Amino acid dipepetide frequency for Clostridium senegalense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.152AlaAla: 3.152 ± 0.083	0.674AlaCys: 0.674 ± 0.031	2.196AlaAsp: 2.196 ± 0.054	2.806AlaGlu: 2.806 ± 0.059	2.367AlaPhe: 2.367 ± 0.056	3.166AlaGly: 3.166 ± 0.064	0.738AlaHis: 0.738 ± 0.027	5.888AlaIle: 5.888 ± 0.084	4.437AlaLys: 4.437 ± 0.081	5.49AlaLeu: 5.49 ± 0.084	1.563AlaMet: 1.563 ± 0.036	2.561AlaAsn: 2.561 ± 0.052	1.257AlaPro: 1.257 ± 0.035	1.258AlaGln: 1.258 ± 0.039	1.638AlaArg: 1.638 ± 0.045	3.103AlaSer: 3.103 ± 0.056	2.729AlaThr: 2.729 ± 0.062	3.69AlaVal: 3.69 ± 0.06	0.28AlaTrp: 0.28 ± 0.018	1.943AlaTyr: 1.943 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.584CysAla: 0.584 ± 0.025	0.258CysCys: 0.258 ± 0.02	0.87CysAsp: 0.87 ± 0.03	0.977CysGlu: 0.977 ± 0.035	0.521CysPhe: 0.521 ± 0.019	1.187CysGly: 1.187 ± 0.038	0.226CysHis: 0.226 ± 0.015	1.264CysIle: 1.264 ± 0.037	1.267CysLys: 1.267 ± 0.038	0.935CysLeu: 0.935 ± 0.028	0.266CysMet: 0.266 ± 0.016	0.999CysAsn: 0.999 ± 0.034	0.498CysPro: 0.498 ± 0.025	0.217CysGln: 0.217 ± 0.014	0.393CysArg: 0.393 ± 0.023	0.855CysSer: 0.855 ± 0.027	0.594CysThr: 0.594 ± 0.023	0.631CysVal: 0.631 ± 0.024	0.062CysTrp: 0.062 ± 0.009	0.492CysTyr: 0.492 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	2.423AspAla: 2.423 ± 0.052	0.675AspCys: 0.675 ± 0.027	2.71AspAsp: 2.71 ± 0.064	4.831AspGlu: 4.831 ± 0.066	2.75AspPhe: 2.75 ± 0.049	3.328AspGly: 3.328 ± 0.06	0.479AspHis: 0.479 ± 0.022	6.277AspIle: 6.277 ± 0.095	5.689AspLys: 5.689 ± 0.083	4.688AspLeu: 4.688 ± 0.072	1.558AspMet: 1.558 ± 0.036	3.541AspAsn: 3.541 ± 0.061	1.107AspPro: 1.107 ± 0.035	0.632AspGln: 0.632 ± 0.024	1.624AspArg: 1.624 ± 0.045	3.065AspSer: 3.065 ± 0.057	2.329AspThr: 2.329 ± 0.048	3.68AspVal: 3.68 ± 0.066	0.337AspTrp: 0.337 ± 0.018	2.535AspTyr: 2.535 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	3.503GluAla: 3.503 ± 0.076	0.793GluCys: 0.793 ± 0.031	4.499GluAsp: 4.499 ± 0.059	6.832GluGlu: 6.832 ± 0.106	3.344GluPhe: 3.344 ± 0.062	3.895GluGly: 3.895 ± 0.059	0.886GluHis: 0.886 ± 0.031	7.317GluIle: 7.317 ± 0.096	8.829GluLys: 8.829 ± 0.102	6.748GluLeu: 6.748 ± 0.095	1.856GluMet: 1.856 ± 0.042	6.502GluAsn: 6.502 ± 0.084	1.346GluPro: 1.346 ± 0.044	1.571GluGln: 1.571 ± 0.04	2.43GluArg: 2.43 ± 0.054	3.731GluSer: 3.731 ± 0.06	3.009GluThr: 3.009 ± 0.058	4.842GluVal: 4.842 ± 0.07	0.383GluTrp: 0.383 ± 0.02	3.088GluTyr: 3.088 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.193PheAla: 2.193 ± 0.048	0.545PheCys: 0.545 ± 0.024	2.397PheAsp: 2.397 ± 0.047	2.886PheGlu: 2.886 ± 0.052	2.092PhePhe: 2.092 ± 0.058	2.657PheGly: 2.657 ± 0.054	0.546PheHis: 0.546 ± 0.023	5.117PheIle: 5.117 ± 0.098	4.415PheLys: 4.415 ± 0.075	4.268PheLeu: 4.268 ± 0.075	1.14PheMet: 1.14 ± 0.033	3.254PheAsn: 3.254 ± 0.061	1.123PhePro: 1.123 ± 0.031	0.959PheGln: 0.959 ± 0.031	1.141PheArg: 1.141 ± 0.038	3.267PheSer: 3.267 ± 0.063	2.35PheThr: 2.35 ± 0.054	2.522PheVal: 2.522 ± 0.048	0.295PheTrp: 0.295 ± 0.016	1.915PheTyr: 1.915 ± 0.043	0.001PheXaa: 0.001 ± 0.001
Gly	3.771GlyAla: 3.771 ± 0.071	0.966GlyCys: 0.966 ± 0.03	3.058GlyAsp: 3.058 ± 0.058	4.252GlyGlu: 4.252 ± 0.074	3.02GlyPhe: 3.02 ± 0.061	4.067GlyGly: 4.067 ± 0.079	0.93GlyHis: 0.93 ± 0.035	6.561GlyIle: 6.561 ± 0.083	5.587GlyLys: 5.587 ± 0.087	5.347GlyLeu: 5.347 ± 0.087	1.765GlyMet: 1.765 ± 0.046	3.404GlyAsn: 3.404 ± 0.063	1.199GlyPro: 1.199 ± 0.042	1.359GlyGln: 1.359 ± 0.04	1.92GlyArg: 1.92 ± 0.047	3.393GlySer: 3.393 ± 0.052	3.344GlyThr: 3.344 ± 0.079	4.531GlyVal: 4.531 ± 0.072	0.425GlyTrp: 0.425 ± 0.022	2.954GlyTyr: 2.954 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	0.572HisAla: 0.572 ± 0.025	0.221HisCys: 0.221 ± 0.015	0.656HisAsp: 0.656 ± 0.021	0.79HisGlu: 0.79 ± 0.027	0.562HisPhe: 0.562 ± 0.026	0.938HisGly: 0.938 ± 0.034	0.24HisHis: 0.24 ± 0.016	1.363HisIle: 1.363 ± 0.036	1.006HisLys: 1.006 ± 0.036	1.096HisLeu: 1.096 ± 0.035	0.327HisMet: 0.327 ± 0.017	0.878HisAsn: 0.878 ± 0.031	0.535HisPro: 0.535 ± 0.025	0.318HisGln: 0.318 ± 0.018	0.482HisArg: 0.482 ± 0.024	0.829HisSer: 0.829 ± 0.026	0.63HisThr: 0.63 ± 0.023	0.714HisVal: 0.714 ± 0.026	0.091HisTrp: 0.091 ± 0.01	0.513HisTyr: 0.513 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.634IleAla: 5.634 ± 0.077	1.427IleCys: 1.427 ± 0.04	5.81IleAsp: 5.81 ± 0.076	7.733IleGlu: 7.733 ± 0.101	4.713IlePhe: 4.713 ± 0.094	6.603IleGly: 6.603 ± 0.087	1.272IleHis: 1.272 ± 0.032	10.66IleIle: 10.66 ± 0.157	9.707IleLys: 9.707 ± 0.11	10.034IleLeu: 10.034 ± 0.123	2.567IleMet: 2.567 ± 0.045	6.842IleAsn: 6.842 ± 0.089	3.198IlePro: 3.198 ± 0.07	2.067IleGln: 2.067 ± 0.046	2.826IleArg: 2.826 ± 0.055	7.312IleSer: 7.312 ± 0.101	5.153IleThr: 5.153 ± 0.067	6.433IleVal: 6.433 ± 0.086	0.511IleTrp: 0.511 ± 0.028	3.81IleTyr: 3.81 ± 0.076	0.0IleXaa: 0.0 ± 0.0
Lys	4.417LysAla: 4.417 ± 0.065	1.021LysCys: 1.021 ± 0.033	6.468LysAsp: 6.468 ± 0.092	9.919LysGlu: 9.919 ± 0.126	3.715LysPhe: 3.715 ± 0.066	5.267LysGly: 5.267 ± 0.07	1.156LysHis: 1.156 ± 0.035	9.162LysIle: 9.162 ± 0.096	9.013LysLys: 9.013 ± 0.119	7.876LysLeu: 7.876 ± 0.082	2.434LysMet: 2.434 ± 0.045	7.909LysAsn: 7.909 ± 0.101	2.138LysPro: 2.138 ± 0.055	2.043LysGln: 2.043 ± 0.045	3.013LysArg: 3.013 ± 0.056	5.573LysSer: 5.573 ± 0.076	4.234LysThr: 4.234 ± 0.073	6.269LysVal: 6.269 ± 0.078	0.583LysTrp: 0.583 ± 0.025	4.376LysTyr: 4.376 ± 0.077	0.0LysXaa: 0.0 ± 0.0
Leu	4.893LeuAla: 4.893 ± 0.075	1.247LeuCys: 1.247 ± 0.033	5.175LeuAsp: 5.175 ± 0.076	6.514LeuGlu: 6.514 ± 0.095	3.7LeuPhe: 3.7 ± 0.066	5.923LeuGly: 5.923 ± 0.087	0.974LeuHis: 0.974 ± 0.039	8.763LeuIle: 8.763 ± 0.127	9.551LeuLys: 9.551 ± 0.099	7.723LeuLeu: 7.723 ± 0.106	2.297LeuMet: 2.297 ± 0.05	6.626LeuAsn: 6.626 ± 0.092	2.632LeuPro: 2.632 ± 0.058	2.067LeuGln: 2.067 ± 0.041	2.82LeuArg: 2.82 ± 0.048	6.498LeuSer: 6.498 ± 0.089	4.534LeuThr: 4.534 ± 0.069	5.398LeuVal: 5.398 ± 0.087	0.57LeuTrp: 0.57 ± 0.028	3.243LeuTyr: 3.243 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.639MetAla: 1.639 ± 0.04	0.284MetCys: 0.284 ± 0.017	1.471MetAsp: 1.471 ± 0.042	1.977MetGlu: 1.977 ± 0.049	1.126MetPhe: 1.126 ± 0.037	1.731MetGly: 1.731 ± 0.042	0.302MetHis: 0.302 ± 0.017	2.34MetIle: 2.34 ± 0.049	2.566MetLys: 2.566 ± 0.045	2.305MetLeu: 2.305 ± 0.05	0.652MetMet: 0.652 ± 0.027	1.789MetAsn: 1.789 ± 0.041	0.843MetPro: 0.843 ± 0.034	0.587MetGln: 0.587 ± 0.023	0.821MetArg: 0.821 ± 0.029	1.707MetSer: 1.707 ± 0.038	1.136MetThr: 1.136 ± 0.029	1.648MetVal: 1.648 ± 0.043	0.154MetTrp: 0.154 ± 0.011	0.91MetTyr: 0.91 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.801AsnAla: 2.801 ± 0.058	0.945AsnCys: 0.945 ± 0.033	3.413AsnAsp: 3.413 ± 0.06	4.948AsnGlu: 4.948 ± 0.076	3.032AsnPhe: 3.032 ± 0.059	3.953AsnGly: 3.953 ± 0.076	0.887AsnHis: 0.887 ± 0.032	8.107AsnIle: 8.107 ± 0.109	7.099AsnLys: 7.099 ± 0.085	6.477AsnLeu: 6.477 ± 0.1	1.79AsnMet: 1.79 ± 0.042	5.142AsnAsn: 5.142 ± 0.097	2.016AsnPro: 2.016 ± 0.047	1.37AsnGln: 1.37 ± 0.036	1.92AsnArg: 1.92 ± 0.045	4.306AsnSer: 4.306 ± 0.066	2.961AsnThr: 2.961 ± 0.059	3.964AsnVal: 3.964 ± 0.067	0.448AsnTrp: 0.448 ± 0.025	3.024AsnTyr: 3.024 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.163ProAla: 1.163 ± 0.035	0.376ProCys: 0.376 ± 0.017	1.199ProAsp: 1.199 ± 0.039	1.885ProGlu: 1.885 ± 0.049	1.313ProPhe: 1.313 ± 0.039	1.486ProGly: 1.486 ± 0.048	0.394ProHis: 0.394 ± 0.019	2.873ProIle: 2.873 ± 0.054	2.317ProLys: 2.317 ± 0.049	2.372ProLeu: 2.372 ± 0.049	0.731ProMet: 0.731 ± 0.028	1.606ProAsn: 1.606 ± 0.043	0.574ProPro: 0.574 ± 0.024	0.713ProGln: 0.713 ± 0.033	0.714ProArg: 0.714 ± 0.027	1.674ProSer: 1.674 ± 0.042	1.494ProThr: 1.494 ± 0.04	1.815ProVal: 1.815 ± 0.051	0.208ProTrp: 0.208 ± 0.015	1.286ProTyr: 1.286 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.042GlnAla: 1.042 ± 0.034	0.349GlnCys: 0.349 ± 0.02	1.093GlnAsp: 1.093 ± 0.033	1.459GlnGlu: 1.459 ± 0.04	0.914GlnPhe: 0.914 ± 0.029	1.403GlnGly: 1.403 ± 0.042	0.287GlnHis: 0.287 ± 0.017	2.015GlnIle: 2.015 ± 0.05	1.749GlnLys: 1.749 ± 0.042	2.037GlnLeu: 2.037 ± 0.047	0.571GlnMet: 0.571 ± 0.026	1.373GlnAsn: 1.373 ± 0.039	0.51GlnPro: 0.51 ± 0.022	0.614GlnGln: 0.614 ± 0.032	0.884GlnArg: 0.884 ± 0.033	1.345GlnSer: 1.345 ± 0.037	0.905GlnThr: 0.905 ± 0.032	1.328GlnVal: 1.328 ± 0.041	0.261GlnTrp: 0.261 ± 0.016	1.011GlnTyr: 1.011 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.654ArgAla: 1.654 ± 0.042	0.37ArgCys: 0.37 ± 0.02	1.553ArgAsp: 1.553 ± 0.039	2.578ArgGlu: 2.578 ± 0.058	1.348ArgPhe: 1.348 ± 0.04	1.821ArgGly: 1.821 ± 0.051	0.446ArgHis: 0.446 ± 0.02	2.865ArgIle: 2.865 ± 0.056	3.013ArgLys: 3.013 ± 0.057	2.656ArgLeu: 2.656 ± 0.052	0.812ArgMet: 0.812 ± 0.03	1.99ArgAsn: 1.99 ± 0.05	0.778ArgPro: 0.778 ± 0.031	0.751ArgGln: 0.751 ± 0.029	1.244ArgArg: 1.244 ± 0.042	1.33ArgSer: 1.33 ± 0.035	1.434ArgThr: 1.434 ± 0.037	2.044ArgVal: 2.044 ± 0.048	0.192ArgTrp: 0.192 ± 0.013	1.359ArgTyr: 1.359 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	2.888SerAla: 2.888 ± 0.056	0.772SerCys: 0.772 ± 0.025	2.965SerAsp: 2.965 ± 0.053	4.043SerGlu: 4.043 ± 0.068	2.999SerPhe: 2.999 ± 0.055	4.005SerGly: 4.005 ± 0.068	0.89SerHis: 0.89 ± 0.031	7.053SerIle: 7.053 ± 0.096	6.267SerLys: 6.267 ± 0.074	5.908SerLeu: 5.908 ± 0.085	1.684SerMet: 1.684 ± 0.043	4.18SerAsn: 4.18 ± 0.073	1.582SerPro: 1.582 ± 0.041	1.583SerGln: 1.583 ± 0.039	1.852SerArg: 1.852 ± 0.046	4.095SerSer: 4.095 ± 0.085	3.082SerThr: 3.082 ± 0.063	3.707SerVal: 3.707 ± 0.065	0.39SerTrp: 0.39 ± 0.02	2.653SerTyr: 2.653 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	2.717ThrAla: 2.717 ± 0.055	0.54ThrCys: 0.54 ± 0.024	2.16ThrAsp: 2.16 ± 0.042	2.898ThrGlu: 2.898 ± 0.059	2.31ThrPhe: 2.31 ± 0.044	3.23ThrGly: 3.23 ± 0.073	0.72ThrHis: 0.72 ± 0.023	5.248ThrIle: 5.248 ± 0.073	3.79ThrLys: 3.79 ± 0.063	5.01ThrLeu: 5.01 ± 0.079	1.18ThrMet: 1.18 ± 0.037	2.778ThrAsn: 2.778 ± 0.05	1.682ThrPro: 1.682 ± 0.042	0.976ThrGln: 0.976 ± 0.036	1.288ThrArg: 1.288 ± 0.039	3.139ThrSer: 3.139 ± 0.062	2.664ThrThr: 2.664 ± 0.058	3.608ThrVal: 3.608 ± 0.1	0.304ThrTrp: 0.304 ± 0.016	1.808ThrTyr: 1.808 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	3.818ValAla: 3.818 ± 0.067	0.899ValCys: 0.899 ± 0.03	3.7ValAsp: 3.7 ± 0.074	4.692ValGlu: 4.692 ± 0.064	2.829ValPhe: 2.829 ± 0.06	4.176ValGly: 4.176 ± 0.064	0.75ValHis: 0.75 ± 0.025	6.539ValIle: 6.539 ± 0.086	5.664ValLys: 5.664 ± 0.084	5.984ValLeu: 5.984 ± 0.083	1.611ValMet: 1.611 ± 0.04	3.661ValAsn: 3.661 ± 0.061	1.84ValPro: 1.84 ± 0.053	1.26ValGln: 1.26 ± 0.033	1.758ValArg: 1.758 ± 0.045	4.258ValSer: 4.258 ± 0.07	3.232ValThr: 3.232 ± 0.076	4.448ValVal: 4.448 ± 0.08	0.386ValTrp: 0.386 ± 0.018	2.454ValTyr: 2.454 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.291TrpAla: 0.291 ± 0.015	0.116TrpCys: 0.116 ± 0.011	0.361TrpAsp: 0.361 ± 0.02	0.424TrpGlu: 0.424 ± 0.021	0.306TrpPhe: 0.306 ± 0.018	0.454TrpGly: 0.454 ± 0.019	0.126TrpHis: 0.126 ± 0.011	0.646TrpIle: 0.646 ± 0.032	0.487TrpLys: 0.487 ± 0.02	0.499TrpLeu: 0.499 ± 0.02	0.189TrpMet: 0.189 ± 0.015	0.446TrpAsn: 0.446 ± 0.023	0.132TrpPro: 0.132 ± 0.013	0.169TrpGln: 0.169 ± 0.013	0.225TrpArg: 0.225 ± 0.014	0.383TrpSer: 0.383 ± 0.021	0.301TrpThr: 0.301 ± 0.016	0.364TrpVal: 0.364 ± 0.018	0.069TrpTrp: 0.069 ± 0.009	0.269TrpTyr: 0.269 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.78TyrAla: 1.78 ± 0.039	0.617TyrCys: 0.617 ± 0.025	2.507TyrAsp: 2.507 ± 0.05	2.961TyrGlu: 2.961 ± 0.055	2.123TyrPhe: 2.123 ± 0.048	2.564TyrGly: 2.564 ± 0.05	0.512TyrHis: 0.512 ± 0.025	4.256TyrIle: 4.256 ± 0.068	4.129TyrLys: 4.129 ± 0.07	3.694TyrLeu: 3.694 ± 0.065	0.992TyrMet: 0.992 ± 0.03	3.121TyrAsn: 3.121 ± 0.06	1.202TyrPro: 1.202 ± 0.032	0.636TyrGln: 0.636 ± 0.024	1.246TyrArg: 1.246 ± 0.034	2.736TyrSer: 2.736 ± 0.05	1.935TyrThr: 1.935 ± 0.045	2.325TyrVal: 2.325 ± 0.051	0.309TyrTrp: 0.309 ± 0.019	1.875TyrTyr: 1.875 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3405 proteins (1045211 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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