Amino acid dipepetide frequency for Pontiella desulfatans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.038AlaAla: 9.038 ± 0.075	1.028AlaCys: 1.028 ± 0.023	5.842AlaAsp: 5.842 ± 0.049	6.157AlaGlu: 6.157 ± 0.055	3.569AlaPhe: 3.569 ± 0.039	8.137AlaGly: 8.137 ± 0.077	1.757AlaHis: 1.757 ± 0.024	4.448AlaIle: 4.448 ± 0.045	4.092AlaLys: 4.092 ± 0.055	8.221AlaLeu: 8.221 ± 0.079	2.437AlaMet: 2.437 ± 0.031	3.299AlaAsn: 3.299 ± 0.038	3.801AlaPro: 3.801 ± 0.045	2.79AlaGln: 2.79 ± 0.033	4.072AlaArg: 4.072 ± 0.052	5.328AlaSer: 5.328 ± 0.051	4.962AlaThr: 4.962 ± 0.053	6.448AlaVal: 6.448 ± 0.05	1.434AlaTrp: 1.434 ± 0.028	2.745AlaTyr: 2.745 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.029CysAla: 1.029 ± 0.021	0.196CysCys: 0.196 ± 0.009	0.711CysAsp: 0.711 ± 0.018	0.639CysGlu: 0.639 ± 0.017	0.501CysPhe: 0.501 ± 0.014	1.14CysGly: 1.14 ± 0.024	0.319CysHis: 0.319 ± 0.013	0.677CysIle: 0.677 ± 0.017	0.441CysLys: 0.441 ± 0.014	0.987CysLeu: 0.987 ± 0.021	0.291CysMet: 0.291 ± 0.009	0.445CysAsn: 0.445 ± 0.011	0.568CysPro: 0.568 ± 0.015	0.285CysGln: 0.285 ± 0.012	0.667CysArg: 0.667 ± 0.018	0.831CysSer: 0.831 ± 0.023	0.66CysThr: 0.66 ± 0.017	0.732CysVal: 0.732 ± 0.018	0.197CysTrp: 0.197 ± 0.008	0.418CysTyr: 0.418 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.755AspAla: 5.755 ± 0.048	0.666AspCys: 0.666 ± 0.017	3.602AspAsp: 3.602 ± 0.045	3.856AspGlu: 3.856 ± 0.036	2.712AspPhe: 2.712 ± 0.032	6.443AspGly: 6.443 ± 0.078	1.359AspHis: 1.359 ± 0.024	3.114AspIle: 3.114 ± 0.039	2.208AspLys: 2.208 ± 0.031	5.538AspLeu: 5.538 ± 0.05	1.367AspMet: 1.367 ± 0.022	2.253AspAsn: 2.253 ± 0.038	3.454AspPro: 3.454 ± 0.043	1.874AspGln: 1.874 ± 0.025	3.091AspArg: 3.091 ± 0.038	3.258AspSer: 3.258 ± 0.041	2.917AspThr: 2.917 ± 0.035	3.948AspVal: 3.948 ± 0.05	1.449AspTrp: 1.449 ± 0.027	2.314AspTyr: 2.314 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	5.629GluAla: 5.629 ± 0.061	0.62GluCys: 0.62 ± 0.015	2.968GluAsp: 2.968 ± 0.038	4.113GluGlu: 4.113 ± 0.051	2.441GluPhe: 2.441 ± 0.031	4.735GluGly: 4.735 ± 0.041	1.416GluHis: 1.416 ± 0.025	3.704GluIle: 3.704 ± 0.045	3.848GluLys: 3.848 ± 0.055	6.557GluLeu: 6.557 ± 0.06	1.801GluMet: 1.801 ± 0.03	2.761GluAsn: 2.761 ± 0.036	2.584GluPro: 2.584 ± 0.036	2.584GluGln: 2.584 ± 0.043	3.537GluArg: 3.537 ± 0.048	3.375GluSer: 3.375 ± 0.037	3.786GluThr: 3.786 ± 0.041	4.105GluVal: 4.105 ± 0.046	1.261GluTrp: 1.261 ± 0.022	2.109GluTyr: 2.109 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.344PheAla: 3.344 ± 0.04	0.58PheCys: 0.58 ± 0.017	3.085PheAsp: 3.085 ± 0.04	2.66PheGlu: 2.66 ± 0.031	1.825PhePhe: 1.825 ± 0.03	3.436PheGly: 3.436 ± 0.036	0.895PheHis: 0.895 ± 0.019	2.219PheIle: 2.219 ± 0.031	1.856PheLys: 1.856 ± 0.03	3.173PheLeu: 3.173 ± 0.035	1.059PheMet: 1.059 ± 0.02	1.838PheAsn: 1.838 ± 0.028	1.728PhePro: 1.728 ± 0.028	1.234PheGln: 1.234 ± 0.021	2.165PheArg: 2.165 ± 0.029	2.98PheSer: 2.98 ± 0.036	2.444PheThr: 2.444 ± 0.032	2.597PheVal: 2.597 ± 0.034	0.62PheTrp: 0.62 ± 0.016	1.425PheTyr: 1.425 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	6.924GlyAla: 6.924 ± 0.076	1.103GlyCys: 1.103 ± 0.02	4.884GlyAsp: 4.884 ± 0.056	4.958GlyGlu: 4.958 ± 0.046	3.825GlyPhe: 3.825 ± 0.038	7.594GlyGly: 7.594 ± 0.107	1.838GlyHis: 1.838 ± 0.027	4.962GlyIle: 4.962 ± 0.047	4.863GlyLys: 4.863 ± 0.053	7.071GlyLeu: 7.071 ± 0.048	2.368GlyMet: 2.368 ± 0.036	3.714GlyAsn: 3.714 ± 0.057	2.336GlyPro: 2.336 ± 0.035	2.718GlyGln: 2.718 ± 0.035	4.272GlyArg: 4.272 ± 0.052	5.63GlySer: 5.63 ± 0.084	5.783GlyThr: 5.783 ± 0.078	5.454GlyVal: 5.454 ± 0.057	1.64GlyTrp: 1.64 ± 0.029	3.178GlyTyr: 3.178 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	1.99HisAla: 1.99 ± 0.029	0.335HisCys: 0.335 ± 0.011	1.267HisAsp: 1.267 ± 0.022	1.278HisGlu: 1.278 ± 0.024	1.006HisPhe: 1.006 ± 0.02	1.945HisGly: 1.945 ± 0.028	0.639HisHis: 0.639 ± 0.016	1.125HisIle: 1.125 ± 0.021	0.817HisLys: 0.817 ± 0.019	2.093HisLeu: 2.093 ± 0.033	0.518HisMet: 0.518 ± 0.015	0.831HisAsn: 0.831 ± 0.02	1.442HisPro: 1.442 ± 0.027	0.666HisGln: 0.666 ± 0.016	1.234HisArg: 1.234 ± 0.021	1.261HisSer: 1.261 ± 0.025	1.109HisThr: 1.109 ± 0.023	1.466HisVal: 1.466 ± 0.026	0.463HisTrp: 0.463 ± 0.012	0.875HisTyr: 0.875 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.674IleAla: 4.674 ± 0.046	0.673IleCys: 0.673 ± 0.017	3.91IleAsp: 3.91 ± 0.042	3.735IleGlu: 3.735 ± 0.048	1.839IlePhe: 1.839 ± 0.028	4.454IleGly: 4.454 ± 0.043	1.301IleHis: 1.301 ± 0.022	2.481IleIle: 2.481 ± 0.034	2.381IleLys: 2.381 ± 0.037	4.286IleLeu: 4.286 ± 0.044	1.15IleMet: 1.15 ± 0.021	2.061IleAsn: 2.061 ± 0.032	2.769IlePro: 2.769 ± 0.033	1.78IleGln: 1.78 ± 0.032	3.07IleArg: 3.07 ± 0.034	3.256IleSer: 3.256 ± 0.044	3.034IleThr: 3.034 ± 0.045	3.417IleVal: 3.417 ± 0.033	0.689IleTrp: 0.689 ± 0.017	1.607IleTyr: 1.607 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.482LysAla: 4.482 ± 0.059	0.371LysCys: 0.371 ± 0.015	2.641LysAsp: 2.641 ± 0.035	3.212LysGlu: 3.212 ± 0.049	1.391LysPhe: 1.391 ± 0.023	3.687LysGly: 3.687 ± 0.048	1.147LysHis: 1.147 ± 0.028	2.444LysIle: 2.444 ± 0.032	3.38LysLys: 3.38 ± 0.06	4.198LysLeu: 4.198 ± 0.051	1.339LysMet: 1.339 ± 0.023	2.124LysAsn: 2.124 ± 0.036	2.689LysPro: 2.689 ± 0.039	1.898LysGln: 1.898 ± 0.028	2.618LysArg: 2.618 ± 0.039	2.477LysSer: 2.477 ± 0.035	3.178LysThr: 3.178 ± 0.038	3.098LysVal: 3.098 ± 0.04	0.904LysTrp: 0.904 ± 0.018	1.405LysTyr: 1.405 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	8.477LeuAla: 8.477 ± 0.077	1.199LeuCys: 1.199 ± 0.022	5.702LeuAsp: 5.702 ± 0.046	6.027LeuGlu: 6.027 ± 0.062	3.693LeuPhe: 3.693 ± 0.04	6.762LeuGly: 6.762 ± 0.059	1.872LeuHis: 1.872 ± 0.028	4.3LeuIle: 4.3 ± 0.045	4.781LeuLys: 4.781 ± 0.06	8.051LeuLeu: 8.051 ± 0.081	2.247LeuMet: 2.247 ± 0.035	3.546LeuAsn: 3.546 ± 0.042	4.571LeuPro: 4.571 ± 0.043	2.786LeuGln: 2.786 ± 0.035	4.764LeuArg: 4.764 ± 0.055	5.77LeuSer: 5.77 ± 0.049	4.896LeuThr: 4.896 ± 0.051	6.065LeuVal: 6.065 ± 0.057	1.221LeuTrp: 1.221 ± 0.024	2.752LeuTyr: 2.752 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.481MetAla: 2.481 ± 0.03	0.205MetCys: 0.205 ± 0.009	1.575MetAsp: 1.575 ± 0.028	1.66MetGlu: 1.66 ± 0.026	0.754MetPhe: 0.754 ± 0.018	1.963MetGly: 1.963 ± 0.028	0.507MetHis: 0.507 ± 0.013	1.267MetIle: 1.267 ± 0.024	1.932MetLys: 1.932 ± 0.029	2.285MetLeu: 2.285 ± 0.033	0.735MetMet: 0.735 ± 0.02	1.162MetAsn: 1.162 ± 0.021	1.302MetPro: 1.302 ± 0.023	0.87MetGln: 0.87 ± 0.02	1.337MetArg: 1.337 ± 0.022	1.311MetSer: 1.311 ± 0.026	1.349MetThr: 1.349 ± 0.024	1.881MetVal: 1.881 ± 0.027	0.277MetTrp: 0.277 ± 0.011	0.522MetTyr: 0.522 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.53AsnAla: 3.53 ± 0.045	0.468AsnCys: 0.468 ± 0.018	2.361AsnAsp: 2.361 ± 0.036	2.195AsnGlu: 2.195 ± 0.028	1.427AsnPhe: 1.427 ± 0.026	4.327AsnGly: 4.327 ± 0.065	1.042AsnHis: 1.042 ± 0.021	2.296AsnIle: 2.296 ± 0.033	1.586AsnLys: 1.586 ± 0.027	3.907AsnLeu: 3.907 ± 0.043	0.96AsnMet: 0.96 ± 0.022	1.771AsnAsn: 1.771 ± 0.042	2.608AsnPro: 2.608 ± 0.033	1.313AsnGln: 1.313 ± 0.022	2.206AsnArg: 2.206 ± 0.029	2.342AsnSer: 2.342 ± 0.048	2.472AsnThr: 2.472 ± 0.04	2.639AsnVal: 2.639 ± 0.037	0.816AsnTrp: 0.816 ± 0.018	1.363AsnTyr: 1.363 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.437ProAla: 4.437 ± 0.047	0.456ProCys: 0.456 ± 0.014	3.385ProAsp: 3.385 ± 0.039	4.208ProGlu: 4.208 ± 0.048	2.136ProPhe: 2.136 ± 0.028	4.003ProGly: 4.003 ± 0.045	1.191ProHis: 1.191 ± 0.022	2.076ProIle: 2.076 ± 0.029	2.034ProLys: 2.034 ± 0.037	3.805ProLeu: 3.805 ± 0.038	1.124ProMet: 1.124 ± 0.024	2.04ProAsn: 2.04 ± 0.029	2.009ProPro: 2.009 ± 0.033	1.422ProGln: 1.422 ± 0.023	1.919ProArg: 1.919 ± 0.033	2.78ProSer: 2.78 ± 0.034	2.512ProThr: 2.512 ± 0.033	3.739ProVal: 3.739 ± 0.042	0.811ProTrp: 0.811 ± 0.02	1.518ProTyr: 1.518 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.022GlnAla: 3.022 ± 0.042	0.346GlnCys: 0.346 ± 0.012	1.511GlnAsp: 1.511 ± 0.026	1.827GlnGlu: 1.827 ± 0.03	1.221GlnPhe: 1.221 ± 0.023	2.426GlnGly: 2.426 ± 0.035	0.732GlnHis: 0.732 ± 0.019	1.68GlnIle: 1.68 ± 0.025	1.618GlnLys: 1.618 ± 0.029	3.242GlnLeu: 3.242 ± 0.039	0.882GlnMet: 0.882 ± 0.019	1.231GlnAsn: 1.231 ± 0.025	1.613GlnPro: 1.613 ± 0.024	1.335GlnGln: 1.335 ± 0.025	1.811GlnArg: 1.811 ± 0.027	1.843GlnSer: 1.843 ± 0.026	1.983GlnThr: 1.983 ± 0.03	2.228GlnVal: 2.228 ± 0.027	0.648GlnTrp: 0.648 ± 0.016	1.02GlnTyr: 1.02 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	3.766ArgAla: 3.766 ± 0.049	0.61ArgCys: 0.61 ± 0.016	2.801ArgAsp: 2.801 ± 0.035	3.38ArgGlu: 3.38 ± 0.049	2.6ArgPhe: 2.6 ± 0.037	3.33ArgGly: 3.33 ± 0.041	1.223ArgHis: 1.223 ± 0.025	3.468ArgIle: 3.468 ± 0.046	2.961ArgLys: 2.961 ± 0.048	4.945ArgLeu: 4.945 ± 0.061	1.583ArgMet: 1.583 ± 0.023	2.307ArgAsn: 2.307 ± 0.031	2.226ArgPro: 2.226 ± 0.036	1.741ArgGln: 1.741 ± 0.031	2.993ArgArg: 2.993 ± 0.05	2.821ArgSer: 2.821 ± 0.032	2.683ArgThr: 2.683 ± 0.035	3.304ArgVal: 3.304 ± 0.039	0.953ArgTrp: 0.953 ± 0.021	1.867ArgTyr: 1.867 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	5.386SerAla: 5.386 ± 0.052	0.672SerCys: 0.672 ± 0.016	3.669SerAsp: 3.669 ± 0.044	3.24SerGlu: 3.24 ± 0.045	2.638SerPhe: 2.638 ± 0.034	6.27SerGly: 6.27 ± 0.076	1.24SerHis: 1.24 ± 0.024	3.356SerIle: 3.356 ± 0.04	2.474SerLys: 2.474 ± 0.036	5.187SerLeu: 5.187 ± 0.05	1.531SerMet: 1.531 ± 0.025	2.577SerAsn: 2.577 ± 0.048	2.814SerPro: 2.814 ± 0.035	1.546SerGln: 1.546 ± 0.025	2.937SerArg: 2.937 ± 0.034	3.972SerSer: 3.972 ± 0.052	3.432SerThr: 3.432 ± 0.046	4.325SerVal: 4.325 ± 0.057	1.066SerTrp: 1.066 ± 0.024	1.87SerTyr: 1.87 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.11ThrAla: 5.11 ± 0.059	0.558ThrCys: 0.558 ± 0.014	3.579ThrAsp: 3.579 ± 0.041	3.023ThrGlu: 3.023 ± 0.034	2.449ThrPhe: 2.449 ± 0.038	5.297ThrGly: 5.297 ± 0.059	1.183ThrHis: 1.183 ± 0.019	3.249ThrIle: 3.249 ± 0.04	1.991ThrLys: 1.991 ± 0.032	5.564ThrLeu: 5.564 ± 0.056	1.224ThrMet: 1.224 ± 0.023	2.805ThrAsn: 2.805 ± 0.058	3.145ThrPro: 3.145 ± 0.037	1.535ThrGln: 1.535 ± 0.029	2.44ThrArg: 2.44 ± 0.03	3.08ThrSer: 3.08 ± 0.049	3.233ThrThr: 3.233 ± 0.045	4.587ThrVal: 4.587 ± 0.054	0.885ThrTrp: 0.885 ± 0.022	1.96ThrTyr: 1.96 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	6.324ValAla: 6.324 ± 0.059	0.95ValCys: 0.95 ± 0.021	4.384ValAsp: 4.384 ± 0.049	4.794ValGlu: 4.794 ± 0.045	2.927ValPhe: 2.927 ± 0.035	5.16ValGly: 5.16 ± 0.052	1.37ValHis: 1.37 ± 0.023	3.209ValIle: 3.209 ± 0.036	3.028ValLys: 3.028 ± 0.043	6.115ValLeu: 6.115 ± 0.054	1.546ValMet: 1.546 ± 0.029	2.51ValAsn: 2.51 ± 0.035	3.551ValPro: 3.551 ± 0.043	2.11ValGln: 2.11 ± 0.029	3.513ValArg: 3.513 ± 0.037	4.701ValSer: 4.701 ± 0.058	3.527ValThr: 3.527 ± 0.052	5.514ValVal: 5.514 ± 0.058	1.094ValTrp: 1.094 ± 0.022	2.113ValTyr: 2.113 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.202TrpAla: 1.202 ± 0.022	0.224TrpCys: 0.224 ± 0.009	1.096TrpAsp: 1.096 ± 0.023	1.02TrpGlu: 1.02 ± 0.021	0.732TrpPhe: 0.732 ± 0.018	1.271TrpGly: 1.271 ± 0.028	0.544TrpHis: 0.544 ± 0.016	0.949TrpIle: 0.949 ± 0.023	1.106TrpLys: 1.106 ± 0.021	1.45TrpLeu: 1.45 ± 0.023	0.536TrpMet: 0.536 ± 0.014	0.992TrpAsn: 0.992 ± 0.021	0.731TrpPro: 0.731 ± 0.017	0.653TrpGln: 0.653 ± 0.018	0.915TrpArg: 0.915 ± 0.019	1.12TrpSer: 1.12 ± 0.024	1.011TrpThr: 1.011 ± 0.025	0.961TrpVal: 0.961 ± 0.021	0.303TrpTrp: 0.303 ± 0.011	0.537TrpTyr: 0.537 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.006TyrAla: 3.006 ± 0.038	0.477TyrCys: 0.477 ± 0.014	2.205TyrAsp: 2.205 ± 0.032	1.954TyrGlu: 1.954 ± 0.028	1.473TyrPhe: 1.473 ± 0.025	2.736TyrGly: 2.736 ± 0.033	0.786TyrHis: 0.786 ± 0.016	1.544TyrIle: 1.544 ± 0.025	1.287TyrLys: 1.287 ± 0.023	2.807TyrLeu: 2.807 ± 0.032	0.676TyrMet: 0.676 ± 0.018	1.361TyrAsn: 1.361 ± 0.028	1.664TyrPro: 1.664 ± 0.029	1.079TyrGln: 1.079 ± 0.019	2.003TyrArg: 2.003 ± 0.029	2.063TyrSer: 2.063 ± 0.03	1.925TyrThr: 1.925 ± 0.032	1.931TyrVal: 1.931 ± 0.032	0.622TyrTrp: 0.622 ± 0.018	1.297TyrTyr: 1.297 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6374 proteins (2580498 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---