Amino acid dipepetide frequency for Streptococcus phage Javan131

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.776AlaAla: 3.776 ± 1.188
0.302AlaCys: 0.302 ± 0.139
4.38AlaAsp: 4.38 ± 0.492
5.512AlaGlu: 5.512 ± 0.772
1.51AlaPhe: 1.51 ± 0.338
4.153AlaGly: 4.153 ± 0.903
1.435AlaHis: 1.435 ± 0.418
4.833AlaIle: 4.833 ± 0.637
7.249AlaLys: 7.249 ± 0.578
6.116AlaLeu: 6.116 ± 1.061
2.19AlaMet: 2.19 ± 0.496
4.38AlaAsn: 4.38 ± 0.637
1.812AlaPro: 1.812 ± 0.33
3.474AlaGln: 3.474 ± 0.691
2.869AlaArg: 2.869 ± 0.439
4.908AlaSer: 4.908 ± 0.733
4.38AlaThr: 4.38 ± 0.66
5.286AlaVal: 5.286 ± 0.82
0.906AlaTrp: 0.906 ± 0.267
2.19AlaTyr: 2.19 ± 0.345
0.0AlaXaa: 0.0 ± 0.0
Cys
0.453CysAla: 0.453 ± 0.173
0.076CysCys: 0.076 ± 0.069
0.378CysAsp: 0.378 ± 0.243
0.68CysGlu: 0.68 ± 0.219
0.302CysPhe: 0.302 ± 0.149
0.604CysGly: 0.604 ± 0.254
0.151CysHis: 0.151 ± 0.118
0.378CysIle: 0.378 ± 0.165
0.529CysLys: 0.529 ± 0.176
0.378CysLeu: 0.378 ± 0.17
0.151CysMet: 0.151 ± 0.113
0.453CysAsn: 0.453 ± 0.152
0.076CysPro: 0.076 ± 0.068
0.302CysGln: 0.302 ± 0.176
0.151CysArg: 0.151 ± 0.11
0.604CysSer: 0.604 ± 0.204
0.227CysThr: 0.227 ± 0.156
0.378CysVal: 0.378 ± 0.155
0.151CysTrp: 0.151 ± 0.101
0.227CysTyr: 0.227 ± 0.127
0.0CysXaa: 0.0 ± 0.0
Asp
3.323AspAla: 3.323 ± 0.546
0.906AspCys: 0.906 ± 0.263
4.908AspAsp: 4.908 ± 0.562
5.21AspGlu: 5.21 ± 0.659
2.567AspPhe: 2.567 ± 0.411
5.361AspGly: 5.361 ± 0.904
0.453AspHis: 0.453 ± 0.153
5.361AspIle: 5.361 ± 0.615
7.325AspLys: 7.325 ± 0.548
6.267AspLeu: 6.267 ± 0.563
1.208AspMet: 1.208 ± 0.306
3.776AspAsn: 3.776 ± 0.358
1.963AspPro: 1.963 ± 0.415
1.586AspGln: 1.586 ± 0.399
2.794AspArg: 2.794 ± 0.436
4.153AspSer: 4.153 ± 0.519
3.323AspThr: 3.323 ± 0.623
3.851AspVal: 3.851 ± 0.562
1.359AspTrp: 1.359 ± 0.32
3.851AspTyr: 3.851 ± 0.591
0.0AspXaa: 0.0 ± 0.0
Glu
5.135GluAla: 5.135 ± 0.66
0.302GluCys: 0.302 ± 0.133
3.927GluAsp: 3.927 ± 0.575
6.041GluGlu: 6.041 ± 0.598
3.02GluPhe: 3.02 ± 0.454
3.02GluGly: 3.02 ± 0.599
0.982GluHis: 0.982 ± 0.264
6.267GluIle: 6.267 ± 0.786
5.89GluLys: 5.89 ± 0.609
8.306GluLeu: 8.306 ± 0.945
2.265GluMet: 2.265 ± 0.433
2.643GluAsn: 2.643 ± 0.402
1.435GluPro: 1.435 ± 0.319
2.567GluGln: 2.567 ± 0.428
3.549GluArg: 3.549 ± 0.574
4.229GluSer: 4.229 ± 0.711
4.38GluThr: 4.38 ± 0.657
5.135GluVal: 5.135 ± 0.728
1.284GluTrp: 1.284 ± 0.298
2.869GluTyr: 2.869 ± 0.452
0.0GluXaa: 0.0 ± 0.0
Phe
3.096PheAla: 3.096 ± 0.473
0.151PheCys: 0.151 ± 0.103
3.247PheAsp: 3.247 ± 0.462
3.02PheGlu: 3.02 ± 0.502
0.831PhePhe: 0.831 ± 0.318
2.718PheGly: 2.718 ± 0.455
0.227PheHis: 0.227 ± 0.132
2.265PheIle: 2.265 ± 0.432
3.549PheLys: 3.549 ± 0.504
1.586PheLeu: 1.586 ± 0.376
0.982PheMet: 0.982 ± 0.275
1.812PheAsn: 1.812 ± 0.36
1.359PhePro: 1.359 ± 0.345
0.604PheGln: 0.604 ± 0.248
1.586PheArg: 1.586 ± 0.47
1.812PheSer: 1.812 ± 0.362
2.341PheThr: 2.341 ± 0.363
2.039PheVal: 2.039 ± 0.402
0.302PheTrp: 0.302 ± 0.173
1.208PheTyr: 1.208 ± 0.359
0.0PheXaa: 0.0 ± 0.0
Gly
4.078GlyAla: 4.078 ± 0.791
0.604GlyCys: 0.604 ± 0.199
4.606GlyAsp: 4.606 ± 0.641
3.398GlyGlu: 3.398 ± 0.479
2.643GlyPhe: 2.643 ± 0.431
4.833GlyGly: 4.833 ± 0.577
1.057GlyHis: 1.057 ± 0.31
4.229GlyIle: 4.229 ± 0.524
6.192GlyLys: 6.192 ± 0.721
5.965GlyLeu: 5.965 ± 0.638
1.737GlyMet: 1.737 ± 0.384
3.625GlyAsn: 3.625 ± 0.526
1.133GlyPro: 1.133 ± 0.302
3.474GlyGln: 3.474 ± 0.527
2.341GlyArg: 2.341 ± 0.399
2.567GlySer: 2.567 ± 0.394
2.869GlyThr: 2.869 ± 0.425
3.927GlyVal: 3.927 ± 0.484
1.586GlyTrp: 1.586 ± 0.43
2.945GlyTyr: 2.945 ± 0.543
0.0GlyXaa: 0.0 ± 0.0
His
0.755HisAla: 0.755 ± 0.224
0.151HisCys: 0.151 ± 0.101
1.208HisAsp: 1.208 ± 0.32
1.661HisGlu: 1.661 ± 0.403
0.831HisPhe: 0.831 ± 0.242
1.057HisGly: 1.057 ± 0.252
0.529HisHis: 0.529 ± 0.246
0.68HisIle: 0.68 ± 0.188
1.057HisLys: 1.057 ± 0.35
0.529HisLeu: 0.529 ± 0.207
0.151HisMet: 0.151 ± 0.114
0.604HisAsn: 0.604 ± 0.208
0.453HisPro: 0.453 ± 0.167
0.604HisGln: 0.604 ± 0.241
0.982HisArg: 0.982 ± 0.257
0.529HisSer: 0.529 ± 0.205
0.831HisThr: 0.831 ± 0.282
0.755HisVal: 0.755 ± 0.221
0.076HisTrp: 0.076 ± 0.077
0.68HisTyr: 0.68 ± 0.268
0.0HisXaa: 0.0 ± 0.0
Ile
5.437IleAla: 5.437 ± 0.628
0.755IleCys: 0.755 ± 0.253
6.57IleAsp: 6.57 ± 0.874
6.041IleGlu: 6.041 ± 0.673
1.435IlePhe: 1.435 ± 0.315
4.455IleGly: 4.455 ± 0.626
1.133IleHis: 1.133 ± 0.342
3.625IleIle: 3.625 ± 0.543
7.098IleLys: 7.098 ± 0.926
4.682IleLeu: 4.682 ± 0.722
0.982IleMet: 0.982 ± 0.246
4.38IleAsn: 4.38 ± 0.683
2.567IlePro: 2.567 ± 0.522
1.51IleGln: 1.51 ± 0.345
2.492IleArg: 2.492 ± 0.378
3.398IleSer: 3.398 ± 0.569
5.059IleThr: 5.059 ± 0.62
4.153IleVal: 4.153 ± 0.337
1.057IleTrp: 1.057 ± 0.297
2.341IleTyr: 2.341 ± 0.39
0.0IleXaa: 0.0 ± 0.0
Lys
7.778LysAla: 7.778 ± 0.595
0.831LysCys: 0.831 ± 0.256
4.833LysAsp: 4.833 ± 0.774
7.098LysGlu: 7.098 ± 0.716
2.945LysPhe: 2.945 ± 0.477
5.663LysGly: 5.663 ± 0.845
0.755LysHis: 0.755 ± 0.237
6.721LysIle: 6.721 ± 0.987
7.249LysLys: 7.249 ± 0.829
6.645LysLeu: 6.645 ± 0.821
2.643LysMet: 2.643 ± 0.384
5.588LysAsn: 5.588 ± 0.629
3.02LysPro: 3.02 ± 0.468
5.361LysGln: 5.361 ± 0.623
2.945LysArg: 2.945 ± 0.556
4.304LysSer: 4.304 ± 0.403
5.965LysThr: 5.965 ± 0.697
6.267LysVal: 6.267 ± 0.688
0.831LysTrp: 0.831 ± 0.202
3.02LysTyr: 3.02 ± 0.5
0.0LysXaa: 0.0 ± 0.0
Leu
6.645LeuAla: 6.645 ± 1.086
0.604LeuCys: 0.604 ± 0.198
6.57LeuAsp: 6.57 ± 0.593
6.796LeuGlu: 6.796 ± 0.946
2.643LeuPhe: 2.643 ± 0.503
5.663LeuGly: 5.663 ± 0.761
1.208LeuHis: 1.208 ± 0.269
5.663LeuIle: 5.663 ± 0.857
8.533LeuLys: 8.533 ± 0.821
6.267LeuLeu: 6.267 ± 0.819
1.737LeuMet: 1.737 ± 0.329
4.984LeuAsn: 4.984 ± 0.634
2.945LeuPro: 2.945 ± 0.45
2.945LeuGln: 2.945 ± 0.438
3.776LeuArg: 3.776 ± 0.515
5.814LeuSer: 5.814 ± 0.722
5.965LeuThr: 5.965 ± 0.607
4.304LeuVal: 4.304 ± 0.452
0.604LeuTrp: 0.604 ± 0.209
2.341LeuTyr: 2.341 ± 0.417
0.0LeuXaa: 0.0 ± 0.0
Met
1.661MetAla: 1.661 ± 0.36
0.151MetCys: 0.151 ± 0.107
1.435MetAsp: 1.435 ± 0.362
1.284MetGlu: 1.284 ± 0.259
1.057MetPhe: 1.057 ± 0.263
1.51MetGly: 1.51 ± 0.324
0.378MetHis: 0.378 ± 0.195
1.737MetIle: 1.737 ± 0.352
1.435MetLys: 1.435 ± 0.298
2.341MetLeu: 2.341 ± 0.443
0.302MetMet: 0.302 ± 0.152
1.057MetAsn: 1.057 ± 0.253
0.604MetPro: 0.604 ± 0.242
0.982MetGln: 0.982 ± 0.25
1.51MetArg: 1.51 ± 0.245
2.039MetSer: 2.039 ± 0.413
1.661MetThr: 1.661 ± 0.365
1.586MetVal: 1.586 ± 0.367
0.227MetTrp: 0.227 ± 0.12
0.453MetTyr: 0.453 ± 0.19
0.0MetXaa: 0.0 ± 0.0
Asn
3.474AsnAla: 3.474 ± 0.578
0.151AsnCys: 0.151 ± 0.182
3.851AsnAsp: 3.851 ± 0.491
3.02AsnGlu: 3.02 ± 0.503
2.341AsnPhe: 2.341 ± 0.437
4.682AsnGly: 4.682 ± 0.602
0.68AsnHis: 0.68 ± 0.188
3.851AsnIle: 3.851 ± 0.598
4.078AsnLys: 4.078 ± 0.657
4.757AsnLeu: 4.757 ± 0.568
1.51AsnMet: 1.51 ± 0.36
3.549AsnAsn: 3.549 ± 0.545
2.114AsnPro: 2.114 ± 0.339
2.114AsnGln: 2.114 ± 0.363
2.416AsnArg: 2.416 ± 0.496
2.869AsnSer: 2.869 ± 0.595
2.718AsnThr: 2.718 ± 0.46
3.323AsnVal: 3.323 ± 0.488
1.208AsnTrp: 1.208 ± 0.27
2.492AsnTyr: 2.492 ± 0.509
0.0AsnXaa: 0.0 ± 0.0
Pro
1.435ProAla: 1.435 ± 0.46
0.076ProCys: 0.076 ± 0.071
2.567ProAsp: 2.567 ± 0.432
1.963ProGlu: 1.963 ± 0.382
1.057ProPhe: 1.057 ± 0.292
1.057ProGly: 1.057 ± 0.279
0.529ProHis: 0.529 ± 0.193
1.284ProIle: 1.284 ± 0.344
3.096ProLys: 3.096 ± 0.582
3.247ProLeu: 3.247 ± 0.513
0.378ProMet: 0.378 ± 0.161
1.737ProAsn: 1.737 ± 0.383
0.453ProPro: 0.453 ± 0.227
1.963ProGln: 1.963 ± 0.582
0.906ProArg: 0.906 ± 0.341
1.661ProSer: 1.661 ± 0.356
2.341ProThr: 2.341 ± 0.372
1.888ProVal: 1.888 ± 0.414
0.0ProTrp: 0.0 ± 0.0
1.359ProTyr: 1.359 ± 0.365
0.0ProXaa: 0.0 ± 0.0
Gln
2.492GlnAla: 2.492 ± 0.462
0.076GlnCys: 0.076 ± 0.068
2.265GlnAsp: 2.265 ± 0.432
3.096GlnGlu: 3.096 ± 0.425
1.963GlnPhe: 1.963 ± 0.297
2.039GlnGly: 2.039 ± 0.46
0.906GlnHis: 0.906 ± 0.27
2.794GlnIle: 2.794 ± 0.411
4.078GlnLys: 4.078 ± 0.538
3.776GlnLeu: 3.776 ± 0.555
1.586GlnMet: 1.586 ± 0.332
1.586GlnAsn: 1.586 ± 0.329
1.435GlnPro: 1.435 ± 0.42
2.567GlnGln: 2.567 ± 0.799
1.888GlnArg: 1.888 ± 0.352
4.002GlnSer: 4.002 ± 0.624
2.416GlnThr: 2.416 ± 0.508
1.586GlnVal: 1.586 ± 0.354
0.604GlnTrp: 0.604 ± 0.198
1.057GlnTyr: 1.057 ± 0.271
0.0GlnXaa: 0.0 ± 0.0
Arg
2.869ArgAla: 2.869 ± 0.353
0.076ArgCys: 0.076 ± 0.081
2.114ArgAsp: 2.114 ± 0.418
2.718ArgGlu: 2.718 ± 0.405
1.284ArgPhe: 1.284 ± 0.328
2.19ArgGly: 2.19 ± 0.285
0.906ArgHis: 0.906 ± 0.252
3.323ArgIle: 3.323 ± 0.625
4.002ArgLys: 4.002 ± 0.522
4.078ArgLeu: 4.078 ± 0.599
0.755ArgMet: 0.755 ± 0.246
2.718ArgAsn: 2.718 ± 0.548
0.831ArgPro: 0.831 ± 0.29
1.661ArgGln: 1.661 ± 0.382
1.888ArgArg: 1.888 ± 0.445
1.661ArgSer: 1.661 ± 0.328
2.341ArgThr: 2.341 ± 0.561
2.643ArgVal: 2.643 ± 0.446
0.453ArgTrp: 0.453 ± 0.234
1.812ArgTyr: 1.812 ± 0.347
0.0ArgXaa: 0.0 ± 0.0
Ser
5.135SerAla: 5.135 ± 0.826
0.302SerCys: 0.302 ± 0.163
4.002SerAsp: 4.002 ± 0.51
3.851SerGlu: 3.851 ± 0.414
2.265SerPhe: 2.265 ± 0.378
4.531SerGly: 4.531 ± 0.597
0.755SerHis: 0.755 ± 0.217
3.851SerIle: 3.851 ± 0.78
5.286SerLys: 5.286 ± 0.568
4.908SerLeu: 4.908 ± 0.468
1.812SerMet: 1.812 ± 0.315
3.171SerAsn: 3.171 ± 0.554
1.208SerPro: 1.208 ± 0.308
3.323SerGln: 3.323 ± 0.472
1.661SerArg: 1.661 ± 0.351
3.02SerSer: 3.02 ± 0.516
2.492SerThr: 2.492 ± 0.425
4.002SerVal: 4.002 ± 0.456
0.529SerTrp: 0.529 ± 0.233
2.416SerTyr: 2.416 ± 0.526
0.0SerXaa: 0.0 ± 0.0
Thr
5.059ThrAla: 5.059 ± 0.859
0.302ThrCys: 0.302 ± 0.14
3.323ThrAsp: 3.323 ± 0.546
3.776ThrGlu: 3.776 ± 0.648
1.661ThrPhe: 1.661 ± 0.355
4.304ThrGly: 4.304 ± 0.54
0.453ThrHis: 0.453 ± 0.162
5.437ThrIle: 5.437 ± 0.607
4.833ThrLys: 4.833 ± 0.621
5.135ThrLeu: 5.135 ± 0.491
1.435ThrMet: 1.435 ± 0.381
3.096ThrAsn: 3.096 ± 0.418
2.341ThrPro: 2.341 ± 0.499
1.812ThrGln: 1.812 ± 0.418
1.359ThrArg: 1.359 ± 0.291
4.153ThrSer: 4.153 ± 0.49
3.02ThrThr: 3.02 ± 0.613
4.38ThrVal: 4.38 ± 0.531
0.755ThrTrp: 0.755 ± 0.214
2.341ThrTyr: 2.341 ± 0.43
0.0ThrXaa: 0.0 ± 0.0
Val
5.21ValAla: 5.21 ± 0.896
0.378ValCys: 0.378 ± 0.144
5.21ValAsp: 5.21 ± 0.608
4.682ValGlu: 4.682 ± 0.574
2.643ValPhe: 2.643 ± 0.437
3.549ValGly: 3.549 ± 0.427
0.604ValHis: 0.604 ± 0.238
4.229ValIle: 4.229 ± 0.491
5.663ValLys: 5.663 ± 0.607
6.721ValLeu: 6.721 ± 0.688
0.604ValMet: 0.604 ± 0.246
3.398ValAsn: 3.398 ± 0.588
1.586ValPro: 1.586 ± 0.317
1.661ValGln: 1.661 ± 0.338
2.265ValArg: 2.265 ± 0.41
4.002ValSer: 4.002 ± 0.542
3.625ValThr: 3.625 ± 0.405
3.851ValVal: 3.851 ± 0.526
0.604ValTrp: 0.604 ± 0.2
1.812ValTyr: 1.812 ± 0.481
0.0ValXaa: 0.0 ± 0.0
Trp
0.755TrpAla: 0.755 ± 0.233
0.076TrpCys: 0.076 ± 0.083
1.284TrpAsp: 1.284 ± 0.401
1.057TrpGlu: 1.057 ± 0.247
0.529TrpPhe: 0.529 ± 0.175
0.831TrpGly: 0.831 ± 0.323
0.302TrpHis: 0.302 ± 0.15
0.906TrpIle: 0.906 ± 0.268
0.982TrpLys: 0.982 ± 0.249
1.359TrpLeu: 1.359 ± 0.333
0.227TrpMet: 0.227 ± 0.197
0.755TrpAsn: 0.755 ± 0.226
0.227TrpPro: 0.227 ± 0.114
0.529TrpGln: 0.529 ± 0.157
0.831TrpArg: 0.831 ± 0.239
0.68TrpSer: 0.68 ± 0.246
0.755TrpThr: 0.755 ± 0.23
0.68TrpVal: 0.68 ± 0.221
0.0TrpTrp: 0.0 ± 0.0
0.302TrpTyr: 0.302 ± 0.173
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.096TyrAla: 3.096 ± 0.576
0.378TyrCys: 0.378 ± 0.165
2.869TyrAsp: 2.869 ± 0.512
2.341TyrGlu: 2.341 ± 0.457
1.208TyrPhe: 1.208 ± 0.36
1.586TyrGly: 1.586 ± 0.289
0.68TyrHis: 0.68 ± 0.237
1.737TyrIle: 1.737 ± 0.47
2.341TyrLys: 2.341 ± 0.515
2.945TyrLeu: 2.945 ± 0.522
0.68TyrMet: 0.68 ± 0.249
1.888TyrAsn: 1.888 ± 0.416
1.435TyrPro: 1.435 ± 0.412
3.171TyrGln: 3.171 ± 0.704
2.114TyrArg: 2.114 ± 0.358
2.114TyrSer: 2.114 ± 0.406
2.265TyrThr: 2.265 ± 0.521
2.265TyrVal: 2.265 ± 0.397
0.604TyrTrp: 0.604 ± 0.223
1.888TyrTyr: 1.888 ± 0.397
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (13244 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski