Amino acid dipepetide frequency for Eubacterium callanderi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.184AlaAla: 8.184 ± 0.11	1.249AlaCys: 1.249 ± 0.032	4.622AlaAsp: 4.622 ± 0.073	5.791AlaGlu: 5.791 ± 0.075	3.773AlaPhe: 3.773 ± 0.061	6.532AlaGly: 6.532 ± 0.087	1.195AlaHis: 1.195 ± 0.031	5.325AlaIle: 5.325 ± 0.078	4.153AlaLys: 4.153 ± 0.068	8.605AlaLeu: 8.605 ± 0.089	2.473AlaMet: 2.473 ± 0.052	2.519AlaAsn: 2.519 ± 0.06	2.625AlaPro: 2.625 ± 0.059	2.512AlaGln: 2.512 ± 0.053	3.249AlaArg: 3.249 ± 0.052	4.054AlaSer: 4.054 ± 0.061	3.306AlaThr: 3.306 ± 0.063	6.94AlaVal: 6.94 ± 0.082	0.6AlaTrp: 0.6 ± 0.023	2.815AlaTyr: 2.815 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.09CysAla: 1.09 ± 0.031	0.283CysCys: 0.283 ± 0.016	0.835CysAsp: 0.835 ± 0.027	0.9CysGlu: 0.9 ± 0.029	0.71CysPhe: 0.71 ± 0.022	1.401CysGly: 1.401 ± 0.037	0.282CysHis: 0.282 ± 0.015	1.005CysIle: 1.005 ± 0.027	0.688CysLys: 0.688 ± 0.022	1.25CysLeu: 1.25 ± 0.034	0.359CysMet: 0.359 ± 0.018	0.421CysAsn: 0.421 ± 0.018	0.694CysPro: 0.694 ± 0.025	0.435CysGln: 0.435 ± 0.018	0.685CysArg: 0.685 ± 0.023	0.792CysSer: 0.792 ± 0.024	0.731CysThr: 0.731 ± 0.025	1.03CysVal: 1.03 ± 0.034	0.118CysTrp: 0.118 ± 0.008	0.506CysTyr: 0.506 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.476AspAla: 4.476 ± 0.07	0.807AspCys: 0.807 ± 0.025	2.848AspAsp: 2.848 ± 0.059	4.206AspGlu: 4.206 ± 0.07	2.823AspPhe: 2.823 ± 0.049	4.291AspGly: 4.291 ± 0.086	1.018AspHis: 1.018 ± 0.028	4.478AspIle: 4.478 ± 0.066	3.619AspLys: 3.619 ± 0.057	4.784AspLeu: 4.784 ± 0.067	1.721AspMet: 1.721 ± 0.037	2.343AspAsn: 2.343 ± 0.049	2.251AspPro: 2.251 ± 0.048	1.697AspGln: 1.697 ± 0.043	2.41AspArg: 2.41 ± 0.044	2.903AspSer: 2.903 ± 0.05	3.252AspThr: 3.252 ± 0.06	3.674AspVal: 3.674 ± 0.06	0.59AspTrp: 0.59 ± 0.023	2.671AspTyr: 2.671 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.333GluAla: 6.333 ± 0.087	0.694GluCys: 0.694 ± 0.021	4.005GluAsp: 4.005 ± 0.065	5.685GluGlu: 5.685 ± 0.09	2.062GluPhe: 2.062 ± 0.039	4.481GluGly: 4.481 ± 0.072	1.146GluHis: 1.146 ± 0.032	5.249GluIle: 5.249 ± 0.07	6.518GluLys: 6.518 ± 0.082	5.967GluLeu: 5.967 ± 0.083	2.371GluMet: 2.371 ± 0.042	4.1GluAsn: 4.1 ± 0.063	2.119GluPro: 2.119 ± 0.042	2.42GluGln: 2.42 ± 0.047	3.341GluArg: 3.341 ± 0.062	3.463GluSer: 3.463 ± 0.06	3.888GluThr: 3.888 ± 0.056	4.333GluVal: 4.333 ± 0.06	0.54GluTrp: 0.54 ± 0.021	2.406GluTyr: 2.406 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.929PheAla: 2.929 ± 0.051	0.715PheCys: 0.715 ± 0.023	2.646PheAsp: 2.646 ± 0.05	2.995PheGlu: 2.995 ± 0.055	2.192PhePhe: 2.192 ± 0.054	3.212PheGly: 3.212 ± 0.056	0.672PheHis: 0.672 ± 0.02	3.338PheIle: 3.338 ± 0.062	2.719PheLys: 2.719 ± 0.049	3.992PheLeu: 3.992 ± 0.073	1.321PheMet: 1.321 ± 0.032	1.984PheAsn: 1.984 ± 0.041	1.391PhePro: 1.391 ± 0.035	1.114PheGln: 1.114 ± 0.028	1.474PheArg: 1.474 ± 0.031	2.998PheSer: 2.998 ± 0.048	2.575PheThr: 2.575 ± 0.052	2.857PheVal: 2.857 ± 0.048	0.414PheTrp: 0.414 ± 0.017	1.864PheTyr: 1.864 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	5.562GlyAla: 5.562 ± 0.081	1.239GlyCys: 1.239 ± 0.037	3.852GlyAsp: 3.852 ± 0.063	4.477GlyGlu: 4.477 ± 0.059	3.29GlyPhe: 3.29 ± 0.054	5.442GlyGly: 5.442 ± 0.099	1.259GlyHis: 1.259 ± 0.032	6.109GlyIle: 6.109 ± 0.08	4.8GlyLys: 4.8 ± 0.068	6.719GlyLeu: 6.719 ± 0.091	2.261GlyMet: 2.261 ± 0.046	2.931GlyAsn: 2.931 ± 0.059	1.672GlyPro: 1.672 ± 0.04	2.324GlyGln: 2.324 ± 0.047	3.235GlyArg: 3.235 ± 0.051	4.321GlySer: 4.321 ± 0.073	4.412GlyThr: 4.412 ± 0.068	5.389GlyVal: 5.389 ± 0.073	0.696GlyTrp: 0.696 ± 0.025	3.086GlyTyr: 3.086 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.06HisAla: 1.06 ± 0.029	0.34HisCys: 0.34 ± 0.017	0.841HisAsp: 0.841 ± 0.023	0.985HisGlu: 0.985 ± 0.029	0.928HisPhe: 0.928 ± 0.027	1.103HisGly: 1.103 ± 0.026	0.447HisHis: 0.447 ± 0.023	1.202HisIle: 1.202 ± 0.03	0.908HisLys: 0.908 ± 0.029	1.611HisLeu: 1.611 ± 0.038	0.444HisMet: 0.444 ± 0.02	0.631HisAsn: 0.631 ± 0.022	0.9HisPro: 0.9 ± 0.027	0.567HisGln: 0.567 ± 0.021	0.79HisArg: 0.79 ± 0.024	0.984HisSer: 0.984 ± 0.026	0.916HisThr: 0.916 ± 0.028	0.988HisVal: 0.988 ± 0.03	0.174HisTrp: 0.174 ± 0.012	0.753HisTyr: 0.753 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.805IleAla: 5.805 ± 0.068	1.107IleCys: 1.107 ± 0.033	4.271IleAsp: 4.271 ± 0.058	4.94IleGlu: 4.94 ± 0.07	3.249IlePhe: 3.249 ± 0.067	5.281IleGly: 5.281 ± 0.081	1.246IleHis: 1.246 ± 0.029	5.363IleIle: 5.363 ± 0.076	4.3IleLys: 4.3 ± 0.057	7.057IleLeu: 7.057 ± 0.102	1.916IleMet: 1.916 ± 0.043	3.219IleAsn: 3.219 ± 0.058	3.266IlePro: 3.266 ± 0.057	2.129IleGln: 2.129 ± 0.045	3.308IleArg: 3.308 ± 0.057	4.353IleSer: 4.353 ± 0.063	4.3IleThr: 4.3 ± 0.068	4.748IleVal: 4.748 ± 0.073	0.527IleTrp: 0.527 ± 0.022	2.532IleTyr: 2.532 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	5.506LysAla: 5.506 ± 0.073	0.64LysCys: 0.64 ± 0.023	3.909LysAsp: 3.909 ± 0.064	5.319LysGlu: 5.319 ± 0.067	1.654LysPhe: 1.654 ± 0.038	4.198LysGly: 4.198 ± 0.06	0.995LysHis: 0.995 ± 0.031	4.899LysIle: 4.899 ± 0.069	5.88LysLys: 5.88 ± 0.085	4.939LysLeu: 4.939 ± 0.066	2.117LysMet: 2.117 ± 0.042	3.736LysAsn: 3.736 ± 0.064	2.229LysPro: 2.229 ± 0.04	2.078LysGln: 2.078 ± 0.041	3.167LysArg: 3.167 ± 0.053	3.329LysSer: 3.329 ± 0.057	4.166LysThr: 4.166 ± 0.073	3.989LysVal: 3.989 ± 0.06	0.537LysTrp: 0.537 ± 0.02	2.258LysTyr: 2.258 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.235LeuAla: 7.235 ± 0.078	1.464LeuCys: 1.464 ± 0.034	5.276LeuAsp: 5.276 ± 0.071	6.435LeuGlu: 6.435 ± 0.085	4.208LeuPhe: 4.208 ± 0.089	6.206LeuGly: 6.206 ± 0.094	1.333LeuHis: 1.333 ± 0.032	6.145LeuIle: 6.145 ± 0.086	6.632LeuLys: 6.632 ± 0.073	8.893LeuLeu: 8.893 ± 0.123	2.906LeuMet: 2.906 ± 0.049	3.914LeuAsn: 3.914 ± 0.061	3.924LeuPro: 3.924 ± 0.063	2.483LeuGln: 2.483 ± 0.044	3.987LeuArg: 3.987 ± 0.062	6.543LeuSer: 6.543 ± 0.093	5.415LeuThr: 5.415 ± 0.07	5.721LeuVal: 5.721 ± 0.076	0.789LeuTrp: 0.789 ± 0.027	3.333LeuTyr: 3.333 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.644MetAla: 2.644 ± 0.049	0.338MetCys: 0.338 ± 0.019	1.924MetAsp: 1.924 ± 0.038	2.155MetGlu: 2.155 ± 0.044	0.921MetPhe: 0.921 ± 0.029	2.201MetGly: 2.201 ± 0.046	0.381MetHis: 0.381 ± 0.018	2.046MetIle: 2.046 ± 0.042	2.361MetLys: 2.361 ± 0.039	2.617MetLeu: 2.617 ± 0.048	0.911MetMet: 0.911 ± 0.03	1.49MetAsn: 1.49 ± 0.037	1.145MetPro: 1.145 ± 0.031	0.912MetGln: 0.912 ± 0.029	1.28MetArg: 1.28 ± 0.031	1.665MetSer: 1.665 ± 0.034	1.836MetThr: 1.836 ± 0.038	2.074MetVal: 2.074 ± 0.041	0.164MetTrp: 0.164 ± 0.011	0.746MetTyr: 0.746 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.5AsnAla: 3.5 ± 0.059	0.637AsnCys: 0.637 ± 0.025	2.189AsnAsp: 2.189 ± 0.047	2.62AsnGlu: 2.62 ± 0.047	1.67AsnPhe: 1.67 ± 0.039	3.304AsnGly: 3.304 ± 0.057	0.821AsnHis: 0.821 ± 0.029	3.456AsnIle: 3.456 ± 0.049	2.488AsnLys: 2.488 ± 0.055	3.918AsnLeu: 3.918 ± 0.061	1.19AsnMet: 1.19 ± 0.031	1.9AsnAsn: 1.9 ± 0.052	2.235AsnPro: 2.235 ± 0.047	1.488AsnGln: 1.488 ± 0.036	2.037AsnArg: 2.037 ± 0.043	2.169AsnSer: 2.169 ± 0.048	2.572AsnThr: 2.572 ± 0.061	2.747AsnVal: 2.747 ± 0.053	0.399AsnTrp: 0.399 ± 0.017	1.707AsnTyr: 1.707 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.9ProAla: 2.9 ± 0.053	0.484ProCys: 0.484 ± 0.019	2.633ProAsp: 2.633 ± 0.05	3.98ProGlu: 3.98 ± 0.06	1.779ProPhe: 1.779 ± 0.039	2.812ProGly: 2.812 ± 0.047	0.573ProHis: 0.573 ± 0.024	2.275ProIle: 2.275 ± 0.042	1.967ProLys: 1.967 ± 0.044	3.31ProLeu: 3.31 ± 0.053	1.006ProMet: 1.006 ± 0.027	1.242ProAsn: 1.242 ± 0.032	1.12ProPro: 1.12 ± 0.037	1.169ProGln: 1.169 ± 0.033	1.167ProArg: 1.167 ± 0.027	1.917ProSer: 1.917 ± 0.042	1.745ProThr: 1.745 ± 0.044	3.379ProVal: 3.379 ± 0.049	0.329ProTrp: 0.329 ± 0.018	1.418ProTyr: 1.418 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.631GlnAla: 2.631 ± 0.052	0.367GlnCys: 0.367 ± 0.018	1.507GlnAsp: 1.507 ± 0.037	2.287GlnGlu: 2.287 ± 0.044	1.182GlnPhe: 1.182 ± 0.031	2.017GlnGly: 2.017 ± 0.036	0.443GlnHis: 0.443 ± 0.019	2.34GlnIle: 2.34 ± 0.041	2.587GlnLys: 2.587 ± 0.047	2.662GlnLeu: 2.662 ± 0.046	1.051GlnMet: 1.051 ± 0.028	1.701GlnAsn: 1.701 ± 0.043	1.045GlnPro: 1.045 ± 0.029	1.048GlnGln: 1.048 ± 0.032	1.415GlnArg: 1.415 ± 0.036	1.802GlnSer: 1.802 ± 0.045	1.823GlnThr: 1.823 ± 0.043	1.957GlnVal: 1.957 ± 0.04	0.314GlnTrp: 0.314 ± 0.019	1.22GlnTyr: 1.22 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.997ArgAla: 2.997 ± 0.053	0.657ArgCys: 0.657 ± 0.027	2.329ArgAsp: 2.329 ± 0.041	3.645ArgGlu: 3.645 ± 0.055	2.022ArgPhe: 2.022 ± 0.04	2.624ArgGly: 2.624 ± 0.049	0.898ArgHis: 0.898 ± 0.028	3.26ArgIle: 3.26 ± 0.051	2.989ArgLys: 2.989 ± 0.055	4.237ArgLeu: 4.237 ± 0.066	1.424ArgMet: 1.424 ± 0.03	1.809ArgAsn: 1.809 ± 0.038	1.439ArgPro: 1.439 ± 0.03	1.7ArgGln: 1.7 ± 0.041	2.395ArgArg: 2.395 ± 0.055	2.127ArgSer: 2.127 ± 0.042	2.051ArgThr: 2.051 ± 0.04	2.949ArgVal: 2.949 ± 0.046	0.36ArgTrp: 0.36 ± 0.015	1.74ArgTyr: 1.74 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.398SerAla: 4.398 ± 0.066	0.75SerCys: 0.75 ± 0.024	3.152SerAsp: 3.152 ± 0.056	3.75SerGlu: 3.75 ± 0.057	2.873SerPhe: 2.873 ± 0.049	5.11SerGly: 5.11 ± 0.072	0.993SerHis: 0.993 ± 0.027	4.03SerIle: 4.03 ± 0.057	3.07SerLys: 3.07 ± 0.047	5.379SerLeu: 5.379 ± 0.068	1.666SerMet: 1.666 ± 0.033	2.007SerAsn: 2.007 ± 0.043	2.048SerPro: 2.048 ± 0.042	1.878SerGln: 1.878 ± 0.04	2.51SerArg: 2.51 ± 0.052	3.19SerSer: 3.19 ± 0.063	2.798SerThr: 2.798 ± 0.056	4.315SerVal: 4.315 ± 0.064	0.565SerTrp: 0.565 ± 0.023	2.067SerTyr: 2.067 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.114ThrAla: 5.114 ± 0.101	0.598ThrCys: 0.598 ± 0.023	3.167ThrAsp: 3.167 ± 0.06	3.517ThrGlu: 3.517 ± 0.056	2.347ThrPhe: 2.347 ± 0.045	5.029ThrGly: 5.029 ± 0.074	0.839ThrHis: 0.839 ± 0.026	4.204ThrIle: 4.204 ± 0.065	2.877ThrLys: 2.877 ± 0.053	5.597ThrLeu: 5.597 ± 0.08	1.408ThrMet: 1.408 ± 0.031	2.007ThrAsn: 2.007 ± 0.048	2.633ThrPro: 2.633 ± 0.051	1.647ThrGln: 1.647 ± 0.036	2.087ThrArg: 2.087 ± 0.047	2.898ThrSer: 2.898 ± 0.051	3.097ThrThr: 3.097 ± 0.064	4.418ThrVal: 4.418 ± 0.088	0.449ThrTrp: 0.449 ± 0.018	1.956ThrTyr: 1.956 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.865ValAla: 4.865 ± 0.077	1.118ValCys: 1.118 ± 0.029	3.907ValAsp: 3.907 ± 0.06	4.493ValGlu: 4.493 ± 0.072	3.412ValPhe: 3.412 ± 0.052	4.431ValGly: 4.431 ± 0.073	1.065ValHis: 1.065 ± 0.028	5.107ValIle: 5.107 ± 0.081	4.342ValLys: 4.342 ± 0.065	7.02ValLeu: 7.02 ± 0.08	2.044ValMet: 2.044 ± 0.041	2.978ValAsn: 2.978 ± 0.048	2.688ValPro: 2.688 ± 0.046	2.009ValGln: 2.009 ± 0.046	2.829ValArg: 2.829 ± 0.047	4.422ValSer: 4.422 ± 0.058	4.293ValThr: 4.293 ± 0.091	4.929ValVal: 4.929 ± 0.077	0.572ValTrp: 0.572 ± 0.024	2.554ValTyr: 2.554 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.596TrpAla: 0.596 ± 0.025	0.131TrpCys: 0.131 ± 0.009	0.52TrpAsp: 0.52 ± 0.023	0.509TrpGlu: 0.509 ± 0.021	0.421TrpPhe: 0.421 ± 0.019	0.599TrpGly: 0.599 ± 0.02	0.188TrpHis: 0.188 ± 0.012	0.633TrpIle: 0.633 ± 0.024	0.529TrpLys: 0.529 ± 0.021	0.853TrpLeu: 0.853 ± 0.031	0.284TrpMet: 0.284 ± 0.016	0.419TrpAsn: 0.419 ± 0.026	0.288TrpPro: 0.288 ± 0.015	0.381TrpGln: 0.381 ± 0.018	0.398TrpArg: 0.398 ± 0.023	0.444TrpSer: 0.444 ± 0.02	0.428TrpThr: 0.428 ± 0.019	0.527TrpVal: 0.527 ± 0.021	0.105TrpTrp: 0.105 ± 0.009	0.361TrpTyr: 0.361 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.699TyrAla: 2.699 ± 0.048	0.597TyrCys: 0.597 ± 0.025	2.428TyrAsp: 2.428 ± 0.054	2.433TyrGlu: 2.433 ± 0.047	1.886TyrPhe: 1.886 ± 0.043	2.803TyrGly: 2.803 ± 0.049	0.779TyrHis: 0.779 ± 0.026	2.453TyrIle: 2.453 ± 0.05	2.117TyrLys: 2.117 ± 0.042	3.435TyrLeu: 3.435 ± 0.064	0.938TyrMet: 0.938 ± 0.032	1.696TyrAsn: 1.696 ± 0.038	1.491TyrPro: 1.491 ± 0.036	1.409TyrGln: 1.409 ± 0.033	1.887TyrArg: 1.887 ± 0.037	2.173TyrSer: 2.173 ± 0.041	2.286TyrThr: 2.286 ± 0.077	2.111TyrVal: 2.111 ± 0.043	0.371TyrTrp: 0.371 ± 0.017	1.692TyrTyr: 1.692 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4506 proteins (1283993 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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