Amino acid dipepetide frequency for Candidatus Cardinium hertigii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.313AlaAla: 8.313 ± 0.328
1.358AlaCys: 1.358 ± 0.067
3.278AlaAsp: 3.278 ± 0.118
4.624AlaGlu: 4.624 ± 0.148
3.275AlaPhe: 3.275 ± 0.101
4.058AlaGly: 4.058 ± 0.128
2.141AlaHis: 2.141 ± 0.086
7.427AlaIle: 7.427 ± 0.175
5.143AlaLys: 5.143 ± 0.128
9.991AlaLeu: 9.991 ± 0.21
2.551AlaMet: 2.551 ± 0.1
2.996AlaAsn: 2.996 ± 0.12
2.514AlaPro: 2.514 ± 0.115
3.552AlaGln: 3.552 ± 0.101
3.16AlaArg: 3.16 ± 0.121
4.913AlaSer: 4.913 ± 0.139
5.413AlaThr: 5.413 ± 0.162
5.336AlaVal: 5.336 ± 0.138
0.777AlaTrp: 0.777 ± 0.05
3.412AlaTyr: 3.412 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
0.926CysAla: 0.926 ± 0.051
0.348CysCys: 0.348 ± 0.046
0.413CysAsp: 0.413 ± 0.037
0.507CysGlu: 0.507 ± 0.037
1.053CysPhe: 1.053 ± 0.058
0.69CysGly: 0.69 ± 0.056
0.336CysHis: 0.336 ± 0.036
1.802CysIle: 1.802 ± 0.1
0.851CysLys: 0.851 ± 0.049
1.861CysLeu: 1.861 ± 0.086
0.538CysMet: 0.538 ± 0.05
0.696CysAsn: 0.696 ± 0.047
0.494CysPro: 0.494 ± 0.039
0.485CysGln: 0.485 ± 0.032
0.547CysArg: 0.547 ± 0.041
1.088CysSer: 1.088 ± 0.073
0.736CysThr: 0.736 ± 0.045
0.674CysVal: 0.674 ± 0.052
0.162CysTrp: 0.162 ± 0.023
0.743CysTyr: 0.743 ± 0.059
0.0CysXaa: 0.0 ± 0.0
Asp
2.759AspAla: 2.759 ± 0.106
0.851AspCys: 0.851 ± 0.082
1.311AspAsp: 1.311 ± 0.069
1.706AspGlu: 1.706 ± 0.072
1.892AspPhe: 1.892 ± 0.076
1.92AspGly: 1.92 ± 0.088
0.823AspHis: 0.823 ± 0.047
2.955AspIle: 2.955 ± 0.107
3.48AspLys: 3.48 ± 0.133
4.671AspLeu: 4.671 ± 0.153
0.761AspMet: 0.761 ± 0.046
1.83AspAsn: 1.83 ± 0.133
2.247AspPro: 2.247 ± 0.081
1.871AspGln: 1.871 ± 0.07
1.961AspArg: 1.961 ± 0.085
2.483AspSer: 2.483 ± 0.091
2.287AspThr: 2.287 ± 0.079
2.309AspVal: 2.309 ± 0.088
0.475AspTrp: 0.475 ± 0.04
1.812AspTyr: 1.812 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
5.929GluAla: 5.929 ± 0.21
0.544GluCys: 0.544 ± 0.042
2.371GluAsp: 2.371 ± 0.109
4.857GluGlu: 4.857 ± 0.169
1.203GluPhe: 1.203 ± 0.061
3.496GluGly: 3.496 ± 0.133
1.029GluHis: 1.029 ± 0.06
3.891GluIle: 3.891 ± 0.124
5.205GluLys: 5.205 ± 0.177
4.636GluLeu: 4.636 ± 0.125
1.224GluMet: 1.224 ± 0.056
2.498GluAsn: 2.498 ± 0.105
1.641GluPro: 1.641 ± 0.07
2.934GluGln: 2.934 ± 0.12
3.024GluArg: 3.024 ± 0.105
3.024GluSer: 3.024 ± 0.114
3.052GluThr: 3.052 ± 0.109
3.282GluVal: 3.282 ± 0.119
0.572GluTrp: 0.572 ± 0.044
1.122GluTyr: 1.122 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
2.53PheAla: 2.53 ± 0.095
0.805PheCys: 0.805 ± 0.056
1.576PheAsp: 1.576 ± 0.087
1.585PheGlu: 1.585 ± 0.068
2.362PhePhe: 2.362 ± 0.113
2.014PheGly: 2.014 ± 0.077
1.035PheHis: 1.035 ± 0.055
3.748PheIle: 3.748 ± 0.154
2.47PheLys: 2.47 ± 0.077
5.186PheLeu: 5.186 ± 0.145
1.122PheMet: 1.122 ± 0.052
1.818PheAsn: 1.818 ± 0.077
2.166PhePro: 2.166 ± 0.091
1.631PheGln: 1.631 ± 0.08
1.635PheArg: 1.635 ± 0.071
3.325PheSer: 3.325 ± 0.117
2.511PheThr: 2.511 ± 0.099
2.415PheVal: 2.415 ± 0.085
0.482PheTrp: 0.482 ± 0.038
1.961PheTyr: 1.961 ± 0.081
0.0PheXaa: 0.0 ± 0.0
Gly
3.971GlyAla: 3.971 ± 0.178
0.973GlyCys: 0.973 ± 0.056
2.06GlyAsp: 2.06 ± 0.087
2.53GlyGlu: 2.53 ± 0.084
2.558GlyPhe: 2.558 ± 0.093
3.841GlyGly: 3.841 ± 0.152
1.734GlyHis: 1.734 ± 0.107
5.367GlyIle: 5.367 ± 0.149
4.441GlyLys: 4.441 ± 0.153
5.749GlyLeu: 5.749 ± 0.127
1.98GlyMet: 1.98 ± 0.102
2.679GlyAsn: 2.679 ± 0.112
1.268GlyPro: 1.268 ± 0.059
1.914GlyGln: 1.914 ± 0.086
2.312GlyArg: 2.312 ± 0.087
3.748GlySer: 3.748 ± 0.117
2.924GlyThr: 2.924 ± 0.094
2.862GlyVal: 2.862 ± 0.118
0.721GlyTrp: 0.721 ± 0.053
2.909GlyTyr: 2.909 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
2.449HisAla: 2.449 ± 0.091
0.423HisCys: 0.423 ± 0.04
0.932HisAsp: 0.932 ± 0.05
0.848HisGlu: 0.848 ± 0.05
1.321HisPhe: 1.321 ± 0.085
1.358HisGly: 1.358 ± 0.063
0.556HisHis: 0.556 ± 0.048
2.231HisIle: 2.231 ± 0.066
1.846HisLys: 1.846 ± 0.078
2.899HisLeu: 2.899 ± 0.112
0.503HisMet: 0.503 ± 0.035
1.314HisAsn: 1.314 ± 0.062
1.069HisPro: 1.069 ± 0.057
1.038HisGln: 1.038 ± 0.062
0.935HisArg: 0.935 ± 0.051
1.243HisSer: 1.243 ± 0.067
1.743HisThr: 1.743 ± 0.088
1.234HisVal: 1.234 ± 0.066
0.435HisTrp: 0.435 ± 0.054
1.625HisTyr: 1.625 ± 0.081
0.0HisXaa: 0.0 ± 0.0
Ile
8.185IleAla: 8.185 ± 0.176
1.187IleCys: 1.187 ± 0.059
3.732IleAsp: 3.732 ± 0.138
4.814IleGlu: 4.814 ± 0.158
2.763IlePhe: 2.763 ± 0.103
5.395IleGly: 5.395 ± 0.165
1.88IleHis: 1.88 ± 0.084
5.578IleIle: 5.578 ± 0.184
5.444IleLys: 5.444 ± 0.148
6.812IleLeu: 6.812 ± 0.162
1.479IleMet: 1.479 ± 0.065
2.822IleAsn: 2.822 ± 0.148
3.49IlePro: 3.49 ± 0.106
3.875IleGln: 3.875 ± 0.109
3.073IleArg: 3.073 ± 0.104
4.223IleSer: 4.223 ± 0.124
5.286IleThr: 5.286 ± 0.141
5.065IleVal: 5.065 ± 0.14
0.746IleTrp: 0.746 ± 0.051
2.669IleTyr: 2.669 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
5.662LysAla: 5.662 ± 0.187
0.631LysCys: 0.631 ± 0.043
3.017LysAsp: 3.017 ± 0.136
6.125LysGlu: 6.125 ± 0.154
1.945LysPhe: 1.945 ± 0.091
4.419LysGly: 4.419 ± 0.167
1.61LysHis: 1.61 ± 0.087
4.804LysIle: 4.804 ± 0.155
6.187LysLys: 6.187 ± 0.189
6.79LysLeu: 6.79 ± 0.169
1.467LysMet: 1.467 ± 0.063
3.238LysAsn: 3.238 ± 0.138
2.222LysPro: 2.222 ± 0.092
4.065LysGln: 4.065 ± 0.112
3.53LysArg: 3.53 ± 0.128
3.176LysSer: 3.176 ± 0.113
3.319LysThr: 3.319 ± 0.103
4.214LysVal: 4.214 ± 0.139
0.718LysTrp: 0.718 ± 0.049
2.219LysTyr: 2.219 ± 0.107
0.0LysXaa: 0.0 ± 0.0
Leu
9.885LeuAla: 9.885 ± 0.27
1.613LeuCys: 1.613 ± 0.073
4.534LeuAsp: 4.534 ± 0.133
5.796LeuGlu: 5.796 ± 0.143
5.578LeuPhe: 5.578 ± 0.148
5.27LeuGly: 5.27 ± 0.142
4.071LeuHis: 4.071 ± 0.186
7.604LeuIle: 7.604 ± 0.196
6.411LeuLys: 6.411 ± 0.156
15.889LeuLeu: 15.889 ± 0.416
2.275LeuMet: 2.275 ± 0.086
3.937LeuAsn: 3.937 ± 0.139
5.879LeuPro: 5.879 ± 0.158
5.637LeuGln: 5.637 ± 0.172
4.161LeuArg: 4.161 ± 0.106
7.293LeuSer: 7.293 ± 0.167
6.215LeuThr: 6.215 ± 0.143
6.05LeuVal: 6.05 ± 0.191
1.377LeuTrp: 1.377 ± 0.069
4.431LeuTyr: 4.431 ± 0.12
0.0LeuXaa: 0.0 ± 0.0
Met
2.334MetAla: 2.334 ± 0.094
0.27MetCys: 0.27 ± 0.029
1.091MetAsp: 1.091 ± 0.06
1.461MetGlu: 1.461 ± 0.09
0.674MetPhe: 0.674 ± 0.053
1.784MetGly: 1.784 ± 0.069
0.858MetHis: 0.858 ± 0.049
1.314MetIle: 1.314 ± 0.065
1.035MetLys: 1.035 ± 0.057
3.359MetLeu: 3.359 ± 0.108
0.36MetMet: 0.36 ± 0.038
0.74MetAsn: 0.74 ± 0.053
1.025MetPro: 1.025 ± 0.052
1.56MetGln: 1.56 ± 0.065
1.234MetArg: 1.234 ± 0.069
1.078MetSer: 1.078 ± 0.055
0.886MetThr: 0.886 ± 0.056
1.983MetVal: 1.983 ± 0.081
0.131MetTrp: 0.131 ± 0.019
0.64MetTyr: 0.64 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
2.809AsnAla: 2.809 ± 0.092
0.622AsnCys: 0.622 ± 0.045
1.454AsnAsp: 1.454 ± 0.078
1.737AsnGlu: 1.737 ± 0.078
1.684AsnPhe: 1.684 ± 0.086
2.486AsnGly: 2.486 ± 0.153
1.022AsnHis: 1.022 ± 0.059
3.179AsnIle: 3.179 ± 0.153
3.94AsnLys: 3.94 ± 0.14
4.264AsnLeu: 4.264 ± 0.145
0.792AsnMet: 0.792 ± 0.046
2.098AsnAsn: 2.098 ± 0.136
1.899AsnPro: 1.899 ± 0.077
2.265AsnGln: 2.265 ± 0.11
2.098AsnArg: 2.098 ± 0.092
2.234AsnSer: 2.234 ± 0.122
2.185AsnThr: 2.185 ± 0.086
2.356AsnVal: 2.356 ± 0.112
0.457AsnTrp: 0.457 ± 0.043
1.516AsnTyr: 1.516 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
2.955ProAla: 2.955 ± 0.122
0.572ProCys: 0.572 ± 0.046
1.594ProAsp: 1.594 ± 0.07
1.805ProGlu: 1.805 ± 0.076
2.377ProPhe: 2.377 ± 0.126
1.644ProGly: 1.644 ± 0.064
0.994ProHis: 0.994 ± 0.057
3.592ProIle: 3.592 ± 0.102
2.213ProLys: 2.213 ± 0.084
5.562ProLeu: 5.562 ± 0.189
1.047ProMet: 1.047 ± 0.059
1.498ProAsn: 1.498 ± 0.075
1.52ProPro: 1.52 ± 0.114
1.501ProGln: 1.501 ± 0.068
1.14ProArg: 1.14 ± 0.06
2.666ProSer: 2.666 ± 0.101
2.766ProThr: 2.766 ± 0.101
2.035ProVal: 2.035 ± 0.085
0.522ProTrp: 0.522 ± 0.049
1.865ProTyr: 1.865 ± 0.086
0.0ProXaa: 0.0 ± 0.0
Gln
4.021GlnAla: 4.021 ± 0.128
0.525GlnCys: 0.525 ± 0.04
1.868GlnAsp: 1.868 ± 0.078
3.462GlnGlu: 3.462 ± 0.121
1.485GlnPhe: 1.485 ± 0.066
2.29GlnGly: 2.29 ± 0.095
1.336GlnHis: 1.336 ± 0.085
2.94GlnIle: 2.94 ± 0.093
3.515GlnLys: 3.515 ± 0.109
5.727GlnLeu: 5.727 ± 0.169
0.833GlnMet: 0.833 ± 0.056
1.647GlnAsn: 1.647 ± 0.065
2.026GlnPro: 2.026 ± 0.1
3.195GlnGln: 3.195 ± 0.161
2.241GlnArg: 2.241 ± 0.096
2.278GlnSer: 2.278 ± 0.092
2.502GlnThr: 2.502 ± 0.102
2.328GlnVal: 2.328 ± 0.097
0.513GlnTrp: 0.513 ± 0.035
1.498GlnTyr: 1.498 ± 0.069
0.0GlnXaa: 0.0 ± 0.0
Arg
2.766ArgAla: 2.766 ± 0.106
0.559ArgCys: 0.559 ± 0.042
1.619ArgAsp: 1.619 ± 0.068
2.418ArgGlu: 2.418 ± 0.097
2.032ArgPhe: 2.032 ± 0.078
2.063ArgGly: 2.063 ± 0.076
1.016ArgHis: 1.016 ± 0.065
3.459ArgIle: 3.459 ± 0.108
3.462ArgLys: 3.462 ± 0.122
4.419ArgLeu: 4.419 ± 0.121
1.293ArgMet: 1.293 ± 0.063
2.088ArgAsn: 2.088 ± 0.078
1.237ArgPro: 1.237 ± 0.067
1.675ArgGln: 1.675 ± 0.077
1.883ArgArg: 1.883 ± 0.128
2.613ArgSer: 2.613 ± 0.093
2.296ArgThr: 2.296 ± 0.084
2.222ArgVal: 2.222 ± 0.088
0.472ArgTrp: 0.472 ± 0.039
1.793ArgTyr: 1.793 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
3.639SerAla: 3.639 ± 0.123
1.246SerCys: 1.246 ± 0.079
2.157SerAsp: 2.157 ± 0.093
2.356SerGlu: 2.356 ± 0.088
3.154SerPhe: 3.154 ± 0.103
3.291SerGly: 3.291 ± 0.124
1.383SerHis: 1.383 ± 0.068
5.808SerIle: 5.808 ± 0.151
3.686SerLys: 3.686 ± 0.14
7.281SerLeu: 7.281 ± 0.195
1.731SerMet: 1.731 ± 0.065
2.654SerAsn: 2.654 ± 0.106
2.209SerPro: 2.209 ± 0.102
1.843SerGln: 1.843 ± 0.082
2.181SerArg: 2.181 ± 0.084
4.205SerSer: 4.205 ± 0.171
3.244SerThr: 3.244 ± 0.101
3.856SerVal: 3.856 ± 0.122
0.538SerTrp: 0.538 ± 0.043
2.551SerTyr: 2.551 ± 0.085
0.0SerXaa: 0.0 ± 0.0
Thr
5.833ThrAla: 5.833 ± 0.169
0.668ThrCys: 0.668 ± 0.055
2.539ThrAsp: 2.539 ± 0.101
2.756ThrGlu: 2.756 ± 0.137
2.539ThrPhe: 2.539 ± 0.093
3.216ThrGly: 3.216 ± 0.108
1.538ThrHis: 1.538 ± 0.063
5.364ThrIle: 5.364 ± 0.166
3.44ThrLys: 3.44 ± 0.134
7.508ThrLeu: 7.508 ± 0.186
1.221ThrMet: 1.221 ± 0.052
1.892ThrAsn: 1.892 ± 0.088
2.722ThrPro: 2.722 ± 0.123
2.349ThrGln: 2.349 ± 0.104
1.762ThrArg: 1.762 ± 0.072
2.738ThrSer: 2.738 ± 0.099
3.508ThrThr: 3.508 ± 0.122
3.372ThrVal: 3.372 ± 0.116
0.41ThrTrp: 0.41 ± 0.04
2.203ThrTyr: 2.203 ± 0.088
0.0ThrXaa: 0.0 ± 0.0
Val
5.407ValAla: 5.407 ± 0.133
0.957ValCys: 0.957 ± 0.052
2.806ValAsp: 2.806 ± 0.093
3.788ValGlu: 3.788 ± 0.108
2.141ValPhe: 2.141 ± 0.082
3.909ValGly: 3.909 ± 0.119
1.137ValHis: 1.137 ± 0.063
3.912ValIle: 3.912 ± 0.114
3.272ValLys: 3.272 ± 0.116
5.935ValLeu: 5.935 ± 0.13
1.442ValMet: 1.442 ± 0.072
2.533ValAsn: 2.533 ± 0.145
2.098ValPro: 2.098 ± 0.082
2.439ValGln: 2.439 ± 0.088
2.405ValArg: 2.405 ± 0.095
3.71ValSer: 3.71 ± 0.125
3.717ValThr: 3.717 ± 0.116
4.186ValVal: 4.186 ± 0.12
0.653ValTrp: 0.653 ± 0.047
2.247ValTyr: 2.247 ± 0.095
0.0ValXaa: 0.0 ± 0.0
Trp
0.839TrpAla: 0.839 ± 0.07
0.134TrpCys: 0.134 ± 0.021
0.497TrpAsp: 0.497 ± 0.038
0.705TrpGlu: 0.705 ± 0.047
0.447TrpPhe: 0.447 ± 0.038
0.659TrpGly: 0.659 ± 0.047
0.354TrpHis: 0.354 ± 0.036
0.858TrpIle: 0.858 ± 0.061
0.668TrpLys: 0.668 ± 0.051
1.308TrpLeu: 1.308 ± 0.07
0.286TrpMet: 0.286 ± 0.036
0.42TrpAsn: 0.42 ± 0.036
0.507TrpPro: 0.507 ± 0.041
0.463TrpGln: 0.463 ± 0.039
0.382TrpArg: 0.382 ± 0.037
0.55TrpSer: 0.55 ± 0.036
0.497TrpThr: 0.497 ± 0.043
0.771TrpVal: 0.771 ± 0.057
0.155TrpTrp: 0.155 ± 0.02
0.395TrpTyr: 0.395 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.024TyrAla: 3.024 ± 0.102
0.665TyrCys: 0.665 ± 0.041
1.557TyrAsp: 1.557 ± 0.064
1.653TyrGlu: 1.653 ± 0.083
1.889TyrPhe: 1.889 ± 0.09
2.735TyrGly: 2.735 ± 0.1
1.15TyrHis: 1.15 ± 0.066
2.685TyrIle: 2.685 ± 0.097
2.648TyrLys: 2.648 ± 0.101
4.058TyrLeu: 4.058 ± 0.127
0.907TyrMet: 0.907 ± 0.047
1.7TyrAsn: 1.7 ± 0.078
1.638TyrPro: 1.638 ± 0.069
1.936TyrGln: 1.936 ± 0.086
1.722TyrArg: 1.722 ± 0.09
2.424TyrSer: 2.424 ± 0.077
2.492TyrThr: 2.492 ± 0.088
2.147TyrVal: 2.147 ± 0.076
0.581TyrTrp: 0.581 ± 0.038
1.989TyrTyr: 1.989 ± 0.094
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 963 proteins (321799 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski