheAla: 3.867 ± 0.05	0.549PheCys: 0.549 ± 0.02	2.332PheAsp: 2.332 ± 0.044	1.673PheGlu: 1.673 ± 0.04	1.696PhePhe: 1.696 ± 0.042	3.292PheGly: 3.292 ± 0.051	0.783PheHis: 0.783 ± 0.023	2.567PheIle: 2.567 ± 0.047	1.2PheLys: 1.2 ± 0.03	3.396PheLeu: 3.396 ± 0.056	1.003PheMet: 1.003 ± 0.028	1.699PheAsn: 1.699 ± 0.035	1.577PhePro: 1.577 ± 0.037	1.101PheGln: 1.101 ± 0.025	1.904PheArg: 1.904 ± 0.038	3.083PheSer: 3.083 ± 0.052	2.412PheThr: 2.412 ± 0.045	2.567PheVal: 2.567 ± 0.051	0.657PheTrp: 0.657 ± 0.024	1.197PheTyr: 1.197 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	6.81GlyAla: 6.81 ± 0.088	1.054GlyCys: 1.054 ± 0.03	3.86GlyAsp: 3.86 ± 0.055	4.469GlyGlu: 4.469 ± 0.062	3.314GlyPhe: 3.314 ± 0.049	5.672GlyGly: 5.672 ± 0.076	1.696GlyHis: 1.696 ± 0.038	5.096GlyIle: 5.096 ± 0.076	3.851GlyLys: 3.851 ± 0.06	7.721GlyLeu: 7.721 ± 0.099	2.465GlyMet: 2.465 ± 0.047	2.714GlyAsn: 2.714 ± 0.05	2.069GlyPro: 2.069 ± 0.042	3.023GlyGln: 3.023 ± 0.047	3.894GlyArg: 3.894 ± 0.065	4.294GlySer: 4.294 ± 0.063	3.808GlyThr: 3.808 ± 0.065	6.102GlyVal: 6.102 ± 0.07	1.328GlyTrp: 1.328 ± 0.03	2.665GlyTyr: 2.665 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.034HisAla: 2.034 ± 0.04	0.323HisCys: 0.323 ± 0.015	1.237HisAsp: 1.237 ± 0.03	1.065HisGlu: 1.065 ± 0.026	1.053HisPhe: 1.053 ± 0.031	1.82HisGly: 1.82 ± 0.041	0.772HisHis: 0.772 ± 0.03	1.324HisIle: 1.324 ± 0.032	0.748HisLys: 0.748 ± 0.025	2.263HisLeu: 2.263 ± 0.042	0.551HisMet: 0.551 ± 0.019	0.817HisAsn: 0.817 ± 0.025	1.357HisPro: 1.357 ± 0.03	1.103HisGln: 1.103 ± 0.027	1.331HisArg: 1.331 ± 0.032	1.234HisSer: 1.234 ± 0.03	1.063HisThr: 1.063 ± 0.029	1.306HisVal: 1.306 ± 0.031	0.378HisTrp: 0.378 ± 0.018	0.888HisTyr: 0.888 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.708IleAla: 6.708 ± 0.08	0.67IleCys: 0.67 ± 0.024	3.528IleAsp: 3.528 ± 0.053	3.039IleGlu: 3.039 ± 0.053	2.039IlePhe: 2.039 ± 0.043	4.644IleGly: 4.644 ± 0.073	1.203IleHis: 1.203 ± 0.032	3.259IleIle: 3.259 ± 0.059	2.104IleLys: 2.104 ± 0.043	4.938IleLeu: 4.938 ± 0.072	1.236IleMet: 1.236 ± 0.032	2.496IleAsn: 2.496 ± 0.048	2.756IlePro: 2.756 ± 0.042	1.769IleGln: 1.769 ± 0.034	3.034IleArg: 3.034 ± 0.052	3.764IleSer: 3.764 ± 0.062	3.506IleThr: 3.506 ± 0.057	4.12IleVal: 4.12 ± 0.057	0.656IleTrp: 0.656 ± 0.025	1.525IleTyr: 1.525 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.056LysAla: 4.056 ± 0.055	0.282LysCys: 0.282 ± 0.013	1.927LysAsp: 1.927 ± 0.044	2.241LysGlu: 2.241 ± 0.048	1.09LysPhe: 1.09 ± 0.03	2.856LysGly: 2.856 ± 0.05	0.829LysHis: 0.829 ± 0.023	2.215LysIle: 2.215 ± 0.043	2.051LysLys: 2.051 ± 0.039	3.904LysLeu: 3.904 ± 0.064	1.197LysMet: 1.197 ± 0.03	1.658LysAsn: 1.658 ± 0.034	2.039LysPro: 2.039 ± 0.037	1.809LysGln: 1.809 ± 0.041	2.475LysArg: 2.475 ± 0.046	2.202LysSer: 2.202 ± 0.045	2.486LysThr: 2.486 ± 0.044	2.775LysVal: 2.775 ± 0.052	0.423LysTrp: 0.423 ± 0.019	1.101LysTyr: 1.101 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	12.038LeuAla: 12.038 ± 0.113	1.385LeuCys: 1.385 ± 0.033	5.333LeuAsp: 5.333 ± 0.063	5.308LeuGlu: 5.308 ± 0.068	4.324LeuPhe: 4.324 ± 0.066	7.44LeuGly: 7.44 ± 0.094	2.276LeuHis: 2.276 ± 0.04	5.767LeuIle: 5.767 ± 0.075	4.327LeuLys: 4.327 ± 0.058	12.226LeuLeu: 12.226 ± 0.142	3.017LeuMet: 3.017 ± 0.048	4.192LeuAsn: 4.192 ± 0.061	5.694LeuPro: 5.694 ± 0.063	4.198LeuGln: 4.198 ± 0.06	6.331LeuArg: 6.331 ± 0.081	7.389LeuSer: 7.389 ± 0.078	6.42LeuThr: 6.42 ± 0.069	7.224LeuVal: 7.224 ± 0.087	1.513LeuTrp: 1.513 ± 0.038	2.591LeuTyr: 2.591 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.053MetAla: 3.053 ± 0.054	0.211MetCys: 0.211 ± 0.013	1.173MetAsp: 1.173 ± 0.029	1.232MetGlu: 1.232 ± 0.031	0.904MetPhe: 0.904 ± 0.026	1.988MetGly: 1.988 ± 0.043	0.521MetHis: 0.521 ± 0.019	1.439MetIle: 1.439 ± 0.035	1.413MetLys: 1.413 ± 0.035	3.241MetLeu: 3.241 ± 0.051	0.948MetMet: 0.948 ± 0.027	1.083MetAsn: 1.083 ± 0.029	1.368MetPro: 1.368 ± 0.031	1.219MetGln: 1.219 ± 0.032	1.541MetArg: 1.541 ± 0.034	1.956MetSer: 1.956 ± 0.037	1.858MetThr: 1.858 ± 0.038	2.032MetVal: 2.032 ± 0.036	0.261MetTrp: 0.261 ± 0.014	0.532MetTyr: 0.532 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.634AsnAla: 3.634 ± 0.05	0.343AsnCys: 0.343 ± 0.016	2.049AsnAsp: 2.049 ± 0.039	1.735AsnGlu: 1.735 ± 0.035	1.249AsnPhe: 1.249 ± 0.031	3.042AsnGly: 3.042 ± 0.052	0.817AsnHis: 0.817 ± 0.027	2.28AsnIle: 2.28 ± 0.044	1.408AsnLys: 1.408 ± 0.035	3.48AsnLeu: 3.48 ± 0.053	0.946AsnMet: 0.946 ± 0.029	1.53AsnAsn: 1.53 ± 0.042	2.081AsnPro: 2.081 ± 0.038	1.444AsnGln: 1.444 ± 0.033	2.035AsnArg: 2.035 ± 0.038	1.926AsnSer: 1.926 ± 0.042	1.989AsnThr: 1.989 ± 0.048	2.575AsnVal: 2.575 ± 0.043	0.512AsnTrp: 0.512 ± 0.02	1.138AsnTyr: 1.138 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.758ProAla: 4.758 ± 0.063	0.404ProCys: 0.404 ± 0.018	2.767ProAsp: 2.767 ± 0.044	3.208ProGlu: 3.208 ± 0.048	1.862ProPhe: 1.862 ± 0.038	3.688ProGly: 3.688 ± 0.059	1.12ProHis: 1.12 ± 0.03	1.726ProIle: 1.726 ± 0.03	1.392ProLys: 1.392 ± 0.033	5.146ProLeu: 5.146 ± 0.064	1.148ProMet: 1.148 ± 0.026	1.267ProAsn: 1.267 ± 0.032	1.688ProPro: 1.688 ± 0.036	2.41ProGln: 2.41 ± 0.045	2.06ProArg: 2.06 ± 0.037	2.156ProSer: 2.156 ± 0.036	2.124ProThr: 2.124 ± 0.041	4.072ProVal: 4.072 ± 0.056	0.812ProTrp: 0.812 ± 0.025	1.161ProTyr: 1.161 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.894GlnAla: 4.894 ± 0.067	0.395GlnCys: 0.395 ± 0.017	1.799GlnAsp: 1.799 ± 0.038	2.183GlnGlu: 2.183 ± 0.047	1.478GlnPhe: 1.478 ± 0.03	3.063GlnGly: 3.063 ± 0.047	1.237GlnHis: 1.237 ± 0.033	2.192GlnIle: 2.192 ± 0.042	1.715GlnLys: 1.715 ± 0.041	4.841GlnLeu: 4.841 ± 0.067	1.244GlnMet: 1.244 ± 0.031	1.427GlnAsn: 1.427 ± 0.035	2.156GlnPro: 2.156 ± 0.047	3.258GlnGln: 3.258 ± 0.063	3.03GlnArg: 3.03 ± 0.057	2.311GlnSer: 2.311 ± 0.05	2.239GlnThr: 2.239 ± 0.04	2.984GlnVal: 2.984 ± 0.05	0.698GlnTrp: 0.698 ± 0.02	1.184GlnTyr: 1.184 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.884ArgAla: 4.884 ± 0.068	0.615ArgCys: 0.615 ± 0.021	3.166ArgAsp: 3.166 ± 0.051	3.793ArgGlu: 3.793 ± 0.076	2.647ArgPhe: 2.647 ± 0.049	3.515ArgGly: 3.515 ± 0.05	1.627ArgHis: 1.627 ± 0.037	3.395ArgIle: 3.395 ± 0.045	2.25ArgLys: 2.25 ± 0.045	6.701ArgLeu: 6.701 ± 0.092	1.625ArgMet: 1.625 ± 0.037	1.969ArgAsn: 1.969 ± 0.042	2.306ArgPro: 2.306 ± 0.039	3.218ArgGln: 3.218 ± 0.057	3.705ArgArg: 3.705 ± 0.067	2.732ArgSer: 2.732 ± 0.049	2.51ArgThr: 2.51 ± 0.048	3.917ArgVal: 3.917 ± 0.061	1.069ArgTrp: 1.069 ± 0.033	2.224ArgTyr: 2.224 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.051SerAla: 6.051 ± 0.072	0.627SerCys: 0.627 ± 0.021	3.043SerAsp: 3.043 ± 0.051	2.937SerGlu: 2.937 ± 0.047	2.277SerPhe: 2.277 ± 0.044	5.369SerGly: 5.369 ± 0.067	1.433SerHis: 1.433 ± 0.032	2.921SerIle: 2.921 ± 0.051	1.901SerLys: 1.901 ± 0.043	6.753SerLeu: 6.753 ± 0.085	1.477SerMet: 1.477 ± 0.029	1.801SerAsn: 1.801 ± 0.037	2.677SerPro: 2.677 ± 0.044	2.506SerGln: 2.506 ± 0.047	3.582SerArg: 3.582 ± 0.059	3.544SerSer: 3.544 ± 0.065	2.94SerThr: 2.94 ± 0.048	4.315SerVal: 4.315 ± 0.063	0.979SerTrp: 0.979 ± 0.026	1.613SerTyr: 1.613 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.215ThrAla: 5.215 ± 0.076	0.527ThrCys: 0.527 ± 0.018	2.587ThrAsp: 2.587 ± 0.051	2.394ThrGlu: 2.394 ± 0.044	2.035ThrPhe: 2.035 ± 0.039	4.639ThrGly: 4.639 ± 0.068	1.265ThrHis: 1.265 ± 0.031	2.828ThrIle: 2.828 ± 0.056	1.356ThrLys: 1.356 ± 0.034	7.617ThrLeu: 7.617 ± 0.074	1.173ThrMet: 1.173 ± 0.032	1.471ThrAsn: 1.471 ± 0.036	3.251ThrPro: 3.251 ± 0.045	2.096ThrGln: 2.096 ± 0.041	3.127ThrArg: 3.127 ± 0.05	2.941ThrSer: 2.941 ± 0.053	2.82ThrThr: 2.82 ± 0.055	3.992ThrVal: 3.992 ± 0.059	0.839ThrTrp: 0.839 ± 0.024	1.115ThrTyr: 1.115 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	7.413ValAla: 7.413 ± 0.083	0.84ValCys: 0.84 ± 0.024	3.829ValAsp: 3.829 ± 0.054	3.875ValGlu: 3.875 ± 0.064	2.712ValPhe: 2.712 ± 0.05	5.091ValGly: 5.091 ± 0.075	1.275ValHis: 1.275 ± 0.032	4.663ValIle: 4.663 ± 0.066	3.056ValLys: 3.056 ± 0.049	7.51ValLeu: 7.51 ± 0.092	2.298ValMet: 2.298 ± 0.047	2.823ValAsn: 2.823 ± 0.045	3.065ValPro: 3.065 ± 0.051	2.363ValGln: 2.363 ± 0.042	3.717ValArg: 3.717 ± 0.05	4.665ValSer: 4.665 ± 0.055	4.309ValThr: 4.309 ± 0.06	5.827ValVal: 5.827 ± 0.082	1.017ValTrp: 1.017 ± 0.028	1.776ValTyr: 1.776 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.039TrpAla: 1.039 ± 0.026	0.199TrpCys: 0.199 ± 0.013	0.63TrpAsp: 0.63 ± 0.019	0.589TrpGlu: 0.589 ± 0.02	0.713TrpPhe: 0.713 ± 0.026	0.986TrpGly: 0.986 ± 0.026	0.451TrpHis: 0.451 ± 0.017	0.713TrpIle: 0.713 ± 0.025	0.499TrpLys: 0.499 ± 0.02	2.389TrpLeu: 2.389 ± 0.047	0.462TrpMet: 0.462 ± 0.017	0.493TrpAsn: 0.493 ± 0.019	0.691TrpPro: 0.691 ± 0.024	1.196TrpGln: 1.196 ± 0.034	1.176TrpArg: 1.176 ± 0.035	0.83TrpSer: 0.83 ± 0.025	0.601TrpThr: 0.601 ± 0.021	1.001TrpVal: 1.001 ± 0.03	0.239TrpTrp: 0.239 ± 0.014	0.418TrpTyr: 0.418 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.527TyrAla: 2.527 ± 0.051	0.364TyrCys: 0.364 ± 0.018	1.536TyrAsp: 1.536 ± 0.034	1.144TyrGlu: 1.144 ± 0.031	1.149TyrPhe: 1.149 ± 0.028	2.256TyrGly: 2.256 ± 0.044	0.684TyrHis: 0.684 ± 0.022	1.426TyrIle: 1.426 ± 0.033	0.875TyrLys: 0.875 ± 0.028	2.987TyrLeu: 2.987 ± 0.046	0.604TyrMet: 0.604 ± 0.021	0.971TyrAsn: 0.971 ± 0.03	1.363TyrPro: 1.363 ± 0.027	1.579TyrGln: 1.579 ± 0.034	1.896TyrArg: 1.896 ± 0.041	1.699TyrSer: 1.699 ± 0.039	1.427TyrThr: 1.427 ± 0.035	1.687TyrVal: 1.687 ± 0.039	0.443TyrTrp: 0.443 ± 0.019	0.898TyrTyr: 0.898 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4393 proteins (1420044 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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